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Purpose: Complete surgical resection is still the mainstay in the treatment of central nervous system low-grade tumors, eventually resulting curative. The complete surgical removal of these lesions, however, may be difficult in some cases because of their infiltrative nature. Intraoperative adjuncts may be a game changer. Sodium fluorescein (SF) is among the ideal candidates as intraoperative tools to favor the actual recognition of the tumor extension, since it accumulates in areas of altered blood–brain barrier, a typical characteristic of pediatric gliomas, and has a low rate of adverse events. This work proposes an update of previous works about the evaluation of the feasibility and usefulness of a systematic use of SF in a low-grade lesion group of pediatric patients. Methods: Pediatric patients operated on for a resection or a biopsy of a low-grade glial or glioneuronal lesion (WHO grade I and II) at our Institution between September 2021 and December 2023, with the intraoperative use of sodium fluorescein (SF), were enrolled in the study. We collected pre-operative and postoperative clinical and radiological data, intraoperative findings, and post-operative pathological diagnoses. Results: No adverse events were registered related to the intraoperative use of SF. SF appeared useful for the localization of boundaries of tumors, especially when characterized by a high degree of infiltration or by a deep-seated location, and for the checking of possible tumor remnants at the end of surgery. A good tumor-to-healthy tissue contrast was registered when tumor visualization was in a range between 1 to 2 h and 30 min after SF injection. Possible "false positives" due to intraoperative vascular wall injury and clearance of SF from both tumor and healthy tissue were observed in some cases and still remain open issues. Conclusions: SF is a feasible and safe intraoperative adjunct tool in the surgical removal of pediatric low-grade tumors. SF may show its usefulness especially in selected cases, such as deep-seated lesions and infiltrating tumors. Its safety profile, user-friendly management, and potential utility in both tumor resections and neuronavigated biopsies favor its wider use in the surgical treatment of pediatric low-grade tumors. [ABSTRACT FROM AUTHOR]

Diapause is a vital survival strategy for insects, enabling them to conserve energy and endure adverse conditions. Understanding how diapause affects insect phenology and population dynamics is crucial for the effective management of insect pests. Predictive pest phenological models can be invaluable tools for providing essential information to support management strategies. This study presents a modelling framework to incorporate diapause into phenological models when biological information on variables regulating and functions describing diapause induction and termination are lacking or limited. In our framework, insect phenology is divided into a set of phases characterized by specific events (diapause induction and termination) and processes (development of diapausing and post‐diapausing biological stages). The phenology is simulated by a stage‐structured model based on the Kolmogorov equation, and the temperature‐dependent development rate functions are described by the Brière functional form. Our modelling framework was tested on a case study involving the prediction of the phenology of the codling moth, (Cydia pomonella L. 1758). Model calibration and validation were performed using four time‐series adult trap catch data collected in the Emilia Romagna Region from 2021 to 2023. The calibration procedure allowed obtaining realistic parameters related to the temperature threshold triggering diapause termination and the development rate function of post‐diapausing larvae and pupae. Model validation proved successful in simulating both the initial emergence and the overall phenological patterns of adults across the three observed generations. The methodological framework proposed here aims to facilitate the introduction of diapause in phenological models improving also their predictive abilities. The model may serve as an accurate and knowledge‐based tool for planning and implementing pest monitoring and control actions based on the realistic predictions provided by the model on the phenological status of the pest. [ABSTRACT FROM AUTHOR]

The article describes the publication of a new stela of the Chief Treasurer Maya from the time of Tutankhamun-Horemheb, with a long hymn to the rising sun. The stela, which was in the possession of Linant de Bellefonds, is only known through a handwritten copy by Auguste Mariette. There is no doubt that it comes from Maya's tomb in Saqqara. The stela shows Maya standing before the deities Atum and Re-Horakhty. The lower part of the stela consists of 20 lines of hieroglyphic text, with the last 3 lines almost completely destroyed. The text consists of two parts: lines 1-8, a hymn to the rising sun, and lines 8 and following, a concluding prayer with a list of blessings that the speaker, Maya, hopes to receive from the sun god. The hymn is an original composition or variation, while the prayer is based on the composer's personal oral improvisation. There are parallels to other inscriptions from the time of Amenhotep III to the end of the dynasty, but the arrangement is unique. The exact meaning of some passages remains uncertain. The Linant stela dates from the New Kingdom and is the only known source from this period. It is the counterpart to a limestone stela that was originally placed on the south side of the west wall of the portico in the outer courtyard of Maya's tomb in Saqqara. The stela was discovered together with three statues and a block in the Leiden National Museum of Antiquities. It is believed that the stela was found before the Lepsius expedition, which explored the tomb in the 1840s. The stela contains hymns to the sun god Re-Horakhty and the night sun god Osiris. The given list includes a number of books and articles on various topics related to ancient Egypt. The mentioned works deal with topics such as Egyptian religion, hieroglyphs, tombs, and texts from the New Kingdom. Various authors and their works are also listed. The list does not provide cohesive information or a main focus, but serves as a reference for further research in the field of Egyptology. The text describes various scientific publications and research in the field of Egyptian archaeology. Various topics are covered, including excavations in Saqqara, the representation of the afterlife in ancient Egypt, and the significance of inscriptions and reliefs. Specific artifacts and tombs are also mentioned, such as the stela of Maya and the tomb of Kheruef. The publications come from different years and were written by different authors. [Extracted from the article]

Apolipoprotein E (ApoE) is a lipid carrier in both the peripheral and the central nervous systems (CNSs). Lipid-loaded ApoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and brain injury repair. In the brain, ApoE is produced predominantly by astrocytes, but it is also abundantly expressed in most neurons of the CNS. In this study, we addressed the role of ApoE in the hippocampus in mice, focusing on its role in response to radiation injury. To this aim, 8-week-old, wild-type, and ApoE-deficient (ApoE−/−) female mice were acutely whole-body irradiated with 3 Gy of X-rays (0.89 Gy/min), then sacrificed 150 days post-irradiation. In addition, age-matching ApoE−/− females were chronically whole-body irradiated (20 mGy/d, cumulative dose of 3 Gy) for 150 days at the low dose-rate facility at the Institute of Environmental Sciences (IES), Rokkasho, Japan. To seek for ApoE-dependent modification during lineage progression from neural stem cells to neurons, we have evaluated the cellular composition of the dentate gyrus in unexposed and irradiated mice using stage-specific markers of adult neurogenesis. Our findings indicate that ApoE genetic inactivation markedly perturbs adult hippocampal neurogenesis in unexposed and irradiated mice. The effect of ApoE inactivation on the expression of a panel of miRNAs with an established role in hippocampal neurogenesis, as well as its transcriptional consequences in their target genes regulating neurogenic program, have also been analyzed. Our data show that the absence of ApoE−/− also influences synaptic functionality and integration by interfering with the regulation of mir-34a, mir-29b, and mir-128b, leading to the downregulation of synaptic markers PSD95 and synaptophysin mRNA. Finally, compared to acute irradiation, chronic exposure of ApoE null mice yields fewer consequences except for the increased microglia-mediated neuroinflammation. Exploring the function of ApoE in the hippocampus could have implications for developing therapeutic approaches to alleviate radiation-induced brain injury. [ABSTRACT FROM AUTHOR]

