10 results on '"Nydert, Per"'
Search Results
2. Cross‐sectional study identifying high‐alert substances in medication error reporting among Swedish paediatric inpatients.
- Author
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Nydert, Per, Kumlien, Antonia, Norman, Mikael, and Lindemalm, Synnöve
- Subjects
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MEDICATION errors , *CROSS-sectional method , *DRUG administration , *MEDICAL care , *UNIVERSITY hospitals - Abstract
Aim: The aims were to characterise paediatric medication errors and to identify the prevalence of known high‐alert substances in these errors. Methods: All paediatric drug‐related incident reports and complaints nationally reported to the Health and Social Care Inspectorate in Sweden 2011‐2017 regarding inpatients were characterised by context and modal details. In addition, drug use at a university hospital was matched to local incident reports. Drug substances were classified using three high‐alert lists. Results: On a national level, there were 160 reports (2.5 per 10 000 patients) in which the three high‐alert lists were found in different degrees (17/35/47%). Morphine (n = 12), vancomycin (n = 11) and potassium (n = 7) were most frequently involved. Eighty per cent of the reports concerned patients aged 0‐6 years. Intravenous was the most common route of administration (66%). On a university hospital level, the prevalence of all types of drug incidents reports was 1.7% among all inpatients. The prevalence of local incident reports involving high‐alert substances was almost double that of non‐alert substances. Conclusion: Existing high‐alert drug lists are relevant for paediatric inpatients. A higher awareness and usage of such lists among hospital staff prescribing, dispensing and administering drugs to children may have the potential to reduce medication errors. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
3. Over-the-counter drug use--estimations within the Swedish paediatric population.
- Author
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Nydert, Per, Kimland, Elin, Kull, Inger, Lindemalm, Synnöve, and Lindemalm, Synnöve
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NONPRESCRIPTION drugs , *PEDIATRIC emergencies , *CHILDREN & drugs - Abstract
We have used three different sources to estimate the use of drugs sold over the counter (OTC) by the Swedish paediatric population during 2007-2008 as part of a European evaluation initiated by the European Medicines Agency. An estimation of the paediatric use from the total numbers of over-the-counter drugs (OTCD) packages sold by Swedish pharmacies and analyses of two separate questionnaires directed towards a population of 11- to 14-year-old children and another towards visitors to one of the paediatric emergency wards in Stockholm County were included in the study. In Sweden, 1.25 OTC packages are sold quarterly per child (0-18 years), and the children in both questionnaire studies use, on average, 0.9 OTC substances. Sixty-five percent of the children visiting an emergency ward and 67% of the 13-year-old Stockholm inhabitants had used at least one OTCD. OTCD use among children is common. Interpretation of OTCD data must be done carefully since questions with regard to OTCD use is subject to recall bias and the number of packages sold to children is hypothesised through a conversion factor. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
4. Chitosan as a carrier for non-viral gene transfer in a cystic-fibrosis cell line.
- Author
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Nydert, Per, Dragomir, Anca, and Hjelte, Lena
- Abstract
The gene transfer mediated by chitosan in CFBE41o− (a cystic-fibrosis bronchial epithelial cell line) and HEK (a human embryonic kidney cell line) has been evaluated. Polyplexes based on chitosan and PEI (polyethyleneimine) using a luciferase and enhanced green fluorescent protein reporter plasmid showed that the transfection efficacy of polyplexes in the CFBE41o− cell line was poor compared with that in HEK cells. In the highly differentiated cystic-fibrosis bronchial epithelial cell line the narrow-size-distributed chitosan shows enhanced transfection at a low pH compared with PEI. The enhanced transfection at lower pH could be a result of damage to the cell surface or changes in the cell-surface charge, leading to better penetration of the cell membrane. [ABSTRACT FROM AUTHOR]
- Published
- 2008
- Full Text
- View/download PDF
5. Pre-packed take-home analgesics in ambulatory surgery
- Author
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Lindahl, Johanna B., Nydert, Per, Giesecke, Kajsa, Persson, Peter M., Movin, Tomas, and Segerdahl, Märta
- Subjects
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AMBULATORY surgery , *ANALGESICS , *ACETAMINOPHEN , *DRUG efficacy , *OUTPATIENT medical care - Abstract
Summary: Clinical studies have revealed that a high percentage of patients experience moderate or severe pain during the first 24–48h following ambulatory surgery. We examined, in a prospective, randomised study, if standardizing by dispensing a pre-packed take-home analgesics (fixed combination codeine phosphate/acetaminophen), would lead to high adherence with pain treatment together with an improved alleviation of pain after discharge compared to normal practice. “Normal practice” implied that analgesics were prescribed at the surgeon''s discretion without any standardisation. A total of 150 patients were included (surgical procedures: knee arthroscopy, breast surgery and surgery of varicose veins or anal fistulae). Analgesic efficacy and influence of pain on daily functions after discharge were evaluated by self-assessment of pain intensity by selected items of the BPI-SF. Adherence to treatment, frequency of adverse events and analgesic intake were also recorded during the study period. No significant difference in pain intensity could be seen regardless of high adherence in the intervention group. We conclude that pre-packed medication is an opportunity to provide patients with an easy method of handling postoperative analgesics, but a high frequency of drug related adverse events and the absence of better analgesia indicates that customised analgesic therapies are warranted. [Copyright &y& Elsevier]
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- 2006
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6. Cross-sectional study identifying high-alert substances in medication error reporting among Swedish paediatric inpatients.
