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This manuscript focuses on the communication factors that affect the willingness of African Americans and Black Caribbean patients to participate in clinical trials and research studies. Low rates of research participation by members of communities of color have long been linked to health disparities. While there are many factors that contribute to low rates of accrual of African American and Black patients to clinical trials, a lack of attention to communication factors that enhance or inhibit the recruitment process is central to the problem. In this study, we describe results from the analysis of six focus groups (N = 31) consisting of African American (k = 3) and Black Caribbean (k = 3) participants. Our analyses focus on verbal and nonverbal communication behaviors and how they affect participants' willingness to participate in clinical trials. Specifically, when clinical research coordinators (CRCs) had a professional appearance, made the effort to explain a study in detail, made eye contact, took the time to listen and answer questions patiently, and gave the sense that the CRC was being truthful and transparent, patients felt respected and valued. Additionally, participants emphasized the importance of the process of developing and maintaining a trusting relationship between study participants and CRCs. The results of this study will be used to develop a clinical trial communication training program designed to enhance the communication skills of clinical research coordinators who discuss research participation with African American and Caribbean Black patients. [ABSTRACT FROM AUTHOR]

This study investigates the role of source credibility on minority participant recruitment, particularly African American and Black Caribbean patients. A total of nine focus groups (N = 48 participants) were conducted with both patient groups and clinical research coordinators (CRCs). Using the elaboration likelihood model as a guiding framework for analysis, this study found that the credibility of research coordinators (or other professionals who recruit for research studies and clinical trials) was instrumental in shaping attitudes of prospective participants. The perspectives of patients and CRCs aligned closely, with few exceptions. For both groups, professionalism and professional displays (clothing, institutional artifacts) enhanced perceived expertise, a core component of credibility. Trustworthiness, another important component of credibility, was fostered through homophily between recruiter and patient, expressions of goodwill and assuaging anxiety about CRCs' financial motivations for recruitment. Additionally, CRCs believed that credibility was supported when CRCs could emphasize transparency and truthfulness in communication. The importance of these findings for the development of empirically-based training programs to improve communication practices in recruitment contexts is discussed. [ABSTRACT FROM AUTHOR]

While it has been established that participation in interdisciplinary teams is likely to have a positive impact on researchers' careers, it has been questioned whether these researchers were already destined for success. If high-achieving faculty members are simply taking advantage of the availability of internal funds to boost their already high rates of productivity, internal programs designed to support the formation of novel teams and to enhance the impact of an institution's research portfolio may not be advancing their objectives. In this study, we examine whether applicants to an interdisciplinary funding program are already more productive than other faculty members, including those who apply for traditional (non-interdisciplinary) internal funding support. Data were drawn from several sources: Academic Analytics, which provides productivity data that allows for comparisons of faculty members within fields; the Office of the Vice Provost for Research's data on internal funding program applications; the Office of Research Administration's data on external grant proposal submissions; data from an internal survey on perceptions of the university's research climate; and Scopus, which provides individual faculty members' h-indices and lists of publications and citations. Results indicate that faculty members who join interdisciplinary research teams and are awarded internal funding are not more or less likely to be "superstars." This not only provides support for assertions that interdisciplinary programs can lead to team innovation and professional growth of individual faculty members, but also provides a blueprint for the establishment of baseline measures that can be used to help evaluate the impact of internal funding programs. [ABSTRACT FROM AUTHOR]

Cancer patients learn about research studies outside of the clinical environment, including websites, print and online advertisements, and interpersonal interactions. When cancer patients share credible information about clinical trials, they also frequently help clarify misunderstandings that may exist in their social networks. The present study investigated how an interactive tailored information aid on clinical trial participation motivated patients' information sharing behaviors. In this study of 312 cancer patients and survivors, an interactive tailored information aid improved patients' likelihood of sharing online and offline information more than a non-interactive tool. Information sharing was directly predicted by cognitive absorption and perceived visual informativeness. In addition, perceived utility and ease of use indirectly impact information sharing positively through the antecedent factors of user engagement and design esthetics. Education level further moderated this effect; information sharing was higher among patients with more education. The implications of these findings are discussed and recommendations for future research are provided. [ABSTRACT FROM AUTHOR]

Despite the disproportionate burden of cervical cancer among Caribbean women, evaluations of targeted communication interventions to increase screening behaviors are sparsely represented in extant literature. Informed by data on the cognitive, affective and sociocultural factors associated with low cervical screening in the English-speaking island of Jamaica, the current study aimed to explore how theory-based message design, coupled with innovative solutions, might increase screening. In this formative research study, we first described the process used to develop culturally-targeted fear appeal messages embedded within an HPV self-sampling kit developed by the researchers. Then, we shared the results of an evaluation of the kit, which was reviewed by 36 Jamaican women in 8 focus groups, to understand the potential impact of the messages and the utility of HPV self-sampling to increase screening behaviors in this population. The results provide data on effective messages for cervical cancer prevention among Jamaican women, which may be further applicable to underscreened women in the English-speaking Caribbean. Additionally, results from this research suggest support for HPV self-sampling to address salient cultural and structural barriers to screening, which provides an impetus for experimental research in message design to inform policy and practice. [ABSTRACT FROM AUTHOR]