The shapes of galaxies, their outer regions in particular, are important guideposts to their formation and evolution. In this work, we report on the discovery of strongly box-shaped morphologies of the otherwise well-studied elliptical and lenticular galaxies NGC 720 and NGC 2768 from deep imaging. The boxiness is strongly manifested in the parameter shape A4/a of −0.04 in both objects, and significant center shifts of the isophotes of ∼2–4 kpc are also seen. One reason for such asymmetries commonly stated in the literature is a merger origin, although the number of such cases is still sparse, and the exact properties of the individual boxy objects are highly diverse. Indeed, for NGC 2768, we identify a progenitor candidate (dubbed "Pelops") in the residual images, which appears to be a dwarf satellite that is currently merging with NGC 2768. At its absolute magnitude of Mr of −12.2 mag, the corresponding Sersic radius of 2.4 kpc is more extended than those of typical dwarf galaxies from the literature. However, systematically larger radii are known to occur in systems that are in tidal disruption. This finding is bolstered by the presence of a tentative tidal stream feature on archival GALEX data. Finally, further structures in the fascinating host galaxy include rich dust lanes and a vestigial X-shaped bulge component. [ABSTRACT FROM AUTHOR]

Background and Objectives: This study aimed to evaluate the effect of cataract extraction on intraocular pressure at 6, 12, and 24 months and their difference compared to the baseline in diverse glaucoma subtypes. Materials and Methods: We carried out research in the MEDLINE, Cochrane Library and EMBASE databases, as of April 2022 for relevant papers, filtered according to established inclusion and exclusion criteria. The meta-analysis evaluated the Mean Reduction and relative Standard Error in these subpopulations at predetermined times. A total of 41 groups (2302 eyes) were included in the systematic review. Due to the significant heterogeneity, they were analysed through a Random Effects Model. Results: We obtained these differences from baseline: (1) Open Angle Glaucoma at 6, 12 and 24 months, respectively: −2.44 mmHg, −2.71 mmHg and −3.13 mmHg; (2) Angle Closure Glaucoma at 6, 12 and 24 months, respectively: −6.81 mmHg, −7.03 mmHg and −6.52 mmHg; (3) Pseudoexfoliation Glaucoma at 12 months: −5.30 mmHg; (4) Ocular Hypertension at 24 months: −2.27 mmHg. Conclusions: Despite a certain variability, the reduction in ocular pressure was statistically significant at 6, 12 and 24 months in both Open Angle Glaucoma and Angle Closure Glaucoma, the latter being superior. Data for Pseudoexfoliation Glaucoma and for Ocular Hypertension are available, respectively, only at 12 months and at 24 months, both being significant. [ABSTRACT FROM AUTHOR]

Background: Inflammatory microenvironment is an essential component of all tumors, including thyroid cancer. Autoimmune thyroid diseases are often associated with thyroid cancer. CD25, expressed in Treg cells and B cells, has been found to be associated with autoimmune thyroid diseases and the NFkB pathway is critical to tumor formation, regulating immune-related genes, and pro-inflammatory cytokine. Methods: Protein expression of CD25 and NFkB and its phosphorylated form was analyzed by immunohistochemistry in 80 patients with thyroid cancer (10 cases of cancers with Hashimoto's thyroiditis and 70 cases without). Results: CD25 was mainly detected in the nucleus of the inflammatory cells such as in the thyrocytes and neoplastic cells. Protein staining was detected in the T-lymphocytes of the outermost zone of the lymphoid follicles. Moreover, in all cancer alterations, there were a higher level of p-NFkB than in the surrounding tissues. Again, p-NFkB staining was evident in neoplastic cells but not evident in inflammatory cells. Conclusions: Strong inflammatory infiltrate in the tumor microenvironment is correlated with an invasive phenotype. CD25 and p-NFkB levels were statistically significantly overexpressed in cancer cells. [ABSTRACT FROM AUTHOR]

Simple Summary: Although the use of antimicrobials and the related selection of antimicrobial-resistant (AMR) pathogens are recognized worldwide, limited or no information is available on the effect of the antibiotic treatment on the genetic structure as well as the dissemination and persistence of plasmids carrying AMR genetic determinants. This is of particular interest for bacterial pathogens like Avian Pathogenic Escherica coli (APEC), which have the potential to persist and be transmitted from broilers to humans through the food chain as well as for their AMR genetic determinants, which have the potential to be mobilized and spread. With a genomic approach, results of the present study revealed that during the enrofloxacin treatment of broilers, initial strains of extraintestinal E. coli disappeared, being substituted by new clones. Plasmid-mediated fluoroquinolone resistance did not appear to disseminate or persist among observed genomes, confirming that QRDR mutations rather than plasmids are the main drivers of quinolone resistance. Interestingly, plasmids carrying other AMR genes than quinolone-determinant ones were disseminated and persistent since they were found in different clones both before and after the treatment. The persistence of plasmids without a direct antimicrobial selective pressure, if confirmed with further studies, might give insights on the so-called plasmid paradox. The aim of the present study was to investigate the genetic diversity and antimicrobial resistance (AMR) of E. coli during enrofloxacin therapy in broilers affected by colisepticemia. Three unrelated farms with ongoing colibacillosis outbreaks were sampled at day 1 before treatment and at days 5, 10 and 24 post-treatment. A total of 179 E. coli isolates were collected from extraintestinal organs and submitted to serotyping, PFGE and the minimum inhibitory concentration (MIC) against enrofloxacin. PFGE clusters shifted from 3–6 at D1 to 10–16 at D5, D10 and D24, suggesting an increased population diversity after the treatment. The majority of strains belonged to NT or O78 and to ST117 or ST23. PFGE results were confirmed with SNP calling: no persistent isolates were identified. An increase in resistance to fluoroquinolones in E. coli isolates was observed along the treatment. Resistome analyses revealed qnrB19 and qnrS1 genes along with mutations in the gyrA, parC and parE genes. Interestingly, despite a fluoroquinolone selective pressure, qnr-carrying plasmids did not persist. On the contrary, two conjugative AMR plasmid clusters (AB233 and AA474) harboring AMR genes other than qnr were persistent since they were identified in both D1 and D10 genomes in two farms. Further studies should be performed in order to confirm plasmid persistence not associated (in vivo) to antimicrobial selective pressure. [ABSTRACT FROM AUTHOR]

Nanotechnology has assumed a significant role over the last decade in the development of various technologies applied to health sciences. This becomes even more evident with its application in controlled drug delivery systems. In this context, peptoids are a promising class of compounds for application as nanocarriers in drug delivery systems. These compounds can be obtained efficiently and with highly functionalized structural diversity via the Ugi 4-component reaction (U-4CR). Herein, we report the design of the process control strategy for the future development of lipid–peptoid-based customized drug delivery system assemblies. Over 20 lipid–peptoid nanocomposites were synthesized via the U-4CR in good to excellent yields. These products were successfully submitted to the nanoparticle formation by the emulsification–evaporation process from lipophilic solution and analyzed via Dynamic Light Scattering (DLS). Several molecules generated nanoparticles with a size ≤200 nm, making them good candidates for drug delivery systems, such as in cancer treatment. [ABSTRACT FROM AUTHOR]

