1. Development of transferrin-bearing vesicles encapsulating aspirin for cancer therapy.
- Author
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Sakpakdeejaroen, Intouch, Somani, Sukrut, Mullin, Margaret, and Dufès, Christine
- Subjects
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ASPIRIN , *CANCER treatment , *TRANSFERRIN , *TREATMENT effectiveness , *POLYMERSOMES , *ANTI-inflammatory agents , *DRUG efficacy , *INTRAVENOUS therapy - Abstract
Originally developed for the treatment of inflammatory disorders, the non-steroidal anti-inflammatory drug aspirin was shown to have a preventive effect against cancer in the past decades. Most importantly, recent studies suggested that it might also provide a therapeutic benefit in the treatment of cancer in vitro. However, this drug failed to specifically reach tumors at a therapeutic concentration following intravenous administration, thus resulting in lack of efficacy on tumors. In this work, we demonstrated that aspirin could be formulated in transferrin-bearing vesicles and that this tumor-targeted formulation could lead to an increase in the anti-proliferative efficacy of the drug in three cancer cell lines in vitro. The in vitro therapeutic efficacy of aspirin was significantly improved when formulated in transferrin-bearing vesicles, by about 2-fold compared to that of drug solution. These results are promising and support the optimization of this delivery system to further improve its potential as a therapeutic tool in combination with other anti-cancer therapies. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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