Objective: Learning about clinical trials is as stressful and challenging for cancer patients as it is for the clinical staff who provide education to patients. Information aids (IAs) can support both discussions and patients' decision-making, especially when IAs offer interactive features that provide information based on individuals' needs and experiences. However, it is not clear which factors contribute to interactive IAs' effectiveness.Methods: An experiment with cancer patients and survivors (n = 313) compared the effects of two IAs about clinical trial participation: one with modality (i.e. website/technological) interactivity only and one with both modality and message interactivity (i.e. provides information contingent on individual users' information needs).Results: The IA with both modality and message interactivity features elicited the higher perceived visual informativeness (PVI) and cognitive absorption (CA) scores. The model supports the moderating role of PVI and cancer information overload (CIO), and the mediating role of CA.Conclusion: The IA with both modality and message interactivity better supported individuals' decision-making and improved attitudes and knowledge scores. CIO was experienced more by participants using the modality interactivity-only IA.Practice Implications: Message interactivity may simplify individuals' cognitive processes. IAs about clinical trial participation should include both message and modality interactivity. [ABSTRACT FROM AUTHOR]

Aim/Purpose There is ample evidence that team processes matter more than the characteristics of individual team members; unfortunately, very few empirical studies have examined communication process variables closely or tied them to team outcomes. Background The University of Miami Laboratory for Integrated Knowledge (U-LINK) is a pilot funding mechanism that was developed and implemented based on empirically- established best practices established in the literature on the Science of Team Science (SciTS). In addition to addressing grand societal challenges, teams engaged in processes designed to enhance the process of "teaming". This study uses the Inputs-Mediator-Outputs-Inputs (IMOI) model as a blueprint for an investigation into how team communication processes (shared communication, shared leadership, formal meetings, informal meetings) influence intermediary team processes (goal clarity, role ambiguity, process clarity, trust) and team outcomes (team satisfaction, team productivity). Methodology Monte Carlo methodologies were used to explore both longitudinal self-report (survey of communication and team outcome variables) data and objective data on scholarly productivity, collected from seventy-eight members of eleven realworld intact interdisciplinary teams to explore how team communication processes affect team outcomes. Contribution This study is among the few that centers communication practice and processes in the operationalization and measurement of its constructs and which provides a test of hypotheses centered on key questions identified in the literature. Findings Communication practices are important to team processes and outcomes. Shared communication and informal meetings were associated with increased team satisfaction and increased research productivity. Shared leadership was associated with increased research productivity, as well as improved process and goal clarity. Formal meetings were associated with increased goal clarity and decreased role ambiguity. Recommendations for Practitioners Team trainings should focus on communication practices that improve shared leadership and shared communication. Additionally, teaching best practices for formal (task-oriented) meetings can help improve goal clarity and decrease role ambiguity. Finally, the benefits of informal socializing should be recognized, and teams should be encouraged to meet informally (socially, without formal task agendas). Recommendations for Researchers Studying intact interdisciplinary research teams requires innovative methods and clear specification of variables. Challenges associated with access to limited numbers of teams should not preclude engaging in research as each study contributes to our larger body of knowledge of the factors that influence the success of interdisciplinary research teams. Impact on Society The success of interdisciplinary teams can be improved with trainings focused on communication skills. The success of these teams is critical to addressing societies' most pressing challenges, and careful consideration of team processes is critical to that success. Future Research Future research should examine different team formation and funding mechanisms and extend observation and data collection for longer periods of time. [ABSTRACT FROM AUTHOR]

Objective: The purpose of this project was to identify the strategies available to educate patients about tinnitus and to provide guidelines and instructions on how to develop better tinnitus education intervention. Method: A scoping review of peer-reviewed published articles about tinnitus education was conducted. After an initial review of 306 articles, 18 were included in the final review. The information extracted included data on the content conveyed to patients about tinnitus, the format employed, the process used to develop the educational materials, and patients' outcomes linked to tinnitus education. Results: The outcomes provided by the interventions were perceptual, behavioral, and clinical in nature. The format and the content provided by the interventions were heterogeneous. Effective tinnitus education interventions provided specific coping strategies in their curriculum. Conclusion: Educating patients about tinnitus is important to improving their perceptions of the condition and their management behaviors. Healthcare providers and patients need to collaborate to create patient-centered, ad hoc plans. It is important to identify patients' expectations about the outcomes and shared goals. The educational curricula should include basic anatomy and physiology of the auditory system as well as coping strategies, such as attention distraction mechanisms and sound therapy. [ABSTRACT FROM AUTHOR]

Enrollment rates for cancer clinical trials remain low, affecting the generalizability of new treatments. Research shows that many patients face significant challenges in understanding basic clinical trial vocabulary and making informed decisions about participation. Informational aids (IA) are developed to address these challenges and support decision making of cancer clinical trial participation. The present study proposed and tested a structural path model to explain the efficacy of three (i.e., interactive, non-interactive, non-cancer control) IAs. The results revealed that clinical trial participation intention was associated with attitudes and social constructs (i.e., social norm, social sharing, and cues to action). Ease of use, rather than knowledge, was the primary communication feature of IA that influenced the outcome variables. The path relations linking messages features, mediators, and outcome variables were different across all three IAs. The results therefore provide theoretical and practical implications for the use and development of IAs to support clinical trial accrual. [ABSTRACT FROM AUTHOR]