Increasing reports on K. pneumoniae strains with antimicrobial resistance and virulence traits from food and farm animals are raising concerns about the potential role of Klebsiella spp. as a foodborne pathogen. This study aimed to report and characterize Klebsiella spp. isolates from two artisanal ready-to-eat food (soft cheese and salami) producing facilities, and to track similar genotypes in different ecological niches. Over 1170 samples were collected during the whole production chain of different food batches. The overall Klebsiella prevalence was 6%. Strains were classified into the three Klebsiella species complexes: K. pneumoniae (KpSC, n = 17), K. oxytoca (KoSC, n = 38) and K. planticola (KplaSC, n = 18). Despite high genetic diversity we found in terms of known and new sequence types (STs), core genome phylogeny revealed clonal strains persisting in the same processing setting for over 14 months, isolated from the environment, raw materials and end-products. Strains showed a natural antimicrobial resistance phenotype-genotype. K. pneumoniae strains showed the highest virulence potential, with sequence types ST4242 and ST107 strains carrying yersiniabactin ybt16 and aerobactin iuc3. The latter was detected in all K. pneumoniae from salami and was located on a large conjugative plasmid highly similar (97% identity) to iuc3+ plasmids from human and pig strains circulating in nearby regions of Italy. While identical genotypes may persist along the whole food production process, different genotypes from distinct sources in the same facility shared an iuc3-plasmid. Surveillance in the food chain will be crucial to obtain a more comprehensive picture of the circulation of Klebsiella strains with pathogenic potential. [ABSTRACT FROM AUTHOR]

Introduction: The digital platforms have become a place for sharing intimate issues, for instance, to talk about one's own illness, what characterize an extimacy movement, boosted by the mediatization process. This dynamic is commonly used by patients with rare diseases -- as Turner Syndrome -- due to its low frequency, the stigmas and the unfamiliarity of doctors and people in general. Objectives: Comprehend and analyze how, in the ambience of mediatization, occurs the process of extimacy in patients with Turner Syndrome on the Instagram profile Turner & Eu and on the Butterfly TV YouTube channel. Methodology: Using the Analysis of Discursive Circulation, the meanings contained in two posts of the Instagram profile and in one video of the YouTube channel were studied through an intertextual analysis of the discursive operations. Results: The extimacy process aims no just to expose intimate issues, but it is also a way of self-affirmation, validation, self-organization, inspiration and it enables the end of stigmas, providing a reconfiguration of the illness. Conclusion: The extimacy involves two dimensions: the temporality of each patient and the digital platform where this movement happens. Besides that, it is also a process collaboratively built. [ABSTRACT FROM AUTHOR]

(1) Background: 22 MHz high frequency ultrasound (HFUS) is a non-invasive imaging technique that gives information on depth, length, volume and shape of skin tumors. (2) Methods: We reviewed the clinical, ultrasound, and histological records of 54 patients with 100 histologically confirmed basal cell carcinoma (BCC) tumors with the use of HFUS. (3) Results: Most infiltrative tumors (n = 16/21, 76.2%) were irregular shaped, followed by five (23.8%) being round shaped; most superficial tumors (n = 25/29, 86.2%) were ribbon shaped, followed by four (13.8%) being round shaped; most nodular tumors (n = 26/33, 78.8%) were round shaped, followed by seven (21.2%) that were irregular shaped; and, lastly, all microdular tumors (n = 2/2, 100%) were round shaped. Strong evidence of association (p = 0.000) was observed between the histological subtype and tumor shape as seen using the HFUS. No evidence of association was found between the histological subtype and tumor margin (p > 0.005). Cohen's Kappa statistic to assess the agreement between BCC subtypes evaluated by histological examination and U/S appearance was calculated equal to 0.8251 (almost perfect agreement). (4) Conclusions: HFUS appears to be a reliable technique for the pre-operative evaluation of BCCs, assisting physicians to decide on the optimal therapeutic approach. [ABSTRACT FROM AUTHOR]

We study alternating strand diagrams on the disk with an orbifold point. These are quotients by rotation of Postnikov diagrams on the disk, and we call them orbifold diagrams. We associate a quiver with potential to each orbifold diagram, in such a way that its Jacobian algebra and the one associated to the covering Postnikov diagram are related by a skew-group algebra construction. We moreover realise this Jacobian algebra as the endomorphism algebra of a certain explicit cluster-tilting object. This is similar to (and relies on) a result by Baur-King-Marsh for Postnikov diagrams on the disk. [ABSTRACT FROM AUTHOR]

Studies have shown that diverse care teams optimize patient outcomes. Describing the current representation of women and minorities has been a critical step in improving diversity across several fields. To address the lack of data specific to pediatric cardiology, the authors conducted a national survey. U.S. academic pediatric cardiology programs with fellowship training programs were surveyed. Division directors were invited (July 2021 to September 2021) to complete an e-survey of program composition. Underrepresented minorities in medicine (URMM) were characterized using standard definitions. Descriptive analyses at the hospital, faculty, and fellow level were performed. Altogether, 52 of 61 programs (85%) completed the survey, representing 1,570 total faculty and 438 fellows, with a wide range in program size (7-109 faculty, 1-32 fellows). Although women comprise approximately 60% of faculty in pediatrics overall, they made up 55% of fellows and 45% of faculty in pediatric cardiology. Representation of women in leadership roles was notably less, including 39% of clinical subspecialty directors, 25% of endowed chairs, and 16% of division directors. URMM comprise approximately 35% of the U.S. population; however, they made up only 14% of pediatric cardiology fellows and 10% of faculty, with very few in leadership roles. These national data suggest a "leaky pipeline" for women in pediatric cardiology and very limited presence of URRM overall. Our findings can inform efforts to elucidate underlying mechanisms for persistent disparity and reduce barriers to improving diversity in the field. [Display omitted] [ABSTRACT FROM AUTHOR]

We explore the stellar mass density and colour profiles of 118 low redshift, massive, central galaxies, selected to have assembled 90 per cent of their stellar mass 6 Gyr ago, finding evidence of the minor merger activity expected to be the driver behind the size growth of quiescent galaxies. We use imaging data in the g, r, i, z, y bands from the Subaru Hyper Suprime-Cam survey and perform SED fitting to construct spatially well-resolved radial profiles in colour and stellar mass surface density. Our visual morphological classification reveals that ∼42 per cent of our sample displays tidal features, similar to previous studies, ∼43 per cent of the remaining sample displays a diffuse stellar halo, and only ∼14 per cent displays no features, down to a limiting μ r -band ∼ 28 mag arcsec−2. We find good agreement between the stacked colour profiles of our sample to those derived from previous studies and an expected smooth, declining stellar mass surface density profile in the central regions (< 3 R e). However, we also see a flattening of the profile (Σ* ∼ 107.5 M⊙ kpc−2) in the outskirts (up to 10 R e), which is revealed by our method of specifically targeting tidal/accretion features. We find similar levels of tidal features and behaviour in the stellar mass surface density profiles in a younger comparison sample, however, a lack of diffuse haloes. We also apply stacking techniques similar to those in previous studies, finding such procedures wash out tidal features and thereby produce smooth declining profiles. The stellar material in the outskirts contributes on average ∼1010 M⊙ or a few per cent of the total stellar mass and has similar colours to SDSS satellites of similar stellar mass. [ABSTRACT FROM AUTHOR]

