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• PARP inhibitors (PARPis) increase the risk of anaemia and thrombocytopenia in patients with ovarian cancer. • Subgroup analysis highlights different risk profiles for each PARPis. • Maintenance therapy after chemotherapy elevates the risk of toxicity in patients. • More haematological averse events emerged in patients who received PARPis comapred with placebo/chemotherapy. • Clinicians should ensure regular blood monitoring during PARPis treatment. Poly (ADP-ribose) polymerase inhibitors (PARPis) are effective treatment options for patients with advanced ovarian cancer (OC). A typical adverse event (AE) of these agents is haematological toxicity, which represents the leading cause of treatment modification and discontinuation. This systematic review and meta -analysis aimed to analyse the risk of haematological AEs, including anaemia, neutropenia and thrombocytopenia due to the use of PARPis in patients with OC. This systematic review and meta -analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement. PubMed, EMBASE and Cochrane databases, and international meeting abstracts were searched systematically for clinical trials concerning the use of PARPis in patients with OC. The search deadline was 30 March 2024. The pooled incidence of all grades and grade 3or more (≥G3) anaemia, neutropenia and thrombocytopenia were analysed. Subsequently, risk ratios (RRs) were calculated for all grades and ≥G3 AEs of PARPis compared with non-PARPis from randomized controlled trials. In total, 12 phase II/III trials with olaparib, niraparib and rucaparib were included in this study. Anaemia was the most common all grade (28.8 %) and ≥G3 (12.1 %) AE. The administration of PARPis increased the risk of developing all grade anaemia [risk ratio (RR) = 2.44], neutropenia (RR = 3.15) and thrombocytopenia (RR = 4.66) significantly compared with non-PARPis. Similarly, a significant increase in the risk of ≥G3 anaemia (RR = 5.73) and thrombocytopenia (RR = 5.44), and a non-significant increase in the risk of neutropenia (RR = 3.41) were detected. In patients with advanced OC, PARPis increase the risk of haematological toxicity compared with other treatments (high-quality evidence). Clinicians should be aware of this risk and the correct management, as these drugs are highly employed in these patients. [ABSTRACT FROM AUTHOR]

Purpose: Adrenocortical carcinoma (ACC) is a rare, aggressive pediatric malignancy. Advanced ACC requires multimodal treatment, including surgery and systemic chemotherapy including cisplatin, etoposide, doxorubicin, and mitotane. This is associated with significant gastrointestinal toxicity, resulting in many patients being unable to complete scheduled therapy. Often, supplemental nutrition is required if oral intake during treatment is poor. We assessed the frequency of nutritional supplement use in pediatric patients treated for advanced ACC. Methods: This was a retrospective observational study of patients with ACC treated at St. Jude Children’s Research Hospital over 10 years (2012–2022). Patient demographics, treatment received, and the need for supplemental enteral or parenteral nutrition were reviewed. Results: A total of 18 patients with ACC were treated from 2012 to 2022, with 11 having advanced ACC. 54.5% of patients required supplemental nutrition, both enteral and parenteral. All patients requiring supplemental nutrition were intolerant of oral intake, with a mean weight loss of 13.8% (range: 5.9–35%). Mean duration of nutritional support was 362 ± 337 days. Patients requiring supplemental nutrition tended to be younger than others (mean age: 4.45 ± 3.63 vs. 9.14 ± 4.59 years; median age: 3.35 vs. 8.40 years; range: 0.90–11.0 vs. 3.30–15.1 years) (p = 0.082). Conclusions: Most patients with stage IV ACC require nutritional support during their treatment course, especially younger patients. Preemptive feeding tube placement should be considered to avoid delays in treatment. [ABSTRACT FROM AUTHOR]

The increasing age of patients with end-stage renal disease raises the issue of hostile arterial access for transplantation, with technical difficulties associated with clamping and suturing the iliac artery. Some of these patients - who theoretically represent those who would benefit the most from transplantation in terms of mortality - are contraindicated because of anatomical and medical issues. In this context, a specific endovascular device called EndoPreKiT (Endovascular Preparation for Kidney Transplantation) has been designed, enabling arterial access for transplantation via a mini-invasive procedure. It consists of a woven Dacron supported by self-expanding nitinol rings, ensuring anchorage and allowing arterial clamping. The middle part of the anterior face of the device is stentless, enabling the anastomosis directly onto the Dacron once the calcified artery wall has been removed. After a cadaveric study validating its technical feasibility, such device was successfully implanted in 10 patients considered unfit for transplantation due to severe wall calcification. Two of them have been successfully transplanted with excellent outcomes after 13 and 3 months of follow-up. EndoPreKiT device may be a significant breakthrough in transplant surgery, that could expand the horizon of eligibility to include even the most fragile patients with challenging arterial access. [ABSTRACT FROM AUTHOR]

Preference tests are commonly used to assess fish behavior and cognition in several research fields. This study aimed to investigate how fish perform in a preference test involving extended habituation to the apparatus, which was expected to reduce stress. We contrasted the choice between a sector of the apparatus with natural vegetation, expected to be the preferred stimulus, and a barren sector. Initially, we demonstrated that guppies' preference for the sector with vegetation increased after a 5‐day habituation period (Experiment 1). Subsequent experiments systematically modified the testing paradigm to observe effects on the preference. Experiment 2 introduced a physical separation between sectors to facilitate discrete choices, Experiment 3 tested groups of fish, and Experiment 4 used wild guppies. Only the modification in Experiment 3 impacted preference scores: guppies tested in groups showed a higher preference for the vegetation stimulus and spent less time in the central, no‐choice sector of the testing apparatus. Overall, this study supports the importance of methodological details in preference tests and highlights the benefits of extended habituation and group testing. Researchers should consider these factors when designing experiments to evaluate cognitive abilities or behavioral preferences in fish. Tailoring testing paradigms to specific research goals can improve the reliability and comparability of results, contributing to a deeper understanding of fish behavior and welfare. [ABSTRACT FROM AUTHOR]

Simple Summary: Uterine carcinosarcoma is a rare and aggressive cancer. This study aims to better understand the characteristics and outcomes of patients with this type of cancer by reviewing the medical records of 80 individuals treated over several years. We analysed the factors that impact on patient survival, including age, tumour size, and stage of cancer at diagnosis. Our findings emphasize the importance of early detection and tailored treatment strategies to improve UCS patients' outcomes. This research may help guide future treatment approaches for this challenging disease and provide valuable insights for healthcare professionals dealing with similar cases. Background/Objectives: Uterine carcinosarcomas (UCSs) are rare and aggressive malignancies with limited epidemiological data. This study aims to evaluate the clinical and pathological features and prognostic factors of UCS in a retrospective cohort of 80 patients, contributing to improved management strategies. Methods: We conducted a retrospective analysis of UCS cases treated from 1995 to 2024 at three institutions. Data on demographics, clinical features, histopathology, treatment, and outcomes were collected. Overall survival (OS) and prognostic factors were assessed using Kaplan–Meier and Cox proportional hazards regression analyses. Results: The median age of patients was 66 years, with a median overall survival of 34.5 months. Disease recurrence occurred in 32.5% of cases, with a median disease-free interval of 17.92 months. Age, tumour stage, and size emerged as significant predictors of survival. Stage I–II patients had a significantly better prognosis than those with Stage III–IV (HR = 0.438, p = 0.008). Tumour size >4 cm was associated with increased mortality (HR = 2.154, p = 0.019). Lymphadenectomy was not independently associated with improved survival. Adjuvant chemotherapy, mainly carboplatin and paclitaxel, was administered to 67.5% of patients, achieving a complete response in 66.67%. Conclusions: Tumour stage and age are significant independent predictors of survival in UCS, underscoring the need for early diagnosis and intervention. Tumour size is also crucial in determining prognosis. The role of lymphadenectomy remains uncertain, emphasizing the importance of individualized treatment approaches. Future research should explore molecular profiling to further refine prognostication and therapeutic strategies for this challenging malignancy. [ABSTRACT FROM AUTHOR]

