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A Python package to evaluate Wannier, Wannier–Stark, and EZ (both energy and location Z resolved) levels for quantum cascade lasers is presented. We provide the underlying theory in detail with a focus on the orthonormality and periodicity of the generated states. [ABSTRACT FROM AUTHOR]

The evolution of nuclear spin state populations is investigated for the case of a 13C2-labeled triyne in solution, for which the near-equivalent coupled pairs of 13C nuclei experience cross-correlated relaxation mechanisms. Inversion-recovery experiments reveal different recovery curves for the main peak amplitudes, especially when the conversion of population imbalances to observable coherences is induced by a radio frequency pulse with a small flip angle. Measurements are performed over a range of magnetic fields by using a sample shuttle apparatus. In some cases, the time constant TS for decay of nuclear singlet order is more than 100 times larger than the time constant T1 for the equilibration of longitudinal magnetization. The results are interpreted by a theoretical model incorporating cross-correlated relaxation mechanisms, anisotropic rotational diffusion, and an external random magnetic field. A Lindbladian formalism is used to describe the dissipative dynamics of the spin system in an environment of finite temperature. Good agreement is achieved between theory and experiment. [ABSTRACT FROM AUTHOR]

Metal–organic frameworks (MOFs) are revolutionizing a spectrum of industries, from groundbreaking gas storage solutions to transformative biological system applications. The intricate architecture of these materials necessitates the use of advanced computational techniques for a comprehensive understanding of their molecular structure and prediction of their physical properties. Coarse-grained (CG) simulations shine a spotlight on the often-neglected influences of defects, pressure effects, and spatial disorders on the performance of MOFs. These simulations are not just beneficial but indispensable for high-demand applications, such as mixed matrix membranes and intricate biological system interfaces. In this work, we propose an optimized CG force field tailored for ZIF-8. Our work provides a deep dive into sorption isotherms and diffusion coefficients of small molecules. We demonstrate the structural dynamics of ZIF-8, particularly how it responds to pressurization, which affects its crystal structure and leads to local changes in aperture size and area. Emphasizing the game-changing potential of CG simulations, we explore the characteristics of amorphization in ZIF-8. Through computational exploration, we aim to bridge the knowledge gap, enhancing the potential applications of nanoporous materials for various applications. [ABSTRACT FROM AUTHOR]

In this paper, we have studied the effect on the structure and magnetic properties of partial Pd substitution by Gd in Fe–Pd thin films of nominal composition Fe56Pd44−xGdx (x = 1, 3, 5, and 7), deposited onto Si(100) and Si(100)/SiO2 substrates by thermal evaporation. Several techniques contribute to the characterization of their microstructure and magnetic properties, such as x-ray diffraction (XRD), scanning electron microscopy, alternating gradient field magnetometry, and magnetic force microscopy (MFM). X-ray diffraction shows that the as-deposited films are either amorphous or contain a disordered FePd phase, depending on the film thickness. The transformation of disordered fcc-FePd into ordered fct-FePd has been induced by a heat treatment at 530 °C for 4 h. The addition of gadolinium leads to a reduction in the coercivity as a consequence of the emergence of soft phases and of the progressive reduction of the fct-FePd phase, which is primarily responsible for the observed maze magnetic domains. The exchange coupling between the soft phase and the hard fct-FePd phase is demonstrated by first-order reversal curves (FORCs). [ABSTRACT FROM AUTHOR]

Acoustic metamaterial concepts, such as metalenses and hyperlenses, have been studied with much interest for super-resolution imaging. However, the physics of wave scattering by sub-wavelength sized defects is still not very well understood. Here, we present studies on acoustic wave interactions with circular defects of sizes varying from over a wavelength to sub-wavelength scale. Near- and far-field scattering patterns of single circular defects are presented, connecting them to analytical frameworks. Scattering field signatures produced by two identical circular defects of different sizes placed side by side are then discussed. The separation distance between the defects is among the parameters varied to understand the effects of geometric features in successful imaging. Experimental results are presented to support the predictions reported in the paper. The insights have important implications for sub-wavelength imaging using acoustic metamaterials. [ABSTRACT FROM AUTHOR]

Biocomposite materials made of natural plant fibers are becoming a viable alternative to the use of synthetic ones such as glass fibers, thanks to many economic, ecological, and technical benefits. However, their massive use in the industry requires optimal control of their mechanical performances, which constitutes a real scientific issue to be overcome. Indeed, biocomposites suffer from an important variability in their mechanical properties because of their multiscale structure, natural growth conditions, and various processing parameters, in addition to eventual chemical treatments. Biocomposites are also highly sensitive to the surrounding environment in terms of humidity and temperature because of the hydrophilic properties of natural plant fibers. In this context, this Perspective aims to provide a critical look at the influence of the main factors that affect the mechanical properties of biocomposites in order to suggest some possible research outlooks that could contribute to optimizing the control of these mechanical properties and expanding the use of biocomposites in industry. [ABSTRACT FROM AUTHOR]