Communicating about clinical trials and medical research is challenging. An appropriate communication is essential to reduce some of the barriers associated with poor patients' enrollment in clinical trials and with patients' uninformed consent or uninformed refusal. An experiment was conducted to assess the effects of educational animations compared to brochures with and without visuals, and with the materials currently used by the NIH. These materials focused on explaining placebos, randomization, the steps necessary to enroll in a clinical trial, and how and by who patients' protection is ensured. A total of 1194 cancer patients and survivors completed this 4 by 4 experiment through a Qualtrics panel. The findings showed that animations improved participants knowledge about and attitudes toward clinical trials and were more effective than brochures presenting information from the NIH, especially for those individuals with low motivation and low ability to comprehend health-related information. Several evidence-based theoretical explanations of the functioning of animations are provided. [ABSTRACT FROM AUTHOR]

Public participation in precision medicine (PM) research is essential to achieving effective health care but has been impeded by a lack of awareness and basic knowledge. There is a critical need for educational materials that can clearly explain PM to foster involvement. This randomized controlled trial with a posttest-only control group design aims to assess the effects of educational messages delivered through animations relative to live-action videos and leaflets on intentions of involvement in PM research. Knowledge as the moderator and four mediators (engagement, vividness, trustworthiness, and cognitive value) of the intended effects were also evaluated. A total of 326 U.S. adults were sampled from Amazon Mechanical Turk. Among participants with less knowledge about PM, animations produced stronger information-seeking intentions and willingness to participate than leaflets. The effects of three message modalities were not significantly different among average and highly knowledgeable participants. Engagement and vividness mediated the effects of animations relative to two other message modalities. Trustworthiness and cognitive value mediated the effects of animations relative to live-action videos. Overall, animations can be an effective communication strategy to motivate involvement in PM but its effectiveness could decline as knowledge increases. The explanations and implications of the findings were discussed. [ABSTRACT FROM AUTHOR]

Few studies have examined the communication behaviors of those who recruit for clinical trials and research studies, particularly of nonmedical professionals who often do the bulk of recruiting. This focus-group study of 63 recruiters analyzes the ways in which nonverbal communication behaviors support the process of recruitment, using the lens of communication accommodation theory. Results indicate that recruiters first “read” potential study participants’ nonverbal communication for clues about their state of mind, then use nonverbal communication to achieve a sense of convergence. Specific nonverbal communication behaviors were discussed by recruiters, including smiling, variations in the use of voice, adjusting body position, the appropriate use of physical touch, the management of eye contact, and the effect of clothing and physical appearance. Implications for recruitment practice are discussed. [ABSTRACT FROM PUBLISHER]

Medical and research professionals who discuss clinical trials and research studies with potential participants face an often daunting challenge, particularly when recruiting from minority and underserved populations. This study reports on findings from a focus group study of 63 research coordinators, study nurses, professional recruiters, and other professionals in Indianapolis, IN and Miami, FL who work to recruit from minority and underserved populations. These professionals discussed the importance of creating a sense of connection with potential participants as part of the recruitment and retention process. Building a relationship, however fleeting, involved a number of concrete behaviors, including listening to personal information, expressing empathy, and then providing reciprocal self-disclosures; having repeated contact, usually by working in the same environment over an extended period of time; demonstrating respect through politeness and the use of honorifics; going the extra mile for participants; offering flexibility in scheduling follow-up appointments; and creating a sense of personal and community trust by being truthful. The implications of these findings for clinical trial and research study accrual are discussed. [ABSTRACT FROM AUTHOR]

The lack of accrual to research studies and clinical trials is a persistent problem with serious consequences: Advances in medical science depend on the participation of large numbers of people, including members of minority and underserved populations. The current study examines a critical determinant of accrual: the approach of patients by professional recruiters who request participation in research studies and clinical trials. Findings indicate that recruiters use a number of verbal strategies in the communication process, including translating study information (such as simplifying, using examples, and substituting specific difficult or problematic words), using linguistic reframing or metaphors, balancing discussions of research participation risks with benefits, and encouraging potential participants to ask questions. The identification of these verbal strategies can form the basis of new communication protocols that will help medical and nonmedical professionals communicate more clearly and effectively with patients and other potential participants about research studies and clinical trials, which should lead to increased accrual in the future. [ABSTRACT FROM AUTHOR]

This study tests a comprehensive model linking Grey’s Anatomy viewing and perceived realism of this program with organ donation knowledge, barriers—including medical mistrust, disgust, bodily integrity, and superstition—and subsequent organ donation attitudes. In addition to testing the hypothesized structural model, ethnic differences were examined by way of (a) the multigroup method to test for differences in path coefficients, (b) multivariate analysis of variance to examine differences among the study variables, and (c) χ2 tests to assess differences in organ donation registrations among African Americans (n = 200), Caucasians (n = 200), and Latinos (n = 200). Support for the overall structural model was found and various differences emerged among the African American, Caucasian, and Latino sample across study variables. The results from this research are discussed with an emphasis on the theoretical and practical implications. [ABSTRACT FROM PUBLISHER]

