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Background: MicroRNAs play an essential role in colorectal cancer development and progression. Aberrant miR-409-3p expression has been reported in several cancers. However, the clinical significance and functions of miR-409-3p in human CRC were not entirely clear. Methods: miR-409-3p expression levels were determined in 45 pairs of primary CRC and their corresponding adjacent non-tumor tissues by qPCR. The effects of ectopic expression of miR-409-3p on CRC cells proliferation, wound healing, metastasis were investigated by CCK-8, transwell assay and peritoneal spreading nude mice model. Results: Statistical analysis of clinical cases revealed that low miR-409-3p expression had inclinations towards lager tumor size and local invasion. Ectopic expression of miRNA mimics suggested that miR-409-3p could inhibits the abilities of proliferation, wound healing, metastasis and invasion in CRC cells. Notably, we found the NLK could be a potential target of miR-409-3p. Conclusion: Our results suggest that miR-409-3p functions as a tumor suppressor by inhibiting the development and metastasis of CRC, suggesting that miR-409-3p is expected to become a new diagnostic marker and a new target of the treatment of CRC. [ABSTRACT FROM AUTHOR]

Background: Anastomotic leakage is a serious complication that can occur after anterior resection of the rectum. There is a question regarding whether the placement of a transanal tube can decrease the rate of anastomotic leakage. The aim of this systematic review and meta-analysis was to evaluate the efficacy of transanal tube placement after anterior resection. Methods: We searched three major databases (PubMed, Embase, and the Cochrane Library) up until January 2015 for studies evaluating the benefit of transanal tubes after anterior resection for rectal cancer. The primary outcome measure was the rate of clinical anastomotic leakage. Secondary outcome was the rate of reoperation. Pooled risk ratios (RR) with 95 % confidence intervals (CI) were obtained using random effects models. Results: One randomized controlled trial and three observational studies involving 909 patients met inclusion criteria. Clinical anastomotic leakage occurred in 3.49 % (14 of 401) of patients with transanal tubes and 12.01 % (61 of 508) of patients without transanal tubes. Meta-analysis of the studies showed a lower risk of anastomotic leakage (RR, 0.32; 95 % CI 0.18-0.58) and reoperation related to leakage (RR, 0.19; 95 % CI 0.08-0.46) when the transanal tube was placed. Conclusions: While studies are few and mostly observational, the data to date indicate that placement of a transanal tube decreases the rate of clinical anastomotic leakage and reoperation related to leakage. More studies are needed to confirm these findings. [ABSTRACT FROM AUTHOR]

After deriving the expression of the intensity of the transmitted beam for a Gaussian beam passing through a misaligned FPI, the influence of the nonparallelism in FPI mirrors alignment on the transmission of a Gaussian beam has been investigated numerically. The results show that the energy profile of the total transmitted beam appears multiple sub-peaks structure; with the increase of the nonparallelism in FPI mirrors alignment, the number of the sub-peaks raises, the peak intensity of the transmitted beam has a declining tendency, and the peak intensity position of the total transmitted beam is shifted. [ABSTRACT FROM AUTHOR]

Heat stress is one of the most important environmental stressors facing poultry production and welfare worldwide. The detrimental effects of heat stress on poultry range from reduced growth and egg production to impaired health. Animal vocalisations are associated with different animal responses and can be used as useful indicators of the state of animal welfare. It is already known that specific chicken vocalisations such as alarm, squawk, and gakel calls are correlated with stressful events, and therefore, could be used as stress indicators in poultry monitoring systems. In this study, we focused on developing a hen vocalisation detection method based on machine learning to assess their thermal comfort condition. For extraction of the vocalisations, nine source-filter theory related temporal and spectral features were chosen, and a support vector machine (SVM) based classifier was developed. As a result, the classification performance of the optimal SVM model was 95.1 ± 4.3% (the sensitivity parameter) and 97.6 ± 1.9% (the precision parameter). Based on the developed algorithm, the study illustrated that a significant correlation existed between specific vocalisations (alarm and squawk call) and thermal comfort indices (temperature-humidity index, THI) (alarm-THI, R = −0.414, P = 0.01; squawk-THI, R = 0.594, P = 0.01). This work represents the first step towards the further development of technology to monitor flock vocalisations with the intent of providing producers an additional tool to help them actively manage the welfare of their flock. [ABSTRACT FROM AUTHOR]