Despite the importance of rhodium complexes in catalysis, and the favorable 100% natural abundance of the spin-1/2 103Rh nucleus, there are few reports of 103Rh nuclear magnetic resonance (NMR) parameters in the literature. In part, this is the consequence of the very low gyromagnetic ratio of 103Rh and its dismal NMR sensitivity. In a previous paper [Harbor-Collins et al., J. Chem. Phys. 159, 104 307 (2023)], we demonstrated an NMR methodology for 1H-enhanced 103Rh NMR and demonstrated an application to the 103Rh NMR of the dirhodium formate paddlewheel complex. In this paper, we employ selective 18O labeling to break the magnetic equivalence of the 103Rh spin pair of dirhodium formate. This allows the estimation of the 103Rh–103Rh spin–spin coupling and provides access to the 103Rh singlet state. We present the first measurement of a 18O-induced 103Rh secondary isotope shift as well as the first instance of singlet order generated in a 103Rh spin pair. The field-dependence of 103Rh singlet relaxation is measured by field-cycling NMR experiments. [ABSTRACT FROM AUTHOR]

Purpose: To evaluate the effectiveness of radial extracorporeal shock wave therapy (r ESWT) as an additional treatment modality for spastic equinus deformity in chronic hemiplegic patients. Methods: 100 eligible stroke patients with calf muscles spasticity were randomized into 2 groups. Group I: 50 patients exposed to rESWT 1.500 pulses, 0.10 mJ to 0.3mJ/mm2, with a frequency 4 Hz once weekly for one month. Group II: 50 patients exposed to Sham rESWT once weekly for one month. Clinical, electrophysiological & musculoskeletal ultrasound assessments were done for all patients. Results: After controlling baseline as covariate, the trend for modified Ashworth scale (MAS), Passive ankle dorsiflexion motion (PADFM), 10 meters walk test (10-MWT), and Ratio of maximum H reflex to maximum M response (H/M ratio) after one & two months was significantly different between the two groups, with improvement of all clinical and electrophysiological parameters in group I. Conclusion: ESWT represents a useful non-invasive, additional modality for the reduction of foot spasticity and equinus deformity in stroke patients. Implications for Rehabilitation: Extracorporeal shock wave therapy represents a useful non-invasive, additional modality for reduction of foot spasticity and equinus deformity in chronic stroke patients. The application of such a modality improves limb posture, range of motion, and muscle extensibility. Early extracorporeal shock wave rehabilitative intervention in stroke patients reduces fat infiltration and fibrosis replacement of spastic muscle. [ABSTRACT FROM AUTHOR]

Europium-hydroxyapatite (Eu-HA) nanocomposite was developed via continuous hydrothermal synthesis. Eu+3 ions partially replaced the Ca+2 ions within hydroxyapatite molecular structure. High quality Eu-HA nanorods of 20 nm width and 6 μm lengths were verified via TEM micrographs. Eu-HA maintained the crystalline structure of HA with minimum change; material studio software confirmed the partial replacement of Ca+2 by Eu+3. XPS analysis demonstrated Eu+3 content of 6.91 atom %. Ca/P ratio was found to be 1.405 and 0.118 for virgin HA and Eu-HA respectively; this was ascribed to the partial replacement of Ca+2 with Eu +3. The EDAX mapping verified the uniform dispersion of Eu ions within Eu-HA structure. Eu-HA nanocomposite was uniformly distributed in silica sol-gel matrix; subsequently it was applied on AZ31 magnesium alloy. The corrosion performance of Eu-HA sol-gel coating nanocomposite (Eu–S) was evaluated using different electrochemical techniques including Potentiodynamic Polarization (PDP), Electrochemical Impedance Spectroscope (EIS), and Electrochemical Noise (EN) in aerated 0.1 M NaCl solution. Corrosion protection was assessed to that of neat silica sol-gel coating (NSG). Pitting was detected over the whole NSG coated sample, after few hours of immersion in the corrosive solution. EuS coated AZ31 withstand up to 144 h without any sign of corrosion or delamination. EIS analysis with PDP parameters suggested the formation of protective layer; that is responsible for the corrosion resistance. Europium has unique ability to form a protective oxide layer acting as a barrier layer that could prevent the penetration of corrosive electrolyte to the underlying metal substrate. [ABSTRACT FROM AUTHOR]