α‐Hydroxy amides are an essential class of compounds found in natural products and bioactive molecules of drug candidates. Herein we report a facile and direct approach to these compounds through oxalic acid decarbonylation/decarboxylation during the Passerini three‐component reaction (P‐3CR) under solvent‐free conditions with microwave heating. This very convenient methodology provides the title compounds through a possible concerted intramolecular decarbonylation/decarboxylation from the α‐acyloxy amide intermediate. [ABSTRACT FROM AUTHOR]

The aim of the present study was to investigate the resistome and virulome diversity of 43 isolates of Listeria monocytogenes, Salmonella enterica and S. aureus collected from artisanal fermented meat and dairy products and their production environments in Portugal, Spain, Italy and Morocco. After DNA extraction, genomes were sequenced, and de novo assembled. Genetic relationships among genomes were investigated by SNP calling and in silico 7- loci MLST. Genomes of the same species belonged to different ST-types demonstrating the circulation of different clones in in the same artisanal production plant. One specific clone included genomes of S. Paratyphi B belonging to ST43 and repeatedly isolated for more than a year in an artisanal sausage production plant. No genomes but three (belonging to Salmonella enterica), were predicted as multiresistant to different antimicrobials classes. Regarding virulence, genomes of L. monocytogenes belonging to ST1, ST3 and ST489, as well as genomes of S.enterica enterica (ST43, ST33, ST314, ST3667, ST1818, ST198) and ST121 S. aureus were predicted as virulent and hypervirulent. The occurrence of virulent and hypervirulent L. monocytogenes, Salmonella enterica and S. aureus strains in artisanal fermented meat and dairy productions as well as in their finished products suggests the need for a specific focus on prevention and control measures able to reduce the risk of these biological hazards in artisanal food productions. [ABSTRACT FROM AUTHOR]

This paper presents the development of an algorithm for open-loop transfer functions identification and reduced-order modelling of a dynamical system, from closed-loop data with highly correlated inputs. Suitable for aeronautical applications (particularly for intrinsically unstable vehicles such as helicopters), it allows the identification of aircraft transfer functions from the knowledge of the time histories of arbitrary external inputs and the corresponding actuated controls and responses. After a numerical verification of the proposed approach considering a simple analytical aircraft dynamical system, it is successfully applied to a realistic engineering problem consisting of identifying the transfer functions of the AW-09 helicopter that relate pilot inputs to vehicle attitude and kinematics. It is shown that helicopter responses to arbitrary pilot inputs predicted by the reduced-order model representation of the helicopter dynamics based on the rational approximation of the identified transfer functions are in good agreement with those determined through the high-fidelity nonlinear flight dynamics solver used to evaluate the closed-loop database. • Open-loop transfer functions identification from closed-loop data. • Highly correlated closed-loop input data. • Reduced-order modelling of dynamical systems. • Proposed methodology successfully applied both to simplified aircraft models and to a complex high-fidelity helicopter model. [ABSTRACT FROM AUTHOR]

In this paper, we show that a two-field model for pantographic sheets generalized to include a more refined description of the deformation of interconnecting pivots and structural dissipation is capable of describing the sheets mechanical behavior for (1) cyclic extension tests in elastic regimes and (2) damage initiation. To this aim, we performed two kinds of experimental tests. In the first ones, we tested, remaining in the elastic regime, pantographic sheets under different cyclic loads. Second, we extended the specimens reaching the first rupture. The numerical model was calibrated in order to predict (1) the observed amplitude and shape of hysteretic cycles and (2) the observed localization of the first rupture. In this framework, (1) a simultaneous rupture of several pivots is observed and theoretically justified, (2) the primary dissipation mechanism and rupture initiation are attributed to pivots' shear deformation. [ABSTRACT FROM AUTHOR]

Background: Psoriasis is an immune‐mediated inflammatory skin disease, in which an interplay between infiltrating immune cells and keratinocytes sustains chronic skin inflammation. Interleukin (IL)‐17A is a key inflammatory cytokine in psoriasis and its main cellular targets are keratinocytes. Objectives: To explore the role of miR‐378a in psoriasis. Methods: Keratinocytes obtained from psoriatic skin and healthy epidermis were separated by magnetic sorting, and the expression of miR‐378a was analysed by quantitative polymerase chain reaction. The regulation and function of miR‐378a was studied using primary human keratinocytes. The expression of miR‐378a was modulated by synthetic mimics, and nuclear factor kappa B (NF‐κB) activity and transcriptomic changes were studied. Synthetic miR‐378a was delivered to mouse skin in conjunction with induction of psoriasiform skin inflammation by imiquimod. Results: We show that miR‐378a is induced by IL‐17A in keratinocytes through NF‐κB, C/EBP‐β and IκBζ and that it is overexpressed in psoriatic epidermis. In cultured keratinocytes, ectopic expression of miR‐378a resulted in the nuclear translocation of p65 and enhanced NF‐κB‐driven promoter activity even in the absence of inflammatory stimuli. Moreover, miR‐378a potentiated the effect of IL‐17A on NF‐κB nuclear translocation and downstream activation of the NF‐κB pathway. Finally, injection of miR‐378a into mouse skin augmented psoriasis‐like skin inflammation with increased epidermal proliferation and induction of inflammatory mediators. Mechanistically, miR‐378a acts as a suppressor of NFKBIA/IκBζ, an important negative regulator of the NF‐κB pathway in keratinocytes. Conclusions: Collectively, our findings identify miR‐378a as an amplifier of IL‐17A‐induced NF‐κB signalling in keratinocytes and suggest that increased miR‐378a levels contribute to the amplification of IL‐17A‐driven skin inflammation in psoriasis. [ABSTRACT FROM AUTHOR]

Background: in recent years, many studies were carried out to explore the role of vaginal microbiota in HPV infections and cervical intraepithelial neoplasia (CIN) progression. The aim of this study was to conduct a review of the literature to analyze the interaction between the vaginal microbiota, the CIN, and the immunological response. Methods: we performed a literature search, considering papers published between November 2015 and September 2021. Results: despite significant evidence suggesting a role of vaginal microbiota in the pathogenesis of HPV-related lesions, some studies still struggle to demonstrate this correlation. However, the vaginal microbiota of HPV-positive women shows an increased diversity, combined with a reduced relative abundance of Lactobacillus spp. and a higher pH. In cervical dysplasia progression, a strong association is found with new bacteria, and with the deregulation of pathways and hyperexpression of cytokines leading to chronic inflammation. Conclusions: in HPV progression, there is a strong correlation between potential biomarkers, such as Sneathia and Delftia found in community state types IV and II, and chronic inflammation with cytokine overexpression. Better analysis of these factors could be of use in the prevention of the progression of the disease and, eventually, in new therapeutic strategies. [ABSTRACT FROM AUTHOR]