- Author
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Nydert, Per, Kumlien, Antonia, Norman, Mikael, and Lindemalm, Synnöve
- Subjects
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RESEARCH , *HOSPITAL patients , *CROSS-sectional method , *RESEARCH methodology , *MEDICATION errors , *MEDICAL cooperation , *EVALUATION research , *COMPARATIVE studies , *RISK management in business - Abstract
Aim: The aims were to characterise paediatric medication errors and to identify the prevalence of known high-alert substances in these errors.Methods: All paediatric drug-related incident reports and complaints nationally reported to the Health and Social Care Inspectorate in Sweden 2011-2017 regarding inpatients were characterised by context and modal details. In addition, drug use at a university hospital was matched to local incident reports. Drug substances were classified using three high-alert lists.Results: On a national level, there were 160 reports (2.5 per 10 000 patients) in which the three high-alert lists were found in different degrees (17/35/47%). Morphine (n = 12), vancomycin (n = 11) and potassium (n = 7) were most frequently involved. Eighty per cent of the reports concerned patients aged 0-6 years. Intravenous was the most common route of administration (66%). On a university hospital level, the prevalence of all types of drug incidents reports was 1.7% among all inpatients. The prevalence of local incident reports involving high-alert substances was almost double that of non-alert substances.Conclusion: Existing high-alert drug lists are relevant for paediatric inpatients. A higher awareness and usage of such lists among hospital staff prescribing, dispensing and administering drugs to children may have the potential to reduce medication errors. [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
- View/download PDF
7. Identifying neonatal adverse events in preterm and term infants using a paediatric trigger tool.
- Author
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Dillner, Pernilla, Unbeck, Maria, Norman, Mikael, Nydert, Per, Härenstam, Karin Pukk, Lindemalm, Synnöve, Wackernagel, Dirk, and Förberg, Ulrika
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PREMATURE infants , *PEDIATRICS , *NURSES , *NEONATAL sepsis , *NEONATOLOGY , *PATIENT safety - Abstract
Aim: To explore the incidence and characteristics of inpatient neonatal adverse events in a Swedish setting. Methods: A retrospective record review, using a trigger tool, performed by registered nurses and a neonatologist, at a University Hospital. The identified adverse events were categorised by, for example, preventability, severity and time of occurrence. Results: A random selection of 150 admissions representing 3531 patient days were reviewed (mean [SD] birthweight 2620 [1120]g). Three hundred and sixty adverse events were identified in 78 (52.0%) infants, and 305 (84.7%) of these were assessed as being preventable. The overall adverse event rate was 240 per 100 admissions and 102.0 per 1000 patient days. Preterm infants had a higher rate than term infants (353 versus 79 per 100 admissions, p = 0.001); however, with regard to the length of stay, the rates were similar. Most adverse events were temporary and less severe (n = 338/360, 93.9%) and the most common type involved harm to skin, tissue or blood vessels (n = 163/360, 45.3%). Forty percent (n = 145) of adverse events occurred within the first week of admission. Conclusion: Adverse events were common in neonatal care, and many occurred during the first days of treatment. Characterisation of adverse events may provide focus areas for improvements in patient safety. [ABSTRACT FROM AUTHOR]
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- 2023
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8. Manipulated Oral and Rectal Drugs in a Paediatric Swedish University Hospital, a Registry-Based Study Comparing Two Study-Years, Ten Years Apart.
- Author
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Andersson, Åsa C., Eksborg, Staffan, Förberg, Ulrika, Nydert, Per, and Lindemalm, Synnöve
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ORAL drug administration , *ORAL medication , *RECTAL administration , *UNIVERSITY hospitals , *ORAL medicine - Abstract
This is a registry-based study with the aim of describing and comparing the frequency of manipulations of solid oral and rectal medicines in 2009 and 2019 at inpatient units and an emergency department in a paediatric hospital within a Swedish university hospital. All patients aged 1 month–18 years with oral or rectal administrations were included. In total, 140,791 oral and rectal administrations were included in 2009, and 167,945 oral and rectal administrations were included in 2019. The frequency of patients receiving at least one manipulated oral medicine decreased between the study years, both in inpatient units and in the emergency department (from 19% to 17%, p = 0.0029 and from 11% to 5%, p < 0.0001, respectively). The frequency of patients receiving a manipulated rectal medicine also decreased between the study years, both in inpatient units and in the emergency department (from 22% to 10%, p < 0.0001 and from 35% to 7% 2019, p < 0.0001, respectively). The results show a decrease in the manipulation of both oral and rectal medicines to paediatric patients in 2019 compared to 2009. Even though this implies a safer practice, there is still a pronounced lack of child-friendly dosage forms and suitable strengths enabling the safe administration of medicines to sick children. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