The Nile River is one of the longest rivers in the world, serving as the lifeline of many countries. The river is subjected to significant anthropogenic pressures, and thus, understanding the magnitude of contamination and its possible consequences is needed. This research aimed to evaluate the presence of heavy metals in the surface water of an understudied region within the Nile River. The distribution and level of 18 elements along the Damietta branch were assessed, and their potential sources were estimated. Additionally, pollution indices and health risks were calculated. The results showed that most metals were within the acceptable levels of USEPA and WHO. However, Na, Mg, and Ca were higher than the permissible level of WHO, and K was higher than the permissible levels for irrigation. Furthermore, heavy metal pollution indicators, degree of contamination indices, heavy metal evaluation indices, Nemerow pollution indices, and water quality indices all pointed to very high standards for water quality. Also, the noncarcinogenic health risk index indicated a safe limit for dermal and oral exposure for adults and children. Overall, this study recommends management focus on anthropogenic activities in the Damietta branch of the Nile River. [ABSTRACT FROM AUTHOR]

Data background: Because the traditional open-TLIF approach has several drawbacks, minimally invasive surgery (MIS) approaches for TLIF (MISTLIF) have been developed to speed up recovery after surgery and minimize pressure on the para-spinal muscles, necessitating a cost-utility analysis for comparison in healthcare reforms. Objectives and aim of the work: This study aimed to compare the radiological and clinical parameters between mini-open TLIF and minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) surgery in patients with single-level lumbar degenerative spondylolisthesis. Hypothesis: This study hypothesizes that both minimally invasive and mini-open methods using sublaminar trimming laminoplasty (SLTL) (while preserving midline structures) and interbody cages have comparable mid- and long-term clinical and radiological outcomes. Methods: Retrospective analyses were performed on 120 patients who underwent single-level TLIF procedures with a minimum of two years of follow-up utilizing either the mini-open (n = 60) or MIS (n = 60) technique. Records of the operation's time frame, intraoperative fluoroscopy, blood loss, postoperative drainage volume, duration of bed rest, and complications were recorded. The Oswestry Disability Index (ODI) and visual analog scale (VAS) scores for both groups were utilized to assess improvements in clinical scores, and t tests were employed to statistically compare the outcomes. For comparison, radiological parameters, including lumbar lordosis, pelvic incidence (PI), and localized lordosis at the index level, were measured preoperatively, postoperatively, and at the final follow-up. To assess postoperative interbody fusion, the Bridwell grading system was used. Results: In the Mini-open TLIF group, the average follow-up time was 24.91 ± 5.7 months, while in the MIS-TLIF group, the average follow-up time was 25.15 ± 4.2 months. In the MIS-TLIF group, the mean operation and radiological time were longer. However, compared to the Mini-open TLIF group, the MISTLIF group experienced less blood loss and a shorter hospital stay. The MIS-TLIF group outperformed the Open-TLIF group in terms of the VAS score for back pain and the ODI at less than 6 months following surgery, and the differences were statistically significant. However, at the final follow-up, there were no statistically significant differences in the VAS score for the back between the two groups, but the ODI score was significantly greater in the MIS-TLIF group. Both groups' lumbar lordosis and focal lordosis significantly improved at the index level, with the Mini-open-TLIF group showing more focal lordosis. The interbody fusion rate did not significantly differ between the two groups. Conclusion: MIS-TLIF and mini-open-TLIF can be surgically effective in treating single-level degenerative lumbar spine spondylolisthesis. [ABSTRACT FROM AUTHOR]

Background: The use of IOUS is increasingly common in recent neurosurgical practice. IOUS has become very valuable in neurosurgery. It plays a key role in the localization of space-occupying lesion location and decreasing operation time and hence improves both surgical efficiency and safety. Ultrasound is very useful in the determination of the lesion location, its most superficial portion, and in differentiation between solid tumors and cystic components. Results: Intraoperative ultrasonography has a significant edge over the other intraoperative aids for image guidance in brain surgery, especially in terms of independence, cost, and adaptability to multiple different clinical scenarios. Ultrasound-based neuro-navigation is an easy-to-use, fast, and safe technique of real-time imaging for various neurosurgical procedures. Conclusion: We conclude that ultrasound-based neuro-navigation is an easy-to-use, fast, and safe technique of real-time imaging for various neurosurgical procedures. [ABSTRACT FROM AUTHOR]

