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Introduction: Hypomelanosis of Ito is (HI) is a rare neurocutaneous disorder characterized by the presence of hypopigmented lesions following the lines of Blaschko, which can be associated with central nervous system (CNS), ocular, dental, musculoskeletical and genitourinary manifestations. CSN symptomatology is the most common extracutaneous manifestation described. It involves intellectual disability, psychomotor development retardation, epilepsy and autism. (Figure 1). Objectives: Our objetive is to describe and analyse the clinical case of a 23 years old male with HI and psychotic symptoms. We also aimed to reach a well defined psychiatric diagnosis. Methods: Clinical case was analysed. Blood test, brain scan and electroencephalogram were done. Wechsler Adult Intelligence Scale IV (WAIS-IV), Boston Aphasia test and Autism Diagnosis Observation Schedule-2 (ADOS-2) Module 4 were administered. We also conduct a literature review about HI and diagnostic complexity between schizophrenia and autism. Results: Blood test, brain scan and electroencephalogram showed no disturbances. WAIS-IV score was 110 (average). At Boston Aphasia test, pragmatic language impairments were detected. Results of ADOS-2 Module 4 showed an autism diagnosis. Conclusions: Organic causes of psychosis and autism should be ruled out in HI patients. Our patient showed thought blocking, stereotiped movements and isolation which were mistakenly categorized as part of a psychotic episode until an autism diagnosis was given. Abnormal thought processes are common in individuals with Autism Spectrum Disorder, but at least 1 month of prominent delusions or hallucinations is required before a diagnosis of schizophrenia is made. [ABSTRACT FROM AUTHOR]

Introduction: Cognitive impairment is usually found in people with Schizophrenia SpectrumDisorder (SDD) (Schaefer et al., 2013). Sustained attention is one of the most characteristic cognitive areas affected and has been largely studied for decades (Hoonakker et al., 2017). Sustained attention is defined as the ability to maintain attention on a given stimulus or task for a span of time (Parasuraman, 1984). Mindfulness is theorized to improve the attentional process. However, the effects of Mindfulness Based Interventions (MBIs) on cognition are still unclear (Lao & Meadows, 2017). Objectives: To test if a MBI (SocialMIND®) improves attentional performance in SDD patients Methods: A parallel-group, single-blind, randomized, controlled (SocialMIND® versus Psychoeducational Multicomponent Intervention [PMI]), clinical trial has been implemented. The participants received 16 weeks group therapy of SocialMIND® or PMI. Sustained attention was measured with the Continuous Performance Test (CPT-IP). Results: 23 participants were included. A better performance on CPT-IP was found in patients allocated to SocialMIND® (M=3.46, SD=0.73) compared to PMI (M=2.79, SD=1.18) after sixteen weeks of treatment (T=2.89, p=0.009, d=1.19). However, this improvement was only found in the 2-digit task. Conclusions: 3-digit and 4-digit tasks increase the difficulty of the test involving greater implication of other cognitive processes such as working memory. Taking this into account, it's possible that MBIs improves sustained attention but has no effects on working memory. [ABSTRACT FROM AUTHOR]

Introduction: Mindfulness-based interventions are showing promising results for people with Schizophrenia Spectrum Disorders (SSD) (Goldberg et al., 2018), though their action mechanisms are yet to be clarified. Social cognition has drawn a great deal of attention in recent decades as people with psychosis tend to perform worse than healthy controls in socio-cognitive tasks (Green et al., 2015). A core component of social cognition is attributional style and people with psychosis tend to perceive more intentionality and hostility in other people's behaviors in negative and ambiguous situations than controls (Savla et al., 2012). Objectives: To explore the changes in hostility bias after Social-MIND® in a sample of people with SSD. Methods: SocialMIND® is a mindfulness-based social cognition training delivered over 9 months, the first two including 8 weekly sessions. 46 patients were included: 25 subjects completed a feasibility trial (Mediavilla et al., 2019a) while 21 subjects are currently enrolled in a Randomized Controlled Trial (Mediavilla et al., 2019b). Assessment included the Ambiguous Intentions Hostility Questionnaire (AIHQ). Results: 46 participants completed weekly sessions and assessment. Participants showed a significant improvement in hostility bias as measured by the AIHQ (p=0,018, d=0,38). Conclusions: SocialMIND® is among the few social cognition trainings to achieve an improvement in hostility bias in people with psychosis (Roberts et al., 2014). Given the role of social cognition in SSD as predictor and mediator of social functioning (Galderisi et al., 2018), future research lines should delve deeper into the action mechanisms and key active ingredients of social cognition trainings for people with psychosis. [ABSTRACT FROM AUTHOR]

Introduction: People with Schizophrenia Spectrum Disorders (SSDs) suffer significant social cognitive impairments (Paker, Foley, Walker & Dark, 2013). Social cognitive trainings are emerging interventions aiming to target these impairments and improve functional outcomes (Green et al., 2015). Social Cognition and Interaction Training (SCIT) (Taylor et al., 2016) and Training of Affect Recognition (TAR) both improve social cognition (Vaskinn et al., 2019). Social-MIND® is the first mindfulness-based social cognition training tailormade for people with psychosis (Mediavilla et al., 2019a). Objectives: To explore the changes in emotion recognition after SocialMIND® in a sample of people with SSD. Methods: SocialMIND® is delivered over 9 months, the first two including 8 weekly sessions. 46 patients were included: 25 subjects completed a feasibility trial while 21 subjects are currently enrolled in a Randomized Controlled Trial (Mediavilla et al., 2019b). Assessment included the RMET. Results: 46 participants completed weekly sessions and assessment. Participants displayed a significant improvement of 3,85 in RMET scores (p=0,012, d=0,42). Conclusions: SocialMIND® is one of the first social cognition trainings for SSD to show an improvement in emotion recognition. Similar pre-to post-intervention results have also been achieved by SCIT (Gordon et al., 2018; Voutilainen, Kouhia, Roberts & Oksanen, 2016) and TAR (Sachs et al., 2012). However, different methodological issues render comparisons impractical as results have been inconsistent (Roberts et al., 2014). Given the role of social cognition in schizophrenia (Galderisi et al., 2018), future research lines should delve deeper into the key active ingredients and action mechanisms of social cognition trainings for people with psychosis. [ABSTRACT FROM AUTHOR]