Aim This article evaluates the practice patterns of European Pediatric Surgeons' Association (EUPSA) members regarding the timing of inguinal hernia (IH) repair in premature infants. Methods Online survey containing 29 questions distributed to EUPSA members during January 2023. Results A total of 180 responds were received. Overall, IH repair prior to discharge was favored by 60% of respondents when there was a history of incarceration and 56% when there was not. In the case of very/extremely premature infants (< 32 weeks) with no history of incarceration, fewer (43%) respondents postpone the surgery until after discharge. The majority of respondents cited the risk of incarceration as the reason for advocating surgery prior to discharge, whereas a reduced risk of apnea was the most cited reason for respondents who prefer delayed surgery. Open approach under general anesthesia was favored by 54% of respondents, with 27% of them preferring open approach with spinal anesthesia. Laparoscopic surgery for premature infants is used in 11% while 7% of them preferred in all premature infants including extremely/very premature ones. Contralateral side evaluation was never done by 40% of respondents and 29% only performed it only during laparoscopic repair. The majority of respondents (77%) indicated that they have an overnight stay policy for premature infants < 45 weeks of gestation. Conclusion There is variation in the practice patterns of pediatric surgeons in the treatment of IH in premature infants. Due to the concern for the high risk of incarceration, IH repair before discharge was the most prevalent practice. Lower risk of postoperative apnea was cited as the most common reason for delaying surgery. Randomized studies are required to establish the optimal timing for IH repair in premature infants. [ABSTRACT FROM AUTHOR]

Objectives: The quality of life in patients undergoing radical cystectomy and urinary diversion is gaining importance. Nowadays a broad consensus about the best urinary diversion does not exist. This study presents an all‐round analysis of the impact of two types of urinary diversion on life's psycho‐social aspects in patients undergoing radical cystectomy. Methods: This is an observational, single‐centre, prospective study. Eligible participants underwent radical cystectomy and urinary diversion for bladder cancer in our department from January 2020 and February 2024. Of 130 included patients, 90 (45 with Bricker's ureteroileocutaneostomy and 45 received orthotopic bladder replacement) patients were matched and the study groups were well balanced for the baseline‐matched variables. Patients completed 4 questionnaires (EORTC QLQ‐C30, PGWBI, HADS, PSQI) at three different times: before the surgical procedure, and at 3 and 12 months. Results: Time shows a statistically significant effect (p < 0.0005) on four of the five functional scales explored (Physical Functioning, Role Functioning, Emotional Functioning, Social Functioning), and for all the nine symptoms/items' scales (p < 0.0005) and the Global Health Status (p = 0.003) in EORTC QLQ‐C30. Neobladder's group shows a statistically significant improvement on the scales of Physical Functioning, Role Functioning, and Social Functioning, and for symptoms of nausea (p = 0.0027), pain (p = 0.0005), dyspnea (p = 0.012), insomnia (p = 0.004), constipation (p = 0.003). Conclusion: We do not find a better urinary diversion in absolute terms. Neobladder obtained better results only for specific items and features. The urinary diversion's choice must be made in concert by the patient, the caregiver, and health professionals with adequate counseling. [ABSTRACT FROM AUTHOR]

In this study, a novel solar dryer is presented and analyzed experimentally and numerically. The proposed device is a small, passive, indirect solar dryer that works in an unconventional way. The product is mainly heated by irradiation from the walls of the drying chamber, while its moisture is removed by an airflow caused by natural convection. In addition, it is a low-cost solar dryer made of readily available materials and has a variable geometry that allows it to increase its thermal performance. Two types of experimental tests were conducted to analyze its performance. Thermal tests without load were carried out to assess the suitability of the drying chamber temperatures. Load tests with various masses and types of food were carried out to evaluate its drying performance. The results of the experimental tests demonstrated that the solar dryer achieved temperatures suitable for food drying and was able to dry the tested foods. Finally, a Computational Fluid Dynamics (CFD) model was developed to predict the performance of the proposed solar dryer. The validation of the numerical model with experimental data confirms their reliability in accurately predicting the temperatures within the dryer. [ABSTRACT FROM AUTHOR]

Simple Summary: This research examines how the loss of the Y chromosome (LoY) in men may contribute to the development and progression of certain cancers, particularly in the urinary system. Traditionally, the Y chromosome was primarily associated with male sex determination and sperm production, but recent studies suggest it plays a wider role in health and disease. LoY appears to disrupt immune function and increase genetic instability, factors that may heighten cancer risk and impact treatment outcomes. Our review highlights that LoY could serve as an early indicator of certain cancers and might help predict cancer behavior. Understanding LoY's role could lead to new diagnostic tools and treatments, especially for cancers where Y chromosome alterations are linked to poorer outcomes. Background: The Y chromosome (ChrY) is essential for male sex determination and spermatogenesis. However, recent studies have revealed its broader role in various physiological processes and disease susceptibility, including cancer. Methods: A comprehensive literature review was conducted using databases like MEDLINE, Scopus, Web of Science, and Google Scholar. The review included clinical and preclinical studies in animals and humans focusing on the role of LoY in urological tumors. Data on the frequency of LoY, its clinical implications, and underlying mechanisms were extracted and analyzed. Results: The evidence suggests that LoY is associated with an increased risk of urologic neoplasms, potentially serving as an early marker of genomic instability. Studies reveal that LoY in urologic cancers correlates with worse survival outcomes and may contribute to tumor progression. LoY may interfere with chromatin structure and epigenetic regulation, suggesting its role as a contributor to early tumorigenesis. Conclusions: LoY appears to be a structural aberration with unique biological and clinical relevance in urologic cancers, possibly serving as a biomarker for genomic instability. Further research is necessary to identify specific Y-linked genes affected by LoY, potentially informing targeted therapies and early diagnostic strategies for these cancers. [ABSTRACT FROM AUTHOR]