Ovarian insufficiency is one of the common reproductive disorders affecting women with limited therapeutic aids. Mesenchymal stem cells have been investigated in such disorders before yet, the exact mechanism of MSCs in ovarian regeneration regarding their epigenetic regulation remains elusive. The current study is to investigate the role of the bone marrow-derived mesenchymal stem cells (BM-MSCs) lncRNA (Neat-1 and Hotair1) and miRNA (mir-21-5p, mir-144-5p, and mir-664-5p) in mitigating ovarian granulosa cell apoptosis as well as searching BM-MSCs in altering the expression of ovarian and hypothalamic IGF-1 – kisspeptin system in connection to HPG axis in a cyclophosphamide-induced ovarian failure rat model. Sixty mature female Sprague Dawley rats were divided into 3 equal groups; control group, premature ovarian insufficiency (POI) group, and POI + BM-MSCs. POI female rat model was established with cyclophosphamide. The result revealed that BM-MSCs and their conditioned media displayed a significant expression level of Neat-1, Hotair-1, mir-21-5p, mir-144-5p, and mir-664-5p. Moreover, BM-MSCs transplantation in POI rats improves; the ovarian and hypothalamic IGF-1 – kisspeptin, HPG axis, ovarian granulosa cell apoptosis, steroidogenesis, angiogenesis, energy balance, and oxidative stress. BM-MSCs expressed higher levels of antiapoptotic lncRNAs and microRNAs that mitigate ovarian insufficiency. [ABSTRACT FROM AUTHOR]

Background: The safety of blood donation requires screening for transfusion-transmitted infections, including human immunodeficiency virus (HIV), syphilis, hepatitis B virus (HBV) and hepatitis C virus (HCV). This study aimed to determine the seroprevalence of HIV, HBV, HCV and syphilis in blood donors of Mogadishu Tertiary Care Hospital, Somalia from 2020 to 2022. Methods: The records of 109,385 blood donors who attended our blood center in Mogadishu-Somalia between 2020 and 2022 were examined retrospectively. Serum samples of donors; HBsAg, anti-HCV, anti-HIV and syphilisscreening tests were studied using the microparticleEnzyme-Linked ImmunoSorbent Assay (ELISA)(Vitros, Ortho-Clinical Diagnostics, U.S) method.The distribution of HBsAg, anti-HCV, anti-HIV and syphilis positivity rates of 109,385 blood donors according to years, gender and age were examined. Kolmogorov Smirnov, Skewness, Kurtosis tests and histogram were used for normality analysis. Chi-squared test (χ2) and Fisher Exact test were used to analyze categorical data. Categorical variables were expressed as frequency (percentage). Analysis of continuous data was performed with the Mann Whitney U test. P < 0.05 value was considered statistically significant. Results: HBsAg positivity was found in 0.6% of the donors, anti-HCV positivity in 0.01%, anti-HIV positivity in 0.03% and syphilispositivity in 0.3%. The results showed that among the blood donors, the prevalence of syphilis, HIV, Hepatitis B, and Hepatitis Cwas notably low. Conclusion: The prevalence of HBV, HCV, HIV, and syphilis among blood donors in Somalia was found to be quite low. Even if our found seroprevalence rates are low, to guarantee the safety of blood for recipients, strict selection of blood donors and thorough screening of donors' blood using accepted procedures are strongly advised. [ABSTRACT FROM AUTHOR]

Moyamoya disease (MMD) is a chronic, rare cerebrovascular disorder of unknown cause featured by extensive narrowing of the terminal internal carotid artery (ICA) and its main branches. As a compensatory mechanism, perforators dilate forming fragile collateral vessels that appear as an abnormal vascular network resembling 'puff of smoke drifting in the air' observed via angiography around stenotic area in the brain. Patients and methods: The database of the current hospital was retrospectively studied. All patients with ischemic strokes owing to MMD treated with surgical revascularization between January 2015 and December 2022 were included. MMD was identified on catheter-based digital subtraction angiography (DSA) by the presence of stenosis at the terminal portions of both internal carotid arteries and the development of abnormal collateral "moyamoya vessels" around the base of the brain. Clinical, radiological and follow-up data were retrospectively analyzed. Results: During the mentioned time window, nine patients were diagnosed with moyamoya disease among all pediatric patients with established diagnosis of ischemic stroke in our institute; six of them underwent surgery. Unilateral EDMS was performed in 5 cases (83.3%), while one patient (16.67%) underwent staged bilateral surgeries with no added neurological deficit. Conclusion: Indirect revascularization surgery for pediatric moyamoya-related stroke patients has high rates of reperfusion and promising outcomes. [ABSTRACT FROM AUTHOR]