Background/Aims: Polycystic ovary syndrome (PCOS), characterized by female infertility and metabolic abnormalities, is one of the most common endocrine disorders. The etiology of PCOS remains unknown. The comprehensive analysis of protein alterations in PCOS patients is meaningful for identifying diagnostic biomarkers of PCOS. Here, we explored the clinical value of serum proteins as novel biomarkers to detect PCOS with low progesterone level. Methods: A total of 43 patients with PCOS and 30 healthy women were enrolled. Protein array was used to detect the variations of serum proteins between PCOS patients and healthy women. The level of five serum proteins was further confirmed by ELISA and western blot. The human ovarian granulosa cells (KGN) was cultured to examine the underlying mechanism of PCOS. CCK8 assay and western blot were carried out to evaluate the alterations in proliferative ability, TUNEL assay and DAPI staining to detect the apoptosis of KGN cells. Results: Among the 507 proteins, we identified 76 differentially expressed serum proteins (≧1.5 fold), with 40 elevated and 36 decreased proteins. Moreover, 47 proteins were newly reported in PCOS. The alterations in the five significantly decreased proteins (EREG, inhibin βA, IDE, PDGF-D and KNG1) were further confirmed by ELISA and western blot. The level of these proteins were directly associated with the low progesterone, and the expression could be upregulated by progesterone. EREG and inhibin βA also promoted the proliferation and inhibited the apoptosis of ovarian granulosa cells. Conclusion: The study highlights that serum proteins are differentially expressed in PCOS patients and healthy women, and EREG and inhibin βA levels are upregulated by progesterone, which are correlated with ovarian functions. The study suggests that EREG and inhibin βA may be applied as novel potential biomarkers for PCOS with low progesterone level. [ABSTRACT FROM AUTHOR]

We present a theoretical investigation of the transmission properties of light through a metallic film perforated with different arrays of compound triangular holes. The extraordinary optical transmission (EOT) in the optical region is obtained by employing the finite-difference time-domain method. The excitation of localized surface plasmon resonances (LSPRs) at the top corners and surface plasmon polaritons (SPPs) on the metal surface, plasmon coupling effects between adjacent apertures, and the waveguide modes for delivering light mainly contribute to the EOT in such structures. The optical characteristics can be effectively tailored by changing the arrangement of triangular holes and the structural parameters. This study may be helpful for plasmonic nanostrucutres based on EOT, and has potential applications in optoelectronic devices. [ABSTRACT FROM AUTHOR]

We propose a new ultra-broadband metamaterial absorber based on a titanium–silica–titanium sandwich structure, which is composed of a periodic array of titanium–silica elliptical nanodisks and a titanium bottom film. The absorption bandwidth reaches 1376 nm in the wavelength range from the visible to near-infrared region with the spectral absorptivity  >90%. Moreover, the spectrally averaged absorption is up to 94.6%, indicating the achievement of ultra-broadband near-perfect absorption. In addition, the near-perfect absorption is polarization-independent and incident-angle insensitive. The ultra-broadband absorption mainly results from the strong plasmonic near-field coupling by the adjacent metal parts and the intrinsic material absorption in the wide wavelength range by the refractory metal. The proposed ultra-broadband metamaterial absorber could have broad application prospects in solar photovoltaic generation, infrared detection, and hot-electron devices. [ABSTRACT FROM AUTHOR]