Morgan SE, Stephenson MT, Afifi W, Harrison TR, Long SD, Chewning LV. The University Worksite Organ Donation Project: a comparison of two types of worksite campaigns on the willingness to donate. Clin Transplant 2011: 25: 600-605. © 2010 John Wiley & Sons A/S. Abstract: To test the impact of different campaign strategies, a year-long campaign was conducted to promote organ donation among university faculty, staff, and students. Two universities were assigned to each of three conditions: a media-only campaign, a mass media-plus-interpersonal outreach condition, and a control condition. Universities were counter-balanced by geographic region and diversity of population. Changes from pretest to post-test on the key-dependent measures, including signing a donor card and discussing donation with family members, were significantly greater in the media-plus-interpersonal condition than either the mass media only or control conditions. Implications for the creation of campaigns to promote other health behaviors are examined. [ABSTRACT FROM AUTHOR]

This article advances the beginnings of a general theory of organizational features to aid in understanding why health campaigns that work well in one organization may be ineffectual in another organization. The physical, social, and information structures of organizations are theorized to create an interaction environment that is distinct to each organization and that influences health campaigns. To test this argument, an organ donation campaign was conducted in 46 organizations. Multilevel modeling yielded mixed findings. Physical structure was negatively associated with signing an organ donor card. Social structure and information structure were positively associated with communication with coworkers about donation and communicative peer influence. Industry type was positively associated with knowledge change. [ABSTRACT FROM AUTHOR]

In this study, 580 participants viewed one of the 30 full-length entertainment television episodes. Fifteen of these episodes centered on an organ donation storyline (ODS) where facts about the process were portrayed inaccurately; the remaining 15 were matched by program, but did not feature organ donation, and served as controls. Results indicated nondonors were significantly impacted by negative organ-donation-related content. ODSs produced more negative attitudes, less accurate knowledge, and perceptions of social and descriptive norms less supportive of organ donation among nondonors. However, participants who had already declared a willingness to donate organs after death were not significantly impacted by entertainment television's depiction of myths about donation. [ABSTRACT FROM AUTHOR]

Drawing on theories of social learning, social representations and the organ donation model, online surveys were used to examine the impact of organ donation storylines of 4 U.S. television dramas (CSI: NY, Numb3rs, House, and Grey’s Anatomy) on viewers’ attitudes, knowledge, and behaviors. Results revealed that viewers acquired knowledge from the content of each drama, despite the fact that some content was inaccurate. Viewers who were not organ donors prior to exposure to the dramas were more likely to decide to donate organs if the drama explicitly encouraged donation, portrayed characters revealing how they had become donors and discussed the merits of donating. Viewers were also more likely to become an organ donor if they were emotionally involved in the narrative. Implications for using dramas to educate and motivate the public were discussed. [ABSTRACT FROM AUTHOR]

Sexual health information could be more accessible to urban adolescents. Many of the sexual health information Web sites are indexed using medical terms instead of slang terms that are typically used by teenagers. Many Americans have poor health literacy; sexually transmitted diseases, including HIV/AIDS, are affecting more and more young people. Actively indexing and mapping natural language terms to the more commonly used terms, by using a database, might enhance access to sexual health information and education. With easier access to this information, young people can learn more and protect themselves. [ABSTRACT FROM AUTHOR]

Researchers are already aware that decision making about health issues is not necessarily driven by rational or cognitive-based decision-making processes. This appears to be especially true for the decision to donate organs. Although hints about what is actually driving the decision-making process are scattered throughout the literature, noncognitive factors have not been tested systematically. Structural equation modeling of data gathered from 4426 participants at six different geographic locations in the United States demonstrates that cognitive-based factors (such as knowledge about donation) are less influential on the decision to donate than noncognitive variables such as the desire to maintain bodily integrity, worries that signing a donor card might 'jinx' a person, and medical mistrust. [ABSTRACT FROM AUTHOR]

In this study, 78 family pair dyads (spouses, parent–child pairs, or siblings) were brought into an interaction laboratory set up like a living room. After being briefed on the study, family members discussed a series of eight questions about their thoughts and opinions about organ donation. Thematic analysis of the thousands of pages of transcripts revealed that family members believe that they receive important information about organ donation through the media. Unfortunately, the most influential information came from sensationalistic, negative media portrayals. The myths that seem to be the most actively referenced by the media include premature declaration of death, the transference of personality traits from donor to recipient, a US black market for organs, corruption in the medical community, and corruption in the organ allocation system (which allows celebrities to get transplants first). Although these are not the only myths that the generally public holds to be true, the media is a powerful source of support for these particular myths. Therefore, such myths must be countered effectively if greater consent for organ donation is to be attained. [ABSTRACT FROM AUTHOR]

It is the purpose of this paper to examine cigar aficionado's use of a progressive conspiratorial storyline designed to discredit anti smoking advocates and their messages. While the rate of cigarette smoking has steadily declined over the last three decades, the rate of cigar consumption has increased by 60 percent. While most cigar smokers are wealthy, well educated white males, adolescents are also picking up the habit. A Robert Wood Johnson Foundation national survey reported that 37 percent of males and 16 percent of females between ages of 14 and 19 have smoke a cigar during the previous year. Infact the National Household Survey on Drug Abuse indicated that 5.6 percent of adolescents said that they were regular cigar users and the number of adolescents who have ever smoked cigars is 39 percent. With this growing popularity of cigar smoking in the U.S., public health officials have been earnestly trying to convince that this seemingly benign fad carries with it many dangers associated with cigarette use.