AbstractThe ongoing global pandemic caused by viral pathogens like SARS-CoV-2 (COVID-19) underscores that viral transmission is not confined by geographical boundaries. Thus, the development of novel antiviral therapies is critical to mitigate this crisis. Pyranopyrazoles have gained significant attention in medicinal chemistry due to their bioactive properties. In this study, we present a new series of pyranopyrazoles and their annulated derivatives, which were assessed for antiviral activity using a validated QSAR model and tested for their inhibitory effects against the viral 3CLpro enzyme. The findings were corroborated by various in silico techniques, including molecular docking, molecular dynamics simulations, and DFT calculations. Additionally, ADME studies were conducted to evaluate the pharmacokinetics and pharmacodynamics of the novel lead compound 2. These investigations identified a series of metabolically stable pyranopyrazoles and their annulated derivatives as effective inhibitors of the SARS-CoV-2 3CLpro enzyme, offering a promising therapeutic option for COVID-19. We believe that pyranopyrazoles warrant further evaluation and chemical optimization for potential use in COVID-19 treatment. [ABSTRACT FROM AUTHOR]

The advent of Internet-of-Things (IoT)-based telemedicine systems has ushered in a new era of technology facilitating early diagnosis and prevention for distant patients. This is particularly crucial for severe illnesses such as Alzheimer's disease, encompassing memory loss and cognitive dysfunction that significantly impairs daily life, necessitating immediate medical attention. The surge in data from intelligent systems, sourced from diverse locations, has heightened complexity and diminished diagnostic accuracy. In response, this study proposes an innovative distributed learning-based classification model, leveraging a deep convolutional neural network (CNN) classifier. This model proficiently manages clinical data images from disparate sources, ensuring disease classification with high accuracy. The research introduces a novel system designed for automated Alzheimer's disease detection and healthcare delivery. Comprising two subsystems, one dedicated to Alzheimer's diagnosis with an impressive 94.91% accuracy using CNN, and another for healthcare treatment, delivering excellent results. Notably, the system is adaptable to various diseases post-training. The study emphasizes the model's robust performance, achieving an outstanding 94.91% accuracy after 200 training epochs, with a loss of 0.1158, and a validation accuracy of 96.60% with a loss of 0.0922 at training without noise and loss: 0.2938 - Accuracy: 0.8713 - val_loss: 0.2387 - val_accuracy: 0.9069 at CNN with noise. Precision, recall, and F1 scores are comprehensively presented in a classification report, underscoring the system's effectiveness in categorizing Mild Demented and Non-Demented cases. While acknowledging room for further enhancements, this study introduces a promising avenue for telemedicine systems. It significantly impacts the early diagnosis and treatment of Alzheimer's disease and related medical conditions, thereby advancing the healthcare sector and improving patients' quality of life. The inclusion of these quantitative results enhances the abstract's appeal to readers, providing a clearer understanding of the study's outcomes. [ABSTRACT FROM AUTHOR]

Background: Progressive familial intrahepatic cholestasis is an autosomal recessive genetic disorder that manifests primarily with jaundice and pruritus and can progresses from persistent cholestasis to cirrhosis and late childhood liver failure. Classically, progressive familial intrahepatic cholestasis is classified into three subtypes: 1, 2, and 3 and results from a defect in a biliary protein responsible for bile formation and circulation in the liver. In the last decade and with the increased use of genetic testing, more types have been known. Case presentation: A 6-month-old Afrocentric boy presented with progressive jaundice and pruritus that started since the age of 2 months. He was thoroughly investigated to be finally diagnosed as progressive familial intrahepatic cholestasis type 4. A low-fat diet, ursodeoxycholic acid, fat-soluble vitamins, and cholestyramine were started. He showed initial improvement then had refractory pruritus and impaired quality of life. He underwent surgical biliary diversion at the age of 1 year with marked improvement of manifestations. Conclusion: Owing to the increased technology of genetic testing, more clinical subtypes of progressive familial intrahepatic cholestasis were diagnosed other than the classical three types. Surgical management using biliary diversion could be beneficial and delays or may even obviate the need for liver transplantation. [ABSTRACT FROM AUTHOR]

Background: Cardiac symptoms are a characteristic feature of chronic obstructive pulmonary disease (COPD), a disorder with lately achieved recognition as a systemic illness according to established standards. The research's objective was aimed at investigating the transthoracic echocardiography role in assessing right ventricular (RV) dysfunction among individuals diagnosed with COPD, as well as to examine the potential correlation between blood pro B-type natriuretic peptide (BNP) concentrations + and this diagnostic procedure. Methods: Arterial blood gasses, spirometry, echocardiography, and serum pro BNP were done for 80 COPD patients and 20 healthy smokers, and some echocardiographic parameters were correlated with degree of airflow limitation. Results: 77.5% of COPD cases exhibited pulmonary hypertension (PHTN), and on classifying our COPD patients, it was found that 65% of patients in group II had PHTN and 90% of patients in group III had PHTN. Systolic pulmonary artery pressure (SPAP), mean pulmonary arterial pressure (MPAP), right ventricular mid diameter (RVMD), right ventricular basal diameter (RVBD), right ventricular longitudinal diameter (RVLD), right ventricular outflow tract (RVOT) above pulmonary and aortic valve, and tricuspid annular plane systolic excursion (TAPSE) along with RVEF exhibited a significant variance among all groups. A negative correlation was observed among forced expiratory volume (FEV) 1% and (RVMD as well as RVBD) and between Pro BNP and (TAPSE and RVEF). Conclusions: PHTN was found in 77.5% of COPD patients and is negatively correlated with FEV1%. Serum pro BNP level exhibits a negative correlation with FEV1% in stable COPD patients. [ABSTRACT FROM AUTHOR]

