1. Maternal-placental axis and its impact on fetal outcomes, metabolism, and development.
- Author
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de Souza Lima, Bruna, Sanches, Ana Paula Varela, Ferreira, Maíra Schuchter, de Oliveira, Josilene Lopes, Cleal, Jane K., and Ignacio-Souza, Letícia
- Subjects
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METABOLISM , *PREGNANCY complications , *PREMATURE labor , *LOW birth weight , *GESTATIONAL diabetes , *HIGH-fat diet - Abstract
Maternal obesity could impact offspring's health. During "critical period" such as pregnancy insults have a significant role in developing chronic diseases later in life. Literature has shown that diet can play a major role in essential metabolic and development processes on fetal outcomes. Moreover, the placenta, an essential organ developed in pregnancy, seems to have its functions impaired based on pre-gestational and gestational nutritional status. Specifically, a high-fat diet has been shown as a potential nutritional insult that also affects the maternal-placental axis, which is involved in offspring development and outcome. Moreover, some classes of nutrients are associated with pregnancy complications such as reduced intake of micronutrients and diabetes, preeclampsia, and preterm delivery. Thus, we will summarize the current literature on maternal environment factors that impacts the placental development and consequently the fetal an offspring health, or the maternal-placental axis, and this on fetal outcomes, metabolism, and development. [Display omitted] • Maternal HFD diet intake compromises placental regions responsible for nutrient transportation to the fetus. • Reduced intake of micronutrients has been associated with gestational diabetes, preeclampsia, preterm delivery, and low birth weight. • Regular moderate-intensity physical exercise initiated early may increase placental blood flow and functional capacity. • Physical exercise and healthy eating habits have been positively associated with health benefits for both mother and newborn. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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