Because organ donation does not take place without the consent of next-of-kin and because family discussion is known to be the strongest predictor of consent to donate, transplant advocates have promoted family communication about organ donation, but without much success. Fewer than half of all people who are willing to be organ donors discuss their wishes with family members. Family discussions about donation in the African-American community are especially critical because the need for organs in this ethnic group dramatically outstrips the availability, thus leading to a disproportionate number of deaths among African Americans. This study, grounded in the Organ Donation Model, surveyed 311 African-American adults about their attitudes and behaviors regarding family discussions about organ donation. Logistic and multiple regression analyses revealed that, as hypothesized, family talk attitudes and behaviors were predicted by attitudes, knowledge, and social norms associated with organ donation. In addition, variables such as bodily integrity, medical mistrust, religiosity, and altruism were found to contribute significantly to the explained variance. The implications of these findings for health communication researchers and campaign organizers are discussed. [ABSTRACT FROM AUTHOR]

Since its first issue in 1992, few periodicals have enjoyed the rapid growth and international popularity of Cigar Aficionado. Although the magazine professes to simply celebrate "the good life and the joys of cigar smoking," we argue that it serves a more insidious function; specifically, the periodical supplies readers with 7 persuasive strategies aimed at rebuking dominant anti-smoking health assertions: (a) the cigars- are-not-cigarettes argument, (b) the life-is-dangerous argument, (c) the health-benefits argument, (d) the moderation argument, (e) the old-smokers argument, (f) the bad-science argument, and (g) the good-science argument. These pro-smoking arguments ultimately serve to relieve the cognitive dissonance associated with the consumption of a potentially deadly product and to maintain a loyal readership, free from guilt or anxiety. [ABSTRACT FROM AUTHOR]

The effective targeting of high sensation-seeking adolescents, who are most at risk for drug abuse, requires the creation of high sensation value messages. Whereas previous research has focused on subjective reactions of receivers as the primary way to define message sensation value (MSV), we conceptualize message sensation value as the formal and content features (audio, visual, and format) of a message that contribute to subjective message sensation evaluations. The three objectives of this study were (a) to identify message design features that would aid in the development of effective prevention messages targeting high sensation seekers, (b) to develop an objective measure of message sensation value based on formal and content features of messages, and (c) to determine whether high message sensation value messages were associated with higher subjective evaluations of message sensation value. In the present study, 418 undergraduates each viewed 10 PSAs selected at random from a pool of 109 PSAs that had been previously coded for message sensation value. Analyses provide support for the central hypothesis of the study, indicating that perceived message sensation value is at least in part a product of the formal and content features of a PSA. [ABSTRACT FROM AUTHOR]

Universities commonly rely upon International Teaching Assistants (ITAs) to teach basic courses. This use of ITAs is a considerable benefit to universities; however, there is substantial evidence to suggest that undergraduate students quite often object to being taught and graded by ITAs. If universities and their academic departments wish to foster a more productive learning environment for undergraduates who are taught by ITAs, it is vitally important that the ITAs be better prepared for this important teaching task. In this paper, we describe a narrative analysis of the stories of 25 undergraduate students. The study reveals that students have coherent, shared narratives of their experiences of ITAs. Based on an analysis of the narratives, we offer a number of positive suggestions for the development of more effective training for ITAs to teach courses at the undergraduate level [ABSTRACT FROM AUTHOR]

While little is known about African Americans' attitudes and knowledge about organ donation, even less is known about how African Americans' attitudes, values, and beliefs affect their behavior and behavioral intentions regarding organ donation; or how African Americans' views are similar to or different from those of European Americans. Adults working 2 sites of a national corporation were randomly selected to complete a survey about organ donation willingness, intention to sign an organ donor card, knowledge and attitudes toward organ donation, and level of altruism. Results indicate that African Americans differ significantly from Whites on several individual attitude and knowledge items. However, the basic relationship between knowledge, attitudes, values, and behaviors regarding organ donation between the 2 groups appears the same. Furthermore, these results indicate that future organ donation promotion campaigns must focus on increasing basic knowledge and countering myths about organ donation for both populations. [ABSTRACT FROM AUTHOR]

Evaluates the worksite organ donation campaign project. Details on the organ donation campaigns; Models of organ donation willingness; Methodology.

Examines the effect of knowledge, attitudes and altruism on behavioral intention of organ donors. Profile of people willing to become organ donors; Role of mass media in raising organ donation awareness; Misconceptions on organ donation practices.