Purpose: Gastroschisis is associated with over 90% mortality in many sub-Saharan African countries. The introduction of the Gastroschisis Care Bundle at Muhimbili National Hospital (MNH) increased survival up to 60%. We aim to explain the impact of using implementation science methods to decentralize the care of babies with gastroschisis to other parts of Tanzania. Methods: We used a Step-Wedge Implementation Science design to scale up gastroschisis care through training of providers, dissemination and current revision of evidence-based care protocols, advocacy, and engagement with stakeholders. We used mixed methods for data collection. Anonymous patient and provider evaluation data were collected using a nationwide Gastroschisis Database via REDCap. We evaluated the implementation and effectiveness of the care bundle in different hospitals in Tanzania. Results: Decentralizing care nationally was feasible, acceptable, and adaptable. A total of nine trainings have been conducted training 420 providers (14 Master Trainers) reaching seven regions of Tanzania. The three advocacy national campaigns have ensured community reach and patient engagement. A countrywide gastroschisis database was developed to collect data on patients with gastroschisis, hosted locally at MNH with 332 patients' data entered in 1 year. The majority (90.2%) were treated using preformed silo bags with an overall survival of 28.5% in all centers. Late presentation and infection remain to be the main challenge. Conclusion: To achieve quality and sustainable surgical care, there is a need to design, implement, evaluate, and continuously improve context-relevant strategies to achieve and sustain the survival of neonates with congenital anomalies. Decentralization enables clear connectedness of hospitals, bringing care closer to patients. [ABSTRACT FROM AUTHOR]

ABSTRACT Background Methods Results Conclusion Patient or Public Contribution Research identified preliminary evidence that artificial intelligence (AI) has emerged as a transformative force in healthcare, revolutionising various aspects of healthcare delivery, from diagnostics to treatment planning. However, integrating AI into healthcare systems in Egypt is challenging, particularly concerning healthcare professionals' acceptance and adoption of these technologies. This mixed‐method study aimed to explore the sentiment of nurses at different organisational levels towards AI and resistance to change in healthcare organisations.A mixed‐method design was employed, with quantitative data collected through a survey of 500 nurses using the general attitudes towards AI and resistance to change scale and qualitative data from semi‐structured interviews with 17 nurses. Quantitative data were analysed using descriptive and inferential statistics, while qualitative data were analysed thematically.The survey demonstrated that positive attitudes were inversely correlated with resistance behaviour and resistance to change. Additionally, perceptions of AI's usefulness, ease of use and value were strongly and positively correlated with positive attitudes and negatively correlated with negative attitudes. Moreover, the influence of colleagues' opinions, self‐efficacy for change and organisational support showed significant positive correlations with positive attitudes towards AI and negative correlations with negative attitudes. Qualitatively, nurses cited obstacles such as lack of familiarity with AI technologies, biases affecting decision‐making, technological challenges, inadequate training and fear of technology replacing human interaction. Readiness for AI integration was associated with the necessity of training and the timing of AI use.Nurses demonstrated varied understanding of AI's applications and benefits. Some acknowledged its potential for efficiency and time‐saving, while others highlighted a need for up‐to‐date knowledge.No patient or public contribution. [ABSTRACT FROM AUTHOR]

