1. Chromosomal abnormalities in acute myeloid leukaemias
- Author
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Mugneret, F., Callier, P., and Favre-Audry, B.
- Subjects
- *
CYTOGENETICS , *ACUTE myeloid leukemia , *KARYOTYPES - Abstract
Cytogenetic studies of acute myeloid leukaemias reveal non-random chromosomal abnormalities in 50–70% of karyotypes. Some are correlated with morphological and immunological parameters and constitute a prognostic factor independent of the other factors of risk: favourable for acute leukaemias myeloid with translocations t(8 ;21), t(15 ;17) and inversion or translocation of the chromosome 16, inv(16)/t(16 ;16), poor with deletion of the long arm of chromosome 5 del(5q), rearrangement of the 11q23 region and complex karyotypes. The distribution of the anomalies depends on the age: 11q23 and t(8;21) more frequent for the child, del(5q) and complex anomalies more frequent for the adult.The karyotypes are essential for the diagnosis, the follow-up of the patients and the evaluation of the relapse. It plays a fundamental part in the detection of new genes and their partners implied in the leucemogenese. The knowledge of their function is essential to open new therapeutic ways. [Copyright &y& Elsevier]
- Published
- 2003
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