The world of complementary and alternative medicine (CAM) encompasses a wide range of practices, treatments, and products that fall outside the realm of conventional (mainstream) medicine. The use of complementary and CAM has become increasingly popular in Western nations. People are turning to CAM for a variety of reasons, including managing chronic diseases, relieving symptoms of various conditions, and improving their overall health and well-being. There's a growing trend of people using and showing interest in complementary and alternative medicine therapies, especially in Western countries. CAM encompasses a wide range of treatments, some offering complete alternatives to conventional medicine, while others aim to complement existing medical approaches. Urologists should stay informed about CAM to guide their patients effectively to treat patients in a modern and personalized way. The aim of review is to analyze the scenario of complimentary and alternative medicine with a specific focus in the urological field. [ABSTRACT FROM AUTHOR]

It is recognized in the literature that advances in technology are one of the main mechanisms to increase technical efficiency and production with less use of inputs. However, technological advancement can also lead to increased emissions due to rebound effects or the Jevons paradox phenomenon. The purpose of this study is to evaluate the role of technology and technological spillovers in CO2 emissions. In a complementary way, the hypothesis of the inverted U-shaped relationship between CO2 emissions and industrial value added is empirically evaluated in a panel of country-sector data. Results show that both the stock of R&D and domestic R&D spillovers play a significant role in reducing CO2 levels. There is weaker evidence for foreign R&D spillovers. [ABSTRACT FROM AUTHOR]

Simple Summary: The majority of newly diagnosed prostate cancer patients are eligible for active surveillance, and those at moderate to high risk frequently receive definitive treatments such as radiotherapy or radical prostatectomy. A considerable proportion of patients will experience biochemical recurrence, as well as localized and distant metastatic recurrence following definitive treatment. Salvage cryotherapy has emerged as a safe and effective alternative for treating localized recurrence. This review examines the oncologic and functional outcomes of whole-gland and focal salvage cryotherapy, as well as the crucial role of multiparametric prostate MRI and PSMA-targeted PET imaging. The outcomes of cryotherapy compared to those of other salvage ablation techniques like high-intensity focused ultrasound (HIFU) are also explored. Prostate cancer is the most common non-cutaneous malignancy in men, with the majority of newly diagnosed patients eligible for active surveillance. Despite definitive treatment, a considerable percentage of men will experience biochemical recurrence and even regional and distant metastatic recurrence after radiation therapy or radical prostatectomy. Salvage prostatectomy, while oncologically effective, poses significant morbidity with poor functional outcomes. Salvage cryotherapy has emerged as a promising alternative for localized recurrence, demonstrating safety and efficacy. This review examines the oncologic and functional outcomes of whole-gland and focal salvage cryotherapy, including disease-free survival, cancer-specific survival, and overall survival. The crucial role of multiparametric prostate MRI and evolving role of next-generation PSMA-targeted PET imaging are also examined. The comparison of outcomes of cryotherapy to other salvage ablation modalities, such as high-intensity focused ultrasound (HIFU), is also explored. [ABSTRACT FROM AUTHOR]

A typical wind system captures wind energy and converts it into electricity, which is then converted to DC for battery storage using an AC/DC converter; an inverter then supplies AC electricity at the grid frequency. However, this solution involves losses in electronic components and incurs costs and environmental impacts associated with battery storage. To address these issues, a different wind system layout configuration is considered, where the energy storage duties are assumed by a hydro storage system employing a reversible hydraulic pump (referred to as a Pump as Turbine). This solution utilises an elevated reservoir connected to the Pump as Turbine to compensate for fluctuations in wind and load; this approach offers lower costs, a longer lifespan, reduced maintenance, and a smaller waste management cost. This study focuses on a comprehensive sensitivity analysis of the new wind system power layout, considering multiple objectives. Specifically, the analysis targets the net change in the mass of water (potential energy) stored in the pumped hydro system, the captured wind energy, and the torque provided in hydraulic turbine mode. On the other hand, the design variables are represented by the Pump as Turbine-specific speed, the hydraulic system gearbox ratio, and the pump head. To assess how solutions are affected by random changes in wind speed and external load, the sensitivity analysis considers the multi-objective optimisation problem showing for both the wind speed and the external load a stochastic contribution. [ABSTRACT FROM AUTHOR]

Coridothymus capitatus is a perennial herb with aromatic leaves and flowers, distinct from Thymus vulgaris in its chemical composition, resulting in a unique Thymus Essential Oil (TEO). A main component of TEO, carvacrol, is known for its antimicrobial and insecticidal activity. Carvacrol has potent antibacterial, antioxidant, anti-inflammatory, and antifungal properties, generating interest in traditional medicine. However, studies on its antiviral activity are limited. Given the rise in viral infections and limitations of synthetic antiviral drugs, natural antiviral agents are promising due to their efficacy, lower resistance development, and reduced side effects. This study assessed the antiviral efficacy of TEO compared to that of pure carvacrol. We tested various viruses, revealing significant inhibitory effects of TEO on the replication of only Simplexvirus humanalpha1 (HSV-1) and Simplexvirus humanalpha2 (HSV-2), with specific interference during the early stages of the viral replication cycle after the adsorption period. TEO exhibited inhibitory effects at doses below the cytotoxic threshold, with IC50 values of 47 μg/mL for HSV-1 and 40 μg/mL for HSV-2. Maximum virus inhibition was achieved when TEO was added within 90 min post-infection, indicating interference with early viral replication steps. These findings highlight the potential of TEO as a natural antiviral agent and suggest further research into its mechanisms and clinical applications. [ABSTRACT FROM AUTHOR]

The incidence of bladder cancer (BC) depends on advancing age and other risk factors, significantly impacting on surgical, functional and oncological outcomes. Radical cystectomy (RC) with urinary diversion is the gold standard therapy for muscle invasive bladder cancer; however, it remains a complex surgery and requires careful analysis of risk factors in order to potentially decrease post-surgical complication rates. Age in surgery is a limiting factor that can modify surgical and oncological outcomes, and is correlated with a high rate of post-dimssion hospital readmissions. The reconstruction of the bladder with the intestine represents a crucial point of radical cystectomy and the urinary derivation (UD) is at the center of many debates. A non-continent UD seems to be the best choice in elderly patients (>75 years old), while orthotopic neobladder (ON) is poorly practiced. We reviewed the literature to identify studies reporting outcomes, complications, patient- selection criteria, and quality-of-life data on elderly patients, who underwent ON following radical cystectomy. Reviewing the literature there is no clear evidence on the use of age as an exclusion criterion. Certainly, the elderly patient with multiple comorbidities is not eligible for ON, preferring other UD or rescue therapies. A careful preoperative selection of elderly patients could greatly improve clinical, surgical and oncological outcomes, giving the chance to selected patients to receive an ON. [ABSTRACT FROM AUTHOR]