AbstractThis study presents a comprehensive characterization of the Pliocene reservoir formation in the Temsah gas field, located 65 km NNW of Port Said in the northeastern Nile Delta Basin. The research integrates seismic data with well log analysis to enhance reservoir characterization. The Temsah gas field is distinguished by its intricate geological structure, featuring numerous normal faults oriented along northeast-southwest and northwest-southeast trends. The field’s stratigraphy is predominantly composed of sandstone and shale facies, which are considered highly prospective for hydrocarbon accumulation. A full geological field analysis was conducted to identify key prospects for enhancing productivity. To accurately delineate seismic features, data from four wells and twenty-nine 2D seismic lines were interpreted. Depth maps of the reservoir layers were constructed, highlighting critical transitions between sandstone and shale facies, which are pivotal for future exploration efforts. A detailed 3D static model was developed to illustrate the impact of lithological composition on reservoir characteristics, with a specific focus on the Upper Sand of Kafr El-Sheikh Formation. Petrophysical properties, including effective porosity (13–23%), shale content (7–31%), and water saturation (30–45%), were meticulously evaluated to inform the creation of a robust 3D property model. This model provides a detailed spatial distribution of rock facies and petrophysical parameters within the Temsah gas field. The integration of these studies identified two promising areas, with estimated original gas in place (OGIP) ranging from 2.86 to 4.04 stock cubic feet (SCF), indicating significant potential for field development and enhancement. [ABSTRACT FROM AUTHOR]

Background: It has been proposed that prolonged use of anti-inflammatory and anti-fibrotic drugs diminish the probability of development of lung fibrosis. Prolonged low-dose corticosteroid may prevent remodeling of the lung in survivors. Pirfenidone and colchicine may exhibit anti-fibrotic and anti-inflammatory properties as well. Methods: This retrospective observational study was conducted at post COVID-19 clinic, Mansoura University Hospitals, during the period between October 2020 and March 2022. This study included 104 patients who had COVID-19 pneumonia confirmed either by RT-PCR or radiologically by CT scan and divided into 3 groups; group A (corticosteroids only) included 33 (31.7%) patients, group B (corticosteroids and colchicine) included 56 (53.8%) patients, and group C (corticosteroids, colchicine, and pirfenidone) included 15 (14.4%) patients. All patients were assessed during follow-up visits in post COVID-19 clinic 1 and 3 months after discharge by evaluation of resting SpO2, spirometry, and radiological assessment. Patients' data during hospitalization was collected from hospital electronic systems. Results: There was non-statistically significant improvement in FEV1 in group A while there was statistically significant improvement in FEV1 in groups B and C (P value = 0.002 and 0.041, respectively) 1 month and 3 months after discharge. Group B exhibited more statistically significant improvement in FVC as well compared to group C (P value = 0.003 and 0.025, respectively) while group A showed non-statistically significant improvement in FVC. There was a statistically significant decrease in CT severity score in all the groups during follow-up with P value < 0.001 in groups A and B and to less extent less statistically significant decrease in group C comparing the 3 groups to each other. Conclusion: The use of colchicine added to corticosteroids after acute phase of COVID-19 pneumonia resulted in statistically significant improvement regarding functional and radiological changes during follow-up when compared to corticosteroids alone. The addition of pirfenidone (which is a relatively expensive drug) to corticosteroids and colchicine did not add more statistically significant improvement in functional or radiological changes. [ABSTRACT FROM AUTHOR]

Renal fibrosis (RF) represents the most widespread pathological condition in chronic kidney disease (CKD). Recently, protein prenylation has been implicated in the fibrosis's progression. The research examined the renoprotective effect of zoledronic acid (ZA) (50 µg/kg/week) in a rat model of carbon tetrachloride (CCl4)-induced RF through targeting protein prenylation. Forty Wistar male rats were split up into the control group, vehicle-treated group, model-RF group, and RF-ZA group. Mean arterial blood pressure (MBP), BUN, serum creatinine, and urine albumin–creatinine ratio (uACR), protein levels of farnesyl pyrophosphate (FPP), tumour necrosis factor-alpha (TNF-α), transforming growth factor-β (TGF-β), and malondialdehyde (MDA), and catalase and gene expression of farnesyl pyrophosphate synthase (FPPS) and nuclear factor-kB (NF-κB) were measured. Immunohistochemical staining for renal interleukin-6 (IL-6), α-smooth muscle actin (α-SMA), and caspase-3, as well as histopathological alterations, were assessed. ZA considerably ceased the reduction in MBP, markedly reduced uACR, serum creatinine, BUN, and expression of FPPS, FPP, NF-κB, TGF-β, TNF-α, and MDA, and significantly increased catalase levels compared to the model-RF rats. ZA ameliorated the CCl4-induced histopathological alterations and suppressed the expression of caspase-3, α-SMA, and IL-6. In conclusion, ZA preserved renal function and prevented renal fibrosis in a rat model. These were achieved through targeting protein prenylation mainly by inhibiting FPPS. [ABSTRACT FROM AUTHOR]