Using data from a large-scale antimarijuana media campaign, this investigation examined the demographic and psychographic variables associated with exposure to public service announcements designed to target high sensation-seeking adolescents. The literature on sensation seeking indicates that adolescents high in this trait are at greater risk for substance abuse. Analyses assessed the predictive utility of various risk and protective factors, normative influences, demographic variables, and marijuana-related attitudes, intentions, and behaviors on campaign message exposure. Results confirm that level of sensation seeking was positively associated with greater message exposure. In addition, viewers reporting greater exposure were younger adolescents who indicated that they had poor family relations, promarijuana attitudes, and friends and family who used marijuana. Implications for designing future antimarijuana messages based on these findings are discussed. [ABSTRACT FROM AUTHOR]

Although numerous studies have examined many of the predictors of signing an organ donor card, including knowledge, attitudes, values, and demographic variables, very few have examined the factors associated with individuals' willingness to communicate about organ donation with family members. Because organ donation does not take place without the permission of a person's next-of-kin, government agencies and organ procurement organizations have targeted communication with family members as a primary objective of organ donation campaigns. This study reports the results of a survey of a stratified random sample of adults at 2 local sites of a national employer. Results indicate that knowledge, attitude, and altruism are significantly related to 2 measures of willingness to communicate: past behavior (whether respondents had already discussed organ donation with family members) and a scale measuring willingness to communicate about organ donation in the future. Because the quality of discussions between the potential donor and his or her family will depend on how well the donor is able to address vital issues regarding donation, it is concluded that campaigns seeking to promote communication between family members about organ donation must simultaneously seek to increase knowledge, debunk myths, and bolster positive attitudes about donation. [ABSTRACT FROM AUTHOR]

We examined p53 protein stability and DNA damage-induced p53-dependent responses in a human leukemic CEM cell line and two teniposide-resistant sublines, CEM/VM-1 and CEM/VM-1-5 (∼40 and 400-fold resistant to teniposide, respectively). Although all cell lines contain the same p53 mutations at codons 175 (Arg→His) and 248 (Arg→Gln), the constitutive levels of p53 were progressively increased with the resistance of the cells to teniposide. By pulse-chase experiments, we found that the half-lives of mutant p53 protein were approximately 12, 17, and >30 h in CEM, CEM/VM-1, and CEM/VM-1-5 cells, respectively. The prolonged half-lives of p53 in these cells is consistent with the fact that the protein harbors the indicated mutations. Of note, however, is the fact that the increased p53 protein half-lives in the two drug-resistant cell lines corresponds to a proportional decrease in MDM2 protein levels but an increase in p53-MDM2 binding interactions. This suggests that MDM2-mediated p53 degradation may be altered in our leukemic cell lines. The DNA damage-induced p53 response is fully functional in the drug-sensitive CEM cells containing a mutant p53, but this pathway is attenuated in the drug-resistant cells. Specifically, while the mutant p53 was phosphorylated at serine-15 in response to ionizing radiation in all these cell lines, mutant p53 induction in response to teniposide or ionizing radiation and induction of the p53-target genes, p21 and GADD45 only occurred in the drug-sensitive CEM cells. As assessed by MTT cytotoxicity assay, CEM cells were also significantly more sensitive to ionizing radiation, compared to the drug-resistant cell lines, and this correlated with p53 induction. Collectively, these results suggest that changes in constitutive mutant p53 protein levels, p53-MDM2 binding interactions, and altered regulation of the DNA damage-inducible p53-dependent pathway may play a role in drug- and radiation-responsiveness in these... [ABSTRACT FROM AUTHOR]

We propose cognitive absorption as a mental state that influences the processing of multimedia messages such as animations. An experiment was designed to assess (1) whether cognitive absorption is experienced when individuals view whiteboard animations; (2) the relationship between cognitive absorption and message elaboration; (3) the relationship between cognitive absorption and outcomes such as perceived argument strength, knowledge, and attitudes related to key concepts relevant to clinical trial participation. The study involved 927 cancer patients and survivors who were exposed to either whiteboard animations or brochures. Several interesting findings emerged. First, individuals experienced greater cognitive absorption while viewing the animations than when reading brochures. Second, cognitive absorption was associated with a systematic elaboration of the information provided by the animations. Third, cognitive absorption mediated the effect the animations had on individuals' perceived argument strength and attitudes, but not knowledge. Theoretical explanations for the educational and persuasive effects of animations are provided. • Experimental study comparing whiteboard animations and brochures providing information about clinical research. • Individuals experience cognitive absorption when watching whiteboard animations. • Cognitive absorption and individuals' processing of the information from whiteboard animations are positively correlated. • Cognitive absorption mediates perceptions of the strength of the arguments presented. • Recommendations for research on, and practice with, whiteboard animations. [ABSTRACT FROM AUTHOR]

The ATM gene product, which is defective in the cancer-prone disorder ataxia telangiectasia, has been implicated in mitogenic signal transduction, chromosome condensation, meiotic recombination and cell cycle control. The ATM gene has homology with the TEL1 gene of yeast, mutations of which lead to shortened telomeres. To test the hypothesis that the ATM gene product is involved in telomere metabolism, we examined telomeric associations (TA), telomere length, and telomerase activity in human cells expressing either dominant-negative or complementing fragments of the ATM gene. The phenotype of RKO colorectal tumor cells expressing ATM fragments containing a leucine zipper (LZ) motif mimics that of ataxia telangiectasia (A-T) cells. These transfected RKO cells relative to transfected controls had a higher frequency of cells with TA and shortened telomeres, but no detectable change in telomerase activity. In addition, the percentage of cells with TA after gamma irradiation was higher in the transfected RKO cells with dominant negative activity of the ATM gene, compared to control cells. SV40 transformed fibroblasts derived from an A-T patient and transfected with a complementing carboxyl terminal kinase region of the ATM gene had a reduced frequency of cells with TA, with no effect on the telomere length or telomerase activity. The present studies using isogenic cells with manipulated ATM function demonstrate a role for the ATM gene product in telomere metabolism. [ABSTRACT FROM AUTHOR]