9. Validation of triggers and development of a pediatric trigger tool to identify adverse events.
- Author
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Unbeck, Maria, Lindemalm, Synnöve, Nydert, Per, Ygge, Britt-Marie, Nylén, Urban, Berglund, Carina, and Härenstam, Karin Pukk
- Subjects
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ADVERSE health care events , *PEDIATRIC errors , *HOSPITAL care of children , *PATIENT safety , *EMERGENCY medical services , *PEDIATRICS - Abstract
Background Little is known about adverse events (AEs) in pediatric patients. Record review is a common methodology for identifying AEs, but in pediatrics the record review tools generally have limited focus. The aim of the present study was to develop a broadly applicable record review tool to identify AEs in pediatric inpatients. Methods Using a broad literature review and expert opinion with a modified Delphi process, a pediatric trigger tool with 88 triggers, definitions, and descriptions including AE preventability decision support was developed and tested in a random sample of 600 hospitalized pediatric patients admitted in 2010 to a single university children's hospital. Four registered nurse-physician teams performed complete two-stage retrospective reviews of 150 records each from either neonatal, surgical/orthopedic, medicine, or emergency medicine units. Results Registered nurse review identified 296 of 600 records with triggers indicating potential AEs. Records (n = 121) with only false positive triggers not indicating any potential AEs were not forwarded to the next review stage. On subsequent physician review, 204 (34.0%) of patients were found to have had 563 AEs, range 1-27 AEs/patient. A total of 442 preventable AEs were found in 161 patients (26.8%), range 1-22. Overall, triggers were found 3,598 times in 417 (69.5%) records, with a mean of 6 (median 1, range 0-176) triggers per patient. The overall positive predictive value of the triggers was 22.9%, (range 0.0-100.0%). The final pediatric trigger tool, developed with a second Delphi round, required 29 triggers. Conclusions AEs are common in pediatric patients and most are preventable. The main contributions of this study are to further develop and adapt trigger definitions, including AE preventability decision support, to introduce new triggers in pediatric care, as well as to apply pediatric triggers in different clinical specialties. Our findings resulted in a national pediatric trigger tool, and might also be adapted internationally. The pediatric trigger tool can help healthcare organizations to measure and analyze the AEs occurring in hospitalized children in order to improve patient safety. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
10. Validation of triggers and development of a pediatric trigger tool to identify adverse events.
- Author
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Unbeck, Maria, Lindemalm, Synnöve, Nydert, Per, Ygge, Britt-Marie, Nylén, Urban, Berglund, Carina, Pukk Härenstam, Karin, and Härenstam, Karin Pukk
- Abstract
Background: Little is known about adverse events (AEs) in pediatric patients. Record review is a common methodology for identifying AEs, but in pediatrics the record review tools generally have limited focus. The aim of the present study was to develop a broadly applicable record review tool to identify AEs in pediatric inpatients.Methods: Using a broad literature review and expert opinion with a modified Delphi process, a pediatric trigger tool with 88 triggers, definitions, and descriptions including AE preventability decision support was developed and tested in a random sample of 600 hospitalized pediatric patients admitted in 2010 to a single university children's hospital. Four registered nurse-physician teams performed complete two-stage retrospective reviews of 150 records each from either neonatal, surgical/orthopedic, medicine, or emergency medicine units.Results: Registered nurse review identified 296 of 600 records with triggers indicating potential AEs. Records (n = 121) with only false positive triggers not indicating any potential AEs were not forwarded to the next review stage. On subsequent physician review, 204 (34.0%) of patients were found to have had 563 AEs, range 1-27 AEs/patient. A total of 442 preventable AEs were found in 161 patients (26.8%), range 1-22. Overall, triggers were found 3,598 times in 417 (69.5%) records, with a mean of 6 (median 1, range 0-176) triggers per patient. The overall positive predictive value of the triggers was 22.9%, (range 0.0-100.0%). The final pediatric trigger tool, developed with a second Delphi round, required 29 triggers.Conclusions: AEs are common in pediatric patients and most are preventable. The main contributions of this study are to further develop and adapt trigger definitions, including AE preventability decision support, to introduce new triggers in pediatric care, as well as to apply pediatric triggers in different clinical specialties. Our findings resulted in a national pediatric trigger tool, and might also be adapted internationally. The pediatric trigger tool can help healthcare organizations to measure and analyze the AEs occurring in hospitalized children in order to improve patient safety. [ABSTRACT FROM AUTHOR]- Published
- 2014
- Full Text
- View/download PDF
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