This study presents a simple correlation for describing the temperature and pressure dependence of the liquid dynamic viscosity of low GWP refrigerants, namely HydroFluoroOlefins (HFOs) and HydroChloroFluoroOlefins (HCFOs). The model has 3 input parameters (i.e., reduced temperature, reduced pressure, and acentric factor) and 6 coefficients which were regressed on 794 experimental data collated from the literature for 7 alternative refrigerants (i.e., R1233zd(E), R1234yf, R1234ze(E), R1234ze(Z), R1224yd(Z), R1336mzz(E), and R1336mzz(Z)). Moreover, a multi-layer perceptron neural network for the liquid dynamic viscosity of the studied fluids was developed from the selected dataset. The artificial network has the same 3 input parameters of the correlation and one hidden layer with 19 neurons. The results of the proposed correlation proved that it is an accurate model for calculating the dynamic viscosity of the studied liquid refrigerants, despite its simplicity. It ensured an average absolute relative deviation of the liquid dynamic viscosity (AARD(η)) of 2.88 %, lower than that given by other literature correlations. As expected, the multi-layer perceptron neural network provided the best results for all the selected refrigerants (AARD(η) = 0.86 % for the complete dataset), proving that it can be considered a reference for the development of other models. [ABSTRACT FROM AUTHOR]

In guava (Psidium guajava), the impact of self-pollination on the quantitative traits of the fruits is not fully understood, necessitating further investigation. This study aimed to estimate the effects of selfing on fruit traits in S1 and S2 inbred families of guava and to explore potential impacts on genetic diversity. Eighteen S1 families were generated through selfing of progenies from biparental crosses, and ten S2 families were produced by selfing superior genotypes from S1 families. The experiment was conducted at the Experimental Station of Ilha Barra do Pomba, in the municipality of Itaocara-Rio de Janeiro, Brazil. It utilized a randomized complete block design, with three replications and ten plants per plot. Evaluated traits included fruit weight, length, diameter, length-diameter ratio, endocarp thickness, mesocarp thickness, pulp weight, and soluble solids content. The data underwent individual analysis of variance, yielding predicted mean trait values for S1 and S2 generations, alongside correlation and homozygosity estimates. Genetic diversity was assessed using Mahalanobis distance and UPGMA cluster analysis, and comparative box plots between inbred populations were created for the evaluated traits. Box plot analysis revealed symmetry in most evaluated traits, suggesting uniformity in the data due to the selfing strategy. Analysis of variance indicated statistically significant differences in all traits, highlighting variability between populations S1 and S2. Fruit and pulp weights exhibited high homozygosity levels, with values of 90.86 and 102.59 respectively, linked to increased fruit traits in the S2 population, indicating their importance in the fixation of favorable alleles. Fruit weight, length, and diameter, endocarp thickness, and mesocarp thickness showed strong correlations, exceeding 0.70. Genetic diversity assessment via Mahalanobis distance indicated a decrease in genetic variability, evidenced by fewer groups in S2 compared to the S1 population. However, this reduction did not noticeably affect the average performance of the S2 population. The results indicate that the two generations of self-pollination did not negatively affect the phenotypic values of the evaluated traits. [ABSTRACT FROM AUTHOR]

Objective: Rare disease Background: Gallbladder anomalies are rare congenital defects with an incidence rate of approximately 2% in the general population. Phrygian cap gallbladder is a common anatomical variant in which the fundus of the gallbladder folds on itself. Gallstone impaction is rare, and it can be associated with acute pancreatitis. This report describes a 42-year-old woman with recurrent pancreatitis associated with gallstones and Phrygian cap gallbladder. Case Report: We report the case of a 42-year-old woman with acute biliary pancreatitis and a history of repeated hospitalizations for episodes of pancreatitis. A preoperative MRI was conducted, which revealed the presence of a Phrygian cap gallbladder that had not been previously reported in imaging studies. The patient underwent cholecystectomy surgery with a laparo-endoscopic approach (rendezvous technique). No intra-or postoperative complications occurred. Conclusions: We report a case of acute biliary pancreatitis caused by stone migration and describe the anatomical variant of the Phrygian cap gallbladder with its clinical implications. The literature contains very few reports of cholecystitis or pancreatitis in patients with a gallbladder anomaly. Continuous reporting of anatomical variations of the gallbladder and biliary tract improves clinical knowledge, and knowledge of gallbladder anomalies is crucial to avoid injury to the biliary tract during laparoscopic cholecystectomy. This case emphasizes the importance of accurate preoperative evaluation to prevent serious surgical complications. [ABSTRACT FROM AUTHOR]

The aim of this study was to develop a sustainable electromagnetic prototype to detect the interior deterioration of walls in buildings in order to mitigate uncertainty as it is a challenge to observe the interior state of walls without utilising destructive procedures. The method used was experimental, developmental and quantitative in its approach. The inductance, electric current, modulated frequency and power of the electromagnetic field were used to penetrate the constructed specimens, which were built of materials such as concrete, brick, adobe, plaster and fine sand and had walls with a thickness of less than 300 millimetres. The results show that the optimum value of the magnetic field was 0.18 µT, which was sufficient to penetrate 150 mm with densities between 1.0 and 2.4 g/cm3 and porosities between 11 and 60%. The current and wave each had a coefficient of determination R2 = 0.8914, and the average inductance value was 184 µH, which was established with an air core of radius 9.75 cm and with 19 turns with AWG-25 wire. The frequency-modulated signal ranged in the audible zone between 10 and 22 kHz. The presented prototype detects the interior deterioration of the walls of the building, and the signal is reflected on a metallic guide on the opposite side of the wall with a reading error of 5%. The use of this prototype does not represent a risk to the operator or the environment. [ABSTRACT FROM AUTHOR]

Background This study aimed to quantify the blood flow of free flaps and compare the blood flow of small vessel (<0.8 mm) and larger vessel (>0.8 mm) anastomosed free flaps. Methods This retrospective study included patients treated successfully with a perforator free flap in the lower extremity between June 2015 and March 2017. A color duplex ultrasound system measured the flow volume through the pedicle by analyzing the mean flow peak velocity, flow volume, and flow volume per 100 g of the flap. Results A total of 69 patients were enrolled in this study. There was no statistical difference in peak velocity between the small vessel anastomosed free flap (25.2 ± 5.6) and larger vessel anastomosed free flap (26.5 ± 5.4). Flow volume (6.8 ± 4.2 vs. 6.3 ± 3.6) and flow volume/100 g (3.6 ± 3.9 vs. 6.2 ± 6.9) also did not show significant differences. Conclusion Small vessel (<0.8 mm) free flaps showed similar flow velocity and flow volume to larger vessel (>0.8 mm) anastomosed free flaps. Blood flow to the small vessel anastomosed free flap was sufficient despite its small vessel size. [ABSTRACT FROM AUTHOR]

The paper presents a novel optimization framework aimed at the minimization of seismic retrofitting-related costs for existing unreinforced masonry building structures. The framework provides topology optimization of reinforcements (reinforced plasters) to implement in masonry walls for the accomplishment of seismic safety checks under the reference seismic load combinations. Optimization is carried out by a genetic algorithm (GA) developed in MATLAB®, which controls a 3D finite element equivalent frame model of the masonry structure developed in OpenSees. The GA routine iterates the reinforcement configurations employing specific genetic operators. The feasibility of each candidate retrofitting solution is assessed by performing in-plane shear and flexural safety checks of masonry walls. The framework is finally tested with a case study masonry structure supposed to be made of average-quality or poor-quality masonry. Results will show that the proposed framework can effectively provide the minimization of seismic retrofitting costs for existing masonry structures, giving as output the optimal configuration of the reinforcements within the structural layout. [ABSTRACT FROM AUTHOR]