A truncated Ti and Si cones metasurface has been proposed for wide-band solar absorber (WSA), which produced a high average absorption of 94.7% in the spectral region from 500 to 4000 nm. A maximal enhancement factor of 166.0% was achieved by the WSA in comparison with the absorption of Ti/Si cylinder resonators based absorber. Under the standard solar radiance, a high full-spectrum solar absorption efficiency of 96.1% was obtained for the WSA in the energy range from 0.28 to 4.0 eV. The spectral bandwidth with absorption above 90% is up to 3.402 μm, which shows an enhancement factor of 165.0% than that of the WSA intercalated by the SiO2. Other semiconductors such as Ge, GaAs have been utilized to form the WSA, which also maintained the near-unity absorption in the wide-band spectrum. The plasmonic resonant response of the Ti material and the strong electromagnetic coupling capability of the Si resonator, and the plasmonic near-field coupling by the adjacent truncated cones were the main contributions for the impressive absorption behaviors. These findings pave a new way for achieving full-spectrum solar absorber via combining the Ti material and semiconductors, which could open potential approaches for active optoelectronic devices such as photo-detectors, hot-electron related modulators, and solar cells, etc. [ABSTRACT FROM AUTHOR]

Monochromatic filtering with ultra-narrowband and high spectral contrast is desirable for wide applications in display, image, and other optoelectronics. However, owing to the inherent omhic losses in the metallic materials, a broadband spectrum with a low Q-factor down to 10 inevitably limits the device performance. Herein, we for the first time theoretically propose and demonstrate an ultra-narrowband color-filtering platform based on the layered all-dielectric meta-material (LADM), which consists of a triple-layer high/low/high-index dielectrics cavity structure. Owing to the lossless dielectric materials used, sharp resonances with the bandwidth down to sub-10 nm are observed in the sub-wavelength LADM-based filters. A spectral Q-factor of 361.6 is achieved, which is orders of magnitude larger than that of the plasmonic resonators. Moreover, for the other significant factor for evaluation of filtering performance, the spectral contrast reaches 94.5%. These optical properties are the main results of the excitation of the resonant modes in the LADMs. Furthermore, polarization-manipulated light filtering is realized in this LADM. The classical Malus law is also confirmed in the reflective spectrum by tuning the polarization state. More interestingly and importantly, the filtering phenomenon shows novel features of the wavelength-independent and tunable resonant intensity for the reflective spectrum when the LADM-based filter is illuminated under an oblique state. High scalability of the sharp reflective spectrum is obtained by tuning the structural parameters. A single-wavelength reflective filtering window is also achieved in the visible frequencies. These features hold promise for the LADM-based filter with wide applications in color engineering, displaying, imaging, etc. [ABSTRACT FROM AUTHOR]

Resonant plasmonic and metamaterial absorbers are of particular interest for applications in a wide variety of nanotechnologies including thermophotovoltaics, photothermal therapy, hot-electron collection and biosensing. However, it is rather challenging to realize ultra-narrow absorbers using plasmonic materials due to large optical losses in metals that inevitably decrease the quality of optical resonators. Here, we theoretically report methods to achieve an ultra-narrow light absorption meta-surface by using photonic modes of the optical cavities, which strongly couple with the plasmon resonances of the metallic nanostructures. Multispectral light absorption with absorption amplitude exceeding 99% and a bandwidth approaching 10 nm is achieved at the optical frequencies. Moreover, by introducing a thick dielectric coupling cavity, the number of absorption bands can be strongly increased and the bandwidth can even be narrowed to less than 5 nm due to the resonant spectrum splitting enabled by strong coupling between the plasmon resonances and the optical cavity modes. Designing such optical cavity-coupled meta-surface structures is a promising route for achieving ultra-narrow multiband absorbers, which can be used in absorption filters, narrow-band multispectral thermal emitters and thermophotovoltaics. [ABSTRACT FROM AUTHOR]