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The article examines the issues of creating a power flexible cable production in the country (Republic of Kazakhstan). The research objective of the study is to assess the technical and economic feasibility for organization of such production. Production program, investment estimation (cost sheet) and model of financial and economic payback for this project were calculated in course of the article's research. The research confirms the effectiveness of the creation for cable production in Kazakhstan, also this project can be recommended for implementation. [ABSTRACT FROM AUTHOR]

We study a superlattice formed by tunnel-coupled identical antidots periodically situated in a two-dimensional topological insulator placed in a magnetic field. The superlattice spectrum can be controlled by gate electrodes or by changing the magnetic flux through the antidots. We demonstrate that a topologically protected qubit appears at the boundary between two regions with different fluxes. The qubit properties depend on the value of the flux jump on the boundary and can be controlled by the gate voltage. We derive the effective Hamiltonian of such a qubit and analyze the dependence of its properties on the main parameters of the superlattice: the tunnel coupling between antidots, and the probability of jumps with the spin flip. [ABSTRACT FROM AUTHOR]

The research was carried out as part of the preparation "Water Resources" section of the 4th National Communication of the Kyrgyz Republic to the UNFCCC. The article presents extensive information on the current state and changes over a long period of observations of water resources, climate and glaciation in Kyrgyzstan (Syr-Darya and Amu-Darya river basins). The representative rivers were selected as the main objects, which are transboundary between Kyrgyzstan, Uzbekistan, Kazakhstan and Tajikistan. The study aims to assess the inter-annual and intra-annual dynamics of the flow of the rivers for the period from 2020 to 2080, based on the climate projections CMIP5 (RCP4.5 and RCP8.5) and CMIP6 (SSP2-4.5 and SSP5-8.5) (IPCC WG II Report, 2022). The hydrological modeling method in the HBV light and HBV EHT models and the inertial mean annual flow change method were used to estimate changes in water resources. On the rivers of the northern part of the Fergana Valley, the average annual runoff is expected to increase by 1-19%, in the Amudarya river basin (Kyzyl-Suu river) - by 27-64% of the values for 2006-2019. In the Naryn river, water discharge for this period will remain within the current values for 2006-2019. The method of inertial change in the average annual runoff showed an increase in runoff for 2030 and 2040 for all the studied catchment areas by 6-19% of the current values for 2006-2020T. he results of the study are intended for decision-makers on the rational use and long-term planning of water resources under climate change. [ABSTRACT FROM AUTHOR]

Naqshibandi sect of Sufism has made a great contribution the Islamic world. Several examples of this influence can be listed in different forms. But its unity mission among the people while safeguarding the national and moral values and in the same time, against the intrusive politics of strangers, has always been among the best examples that is worth to be mentioned. The Mahmoudiyya branch of the Naqshibandiyya sect of Sufism, which had been scattered in Azerbaijan in the 19th century, was demonstrating such a feature. The successors of this Sufi school have a role in the formation of Sufi literature. Pilgrims and the Mecca Pilgrimage have a special place in this literature. This ubiquitous value, which had led to the moral unity of Muslims in general, was also disturbing theTsarist policy at that time. Our article outlines such features. [ABSTRACT FROM AUTHOR]