Coffee leaf rust, caused by the fungus Hemileia vastatrix , has become a major concern for coffee-producing countries. Additionally, there has been an increase in the resistance of certain races of the fungus to fungicides and breeding cultivars, making producers use alternative control methods. In this work, we transplanted the leaf surface microbiota of rust-resistant coffee species (Coffea racemosa and Coffea stenophylla) to Coffea arabica and tested whether the new microbiota would be able to minimize the damage caused by H. vastatrix. It was seen that the transplant was successful in controlling rust, especially from C. stenophylla , but the protection depended on the concentration of the microbiota. Certain fungi, such as Acrocalymma, Bipolaris, Didymella, Nigrospora, Setophaeosphaeria, Simplicillium, Stagonospora and Torula , and bacteria, such as Chryseobacterium, Sphingobium and especially Enterobacter , had their populations increased and this may be related to the antagonism seen against H. vastatrix. Interestingly, the relative population of bacteria from genera Pantoea, Methylobacterium and Sphingomonas decreased after transplantation, suggesting a positive interaction between them and H. vastatrix development. Our findings may help to better understand the role of the microbiota in coffee leaf rust, as well as help to optimize the development of biocontrol agents. [ABSTRACT FROM AUTHOR]

Spectral indexes are tools widely used to analyze the composition of planetary surfaces. Many indexes have been formulated over the years to map the lunar surface, but there is no unified database for them. In this work we describe an Open‐Source Python package called MoonIndex, that recreates 38 indexes compiled from the literature, using data from the Moon Mineralogy Mapper (M3). The processing started with the filtering of the data cubes to reduce the noise, the continuum of the spectrum was then removed using a convex hull or a second‐and‐first‐order fit method. Later, the indexes were calculated, following as possible the original formulations. The results on spectral indexes calculated before the continuum removal were similar to those of the original formulations. Conversely, the results obtained for spectral indexes calculated after the continual removal were not always coherent. Some indexes, like the band depth, are especially sensitive to the removal method, as well as the derived band areas and asymmetries. We also recreated RGB composite maps, our results highlight the compositional patterns in a similar way as the ones in the literature, even if the color ramps can differ. The products of MoonIndex are open, ready for interpretation, versatile, consistent, and cross‐comparable. Plain Language Summary: Spectral indexes are parameters defined from the characteristics of reflectance spectra, and they are useful to investigate the spectral properties of a surface and to retrieve mineralogical properties of a planetary body. They can reveal the presence of specific minerals in rocks, indicate mineralogical variations from different units, highlight physical properties of a surface, or show the effect of the exposure to the space environment. For the Moon, several spectral indexes have been formulated over time using data from many spacecraft, but no unified database is available. In this work, we created an open‐source Python package called MoonIndex, which recreates 38 indexes to study the lunar surface. The indexes were collected from the literature, and our results achieved various levels of fidelity. Some of the indexes we calculated exactly reproduce those found in the literature, while in other cases, index calculations differ due to processing constraints or due to missing information in the original formulations, such as the continuum removal method used, or the band operations conducted to create the indexes. MoonIndex is a reliable and versatile tool to approach the compositional analysis of the lunar surface. Key Points: MoonIndex is an open‐source tool that successfully recreates spectral indexes for the Moon taken from the literatureThe continuum‐removal method has a major impact in the resulting indexes, so its selection should be considered when interpreting the dataThe indexes obtained with MoonIndex are consistent whit the results of previous authors, which usually used licensed software [ABSTRACT FROM AUTHOR]

Simple Summary: The role of neurogenic locus notch homolog protein 1 (NOTCH1)- and nuclear factor erythroid 2-related factor 2 (NRF2)-related pathways is highly heterogeneous in small cell lung cancer (SCLC) and, when they are both abnormally activated, they can synergistically cause neoplastic proliferation. In this paper, we investigate the possible role of KEAP1 silencing in NRF2 and NOTCH axis deregulation in SCLC by evaluating its impact on the modulation of cellular defense systems, cell growth, and differentiation. We also investigate the impact of these systems' impairment in response to conventional chemotherapies and NOTCH inhibitors in silenced SCLC cell lines with different Kelch-like ECH-associated protein 1 (KEAP1) alterations. The KEAP1/NRF2 pathway is a master regulator of several redox-sensitive genes implicated in the resistance of tumor cells against therapeutic drugs. The dysfunction of the KEAP1/NRF2 system has been correlated with neoplastic patients' outcomes and responses to conventional therapies. In lung tumors, the growth and the progression of cancer cells may also involve the intersection between the molecular NRF2/KEAP1 axis and other pathways, including NOTCH, with implications for antioxidant protection, survival of cancer cells, and drug resistance to therapies. At present, the data concerning the mechanism of aberrant NRF2/NOTCH crosstalk as well as its genetic and epigenetic basis in SCLC are incomplete. To better clarify this point and elucidate the contribution of NRF2/NOTCH crosstalk deregulation in tumorigenesis of SCLC, we investigated genetic and epigenetic dysfunctions of the KEAP1 gene in a subset of SCLC cell lines. Moreover, we assessed its impact on SCLC cells' response to conventional chemotherapies (etoposide, cisplatin, and their combination) and NOTCH inhibitor treatments using DAPT, a γ-secretase inhibitor (GSI). We demonstrated that the KEAP1/NRF2 axis is epigenetically controlled in SCLC cell lines and that silencing of KEAP1 by siRNA induced the upregulation of NRF2 with a consequent increase in SCLC cells' chemoresistance under cisplatin and etoposide treatment. Moreover, KEAP1 modulation also interfered with NOTCH1, HES1, and DLL3 transcription. Our preliminary data provide new insights about the downstream effects of KEAP1 dysfunction on NRF2 and NOTCH deregulation in this type of tumor and corroborate the hypothesis of a cooperation of these two pathways in the tumorigenesis of SCLC. [ABSTRACT FROM AUTHOR]

Motivated by the requirement of a refined and flexible treatment of electroweak corrections to the neutral current Drell–Yan process, we report on recent developments on various input parameter/renormalization schemes for the calculation of fully differential cross sections, including both on-shell and M S ¯ schemes. The latter are particularly interesting for direct determinations of running couplings at the highest LHC energies. The calculations feature next-to-leading order precision with additional higher order contributions from universal corrections such as Δ α and Δ ρ . All the discussed input parameter/renormalization scheme options are implemented in the package of POWHEG-BOX-V2 dedicated to the neutral current Drell–Yan simulation, i.e. Z_ew-BMNNPV, which is used to obtain the presented numerical results. In particular, a comprehensive analysis on physical observables calculated with different input parameter/renormalization schemes is presented, addressing the Z peak invariant mass region as well as the high energy window. We take the opportunity of reporting also on additional improvements and options introduced in the package Z_ew-BMNNPV after svn revision 3376, such as different options for the treatment of the hadronic contribution to the running of the electromagnetic coupling and for the handling of the unstable Z resonance. [ABSTRACT FROM AUTHOR]

