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3. Outcomes of induction chemotherapy followed by concurrent chemoradiation for nasopharyngeal carcinoma

Author

Golden, D.W., Rudra, S., Witt, M.E., Nwizu, T., Cohen, E.E.W., Blair, E., Stenson, K.M., Vokes, E.E., and Haraf, D.J.

Subjects
*CANCER chemotherapy, *CANCER radiotherapy, *NASOPHARYNX cancer, *RADIATION doses, *ADJUVANT treatment of cancer, *HEALTH outcome assessment, *CANCER treatment
Abstract

Summary: Purpose: Current standard therapy for nasopharyngeal carcinoma (NPC) is concurrent chemoradiation based on randomized data. However, limited randomized data exist to support the addition of induction chemotherapy (ICT). Methods: 58 Patients with NPC were treated from 1990 to 2010. All patients received platinum-based ICT. All 58 patients were treated with chemoradiation, 57 in a week-on/week-off (WOWO) fashion. Concurrent chemotherapy included hydroxyurea/5-fluorouracil for all patients. Median radiation dose was 70Gy. No patient received adjuvant chemotherapy. Results: AJCC 2009 stage was II=13, III=21, IVa=13, and IVb=11. Median follow-up for surviving patients was 66months. Response to ICT was complete response (CR) 17% and partial response (PR) 64%. The CR rate after chemoradiation was 96%. Five-year actuarial freedom from local failure (FFLF), freedom from distant failure (FFDF), cause-specific survival (CSS), and overall survival (OS) was 98%, 90%, 90%, and 76%, respectively. Analysis of pediatric patients (n =9) demonstrated 5-year actuarial FFLF, FFDF, CSS, and OS of 100%, 88%, 80%, and 80%, respectively. Conclusions: ICT followed by concurrent chemoradiation demonstrates excellent FFLF, FFDF, CSS, and OS with tolerable toxicity. Induction chemotherapy followed by concurrent chemoradiation for patients with NPC should be explored further in a randomized setting. [ABSTRACT FROM AUTHOR]

Published
2013
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4. Successful Development, Implementation, and Assessment of a Clinical Care Path (CP) Guide for the Treatment of Human Papillomavirus (HPV)-Initiated Oropharynx Cancer.

Author

Adelstein, D.J., Koyfman, S., Burkey, B.B., Houston, N., Tullio, K., Lamarre, E., Scharpf, J., Lorenz, R., Khan, M., Nwizu, T., Jr.Greskovich, J.F., Ives, D., Rahe, M., Bodmann, J., Harr, B., Cummings, C., and Bolwell, B.

Subjects
*MEDICAL care, *PAPILLOMAVIRUS diseases, *OROPHARYNGEAL cancer, *CANCER radiotherapy, *MEDICAL research, *CANCER treatment, *THERAPEUTICS
Published
2016
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6. Dramatic Reduction in the Need for Feeding Tube Use in Human Papillomavirus–Positive Oropharyngeal Cancer in the Intensity Modulated Radiation Therapy Era.

Author

Koyfman, S., Ward, M.C., Houston, N., Joshi, N.P., Harr, B.A., Bodmann, J., Ives, D., Rahe, M., Nwizu, T., Adelstein, D.J., and Jr.Greskovich, J.F.

Subjects
*OROPHARYNGEAL cancer, *INTENSITY modulated radiotherapy, *CETUXIMAB, *PAPILLOMAVIRUSES, *FEEDING tubes, *CANCER treatment, *THERAPEUTICS
Published
2016
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7. Genomic Instability in Larynx Cancer.

Author

Deeb, A., Beck, J., Schuetz, E., Nwizu, T., Romick-Rosendale, L., Lucas, F., Butler, R., Wise-Draper, T., Mirezwa, M., Morris, J.C., Casper, K., Adelstein, D.J., Grandis, J., Bahassi, E.M., Urnovitz, H., and hashemi Sadraei, N.

Subjects
*LARYNGEAL cancer treatment, *GENOMICS, *ONCOLOGY periodicals, *PUBLISHING, *PERIODICAL publishing
Published
2016
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8. Predictors of Unplanned Hospital Admissions and/or Feeding Tube Placement in Patients With Oropharyngeal Cancer Treated With Cisplatin-Based Chemoradiation.

Author

Harr, B., Bodmann, J., Joshi, N.P., Ward, M.C., Ives, D., Rahe, M., Reddy, C.A., Hamker, J., Jr.Greskovich, J.F., Nwizu, T., Adelstein, D.J., and Koyfman, S.

Subjects
*OROPHARYNGEAL cancer, *HOSPITAL admission & discharge, *FEEDING tubes, *CISPLATIN, *CANCER chemotherapy, *CANCER treatment
Published
2016
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9. Clinical Predictors of Locoregional Failure in Advanced Laryngeal Cancer Treated With Definitive Chemotherapy and Radiation.

Author

Khan, A.M., Ward, M.C., Adelstein, D.J., Koyfman, S., Reddy, C.A., Bhateja, P., Funchain, P., Lamarre, E., Burkey, B.B., Khan, M., Scharpf, J., Prendes, B., Jr.Greskovich, J.F., Lorenz, R., Joshi, N.P., Rahe, M., Ives, D., Harr, B., Bodmann, J., and Nwizu, T.

Subjects
*LARYNGEAL cancer treatment, *CANCER chemotherapy, *CANCER radiotherapy, *LARYNGEAL cancer patients, *MEDICAL errors
Published
2016
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13. Cetuximab-based Bioradiation Therapy Is Associated With Higher Rates of Distant Metastases Than Platinum-based Chemoradiation Therapy in Human Papillomavirus–Positive Oropharyngeal Cancer.