Background: In clinical trials, poly (ADP-ribose) polymerase inhibitors (PARPi) versus chemotherapy resulted in significantly improved progression-free survival, manageable adverse event profiles, and favorable patient-reported outcomes (PROs) in patients with human epidermal growth factor receptor 2–negative (HER2−) advanced breast cancer (ABC) and germline BRCA1/2 mutations (gBRCA1/2mut). The objective of this study was to evaluate PROs and physician satisfaction with treatment in patients with gBRCA1/2mut HER2− ABC receiving PARPi or physician's choice of chemotherapy in a multi-country, real-world setting. Methods: This retrospective analysis used data from the Adelphi Real World ABC Disease Specific Programmes in the United States, European Union, and Israel. PROs were assessed at a single timepoint using the EuroQol 5-Dimensions 5-Level (EQ-5D-5L) scale, Cancer Therapy Satisfaction Questionnaire (CTSQ), and European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire Core 30 (EORTC QLQ-C30) and the breast cancer−specific module (QLQ-BR23). Baseline PROs were not assessed. Physician satisfaction with treatment scores was dichotomized to a 0/1 variable (0 = very dissatisfied/dissatisfied/moderately satisfied; 1 = satisfied/very satisfied). Scores were compared using inverse-probability−weighted regression adjustment, controlling for multiple confounding factors. Results: The study included 96 patients (PARPi, n = 38; platinum/non–platinum-based chemotherapy, n = 58). Patients receiving PARPi versus chemotherapy reported significantly better scores on the EQ-5D-5L Health Utility Index. On the EORTC QLQ-C30 functional scales, patients receiving PARPi reported significantly better scores (mean ± SE) for physical functioning (80.0 ± 2.4 vs 71.9 ± 3.4; p < 0.05) and social functioning (82.0 ± 6.2 vs 63.6 ± 3.7; p < 0.05) and, on the symptom scales, reported significantly better scores for constipation (1.9 ± 1.8 vs 18.7 ± 3.2; p < 0.001), breast symptoms (0.4 ± 3.9 vs 13.3 ± 2.6; p < 0.01), arm symptoms (2.6 ± 1.3 vs 11.4 ± 2.4; p = 0.001), and systemic therapy side effects (13.5 ± 1.8 vs 29.4 ± 2.3; p < 0.001). In contrast, patients receiving chemotherapy scored significantly better on the nausea/vomiting scale (18.3 ± 2.8 vs 34.5 ± 5.1; p < 0.01). Patients receiving PARPi reported numerically better satisfaction scores on the CTSQ scales. Physicians were more likely to be satisfied/very satisfied with PARPi versus chemotherapy (95.4% ± 7.3% vs 40.8% ± 6.2%; p < 0.001). Conclusions: The PRO findings in this real-world population of patients with gBRCA1/2mut HER2− ABC complement those from the pivotal clinical trials, providing further support for treatment with PARPi in these patients. [ABSTRACT FROM AUTHOR]

The following paper explores the development of a statistically based index evaluating digitalization processes to assess the digital divide between the regions of Kazakhstan: resource-based (oil and gas) regions and regions where the service sector dominates the GRP. As a method for forming such an indicator, the authors suggest using factor analysis, which reduces the dimension of factors while maintaining the reasoning behind a significant part of the data variability. This approach is preferable because the index is formed on the basis of statistically objective estimates rather than that of subjective expert opinion. The results of the factor analysis were interpreted as the following two qualitatively different subindices that formed the final Economy and Society Digitalization Index, namely, for resource-based (oil and gas) regions: subindex of digital consumption by households and subindex of digital consumption by organizations; for service-dominated regions: subindex of digital consumption by households and organizations, and subindex of digitalization of labor management processes. The combined values of the calculated subindices allowed us to conclude that the introduction of information and communication technologies into the consumer environment is greater than into the activities of economic entities. Open innovations are revealed to create additional opportunities for obtaining new knowledge and additional tools and ideas that can lead to bridging the digital divide in the regions of Kazakhstan. The analysis of descriptive statistics of these values allowed us to draw a number of conclusions available that can be used to form regional digital policy. First, the regional population shows a fairly homogeneous high level of consumption of telecommunications services, which indicates their availability. Second, the majority of economic entities throughout the country have successfully passed the first stage of digitalization, which consists in the use of Internet technologies; although, not all of them are characterized by a trend toward the digitalization of business processes. Thirdly, for most organizations, the digital development of human capital still remains an important task. Further statistical research of regional differentiation of the values of the proposed digital development indicator will allow a deeper understanding of the reasons for the digital divide in Kazakhstan. [ABSTRACT FROM AUTHOR]