This study determined the implications of strengthening community mobilization programs for building police community relations in Batangas Province and utilized a descriptive-quantitative approach with the use of a self-constructed questionnaire based on the parameters of PRO 4A MC No. 2017-02. A total of 392 respondents (15 PCADU personnel and 377 residents from the 13 certified mobilized barangays of Bauan, Batangas) were chosen as the respondents of the study through stratified proportional sampling. The data was gathered two weeks before it was completed and treated with statistical tools such as percentage, weighted mean, and independent t-test. The study revealed that most of the police personnel are Police Corporal, under 5 years in PCADU, and have acquired PCAD Course, Online PCAD Executive Course, and Preparedness Search and Rescue and Relief Operation Seminar. Meanwhile, majority of the community members belong to the middle class, businessman, and live in a rural community. Moreover, the majority of PCADU personnel described CMPs in terms of community organization, community information and education, community empowerment and mobilization, and certification of mobilized barangays as always implemented, with weighted mean of 3.24, 3.23, 3.25, and 3.27, respectively, while the community members described them as often implemented, with weighted mean of 3.18, 3.17, 3.19, and 3.21, respectively. Majority of the respondents strongly agreed on the effects of strengthening CMPs, with weighted mean of 3.29 and 3.23, respectively. The output of the study is a proposed input to help improve the sustainability of CMPs in Batangas Province based on the least-rated items. [ABSTRACT FROM AUTHOR]

Simple Summary: The dramatic improvement in the prognosis of patients with advanced epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) became possible thanks to the advent of EGFR-tyrosine kinase inhibitors (EGFR-TKIs). In a subgroup of EGFR mutations, known as uncommon (ucEGFRmuts) and rare, NSCLC-mutated patients show, most of the time, lower EGFR-TKIs sensitivity than most common mutations, making this a great clinical point of discussion. Here, we summarized recent data about EGFR exon 20 insertion-positive NSCLC patients and Phase 3 trials ongoing, with a specific focus on the PAPILLON study. Uncommon (ucEGFRmuts) and rare epidermal growth factor receptor (EGFR) mutations account for 10–15% of diagnosed cases and consist of a heterogeneous group represented by several clusters within exons 18–21 (e.g., exon 18 point mutations, exon 21 L861X, exon 20 S768I), as well as exon 20 insertions (Ex20ins). Their incidence is under molecular and clinical investigation following recent findings that reported an increase of sensitivity and specificity of next-generation sequencing (NGS) methods. Consequently, their detection allows for the selection of emerging treatment options to significantly improve patients' outcomes in these particular subgroups of EGFR-mutated advanced non-small cell lung cancer (NSCLC). Specifically, this commentary is focused on the notable progress of the Phase 3 PAPILLON study that showed primary efficacy results from amivantamab, a bispecific antibody with specific binding and affinity to extracellular domains of EGFR and MET, plus chemotherapy in the first-line setting for EGFR exon 20 insertion–mutated advanced or metastatic NSCLC patients, as compared with chemotherapy alone, thus becoming the new standard of care in this group of patients. [ABSTRACT FROM AUTHOR]

Net erosion recorded in lithological columns of hundreds of wells from the proximal domain of the Sergipe-Alagoas Basin was quantified through palaeoburial indicators: transit time sonic logs (DT) and vitrinite reflectance profiles (VRe). The preferred determinations with DT logs of pelitic rocks compound a large database and are less subject to variations in sampling and laboratory procedures. The sonic log profiles of 485 wells have been used for the calculation of the net erosion grid, while just 60 VRe profiles have been used for this purpose. Net erosion varies typically from 100 to 700 m in the Sergipe Sub-basin to the south, probably as a result of isostatic compensation to the sedimentary loads of the post-rift stratigraphic sequences. The Alagoas Sub-basin to the north stands as the most eroded. The average net erosion in the Alagoas SB is around 750 m but reaches more than 1,200 m in the north. The main cause of the erosion of the syn-rift strata in the Alagoas SB is probably the long-time sub-aerial exposure of uplifted rift flanks. Late Albian tectonic inversion, focused on northern Alagoas SB, enhanced erosion as evidenced in seismic sections, especially those parallel to the coast. [ABSTRACT FROM AUTHOR]

Mast cells (MCs) are derived from hematopoietic progenitors, mature in vascularized tissues, and participate in innate and acquired immunity. Neuroinflammation is a highly debated topic in the biomedical literature; however, the impact of tumor necrosis factor (TNF) and IL-33 on MCs in the brain has not been widely addressed. MCs can be activated by IgE binding to FcεRI, as well as by different antigens. After activation, MCs mediate various immunological and inflammatory responses through TNF and IL-33. TNF has two receptors: TNFR1, a p55 molecule, and TNFR2, a p75 molecule. This cytokine is the only one of its kind to be stored in the granules of MCs and can also be generated by de novo synthesis via mRNA. In the central nervous system (CNS), TNF is produced almost exclusively by microglial cells, neurons, astrocytes, and, minimally, by endothelial cells. After its release into brain tissue, TNF rapidly induces the adhesion molecules endothelial leukocyte adhesion molecule 1 (ELAM-1), intercellular adhesion molecule 1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1) in endothelial cells. TNF causes the chemoattraction of neutrophils by inducing several molecules, including CXC chemokines (IL-8). Both MCs and microglial cells act as a primary barrier against foreign molecules in the CNS, producing pro-inflammatory cytokines such as IL-33. IL-33 belongs to the IL-1 family, is activated through the ST2L/IL1-RAcP receptor complex, and mediates both the innate and adaptive immune response. IL-33 is a nuclear transcription factor expressed in the brain, where it induces pro-inflammatory cytokines (TNF and IL-1) and chemokines (CCL2, CCL3, CCL5, and CXCL10). Therefore, MCs and microglia in the CNS are a source of pro-inflammatory cytokines, including TNF and IL-33, that mediate many brain diseases. The inhibition of TNF and IL-33 may represent a new therapeutic approach that could complement existing neuroinflammatory therapies. [ABSTRACT FROM AUTHOR]

The massive adoption of social networks increased the need to analyze users' data and interactions to detect and block the spread of propaganda and harassment behaviors, as well as to prevent actions influencing people towards illegal or immoral activities. In this paper, we propose HURI, a method for social network analysis that accurately classifies users as safe or risky, according to their behavior in the social network. Specifically, the proposed hybrid approach leverages both the topology of the network of interactions and the semantics of the content shared by users, leading to an accurate classification also in the presence of noisy data, such as users who may appear to be risky due to the topic of their posts, but are actually safe according to their relationships. The strength of the proposed approach relies on the full and simultaneous exploitation of both aspects, giving each of them equal consideration during the combination phase. This characteristic makes HURI different from other approaches that fully consider only a single aspect and graft partial or superficial elements of the other into the first. The achieved performance in the analysis of a real-world Twitter dataset shows that the proposed method offers competitive performance with respect to eight state-of-the-art approaches. [ABSTRACT FROM AUTHOR]