Introduction: Social media is an important mean of communication today. However, if not used correctly, they can negatively impact people's mental health, especially women. The growing dissatisfaction with one's own body is due, for one reason, to the frequent online comparison. It is known that two of the main risk factors for the development of Eating Disorders (ED) are body dissatisfaction and disordered eating behavior. Objective: to relate eating behavior and body dissatisfaction with the use of social media in students of the Life Sciences Area at a private university in the southern region of the country. Materials and Methods: cross-sectional observational research, carried out through the application of an online questionnaire, using the Google Forms platform. The EAT-26 and BSQ-34 questionnaires were also used. Results and Discussion: of the 205 students, 57.5% were dissatisfied with their own body image and 29.7% were at risk for ED. Of these, 69.8% reported comparing themselves with other people in the online environment and 92.2% wished to have the body of someone from the social media, as well as 59.5% said they felt anxiety and 52.2% reported worsening of selfesteem after using some social media. Conclusion: social media can exert a high influence on mental health, especially for women, and can negatively impact body image perception and, consequently, eating behavior. [ABSTRACT FROM AUTHOR]

The present study aimed at assessing the occurrence of microbiological hazards (Listeria monocytogenes, Staphylococcus aureus, Salmonella spp. and Escherichia coli O157) in an artisanal soft cheese produced in northern Italy. In the same product total bacterial count, lactic acid bacteria and Enterobacteriaceae were enumerated, and pH and water activity measured in two batches sampled in summer and winter. Samples of raw materials, environmental swabs from the production processes and cheese during 15 days of storage at 2 and 8°C as well as dynamic temperature of 2°C for 5 days and 8°C for 10 days were collected and tested. The load of total bacterial count was significantly higher in the winter batch in comparison to the summer one, with a significant increase at the end of the storage period also noticed for lactic acid bacteria. Statistical higher values of pH were registered in raw materials and end of storage in winter batch. S. aureus was confirmed only in the winter batch within samples (n=4) of stored cheese. On plates used for E. coli O157 detection, colonies of Klebsiella pneumoniae and Klebsiella oxytoca were isolated. The results suggest that the highest bacterial population in the winter batch was associated to a higher pH in stored cheese and a higher number of biological hazards identified. Their isolation started in the maturation room suggesting this step as relevant for possible cheese contamination. [ABSTRACT FROM AUTHOR]

There is a growing literature on the impact of Covid-19 on commercial and labour conditions at suppliers in apparel global value chains (GVCs). Yet much less is known about the implications for suppliers operating in regional value chains (RVCs) in the global South. In this article, we focus on Eswatini, which has grown to become the largest African manufacturer and exporter of apparel to the region. We draw on a combination of firm-level export data and interviews with stakeholders before and after the Covid-19 lockdown to shed light on the influence of private and public governance on suppliers' economic and social upgrading and downgrading. We point to the coexistence of two separate private governance structures: the first characterised by direct contracts between South African retailers and large manufacturers (direct suppliers); the second operating through indirect purchasing via intermediaries from relatively smaller producers (indirect suppliers). While direct suppliers enjoyed higher levels of economic and social upgrading than indirect suppliers before Covid-19, the pandemic reinforced this division, with severe price cuts for indirect suppliers. Furthermore, while retailers provided some direct suppliers with support throughout the crisis, this was not the case for indirect suppliers, who remain comparatively more vulnerable. In terms of public governance, the negative consequences of the lockdown on firms' income and workers' livelihoods have been compounded by the state's ineffective response. Our paper contributes to the research on RVCs in the global South, enhancing our understanding of how different governance structures and external shocks affect firms' and workers' upgrading and downgrading prospects. [ABSTRACT FROM AUTHOR]

We present a novel approach to the riddle of star cluster multiple populations. Stars form from molecular cores. But not all cores form stars. Following their initial compression, such "failed" cores re-expand, rather than collapsing. We propose that their formation and subsequent dispersal regulate the gas density of cluster-forming clumps and, therefore, their core and star formation rates. Clumps for which failed cores are the dominant core type experience star formation histories with peaks and troughs (i.e., discrete star formation episodes). In contrast, too few failed cores results in smoothly decreasing star formation rates. We identify three main parameters shaping the star formation history of a clump: the star and core formation efficiencies per free-fall time, and the timescale on which failed cores return to the clump gas. The clump mass acts as a scaling factor. We use our model to constrain the density and mass of the Orion Nebula Cluster progenitor clump, and to caution that the star formation histories of starburst clusters may contain close-by peaks concealed by stellar age uncertainties. Our model generates a great variety of star formation histories. Intriguingly, the chromosome maps and O–Na anticorrelations of old globular clusters also present diverse morphologies. This prompts us to discuss our model in the context of globular cluster multiple stellar populations. More massive globular clusters exhibit stronger multiple stellar population patterns, which our model can explain if the formation of the polluting stars requires a given stellar mass threshold. [ABSTRACT FROM AUTHOR]

Background: The value of neoadjuvant chemotherapy in soft tissue sarcoma (STS) is not completely understood. This study investigated the benefit of neoadjuvant chemotherapy according to prognostic stratification based on the Sarculator nomogram for STS. Methods: This study analyzed data from ISG‐STS 1001, a randomized study that tested 3 cycles of neoadjuvant anthracycline plus ifosfamide (AI) or histology‐tailored (HT) chemotherapy in adult patients with STS. The 10‐year predicted overall survival (pr‐OS) was estimated with the Sarculator and was stratified into higher (10‐year pr‐OS < 60%) and lower risk subgroups (10‐year pr‐OS ≥ 60%). Results: The median pr‐OS was 0.63 (interquartile range [IQR], 0.51‐0.72) for the entire study population, 0.62 (IQR, 0.51‐0.70) for the AI arm, and 0.64 (IQR, 0.51‐0.73) for the HT arm. Three‐ and 5‐year overall survival (OS) were 0.86 (95% confidence interval [CI], 0.82‐0.93) and 0.81 (95% CI, 0.71‐0.86) in lower risk patients and 0.69 (95% CI, 0.70‐0.85) and 0.59 (95% CI, 0.51‐0.72) in the higher risk patients (log‐rank test, P =.004). In higher risk patients, the 3‐ and 5‐year Sarculator‐predicted and study‐observed OS rates were 0.68 and 0.58, respectively, and 0.85 and 0.66, respectively, in the AI arm (P =.04); the corresponding figures in the HT arm were 0.69 and 0.60, respectively, and 0.69 and 0.55, respectively (P >.99). In lower risk patients, the 3‐ and 5‐year Sarculator‐predicted and study‐observed OS rates were 0.85 and 0.80, respectively, and 0.89 and 0.82, respectively, in the AI arm (P =.507); the corresponding figures in the HT arm were 0.87 and 0.81, respectively, and 0.86 and 0.74, respectively (P =.105). Conclusions: High‐risk patients treated with AI performed better than predicted, and this adds to the evidence for the efficacy of neoadjuvant AI in STS. Lay Summary: People affected by soft tissue sarcomas of the extremities and trunk wall are at some risk of developing metastasis after surgery.Preoperative or postoperative chemotherapy has been tested in clinical trials to reduce the chances of distant metastasis. However, study findings have not been conclusive.This study stratified the risk of metastasis for people affected by sarcomas who were included in a clinical trial testing neoadjuvant chemotherapy. Exploiting the prognostic nomogram Sarculator, it found a benefit for chemotherapy when the predicted risk, based on patient and tumor characteristics, was high. This analysis of the ISG‐STS 1001 trial, which compares anthracycline plus ifosfamide and histology‐tailored chemotherapy in 5 high‐risk soft tissue sarcomas of the extremities and trunk wall, supports the Sarculator nomogram for stratifying patient risk in clinical practice and in clinical trials that will investigate perioperative therapies for soft tissue sarcomas. [ABSTRACT FROM AUTHOR]