Simple Summary: Poly(adenosine diphosphate-ribose) polymerase inhibitors have recently been shown to be effective for patients with human epidermal growth factor receptor 2—negative (HER2−) advanced breast cancer (ABC) who have a germline mutation in their breast cancer susceptibility gene 1 or 2 (BRCA1/2mut). This study evaluated differences in patient demographics, clinical characteristics, and BRCA1/2mut testing within the United States (US), European Union 4 (EU4; France, Germany, Italy, and Spain), and Israel in a real-world patient population with HER2− ABC. In the US, EU4, and Israel, 73%, 42%, and 99% of patients were tested for BRCA1/2mut, respectively. In the US and the EU4, patients who were not tested versus tested for BRCA1/2mut were more likely to have hormone receptor–positive (HR+)/HER2− ABC than triple-negative breast cancer, less likely to have a known family history of BRCA1/2-related cancer and were older. Efforts should be made to improve BRCA1/2 testing rates in the US and Europe. Poly(adenosine diphosphate-ribose) polymerase inhibitors are approved to treat patients harboring a germline breast cancer susceptibility gene 1 or 2 mutation (BRCA1/2mut) with human epidermal growth factor receptor 2—negative (HER2−) advanced breast cancer (ABC). This study evaluated differences in patient demographics, clinical characteristics, and BRCA1/2mut testing within the United States (US), European Union 4 (EU4; France, Germany, Italy, and Spain), and Israel in a real-world population of patients with HER2− ABC. Oncologists provided chart data from eligible patients from October 2019 through March 2020. In the US, EU4, and Israel, 73%, 42%, and 99% of patients were tested for BRCA1/2mut, respectively. In the US and the EU4, patients who were not tested versus tested for BRCA1/2mut were more likely to have hormone receptor—positive (HR+)/HER2− ABC (US, 94% vs. 74%, p < 0.001; EU4, 96% vs. 78%, p < 0.001), less likely to have a known family history of BRCA1/2-related cancer (US, 6% vs. 19%, p = 0.002; EU4, 10% vs. 28%, p < 0.001), and were older (US, 68.9 vs. 62.5 years, p < 0.001; EU4, 66.7 vs. 58.0 years, p < 0.001). Among tested patients, genetic counseling was received by 45%, 53%, and 98% with triple-negative breast cancer, and 36%, 36%, and 98% with HR+/HER2− ABC in the US, EU4, and Israel, respectively. Efforts should be made to improve BRCA1/2 testing rates in the US and Europe. [ABSTRACT FROM AUTHOR]

We review recent studies of the spin-dependent tunneling transport via an Aharonov–Bohm interferometer (ABI) formed by helical edge states. We focus on the experimentally relevant case of relatively high temperature, T, as compared to level spacing, Δ. The tunneling conductance of helical ABI is structureless in ballistic case but shows sharp periodic antiresonances as a function of magnetic flux with the period in presence of magnetic impurities. The incoming unpolarized electron beam acquires finite polarization after transmission through the helical ABI provided that the edges contain at least one magnetic impurity. The finite polarization appears even in the fully classical regime and is therefore robust to dephasing. There is also a quantum contribution to the polarization, which shows sharp identical resonances as a function of magnetic flux with the same period as conductance. This polarization survives at relatively high temperature. The interferometer can be described in terms of ensemble of flux-tunable qubits giving equal contributions to conductance and spin polarization. Hence, with increasing the temperature number of active qubits participating in the charge and spin transport increases. These features of tunneling helical ABI open a wide avenue for applications in the area of quantum computing. [ABSTRACT FROM AUTHOR]

This article describes the use and advantages of the MATLAB-based program ReshmoBeam, developed to perform beam analysis, as it is done in statics courses of engineering curricula. An important goal of the article is to facilitate the dissemination of the program among faculty teaching these courses. The program is offered free to interested faculty for potential application in their courses. The program is not intended to compete with existing software for this purpose. Existing programs can be comprehensive; however, the user must pay to use all or some of their features. ReshmoBeam covers a limited, but important range of situations in beam analysis. The program determines the reactions at the beam supports, the shear and bending moment values at points specified by the user if desired, and the maximum values of shear and bending moment. The program also generates the loading, shear, and bending moment diagrams for the beam situation under analysis. Students can quickly verify the correctness of their manual calculations and also explore a diverse range of loading conditions. Furthermore, its use could facilitate a deeper understanding of the material taught in the course. [ABSTRACT FROM AUTHOR]

