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The cell cycle includes two checkpoint arrests allowing to repair of damaged DNA. Many cancer cell lines exhibit weak G1 checkpoint mechanisms relying significantly more on the G2 checkpoint than do healthy cells. Inhibition of Myt1 kinase (PKMYT1), a forgotten member of the Wee family, cyclin-dependent kinase 1 (Cdk1) inhibitory kinase, target for G2 checkpoint abrogation, whose inhibition forces cells into premature unchecked mitosis resulting in cell death, is a promising concept for anticancer therapy. There are not many inhibitors of this emerging, potentially clinically important kinase. Herein, the valuable insight into structural features and binding mechanisms of diaminopyrimidines, aminoquinolines, quinazolines, pyrido[2,3- d ]pyrimidines, pyrazolo[3,4- d ]pyrimidines, and pyrrolo[2,3- b ]quinoxalines, as well as finally made a general scheme of fragmented structures of Myt1 inhibitors with the enzyme, offer potential frameworks useful for future directions, for further chemical optimizations, in the discovery and the design of novel effective structures, potential therapeutics. [Display omitted] • Inhibition of Myt1 kinase is promising concept for anticancer therapy. • Inhibitors of Myt1, regulator of G2/M transition, were reviewed and classified. • The most common scaffolds are diaminopyrimidine, aminoquinoline and 7-azaindole. • Fragmented schemes with common interaction patterns of inhibitors were consolidated. • Analyzed structural features offer potential frameworks for further optimizations. [ABSTRACT FROM AUTHOR]

The concept of reconciliation as a political-psychological concept came into being at the beginning of the nineties of the last century. It took a lot of time for the experts, who were engaged in peacebuilding in the post-conflict period, to understand that political, economic and other social processes were not sufficient for the reconciliation process, but that psychological aspects of reconciliation should also be included. In such a way, the process of reconciliation, in which subjects of reconciliation are race, people, nations, was lowered from the collective to the individual level. An example of such an attempt relates to the events after the apartheid in the South African Republic and the establishment of the Commission for Truth and Reconciliation. In this regard, this paper aims to identify the basic ideas and principles of the reconciliation process in the South African Republic and try to place it in the context of reconciliation between formerly warring parties in the former Yugoslavia. In the analysis of the concept of reconciliation that has been relatively successfully applied in the South African Republic, three key ideas have been identified. The first idea suggests that the process of reconciliation from the level of "political elites" should be lowered to the level of "ordinary people". The second, it is necessary to have a so-called Third party for the reconciliation process that will manage the whole process. And the third, that the truth is an unavoidable factor in the process of reconciliation. In this paper, a proposal for a possible model of reconciliation among the countries and nations of the former Yugoslavia is given on the basis of analysis of the post-conflict processes in the South African Republic and current events in the post-Yugoslav space. [ABSTRACT FROM AUTHOR]