We propose a way to model the underdetection of infected and removed individuals in a compartmental model for estimating the COVID-19 epidemic. The proposed approach is demonstrated on a stochastic SIR model, specified as a system of stochastic differential equations, to analyse data from the Italian COVID-19 epidemic. We find that a correct assessment of the amount of underdetection is important to obtain reliable estimates of the critical model parameters. The adaptation of the model in each time interval between relevant government decrees implementing contagion mitigation measures provides short-term predictions and a continuously updated assessment of the basic reproduction number. [ABSTRACT FROM AUTHOR]

This study aims to observe the clinical characteristics and outcomes of recovered patients from coronavirus disease 2019 (COVID-19) related to the vaccination status. We examined results of 205 COVID-19-recovered patients from 15 December 2021 to 1 March 2022 in two hospitals of Local Health Authority of Alessandria (Italy) during the fourth pandemic wave. 77% of patients were hospitalized for acute respiratory failure (ARF) with radiological pneumonia pattern (recovered for COVID), 23% for other causes with occasional positivity finding (recovered with COVID). 32% of patients were not vaccinated for SARS-CoV-2, 37% had three doses, 25% two doses, 5% only one dose. All patients without vaccination were hospitalized for ARF and they had a 7 times higher risk of hospitalization than the vaccinated. 60% of all patients had =3 comorbidities, of these 50% was vaccinated with three doses. In the fourth pandemic wave compared to the other not all patients were hospitalized for ARF and pneumonia and the presence of comorbidities =3 is a risk factor for hospitalization regardless of vaccination status. This justifies the administration of the fourth dose to frail patients. [ABSTRACT FROM AUTHOR]

Background: Images are an important element of any scientific publication, more so for a very visual specialty such as dermatology. Dermatology journals generally include detailed instructions related to images submitted with the manuscripts, including technical aspects such as file format, resolution, and editing. We aimed to review and critically analyze instructions for images in the top 50 dermatology journals [as per the latest Clarivate journal citation report (JCR) ranking]. Methods: The top 50 journals as per the latest Clarivate JCR were included in the study. Instructions for images were reviewed for each of the journals. The main points analyzed included file type, resolution, size limits, editing limits, support for post-processing of images and details regarding patient consent. Results: Only half the journals (25) had clear, detailed, and specific instructions for the images. Only one journal specifically mentioned pixels per inch (PPI) as the descriptive term, and the remaining used dots per inch (DPI), whereas 6 did not mention either. Twenty-three journals did not mention the recommended size of the image. The most common minimum resolution mentioned was 300 DPI (41 journals). Although 24 of the journals mentioned editing limits, none of the journals elaborated on image plagiarism in the instructions. Twenty-one of the fifty did not mention a clear policy on patient consent. Conclusions: Image submission guidelines for dermatology journals need to be made more elaborate yet easier to understand. Developing a consensus, followed by standardization of these submission guidelines, can help both authors and journals. [ABSTRACT FROM AUTHOR]

This study aims to show the power of language in social organization. For this, the analysis of George Orwell's literary work, 1984, is made, in particular, of the creation of a new language in the fictional country of Oceania, which proves to be an important mechanism of population control. For the analysis of this new language, called Newspeak, we seek in the notion of ideological sign, as understood by the Circle of Bakhtin, especially in the work Marxism and philosophy of language (2017), by Volóchinov, the necessary theoretical contribution makes explicit how the use of language can contribute to the control and domination of a people. As a result, it is possible to observe that the elimination of the language spoken by the population and the creation of a new language aims at canceling critical thinking, making people mere reproducers of opinions, without any kind of reflection. [ABSTRACT FROM AUTHOR]

Transposable elements (TEs) are widespread genomic components with substantial roles in genome evolution and sex chromosome differentiation. In this study, we compared the TE composition of three closely related fish with different sex chromosome systems: Megaleporinus elongatus (Z1Z1Z2Z2/Z1W1Z2W2), Megaleporinus macrocephalus (ZZ/ZW) (both with highly differentiated W sex chromosomes), and Leporinus friderici (without heteromorphic sex chromosomes). We created custom TE libraries for each species using clustering methods and manual annotation and prediction, and we predicted TE temporal dynamics through divergence-based analysis. The TE abundance ranged from 16% to 21% in the three mobilomes, with L. friderici having the lowest overall. Despite the recent amplification of TEs in all three species, we observed differing expansion activities, particularly between the two genera. Both Megaleporinus recently experienced high retrotransposon activity, with a reduction in DNA TEs, which could have implications in sex chromosome composition. In contrast, L. friderici showed the opposite pattern. Therefore, despite having similar TE compositions, Megaleporinus and Leporinus exhibit distinct TE histories that likely evolved after their separation, highlighting a rapid TE expansion over short evolutionary periods. [ABSTRACT FROM AUTHOR]

Background: In alfalfa (Medicago sativa), the coexistence of interfertile subspecies (i.e. sativa, falcata and coerulea) characterized by different ploidy levels (diploidy and tetraploidy) and the occurrence of meiotic mutants capable of producing unreduced (2n) gametes, have been efficiently combined for the establishment of new polyploids. The wealth of agronomic data concerning forage quality and yield provides a thorough insight into the practical benefits of polyploidization. However, many of the underlying molecular mechanisms regarding gene expression and regulation remained completely unexplored. In this study, we aimed to address this gap by examining the transcriptome profiles of leaves and reproductive tissues, corresponding to anthers and pistils, sampled at different time points from diploid and tetraploid Medicago sativa individuals belonging to progenies produced by bilateral sexual polyploidization (dBSP and tBSP, respectively) and tetraploid individuals stemmed from unilateral sexual polyploidization (tUSP). Results: Considering the crucial role played by anthers and pistils in the reduced and unreduced gametes formation, we firstly analyzed the transcriptional profiles of the reproductive tissues at different stages, regardless of the ploidy level and the origin of the samples. By using and combining three different analytical methodologies, namely weighted-gene co-expression network analysis (WGCNA), tau (τ) analysis, and differentially expressed genes (DEGs) analysis, we identified a robust set of genes and transcription factors potentially involved in both male sporogenesis and gametogenesis processes, particularly in crossing-over, callose synthesis, and exine formation. Subsequently, we assessed at the same floral stage, the differences attributable to the ploidy level (tBSP vs. dBSP) or the origin (tBSP vs. tUSP) of the samples, leading to the identification of ploidy and parent-specific genes. In this way, we identified, for example, genes that are specifically upregulated and downregulated in flower buds in the comparison between tBSP and dBSP, which could explain the reduced fertility of the former compared to the latter materials. Conclusions: While this study primarily functions as an extensive investigation at the transcriptomic level, the data provided could represent not only a valuable original asset for the scientific community but also a fully exploitable genomic resource for functional analyses in alfalfa. [ABSTRACT FROM AUTHOR]