The Fano factor, \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\mathcal{F}$$\end{document}, of the shot noise of the current through the edge states of a two-dimensional topological insulator with contacts of generic type is calculated. A magnetic static defect changes \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\mathcal{F}$$\end{document} significantly. For metallic contacts, as the strength of the defect increases, the Fano factor increases from \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\mathcal{F}$$\end{document} = 0 to its maximum value, \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$${{\mathcal{F}}_{{\max }}}$$\end{document} ≈ 0.17, and then decreases back to zero value in the limit of strong defect. For tunnel contacts in the limit of weak tunnel coupling, the Fano factor is insensitive to the strength of the defect: \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\mathcal{F}$$\end{document} → 1/2. For weak but finite tunnel coupling strength, \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\mathcal{F}$$\end{document} exhibits a periodic series of sharp peaks of small amplitude as a function of the magnetic flux piercing the sample. The peaks transform into Aharonov–Bohm harmonic oscillations with increasing the strength of the tunnel coupling. [ABSTRACT FROM AUTHOR]

Background: Pompe disease is a lysosomal storage disorder that results from an inborn error of metabolism involving abnormal glycogen storage. Infantile-onset Pompe disease is the most severe phenotype, and enzyme replacement therapy with alglucosidase alfa (Lumizyme) improves medical and functional outcomes in patients with infantile-onset Pompe disease. Case Report: We report the case of a patient with infantile-onset Pompe disease who presented with severe hypertrophic cardiomyopathy, systolic and diastolic cardiac dysfunction, and hypotonia. She experienced significant improvement in cardiac systolic function while receiving enzyme replacement therapy. Conclusion: Typically, patients with infantile-onset Pompe disease and severe hypertrophic cardiomyopathy are not as responsive to enzyme replacement therapy as patients with mild or no hypertrophic cardiomyopathy. We demonstrated the efficacy of enzyme replacement therapy in a patient with severe hypertrophic cardiomyopathy. [ABSTRACT FROM AUTHOR]

Autism spectrum disorder (ASD) affects ~ 2% of children in the United States. The etiology of ASD likely involves environmental factors triggering physiological abnormalities in genetically sensitive individuals. One of these major physiological abnormalities is mitochondrial dysfunction, which may affect a significant subset of children with ASD. Here we systematically review the literature on human studies of mitochondrial dysfunction related to ASD. Clinical aspects of mitochondrial dysfunction in ASD include unusual neurodevelopmental regression, especially if triggered by an inflammatory event, gastrointestinal symptoms, seizures, motor delays, fatigue and lethargy. Traditional biomarkers of mitochondrial disease are widely reported to be abnormal in ASD, but appear non-specific. Newer biomarkers include buccal cell enzymology, biomarkers of fatty acid metabolism, non-mitochondrial enzyme function, apoptosis markers and mitochondrial antibodies. Many genetic abnormalities are associated with mitochondrial dysfunction in ASD, including chromosomal abnormalities, mitochondrial DNA mutations and large-scale deletions, and mutations in both mitochondrial and non-mitochondrial nuclear genes. Mitochondrial dysfunction has been described in immune and buccal cells, fibroblasts, muscle and gastrointestinal tissue and the brains of individuals with ASD. Several environmental factors, including toxicants, microbiome metabolites and an oxidized microenvironment are shown to modulate mitochondrial function in ASD tissues. Investigations of treatments for mitochondrial dysfunction in ASD are promising but preliminary. The etiology of mitochondrial dysfunction and how to define it in ASD is currently unclear. However, preliminary evidence suggests that the mitochondria may be a fruitful target for treatment and prevention of ASD. Further research is needed to better understand the role of mitochondrial dysfunction in the pathophysiology of ASD. [ABSTRACT FROM AUTHOR]

The actual at the present stage in neurology is the study and rehabilitation of the longterm effects of central nervous system damage in children (encephalitis, myelitis, encephalomyelitis) which often lead to disability of patients. The actual at the present stage in neurology is the study and rehabilitation of the long-term effects of central nervous system damage in children (encephalitis, myelitis, encephalomyelitis) which often lead to disability of patients. [ABSTRACT FROM AUTHOR]

A special place among the infectious diseases of the central nervous system (CNS) occupy encephalitis (brain inflammation), and myelitis (segmental spinal cord injury caused by acute inflammation) in children. One of the treatments, the use of which is possible in the acute stage and the recovery stage is ozone. Thus, the proposed scientific research is devoted to solving problems identifying of morphopathogenesis CNS lesions, early morfodiagnostik comprehensive, effective treatment, reduce disability and mortality myelitis and encephalomyelits. [ABSTRACT FROM AUTHOR]