Author

Weller, M.A., Ward, M.C., Berriochoa, C.A., Reddy, C.A., Trosman, S., Greskovich, J.F., Nwizu, T., Burkey, B.B., Adelstein, D.J., and Koyfman, S.

Subjects
*CETUXIMAB, *METASTASIS, *CANCER chemotherapy, *CANCER radiotherapy, *PAPILLOMAVIRUS diseases, *PHARYNGEAL cancer, *CANCER treatment
Published
2015
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15. Advanced Practice Nurse, Follow-up Clinic Reduces Emergency Room Visits and Admissions in High-Risk Patients After Chemoradiation Therapy for Head and Neck Cancer.

Author

Harr, B., Hamker, J., Joshi, N.P., Ward, M.C., Bodmann, J., Ives, D., Rahe, M., Nwizu, T., Adelstein, D.J., Greskovich, J.F., and Koyfman, S.

Subjects
*MEDICAL practice, *FOLLOW-up studies (Medicine), *MEDICAL emergencies, *HOSPITAL admission & discharge, *CANCER radiotherapy, *HEAD & neck cancer treatment
Published
2015
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16. A Safety and Efficacy Comparison of High Dose Definitive (>70 Gy) Versus Postoperative Reirradiation Using Intensity Modulated Radiation Therapy (IMRT) in Recurrent or Second Primary Head and Neck Cancer.

Author

Zakem, S.J., Koyfman, S., Ward, M.C., Nwizu, T., Reddy, C.A., Lamarre, E., Scharpf, J., Burkey, B.B., Jr.Greskovich, J.F., and Adelstein, D.J.

Subjects
*HEAD & neck cancer treatment, *INTENSITY modulated radiotherapy, *CANCER relapse, *POSTOPERATIVE care, *RADIATION doses, *TREATMENT effectiveness
Published
2015
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17. A Comparison of Control and Toxicity Outcomes for Conventional Versus Accelerated Fractionation Schedules of IMRT-Based Chemoradiation Therapy in Head and Neck Cancer.

Author

Manyam, B., Ward, M.C., Joshi, N.P., Noble, A., Harr, B., Houston, N., Nwizu, T., Adelstein, D.J., Jr.Greskovich, J.F., and Koyfman, S.

Subjects
*HEAD & neck cancer treatment, *INTENSITY modulated radiotherapy, *HEALTH outcome assessment, *CANCER chemotherapy, *COMPARATIVE studies
Published
2015
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18. Reduction of Severe Late Toxicity After Definitive Chemoradiation Therapy (CRT) Using Intensity Modulated Radiation Therapy (IMRT) in Non-HPV–Associated Head and Neck Squamous Cell Carcinoma (HNSCC): More than Xerostomia.

Author

Ward, M.C., Bhateja, P., Reddy, C.A., Adelstein, D.J., Bledsoe, T.B., Xia, P., Nwizu, T., Greskovich, J.F., Burkey, B.B., and Koyfman, S.A.

Subjects
*CANCER chemotherapy, *INTENSITY modulated radiotherapy, *HEAD & neck cancer treatment, *SQUAMOUS cell carcinoma, *CANCER treatment, *XEROSTOMIA, *CANCER radiotherapy complications
Published
2014
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19. Nasogastric Enteral Feeding Is Superior to Percutaneous Gastrostomy in Preventing Late Pharyngeal Dysfunction in Long-Term Survivors of Locoregionally Advanced Head and Neck Squamous Cell Cancer (HNSCC) Treated With Definitive Chemoradiation Therapy (CRT)

Author

Ward, M.C., Bhateja, P., Bledsoe, T.B., Adelstein, D.J., Nwizu, T., Greskovich, J.F., Reddy, C.A., Burkey, B.B., Xia, P., and Koyfman, S.A.

Subjects
*SQUAMOUS cell carcinoma, *CANCER treatment, *PHARYNGEAL cancer, *GASTROSTOMY, *HEAD & neck cancer, *CANCER chemotherapy, *CANCER radiotherapy
Published
2014
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20. Intensity Modulated Radiation Therapy (IMRT) Reduces Late Toxicity in Patients With Human Papillomavirus–Associated (HPV+) Oropharyngeal Carcinoma Treated With Chemoradiation Therapy (CRT).

Author

Koyfman, S., Bledsoe, T.B., Barnett, J., Reddy, C.A., Chute, D., Nwizu, T., Saxton, J.P., Burkey, B.B., Greskovich, J.F., and Adelstein, D.J.

Subjects
*INTENSITY modulated radiotherapy, *PAPILLOMAVIRUSES, *OROPHARYNGEAL cancer, *CANCER chemotherapy, *CANCER radiotherapy
Published
2014
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24. Improving Healthcare Value in Patients With Stage III-IV Squamous Cell Carcinoma of Head and Neck (HNSCC): Cost and Outcome Comparison of 2 Arms of a Randomized, Phase 3 Trial of Definitive Chemoradiation (ChemoRT).

Author

Greskovich, J.F., Gordian, M., Koyfman, S.A., Lorenz, R., Scharpf, J., Khan, M., Burkey, B., Nwizu, T., Rodriguez, C., and Adelstein, D.

Subjects
*HEAD & neck cancer patients, *SQUAMOUS cell carcinoma, *CANCER chemoprevention, *CANCER radiotherapy, *HEALTH outcome assessment, *MEDICAL care costs, *CLINICAL trials
Published
2013
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