Selectivity is one of the most fundamental concepts in natural sciences, and it is also critically important in various technological, industrial, and medical applications. Although there are many experimental methods that allow to separate molecules, frequently they are expensive and not efficient. Recently, a new method of separation of chemical mixtures based on utilization of channels and nanopores has been proposed and successfully tested in several systems. However, mechanisms of selectivity in the molecular transport during the translocation are still not well understood. Here, we develop a simple theoretical approach to explain the origin of selectivity in molecular fluxes through channels. Our method utilizes discrete-state stochastic models that take into account all relevant chemical transitions and can be solved analytically. More specifically, we analyze channels with one and two binding sites employed for separating mixtures of two types of molecules. The effects of the symmetry and the strength of the molecular-pore interactions are examined. It is found that for one-site binding channels, the differences in the strength of interactions for two species drive the separation. At the same time, in more realistic two-site systems, the symmetry of interaction potential becomes also important. The most efficient separation is predicted when the specific binding site is located near the entrance to the nanopore. In addition, the selectivity is higher for large entrance rates into the channel. It is also found that the molecular transport is more selective for repulsive interactions than for attractive interactions. The physical-chemical origin of the observed phenomena is discussed. [ABSTRACT FROM AUTHOR]

We investigate how cosmic web environment impacts the average properties of central galaxies in the Sloan Digital Sky Survey (SDSS). We analyse how the average specific star formation rate, stellar age, metallicity, and element abundance ratio [α/Fe] of SDSS central galaxies depend on distance from the cosmic web nodes, walls, and filaments identified by the Discrete Persistent Structures Extractor (DisPerSE). In our approach we control for galaxy stellar mass and local density differentiated between field and group environment. Our results confirm the known trend whereby galaxies exhibit lower specific star formation rates with decreasing distance to the cosmic web features. Furthermore, we show that centrals closer to either nodes, walls, or filaments are on average older, metal richer, and α-enhanced compared to their equal mass counterparts at larger distances. The identified property gradients appear to have the same amplitude for central galaxies in the field as for those in groups. Our findings support a cosmic web quenching that stems from nurture effects, such as ram pressure stripping and strangulation, and/or nature effects linked to the intrinsic properties of the cosmic web. [ABSTRACT FROM AUTHOR]

We study analytically the dynamics of two-dimensional rectangular lattices with periodic boundary conditions. We consider anisotropic initial data supported on one low-frequency Fourier mode. We show that, in the continuous approximation, the resonant normal form of the system is given by integrable PDEs. We exploit the normal form in order to prove the existence of metastability phenomena for the lattices. More precisely, we show that the energy spectrum of the normal modes attains a distribution in which the energy is shared among a packet of low-frequencies modes; such distribution remains unchanged up to the time-scale of validity of the continuous approximation. [ABSTRACT FROM AUTHOR]

This Letter reports an original spin valve device that is based on a chiral templated nickel material. Chirality in Ni is induced by exploiting co-electrodeposition of an organic chiral template. In this specific case, the chiral templating is enantiopure tartaric acid (TA). Facile electrodeposition (co-deposition) in ambient conditions produces a nickel chiral-templated material. Z-shaped magnetoresistance curves, switching sign as a function of TA handedness, prove the peculiar ferromagnetic character induced by the presence of a chiral compound. Synchrotron measurements using circular polarized light, x-ray natural circular dichroism, confirm the chirality of the Ni in the TA/Ni composite. Density functional theory calculation proves the existence of a strong electronic delocalization involving the tartaric acid and Ni. The significant finding of this Letter is that chiral templated Ni paves the way for future spin valve, which will be able to control the spin without an external magnetic field (as indeed foreseen within the chiral induced spin selectivity-effect framework). [ABSTRACT FROM AUTHOR]

A large variety of positive outcomes including social adjustment, psychological well-being and health, have been recently closely associated with positivity (POS). On the assumption that differences in the POS degree might be associated with different individual neuroendocrine assets that enables people to cope effectively with stress, the present study examined the association between POS, salivary cortisol and α-Amylase (α-Amy) production in a group of healthy male volunteers university students, respectively scoring high (POS-H, N = 10) and low (POS-L, N = 10) in POS. Participants were selected from a larger sample of 300 students of the Medical School at Sapienza University of Rome on the basis of their positivity level: POS was analysed and the upper and lower 25% were invited to participate in this new study. The findings report a distinct salivary cortisol and α-Amy production in the study population: in comparison to the POS-H group, the POS-L subjects presented a lower salivary cortisol awake response (CAR) and a flattened α-Amy production at 30 and 60 min after awakening. In addition, salivary cortisol and α-Amy areas under the curve (AUCs), which were calculated as indicators of the two subclinical biomarkers production during the first hour after awakening, resulted significantly lower in the POS-L group in comparison to the POS-H group. Further studies on larger and different populations are needed to definitively confirm that the different cortisol and α-Amy secretion patterns between POS-H and POS-L individuals is associated with a potentially better capacity to preserving an adequate quality of life in individuals being equipped with a system apparently able to better respond to external and/or internal stimuli. Lastly, a better understanding of the biological correlates of POS is crucial to design psychological interventions able to take advantage of individuals' assets and thus to integrate and strengthen the efficacy of traditional medications. [ABSTRACT FROM AUTHOR]

Ugi reactions are still a challenge when the concomitant use of ammonia and formaldehyde is required. Herein, we propose a strategy to overcome this challenge using hexamethylenetetramine (HMTA) as a singular key for the employment of these two simple starting materials in the Ugi reaction. Acylaminoacetamide derivatives were prepared in good to excellent yields by this new methodology. The scope and optimization of the reaction conditions were investigated. This novel methodology was successfully applied in the synthesis of two different diketopiperazines (DKPs) using the Ugi/Deprotection+Activation/Cyclization (UDAC) method. A continuous flow approach was also used in this methodology. [ABSTRACT FROM AUTHOR]

Background: Dedifferentiated liposarcoma (DDLPS), a tumor that lacks effective treatment strategies and is associated with poor outcomes, expresses amplified MDM2 in the presence of wild-type p53. MDM2 ubiquitination of p53 facilitates its XPO1-mediated nuclear export, thus limiting p53 tumor suppressor functions. Consequently, nuclear export is a rational target in DDLPS. We directly compared the antitumor activity of the first-in class XPO1 inhibitor selinexor and doxorubicin, the standard front-line therapy in sarcomas, in DDLPS patient-derived xenografts (PDXs) and primary cell lines. Methods: Drug activity was assessed in three PDXs (and two corresponding cell lines) established from the dedifferentiated component of primary untreated retroperitoneal DDLPS with myogenic (N = 2) and rhabdomyoblastic (N = 1) differentiation from patients who underwent surgery. These models were marked by amplification of MDM2, CDK4 and HMGA2 genes. Results: Selinexor was moderately active in the three PDXs but achieved greater tumor response compared to doxorubicin (maximum tumor volume inhibition: 46–80 % vs. 37–60 %). The PDX harboring rhabdomyoblastic dedifferentiation showed the highest sensitivity to both agents. PDX response to selinexor and doxorubicin was not associated with the extent of MDM2 and CDK4 gene amplification. Interestingly, the most chemosensitive PDX model showed the lowest extent of HMGA2 amplification. Selinexor was also more efficient than doxorubicinin in inducing an apoptotic response in PDXs and cell lines. Consistently, an increased nuclear accumulation of p53 was seen in all selinexor-treated models. In addition, a time-dependent decrease of survivin expression, with an almost complete abrogation of the cytoplasmic anti-apoptotic pool of this protein, was observed as a consequence of the decreased acetylation/activation of STAT3 and the increased ubiquitination of nuclear survivin. Conclusions: Selinexor showed a moderate antitumor activity in three DDLPS PDXs, which was, however, consistently higher than doxorubicin across all different models regardless the extent of MDM2 amplification and the histological differentiation. The depletion of survivin protein seems to significantly contribute to the induction of apoptosis through which selinexor exerts its antitumor activity. [ABSTRACT FROM AUTHOR]