The modulated magnetic phase of a structurally heterogeneous easy-plane weak ferromagnet is considered in terms of the thermodynamic Landau theory of phase transitions. The temperature and field dependences of the main magnetic order modulation parameters are determined. The results obtained are compared with the experimental data obtained for the orientational phase transition into a modulated magnetic state that occurs in hematite and iron borate crystals doped with diamagnetic ions to create structural heterogeneity. The proposed theoretical model is shown to describe the entire set of experimental results consistently with some exceptions. [ABSTRACT FROM AUTHOR]

Based on the Landau thermodynamic theory, phase transformations observed in a FeBO single crystal subject to spatially non-uniform mechanical stresses are analyzed. It is demonstrated that the main results of theoretical consideration of structural and magnetic phase transitions in the examined crystal do not contradict with the available experimental data. [ABSTRACT FROM AUTHOR]

Using matching and regression analyses, we measure the difference in citations between articles posted to Academia.edu and other articles from similar journals, controlling for field, impact factor, and other variables. Based on a sample size of 31,216 papers, we find that a paper in a median impact factor journal uploaded to Academia.edu receives 16% more citations after one year than a similar article not available online, 51% more citations after three years, and 69% after five years. We also found that articles also posted to Academia.edu had 58% more citations than articles only posted to other online venues, such as personal and departmental home pages, after five years. [ABSTRACT FROM AUTHOR]

We study the conductance renormalization for the four-lead junction of semi-infinite wires in the scattering state formalism. We use the model of spinless fermions with a short-range Luttinger-type interaction and find the renormalization group (RG) equations for the conductances of the system in the first order of the fermionic interaction. In contrast to the well-known cases of two-lead and three-lead junctions, the four-lead case does not admit a formulation of the RG equations solely in terms of conductances. The arising ambiguity with arbitrariness in the choice of the sign of S-matrix elements related to identical conductance matrices might be connected with a symmetry of the particle-hole type in the Hamiltonian. We show that there are two distinct RG flows from any initial point in the space of conductances. The discovered ambiguity does not affect the scaling exponents at the fixed points. [ABSTRACT FROM AUTHOR]

Existing approaches to the registration, insurance, and application of biotechnological drugs in Russia were analyzed using monoclonal antibody drugs and those produced using recombinant DNAtechnology as examples. Pharmacoeconomic aspects of using these drugs in the RF were described and compared with WHO recommendations for their use. [ABSTRACT FROM AUTHOR]

The magnetooptical method is used to investigate transformation of the domain structure of a cubic TbYFeO ferrimagnetic material at the temperature of spontaneous spin flip phase transition (SFPF). It is demonstrated that the SFPF is observed in a certain temperature interval in which low- and high-temperature magnetic phase domains coexist. It is established that the character of evolution of the domain configuration in the temperature interval of the spin flip depends significantly on the mechanical stresses presented in the crystal. Experimental results are interpreted in the context of the existing SFPF theory for the cubic crystal. [ABSTRACT FROM AUTHOR]

Abstract: Objective: To compare fMRI activations during movement and motor imagery to corresponding motor evoked potential (MEP) maps obtained with the TMS coil in three different orientations. Methods: fMRI activations during executed (EM) and imagined (IM) movements of the index finger were compared to MEP maps of the first dorsal interosseus (FDI) muscle obtained with the TMS coil in anterior, posterior and lateral handle positions. To ensure spatial registration of fMRI and MEP maps, a special grid was used in both experiments. Results: No statistically significant difference was found between the TMS centers of gravity (TMS CoG) obtained with the three coil orientations. There was a significant difference between fMRI centers of gravity during IMs (IM CoG) and EMs (EM CoG), with IM CoGs localized on average 10.3mm anterior to those of EMs in the precentral gyrus. Most importantly, the IM CoGs closely matched cortical projections of the TMS CoGs while the EM CoGs were on average 9.5mm posterior to the projected TMS CoGs. Conclusions: TMS motor maps are more congruent with fMRI activations during motor imagery than those during EMs. These findings are not significantly affected by changing orientation of the TMS coil. Significance: Our results suggest that the discrepancy between fMRI and TMS motor maps may be largely due to involvement of the somatosensory component in the EM task. [Copyright &y& Elsevier]