Studies show significant association between cancer risk and being a firefighter. After exposure to even routine firefighting, firefighters' bunker gear often contains carcinogens that may be absorbed through contact or inhaled through off-gassing, thereby increasing cancer risk. Awareness of increased cancer risk has given rise to policies and practices focused on gear cleaning and decontamination processes to decrease risk; yet, these efforts are in their infancy and tend to be somewhat piecemeal in nature. This study presents a theory-based communication intervention tailored to the unique context of high-reliability organizations (HROs). The intervention focused on increasing postfire decontamination behaviors to reduce exposure to carcinogens among firefighters. Results of the intervention across 14 fire stations from 2 fire departments in South Florida show significant increases in attitudes, norms, and self-efficacy, decreases in perceived barriers, and increased intention to engage in decontamination processes. While the intervention was highly successful in both fire departments, there were significant differences in between organizations; attitudes perceived norms, and barriers to gear cleaning remained significantly different. This highlights the need to examine the specific context of the organization in designing interventions. In line with previous research on HROs, regression models showed that norms and self-efficacy are the strongest predictors of current behavior. However, postintervention, attitudes emerge as the strongest predictor of future behavior. The results of this study provide valuable evidence for utilizing theoretical elements in message design for interventions in HROs, and of the importance of designing communication for specific sites of intervention. [ABSTRACT FROM AUTHOR]

Recruiting diverse participants for precision medicine (PM) research programs should overcome low literacy and varied expectations. Information aids (IA) can address these barriers through patient-centered education. The purpose of this study was to evaluate the effectiveness of three information aids (IA) on participating in PM. An experiment with 290 U.S. participants recruited from Mturk was conducted to compare the effects of three IAs on the outcomes related to participation. Three conditions included an interactive IA (i.e., providing PM-related information responding to each participant's questions), a static IA (i.e., providing uniform PM-related information), and a control condition (i.e., providing non-interactive information irrelevant to PM). Both interactive and non-interactive IAs increased attitudes and information-seeking intentions, but not knowledge or participation intention. Perceived control and responsiveness mediated the effects of interactive IA. Both interactive and static IAs supported enrollment efforts for PM through fostering attitudes and follow-up information-seeking. Increased perceived control and responsiveness are key to the effects of interactive IA. IAs provide effective education and enrollment support for PM. Interactive IA can respond to individuals' inquiries and control the learning process. • Interactive and static IAs improved attitudes and information-seeking intentions. • Interactive IA elevated perceptions of control and responsiveness than static IA. • Perceptions of control and responsiveness mediated the effects of interactive IA. [ABSTRACT FROM AUTHOR]

Background This study extends previous direct-mail campaigns by evaluating the effectiveness of a marketing campaign promoting organ donation message strategies from the vantage point of organ donors, organ recipients, individuals on the waiting list, or a combination of these three frames. Methods Illinois residents were randomly assigned to one of four organ donation brochures disseminated via U.S. postal mail. Registrations occurred via the Internet and U.S. postal mail. Results Individuals register at a greater rate following exposure to the combination framed message compared to organ donor, organ recipient, and waiting list narratives. The campaign revealed that individuals are more likely to register via U.S. postal mail than the Internet. Conclusion Direct-mail marketing efforts were shown to be an effective approach to promote organ and tissue donation registrations. The results demonstrated a preference for the combination framed brochure. The results are discussed with an emphasis on the practical implications of utilizing direct-mail marketing efforts to promote organ donation among young adults. [ABSTRACT FROM AUTHOR]

Consistent with earlier research supporting the use of narratives to increase message persuasiveness, this study examined the role of guilt and happiness following exposure to organ donation narratives presented in professionally produced radio ads. As hypothesized, the loss-frame narrative was significantly associated with heightened guilt, which was related to greater freedom threat perceptions and psychological reactance. Conversely, the loss-frame narrative was negatively associated ( p = .06) with increased happiness. Contrary to what was hypothesized, reactance was not significantly negatively associated with favorable attitudes toward registering as an organ donor. Instead, freedom threat was directly negatively related to favorable attitudes. Our results are discussed with an emphasis on the theoretical and practical implications. [ABSTRACT FROM AUTHOR]