The High-Luminosity Large Hadron Collider upgrade at CERN will result in an increase in the energy stored in the circulating particle beams, making it necessary to assess the thermomechanical performance of currently used and newly developed materials for use in beam intercepting devices such as collimators and absorbers. This study describes the thermomechanical characterisation of a novel copper diamond grade selected for use in tertiary collimators of the HL-LHC. The data obtained are used to build an elastoplastic material model and implemented in numerical simulations performed to benchmark experimental data obtained from the recently completed MultiMat experiment conducted at CERN's HiRadMat facility, where various materials shaped as slender rods were tested under particle beam impact. The analyses focus on the dynamic longitudinal and flexural response of the material, with results showing that the material model is capable of replicating the material behaviour to a satisfactory level in both thermal and structural domains, accurately matching experimental measurements in terms of temperature, frequency content, and amplitude. [ABSTRACT FROM AUTHOR]

The growth of intra‐regional trade in the Global South begs the question of whether frameworks developed for the study of North–South global value chains can be used to study labour standards in emerging South–South networks. Critical of the structuralist approaches characterizing the literature, in this article I tackle the question of how formal and informal institutions interact to shape labour standards in South–South regional value chains. This is achieved in two stages. In the first part of the article, I build on Habermas's theory of communicative action to frame labour standards as the outcome of agents' interactions within and across firms, politico‐administrative institutions and workers' private and public spheres. Drawing on this framework, in the second part of the article I compare labour standards across the Kenya handbag and footwear sectors. While, in the former, interaction across informal institutions favoured an inclusive and consensual debate between workers and employers; in the latter, an overwhelming process of marketization and bureaucratization failed to provide an interactive space for workers' concerns to be voiced and negotiated. [ABSTRACT FROM AUTHOR]

Morphometric characteristics are quantitative indicators of basin elements, which influence the magnitude and variability of hydrological processes. The main objective of this work is to determine morphometric parameters related to the geometry, relief and drainage network of 34 subbasins located in the WEST of Mendoza capital city (Argentina), between parallels 32° 55' and 32° 58' S and meridians 68° 53' and 69° 05' W. This information will allow understanding and characterize the hydrological processes in the eastern slope of the Precordillera, Piedmont and Mogotes low hills range. Based on previous cartography, a base map was made, where basins were delimited, riverbed and level curves were digitized and the dimensions of basins and hypsometric bands were subsequently determined. In this way, the basic information was obtained from the calculation of the shape indexes, hypsometric curve, height and mean slope, network parameters and Horton's laws. A Geographical Information System (GIS) has been used for the delineation and calculation of the morphometric parameters of the basins, using free software GvSIG. [ABSTRACT FROM AUTHOR]

The bulbaceous plant Boophone disticha – known mainly by the term leshoma given by the Sotho ethnic group – is characterized by powerful hallucinogenic properties and is used as initiatory and divinatory plant among many southern African ethnicities. Once known as the main compound of San arrow poisons, its psychoactive properties have been recognized by Western scholars only in the last 50 years, since its ritual use was strictly kept secret by its initiates. Through the analysis of the few ancient and modern ethnographic observations that have been able to bypass the wall of secrecy that envelop the use of this plant, the Sotho male initiation rite (lebollô la banna) and the use of the plant as divinatory “bioscope ” among the South African sangoma (healers) are described. As evidenced by archaeological findings, man’s relationship with this plant has lasted for at least 2000 years. [ABSTRACT FROM AUTHOR]

We consider three-dimensional doubly periodic steady water waves with vorticity, under the action of gravity and surface tension; in particular we consider so-called Beltrami flows, for which the velocity field and the vorticity are collinear. We adapt a recent formulation of the corresponding problem for localised waves which involves a generalisation of the classical Dirichlet–Neumann operator. We study this operator in detail, extending some well-known results for the classical Dirichlet–Neumann operator, such as the Taylor expansion in homogeneous powers of the wave profile, the computation of its differential and the asymptotic expansion of its associated symbol. A new formulation of the problem as a single equation for the wave profile is also presented and discussed in a similar vein. As an application of these results we prove existence of doubly periodic gravity-capillary steady waves and construct approximate doubly periodic gravity steady waves. [ABSTRACT FROM AUTHOR]

The Reynolds decomposition is used to derive a new set of mean-flow equations for linear viscous fluids, with low compressibility (fluids in the liquid state). Additional shear and normal stresses are related to the velocity turbulent fluctuations in order to interpret the considerable energy dissipation in processes which are accompanied by rapid changes in liquid density, at least within the frame of the local thermodynamic equilibrium (LTE) approximation. A constitutive equation for the normal turbulent stresses, which involves the turbulent bulk viscosity, is given. A closure equation for the turbulent bulk viscosity is suggested. In the field of hydraulic engineering, the model is applied to investigate the classical problem of 1D finite amplitude pressure waves propagation in liquid-filled pipes (water hammer phenomenon). Available experimental pressure data are used to calibrate the model parameters and to demonstrate the capability of the proposed theoretical model in reproducing the experimental trials. The model results are discussed with attention paid to the role played by the turbulent bulk viscosity on the energy dissipation processes. [ABSTRACT FROM AUTHOR]

It is well established that a gas density gradient inside molecular clouds and clumps raises their star formation rate (SFR) compared with what they would experience from a gas reservoir of uniform density. This effect should be observed in the relation between dense-gas mass Mdg and SFR of molecular clouds and clumps, with steeper gas density gradients yielding higher SFR/Mdg ratios. The content of this paper is twofold. First, we build on the notion of a magnification factor introduced by Parmentier to redefine the dense-gas relation (i.e., the relation between Mdg and SFR). Not only does the SFR/Mdg ratio depend on the mean freefall time of the gas and on its (intrinsic) star formation efficiency per freefall time, but it also depends on the clump density profile (e.g., the logarithmic slope of the gas density profile and on the relative extent of the constant-density region at the clump center). Second, we show that nearby molecular clouds follow the newly defined dense-gas relation, provided that their dense-gas mass is defined based on a volume density criterion. We also find the same trend for the dense molecular clouds of the Central Molecular Zone (CMZ) of the Galaxy, although this one is scaled down by a factor of 10 compared with nearby clouds, even when including the Sgr C and Sgr B2 clouds. The respective locii of both nearby and CMZ clouds in the parameter space is discussed. [ABSTRACT FROM AUTHOR]