Despite tremendous progress in recent years in measuring single nucleon momentum distributions in nuclei, two-nucleon momentum distributions remain largely unmeasured. Here we report on a measurement of ³He(e,e'pp)n that is primarily sensitive to the two-nucleon momentum distribution and relatively uncontaminated by final state rescattering or by two-body currents. [ABSTRACT FROM AUTHOR]

We have measured the 3He (e, e'pp)n reaction in the Jefferson Lab CLAS with 2.2 and 4.4 GeV electrons. We looked at the energy distribution of events with all three nucleons at high momentum (p > 250 MeV/c). This distribution has peaks where two nucleons each have 20% or less of the energy transfer (i.e., the third or ?leading? nucleon carries most of the kinetic energy). The angular distribution of these two ?fast? nucleons shows a very large back-to-back peak, indicating the effect of correlations. While there is some theoretical disagreement, experimental evidence, plus calculations at lower energy by W. Glöckle, indicates that these events are primarily sensitive to NN correlations. [ABSTRACT FROM AUTHOR]

Polymers crosslinked via furan/maleimide thermo-reversible chemistry have been extensively explored as reprocessable and self-healing thermosets and elastomers. For such applications, it is important that the thermo-reversible features are reproducible after many reprocessing and healing cycles. Therefore, side reactions are undesirable. However, we have noticed irreversible changes in the mechanical properties of such materials when exposing them to temperatures around 150 °C. In this work, we study whether these changes are due to the self-reaction of maleimide moieties that may take place at this rather low temperature. In order to do so, we prepared a furan-grafted polyketone crosslinked with the commonly used aromatic bismaleimide (1,1′-(methylenedi-4,1-phenylene)bismaleimide), and exposed it to isothermal treatments at 150 °C. The changes in the chemistry and thermo-mechanical properties were mainly studied by infrared spectroscopy, 1H-NMR, and rheology. Our results indicate that maleimide self-reaction does take place in the studied polymer system. This finding comes along with limitations over the reprocessing and self-healing procedures for furan/maleimide-based reversibly crosslinked polymers that present their softening (decrosslinking) point at relatively high temperatures. On the other hand, the side reaction can also be used to tune the properties of such polymer products via in situ thermal treatments. [ABSTRACT FROM AUTHOR]

Conclusions Among HER2- BRCA1/2mut ABC patients, CT use was common and frequent healthcare visits were observed in the 1 SP st sp -line ABC setting. BRCA1/2mut advanced TNBC patients incurred greater HRU than HR+/HER2- patients. Opportunities exist to implement treatment strategies that may reduce the HRU burden in HER2- BRCA1/2mut ABC such as chemotherapy-free treatment options (e.g. targeted agents). [Extracted from the article]

Prior to the development of poly ADP ribose polymerase inhibitors (PARPi), treatment options were limited for patients with human epidermal growth factor receptor 2 negative (HER2-) advanced breast cancer (ABC) and BRCA1/2 mutation(s). This study describes real-world patient-reported treatment travel time and work productivity and activity impairment (WPAI) among adult women with HER2- ABC and BRCA1/2 mutation(s). [Extracted from the article]

The mechanical properties of industrial plexiglas (polymethylmethacrylate) of various sizes (lengths, widths) have been studied when tested for plane straight bending with one concentrated force in the middle of the sample. By a result of the experimental work, the relationship between deformation and stress was obtained. It is clearly shown in the work that the experimental curves substantially depend on the parameters of the starting materials and are satisfactorily described by a linear model. The slope of tangent (a) for the curves ranges from 0,32 to 0,62 %MPa-1. The dependence of a a on the length and width of the samples changes significantly. Moreover, the maximum deformation varies in the range of 50 - 60 %, which confirms the dependence of the deformation properties of the material on horizontal components, in particular, on the length of the sample. The tensile strength of the material also differs between specimens of different sizes. [ABSTRACT FROM AUTHOR]