Neuroblastoma (NB) is the most frequent paediatric extracranial solid tumour. The surgical management of these tumours in newborns changed recently, performing resections in cases with tumour size increase after birth. Minimally invasive procedures were mostly reported in cases without pre-operative image-defined risk factors (IDRFs), defined by vascular and organ involvement. Thoracoscopic resection represents a minority of the overall surgical procedures for neuroblastic tumour management, as the posterior mediastinum is one of the least frequent locations of NB. A thoracoscopic resection was performed on a 22-month-old child with a NB encasing the aorta and a 6-month-old child with the encasement of the left subclavian and vertebral artery. A step-by-step minimally invasive procedure was described, highlighting anatomical landmarks and dissection techniques. The described technique was performed in 130 min. Thoracoscopic resection provided a macroscopic resection without surgical complications and patient was discharged on the 3rd post-operative day. The study shows a feasible and safe thoracoscopic approach for paediatric thoracic NB with IDRFs. [ABSTRACT FROM AUTHOR]

Objective: The combination of immune checkpoint inhibitors (ICIs) plus chemotherapy is currently being tested as the first‐line treatment of advanced endometrial. We aimed to evaluate the efficacy and safety of this combination. Design: We performed a meta‐analysis of randomized clinical trials. Population and setting: Patients with advanced endometrial carcinoma receiving ICIs plus chemotherapy in the experimental arm, compared with chemotherapy plus placebo in the control arm, were included. Methods and Outcomes: We evaluated the progression‐free survival (PFS) as an efficacy outcome and the number and grades of adverse events (AEs) for safety. Hazard ratios (HR) for PFS and risk ratios (RR) for AEs, with 95% confidence intervals (CI), were calculated. Results: 1303 patients were treated in the included studies. Adding ICIs to chemotherapy significantly improved PFS in mismatch repair deficient (dMMR—HR 0.29; 95% CI, 0.20–0.42; p < 0.00001) and in mismatch repair proficient (pMMR—HR 0.64; 95% CI, 0.46–0.90; p = 0.01) patients. No difference emerged for all‐grades AEs (RR 1.00; p = 0.98), but the risk of ≥G3 AEs was increased in the ICIs + chemotherapy group (RR 1.22; 95% CI, 1.11–1.34; p < 0.0001). Conclusions: Adding ICIs to chemotherapy significantly improves PFS in first‐line endometrial cancer, regardless of MMR status. [ABSTRACT FROM AUTHOR]

Introduction: Over the years, congenital lung malformations (CLM) management remains a controversial topic in pediatric thoracic surgery. The Italian Society of Pediatric Surgery performed a national survey to study the current management variability among centers, trying to define national guidelines and a standardized approach of children with congenital lung malformations. Methods: Following a National Society approval, an electronic survey including 35 items on post-natal management was designed, focusing on surgical, anesthesiology, radiology and pneumology aspects. The survey was conducted contacting all pediatric surgical units performing thoracic surgery. Results: 39 pediatric surgery units (97.5%) participated in the study. 13 centers (33.3%) were classified as high-volume (Group A), while 26 centers (66.7%) were low volume (Group B). Variances in diagnostic imaging protocols were observed, with Group A performing fewer CT scans compared to Group B (p = 0.012). Surgical indications favored operative approaches for asymptomatic CLM and pulmonary sequestrations in both groups, while a wait-and-see approach was common for congenital lobar emphysema. Surgical timing for asymptomatic CLM differed significantly, with most high-volume centers operating on patients younger than 12 months (p = 0.02). Thoracoscopy was the preferred approach for asymptomatic CLM in most of centers, while postoperative long-term follow-up was not performed in most of the centers. Conclusion: Thoracoscopic approach seems uniform in asymptomatic CLM patients and variable in symptomatic children. Lack of uniformity in surgical timing and preoperative imaging assessment has been identified as key areas to establish a common national pattern of care for CLM. [ABSTRACT FROM AUTHOR]

Celiac disease (CD) is frequently associated with other autoimmune disorders. Different studies have explored the association between CD and single autoimmune endocrine disease (AED), especially autoimmune thyroiditis (AIT) and type-1 diabetes mellitus (T1DM). Data about CD as a component of autoimmune polyendocrine syndrome (APS) are scant. We analyzed a large dataset including prospectively collected data from 920 consecutive adult CD patients diagnosed in a third-level Italian institution in the 2013–2023 period, The prevalence of isolated autoimmune endocrine diseases and APS were collected. A total of 262 (28.5%) CD patients had at least one associated AED, with AIT (n = 223, 24.2%) and T1DM (n = 27, 2.9%) being the most frequent conditions. In most cases (n = 173, 66%), AEDs were diagnosed after CD. Thirteen patients (1.4%) had at least two of the requested three endocrinopathies, satisfying the diagnosis of APS. APS is a rare but not exceptional occurrence among Italian CD patients, underscoring the intricate and multifaceted nature of autoimmune disorders. Periodic evaluations of thyroid function and glycaemia should be recommended after the diagnosis of CD together with testing for autoantibodies that may be helpful in assessing disease risk before disease onset. Likewise, implementation of a systematic screening for CD amongst T1DM and other autoimmune endocrine diseases are paramount. [ABSTRACT FROM AUTHOR]

Introduction: Over the years, congenital lung malformations (CLM) management remains a controversial topic in pediatric thoracic surgery. The Italian Society of Pediatric Surgery performed a national survey to study the current management variability among centers, trying to define national guidelines and a standardized approach of children with congenital lung malformations. Methods: Following a National Society approval, an electronic survey including 35 items on post-natal management was designed, focusing on surgical, anesthesiology, radiology and pneumology aspects. The survey was conducted contacting all pediatric surgical units performing thoracic surgery. Results: 39 pediatric surgery units (97.5%) participated in the study. 13 centers (33.3%) were classified as high-volume (Group A), while 26 centers (66.7%) were low volume (Group B). Variances in diagnostic imaging protocols were observed, with Group A performing fewer CT scans compared to Group B (p = 0.012). Surgical indications favored operative approaches for asymptomatic CLM and pulmonary sequestrations in both groups, while a wait-and-see approach was common for congenital lobar emphysema. Surgical timing for asymptomatic CLM differed significantly, with most high-volume centers operating on patients younger than 12 months (p = 0.02). Thoracoscopy was the preferred approach for asymptomatic CLM in most of centers, while postoperative long-term follow-up was not performed in most of the centers. Conclusion: Thoracoscopic approach seems uniform in asymptomatic CLM patients and variable in symptomatic children. Lack of uniformity in surgical timing and preoperative imaging assessment has been identified as key areas to establish a common national pattern of care for CLM. [ABSTRACT FROM AUTHOR]

