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The article discusses case study of a 45-year-old woman complaining of dyspnea on exertion, fatigue and confusion. It is stated that the patient had history of endometriosis and dysmenorrhea, medical conditions that had been treated with a levonorgestrel-releasing intrauterine system. It is noted that the hypertension, hypokalemia, and metabolic alkalosis are due to aldosterone-induced activation of the mineralocorticoid receptor in kidney

The article presents a case study of a 52-year-old man suffering from primary hyperaldosteronism. It is stated that despite treatment with four antihypertensive agents, he had fluctuated blood pressure, hypertension, metabolic alkalosis and hypokalemia. It discusses details of the primary aldosteronism, risk factors associated with the condition and how it could be detected and diagnosed.

The article describes the case of a 52-year-old man with upper respiratory symptoms and low oxygen saturation levels. The patient had developed fever, fatigue, headache, nasal and sinus congestion, sore throat, and a nonproductive cough. Due to dapsone, which the patient took for his dermatitis herpetiformis, the patient had incurred methemoglobinemia and hemolysis that resulted to falsely low SpO2 and hemoglobin A1c levels.

Abstract: The G protein coupled receptor, GPR54, is a key regulator of puberty and reproductive function. Despite its prismatic role, few patients with mutations in GPR54 and the phenotype of hypogonadotropic hypogonadism have been described. This report explores the neuroendocrine, gonadal, placental and obstetric phenotypes of patients with idiopathic hypogonadotropic hypogonadism (IHH) carrying missense (L148S), nonsense (R331X), and nonstop (X399R) mutations in GPR54. A male patient harboring the mutations R331X and X399R demonstrated (1) increased sensitivity to exogenous pulsatile GnRH compared to a cohort of IHH patients undergoing similar therapy and (2) steady increases in testicular volume, spermatogenesis, and fertility while on long-term GnRH therapy. A female patient homozygous for the L148S mutation had (1) intact responses to exogenous GnRH and gonadotropins, (2) multiple conceptions, (3) two uncomplicated pregnancies of healthy children, suggesting grossly intact placental function, (4) spontaneous initiation of uterine contractions, and (5) lactation for several months post-partum. Taken together, these observations help to tease apart the neuroendocrine and gonadal phenotypes of patients bearing mutations in GPR54. [Copyright &y& Elsevier]

The article focuses on utilizing mass cytometry immunophenotyping to assess immune dysregulation in patients with unusual autoimmune conditions. Topics discussed include the identification of unique immunologic aberrations in certain patients, such as the expansion of regulatory T cells (Tregs) and abnormal B cell clusters.

This article presents a response by the authors to letters regarding hypocalciuric hypercalcemia, as reported in the July 22, 2007, issue.

Presents a brief report on acquired hypocalciuric hypercalcemia due to autoantibodies against the calcium-sensing receptor.

A 21-year-old man was admitted to this hospital because of fatigue, weight loss, tender gynecomastia, hyperthyroidism, and lesions in the lungs and liver on radiographic imaging. Diagnostic procedures were performed. [ABSTRACT FROM AUTHOR]

The article describes the case of a 34-year-old woman with glucose homeostasis and hypoglycemia. The patient experienced symptoms such as episodes of altered mental status and amnesia. She underwent the differential diagnosis of altered mental status and an electrocardiogram. Causes of hypoglycemia include the treatment of diabetes.

A letter to the editor is presented in response to the article "Case Records of the Massachusetts General Hospital," by Pallais and colleagues in the October 25, 2012 issue.