1. Centroacinar cells: At the center of pancreas regeneration.
- Author
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Beer, Rebecca L., Parsons, Michael J., and Rovira, Meritxell
- Subjects
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PANCREATIC regeneration , *CELL populations , *INSULIN , *PEOPLE with diabetes , *ZEBRA danio - Abstract
The process of regeneration serves to heal injury by replacing missing cells. Understanding regeneration can help us replace cell populations lost during disease, such as the insulin-producing β cells lost in diabetic patients. Centroacinar cells (CACs) are a specialized ductal pancreatic cell type that act as progenitors to replace β cells in the zebrafish. However, whether CACs contribute to β-cell regeneration in adult mammals remains controversial. Here we review the current understanding of the role of CACs as endocrine progenitors during regeneration in zebrafish and mammals. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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