The article is a review of a book that addresses the phenomenon of countertransference in psychoanalysis. The authors use clinical vignettes to illustrate concepts and highlight the importance of understanding and specifying countertransference in clinical practice. Different clinical situations are explored, such as early traumas, eating disorders, and psychotic functioning, and the importance of the clinician's sensitivity and self-awareness is emphasized. The different tasks of the analyst are also mentioned, and questions about clinical mechanisms are raised. [Extracted from the article]

During 2022, a field survey and rescue archaeological excavations of dry-stone wall structures were conducted on Mačjak hill above Prtljug cove on the western side of the island of Ugljan. The research provided insight into the historical landscape, revealing various types of drystone structures categorized as walls, shelters, folds, and structures of unknown purpose. Based on a comparative analysis of historical, topographical, and cartographic data, the paper analyses the formation of the historic landscape, which is dominantly impacted by livestock land use. Through the example of the research results, the paper also highlights the archaeological features of pastoral open-air sites in the Adriatic karst environment. [ABSTRACT FROM AUTHOR]

This paper examines a collection of pottery and glass finds recovered during non-professional excavations conducted in 1989 on the ground floor of a building at Mile Magdića Street 8 (c.p. 584) in Senj. The pottery consists primarily of numerous fragments of amphorae and a smaller quantity of tableware, predominantly from the late antique period. Some of the finds, however, can be attributed to the significantly later period of the 15th-17th centuries, including kitchen and glazed tableware, as well as a single glass goblet. Although information on the stratigraphic context of the finds is incomplete, the finds are very significant because they provide new topographic data that enhance our understanding of the archaeological stratigraphy and topography of the southern part of Senj's historic core. Moreover, they shed light on trade contacts and the circulation of objects during the represented periods. [ABSTRACT FROM AUTHOR]

Objective: To identify perceptions of primary care health professionals regarding the conceptual aspects of child development and propose strategies to address difficulties. Methods: This descriptive-analytical study was conducted in a small municipality in the countryside of the State of São Paulo, Brazil. The primary health care in this region is comprised of Family Health Units and Basic Health Units. The sample included 52 participants, consisting of doctors and primary care nurses. A questionnaire with open and closed questions was utilized, covering knowledge and practices related to child development. For this study, the first question of the questionnaire, which asked for a descriptive response about participants’ understanding of child development, was employed. The responses were transcribed, and content analysis using the thematic approach was conducted. Results: Among the participants, 54% were nurses, and the average duration of working with the pediatric population was ten years. 80% reported never having undergone training in child development. The analysis of the responses revealed heterogeneity in the professionals’ understanding of the conceptual dimension of child development. Additionally, there was an insufficient grasp of the theoretical and practical aspects and a scarcity of resources to support comprehensive care for children. A predominant biomedical model focusing on disease and biological aspects of child health was evident in defining the understanding of the subject. Conclusions: The findings underscore the necessity of implementing health education initiatives and service projects in primary care settings. It is crucial to strengthen a comprehensive perspective of child health within the biopsychosocial model of the health-disease process. [ABSTRACT FROM AUTHOR]

The estimate of precipitation from satellite measurements is an indirect estimate if compared to rain gauges or disdrometer measurements, but it has the advantage of complete coverage over oceans, mountainous regions, and sparsely populated areas where other sources of precipitation data (e.g., weather radar) are unavailable or unreliable. Among the satellite-based precipitation estimates, geostationary (GEO) data ensure the highest spatial and temporal resolution. At the same time, the IR/VIS channels deployed on GEO satellites have lower capabilities than microwave (MW) channels in characterizing the cloud structure. Machine learning (ML) techniques can be considered a powerful tool to overcome the limitations related to the physical relationship between IR/VIS channels and precipitation estimation. This study describes the development of a convolutional neural network (U-Net) to retrieve the precipitation rate using IR measurements only from the Meteosat Second Generation (MSG) satellite. Its performances are evaluated through a comparison with H SAF and NASA operational products (e.g., H60B or H03B and IMERG-E, respectively), of which the algorithms are based on different principles. The results highlight a lower error in precipitation rate estimates for the U-Net with respect to the other products but also some issues in correctly estimating the more intense precipitation (>5 mmh−1). On the other hand, the precipitation detection capabilities of the U-Net outperform the H SAF products for lower precipitation rate, while IMERG-E shows the best performance regardless of the precipitation regime. Furthermore, the U-Net is able to account for and correct the parallax displacement that affects the measurement as the satellite viewing angle increases. [ABSTRACT FROM AUTHOR]

Background: Hemicellulose extraction from lignocellulosic biomasses has gained interest over the years, and hydrothermal treatment is one of the most common methods employed for this purpose. This work aimed to deeply study hazelnut (Corylus avellana L.) shells as a new source of dietary fibre, evaluating the effect of hydrothermal treatment temperatures on the type and structure of fibre extracted, but also on the formation of side‐products derived from lignocellulose degradation. Results: Different process temperatures led to diverse polysaccharides in the hydrothermal extract. Pectin was identified for the first time in hazelnut shells when experimenting with extraction at 125 °C, whereas at 150 °C a heterogeneous mixture of pectin, xylan, and xylo‐oligosaccharides was present. The highest yield in terms of total fibre was gained at 150 and 175 °C, and then decreased again at 200 °C. Finally, more than 500 compounds from different chemical classes were putatively identified and they appeared to be present in the extracted fibre with a different distribution and relative amount, depending on the heat treatment severity. A generally high content of phenols, phenyls, oligosaccharides, dehydro‐sugars, and furans was observed. Conclusions: Modulation of the hydrothermal treatment temperature allows fibre extracts with very different compositions, and therefore different potential end uses, to be obtained from hazelnut shells. A sequential temperature‐based fractionation approach, as a function of the severity of the extraction parameters, can also be considered. Nevertheless, the study of the side‐compounds formed from lignocellulosic matrix degradation, as a function of the applied temperature, needs to be fully addressed for a safe introduction of the fibre extract within the food chain. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry. [ABSTRACT FROM AUTHOR]

The article discusses the importance of publishing in the field of medicine and academia. It explores the phrase "publish or perish" and its prevalence in various disciplines. The authors argue that publishing is essential for staying up-to-date with the latest research and improving patient care. However, they also acknowledge that there are negative aspects to the pressure to publish, such as unethical practices and the focus on quantity over quality. The article suggests that online access and social media can be valuable tools for disseminating research. [Extracted from the article]

This article explores the applications and potential health benefits of probiotics, focusing on their role in promoting a balanced gut microbiome. The research on probiotics began in the 20th century with the work of Elie Metchnikoff, who suggested that consuming lactic acid bacteria could confer health benefits by modulating the gut microbiota. Recent advancements in technology have allowed for the discovery of strains that could be beneficial for humans and animals. Probiotics have shown promise in modulating the immune system, managing gastrointestinal disorders, improving metabolic health, and even impacting mental health conditions. However, challenges such as strain-specific effects and regulatory standards need to be addressed. The study of probiotics is approached through the One Health perspective, recognizing the interconnectedness of human, animal, and environmental health. [Extracted from the article]