There has not been a significant improvement in the rate of clinical trial accrual in more than 20 years. Worse, the challenge of inadequate representation among racial and ethnic minorities also persists, deepening disparities in health. Community-Based Participatory Research (CBPR) is a participatory communication method that centers on effective dialogue between researchers and community stakeholders with the goal of creating an equitable partnership for health and social change. The objective of the current study was to provide an update since a systematic review in 2012, on the current status of the empirical research, with a particular focus on the elements of CBPR methods used to improve the rate of accrual of members of racial and ethnic minority communities for clinical trials. Our systematic review found a large increase in the number of CBPR related studies and studies related to racial and ethnic representation in research. More than 85% of studies employing CBPR methods saw statistically positive outcomes. Specifically, the elements of CBPR that are associated with these positive outcomes include community partner participation in (1) a study advisory committee, (2) data collection, (3) the development of interventions, and (4) participant recruitment. However, the results of our study indicate that researchers need to be more transparent about the extent of community participation as well as more thoroughly and accurately describe the nature of the partnership with members of minority communities in order to build upon the scientific literature on community-engaged methods. [ABSTRACT FROM AUTHOR]

Health communication experts continually seek out effective strategies to strengthen persuasive campaigns. While there is evidence that verbal metaphors can improve persuasion, little attention has been given to the potential of visual metaphors to enhance health communication effects. To fill this gap, an experiment was conducted to test the effects of metaphor modality (visual vs. verbal) and type of fear appeal used (death-based or appearance-based) on skin protection intentions. Additionally, the moderating role of an individual characteristic (need for cognition), and the mediating role of two processing outcomes (message elaboration and perceived message effectiveness) were examined. Results indicated that there was no significant difference between the main effects of metaphor modality and type of fear appeal, but these message features interacted making the death-based fear appeal the most effective strategy. Need for cognition directly affected perceptions of effectiveness but did not affect skin protection intentions nor message elaboration. Of the two message processing outcomes examined, only perceived message effectiveness mediated the relationship between metaphor modality and skin protection intentions. Theoretical explanations and practical implications are discussed. [ABSTRACT FROM AUTHOR]

Enrollment rates of cancer clinical trials remain low, affecting the delivery of effective medical treatments. Recent research has documented common factors affecting trial participation, but to improve these efforts more studies are needed to further understand specific concerns and issues of potential participants in multiple contexts. Forums and other online peer-to-peer health communities are crucial to the coping and survivorship of cancer patients. Online health communities will offer valuable information to understand how patients discuss perceptions, motivations, and challenges associated with clinical trial participation, and to understand how patients provide support to each other. The present study conducted a content analysis of 270 posts shared by 154 unique users between August 2017 and January 2018 on a popular online breast cancer forum. The analysis identifies common characteristics of patient users, salient post themes, perceived barriers, emotions, and misconceptions regarding clinical trial participation. The study findings are generally consistent with previous studies but provide in-depth insights into online support between cancer patients about clinical trial participation. Implications for practice and future research are also discussed. [ABSTRACT FROM AUTHOR]

Firefighters are exposed to carcinogens such as volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs) during fires and from their personal protective equipment (PPE). Recent research has shown that decontamination processes can reduce contamination on both gear and skin. While firefighter cultures that honor dirty gear are changing, little is known about current attitudes and behaviors toward decontamination in the fire service. Four hundred eighty-five firefighters from four departments completed surveys about their attitudes, beliefs, perceived norms, barriers, and behaviors toward post-fire decontamination processes. Overall, firefighters reported positive attitudes, beliefs, and perceived norms about decontamination, but showering after a fire was the only decontamination process that occurred regularly, with field decontamination, use of cleansing wipes, routine gear cleaning, and other behaviors all occurring less frequently. Firefighters reported time and concerns over wet gear as barriers to decontamination. [ABSTRACT FROM AUTHOR]

Fire rescue organizations are central to community models of resilience, especially in the context of crisis. The ability of fire rescue organizations to fulfill their role relies on their ability to operate at full capacity; however, fire rescue services may face internal crises that require these organizations to be resilient in their own right. This study uses grounded theory drawing on concepts of organizational culture and resilience to show how one key partner in the community model of resilience (Palm Beach County Fire Rescue) is working to address their own crisis-an epidemic of cancer. Firefighters are engaging in behaviours to increase resilience by working towards cultural change to reduce cancer risk, using social capital to increase networks and expertise, and utilizing internal assets to enact change. Barriers to change include cultural practices, perceived threats to occupational practice, and logistics and resources to enact desired change. A model of risk reduction and resilience is advanced that explores how organizational culture and practice both support and undermine individual resilience and organizational resilience. Implications for communication and change efforts are explored. [ABSTRACT FROM AUTHOR]

The article discusses studies which examined the factor structure and construct validity of the mood-based indoor tanning scale (MITS). Topics covered include the factors that may increase indoor tanning dependence, the use of the control theory model of mood regulation as a guiding theoretical framework and the classification of tanning beds under the highest cancer risk category of the World Health Organization.

An inconsistency in the research indicates positive attitudes toward organ donation do not map reliably onto organ donor registrations. Various models have sought to explain this inconsistency and the current analysis formally compared three models: the Bystander Intervention Model (BIM), the Organ Donor Model (ODM), and Vested Interest Theory (VIT). Mature (N = 688) adults between the ages of 50 to 64 years completed surveys related to organ donation. Results revealed that VIT accounted for the most variance in organ donation registrations followed by the BIM and ODM. The discussion emphasizes the importance of employing theories to explain a phenomenon as well as the practical implications of the findings. [ABSTRACT FROM AUTHOR]