Exome or genome sequencing was performed to identify the genetic etiology for the clinical presentation of global developmental delay, intellectual disability, and sensorimotor neuropathy with associated distal weakness in two unrelated families. A homozygous frameshift variant c.186delA (p.A63Qfs*3) in the NUDT2 gene was identified in cases 1 and 2 from one family and a third case from another family. Variants in NUDT2 were previously shown to cause intellectual disability, but here we expand the phenotype by demonstrating its association with distal upper and lower extremity weakness due to a sensorimotor polyneuropathy with demyelinating and/or axonal features. [ABSTRACT FROM AUTHOR]

Alkylglycerol monooxygenase (AGMO) is the only enzyme known to cleave the O-alkyl bonds of ether lipids (alkylglycerols) which are essential components of cell membranes. A homozygous frameshift variant [p.(Glu324LysfsTer12)] in AGMO has recently been reported in two male siblings with syndromic microcephaly. In this study, we identified rare nonsense, in frame deletion, and missense biallelic variants in AGMO in two unrelated individuals with neurodevelopmental disabilities. We assessed the activity of seven disease associated AGMO variants including the four variants identified in our two affected individuals expressed in human embryonic kidney (HEK293T) cells. We demonstrated significantly diminished enzyme activity for all disease-associated variants, supporting the mechanism as decreased AGMO activity. Future mechanistic studies are necessary to understand how decreased AGMO activity leads to the neurologic manifestations. [ABSTRACT FROM AUTHOR]

We study the four-terminal junction of spinless Luttinger liquid wires, which describes either a corner junction of two helical edge states of topological insulators or the tunneling from the spinful wire into the helical edge state. We use the fermionic representation and the scattering state formalism, in order to compute the renormalization group (RG) equations for the linear response conductances. We establish our approach by considering a junction between two possibly nonequivalent helical edge states and find an agreement with the earlier analysis of this situation. Tunneling from the tip of the spinful wire to the edge state is further analyzed which requires some modification of our formalism. In the latter case we demonstrate (i) the existence of both fixed lines and conventional fixed points of RG equations, and (ii) certain proportionality relations holding for conductances during renormalization. The scaling exponents and phase portraits are obtained in all cases. [ABSTRACT FROM AUTHOR]

We developed and clinically implemented PlanQ, an innovative AI-based approach to managing radiotherapy workflows. The primary objective of this platform is to simplify radiation therapy workflow management, thereby enhancing clinical decision-making. PlanQ achieves this by creating comprehensive digital profiles for patients, which link clinical events across their treatment journey, aiming for heightened efficiency and scalability for diverse user needs in clinical settings. Developed with extensibility in mind, PlanQ supports data integration from multiple systems, enabling the seamless curation of multimodal data in real-time, guided by FAIR (Findable, Accessible, Interoperable, and Reusable) principles. The platform incorporates human feedback for some elements to ensure data integrity. By utilizing advanced natural language processing and a large language model, PlanQ adeptly connects sparse clinical events to form longitudinal patient journeys, facilitating the search and analysis of prior patient treatments due to risks associated with re-irradiation. An AI-based Operational Research model is implemented to manage and optimize treatment planning coordination and scheduling. This model considers various factors such as plan complexity and urgency to efficiently allocate resources among a team. PlanQ was designed to make the clinical workflow visible, enabling real-time management and oversight of the entire treatment planning process. PlanQ has led to operational efficiency improvements across our environment, which consists of 30 linear accelerators. Notably, there was a 70% reduction in the workload associated with treatment planning coordination, a 10% decrease in the workload of planners, and a reduction in plan check time, saving an average of one hour per day. These enhancements are attributed to the platform's efficient data curation capabilities, which streamline the process of accessing patient journeys, thus reducing the time users of different groups spend searching for clinical records and supporting patient safety. The platform's NLP model demonstrated a high accuracy rate of 95% in linking isolated clinical events. PlanQ is adaptable with vendor-neutral architecture and is being developed for compatibility with another electronic medical record system. Through its innovative design and application of AI, PlanQ offered a scalable solution to the challenges of treatment planning and execution, with promising implications for the future of patient care in radiation therapy. [ABSTRACT FROM AUTHOR]

Dependence of deformation on time in polytetrafluoroethylene of various thicknesses irradiated by electrons at various static strains and exposure doses was studied. Significant changes in the mechanical properties were found. The obtained curves for both unirradiated and irradiated material are satisfactorily described in terms of the exponential model. [ABSTRACT FROM AUTHOR]