The current study aims to evaluate the performance of the ultrasonic vibration-assisted milling (USVAM) process when machining two different materials with high deviations in mechanical properties, specifically 7075 aluminium alloy and Ti-6Al-4V titanium alloy. Additionally, this study seeks to develop an AI-based model to predict the process performance based on experimental data for the different workpiece characteristics. In this regard, an ultrasonic vibratory setup was designed to provide vibration oscillations at 28 kHz frequency and 8 µm amplitude in the cutting feed direction for the two characterised materials of 7075 aluminium alloy (150 BHN) and Ti-6Al-4V titanium alloy (350 BHN) workpieces. A series of slotting experiments were conducted using both conventional milling (CM) and USVAM techniques. The axial cutting force and machined slot surface roughness were evaluated for each method. Subsequently, Support Vector Regression (SVR) and artificial neural network (ANN) models were built, tested and compared. AI-based models were developed to analyse the experimental results and predict the process performance for both workpieces. The experiments demonstrated a significant reduction in cutting force by up to 30% and an improvement in surface roughness by approximately four times when using USVAM compared to CM for both materials. Validated by the experimental findings, the ANN model accurately and better predicted the performance metrics with RMSE = 0.11 µm and 0.12 N for Al surface roughness and cutting force. Regarding Ti, surface roughness and cutting force were predicted with RMSE of 0.12 µm and 0.14 N, respectively. The results indicate that USVAM significantly enhances milling performance in terms of a reduced cutting force and improved surface roughness for both 7075 aluminium alloy and Ti-6Al-4V titanium alloy. The ANN model proved to be an effective tool for predicting the outcomes of the USVAM process, offering valuable insights for optimising milling operations across different materials. [ABSTRACT FROM AUTHOR]

This study reviews methods for detecting fracture closure pressure in both unconventional and conventional reservoirs using mathematical models and fluid flow equations. It evaluates techniques such as the Nolte method, tangent method, and compliance method. The investigation relies on observing changes in fluid flow regimes from preclosure to postclosure using fluid flow equations to examine the postclosure flow regime effect on the G function. Reverse calculations model pressure decline across synthesized flow regimes, facilitating a detailed investigation of the closure process. The analysis reveals that the tangent method is sensitive to postclosure fluid flow, while the compliance method is less effective in reservoirs with significant tortuosity or natural fractures. This paper recommends assessing natural fractures' characteristics and permeability to identify the source of leak-off before selecting a technique. It proposes integrating various methods to comprehensively understand subsurface formations, combining their strengths for accurate fracture closure identification and a better understanding of subsurface formations. The new proposed workflow employs the continuous wavelet transform (CWT) technique for fracture closure detection, avoiding physical model preassumptions or simplifications to confirm the results. This approach offers guidance on selecting appropriate methods by integrating different techniques. [ABSTRACT FROM AUTHOR]

Cervical cancer related to high-risk human papillomavirus (HR-HPV) is the second female cancer in Mauritania (Northwest Sahelian Africa). We assessed the distribution of HPV genotypes in Mauritanian women with high-grade cervical intraepithelial neoplasia (CIN2/3) or invasive cervical cancer (ICC). A prospective study was conducted in the Centre Hospitalier National, Nouakchott, Mauritania, to collect cervical biopsies among women suspected of CIN2/3 or cancer. HPV DNA detection and genotyping were carried out from formalin-fixed, paraffin-embedded biopsies using multiplex PCR (Human Papillomavirus Genotyping Real-Time PCR Kit, Bioperfectus Technologies Co., Taizhou, China). Fifty biopsies were included from women (mean age: 56.7 years) suffering from CIN2/3 (28.0%) and ICC (72.0%) which corresponded to 32 (64.0%) squamous cell carcinomas (SCC) and 4 (8.0%) adenocarcinomas (ADC). HPV DNA detection was successful in 47 (94.0%) samples. The most prevalent HR-HPV genotypes were HPV-45 (40.4%), HPV-16 (38.3%), HPV-39 and HPV-52 (23.4%), HPV-33 (17.0%), HPV-18 (14.9%), HPV-35 (4.2%), and HPV-56 (2.1%). The majority (93.6%) of HPV-positive biopsies contained at least one HPV type covered by the 9-valent Gardasil-9® vaccine, and 40.9% were infected by multiple vaccine HPV genotypes. To eradicate cervical cancer in Mauritania, prophylactic HPV vaccination must be combined with primary molecular screening of cervical HR-HPV infection. [ABSTRACT FROM AUTHOR]

This paper proposes a neutrosophic model for measuring and evaluating the role of digital transformation in improving sustainable performance using the balanced scorecard in Egyptian universities. The model takes into account uncertainty, ambiguity, and incompleteness in the data. The model first calculates the neutrosophic measures of digital transformation and sustainable performance for each university. Then, it uses neutrosophic logic to evaluate the causal relationship between digital transformation and sustainable performance. The results of the analysis can used to identify the digital transformation indicators that have the greatest impact on sustainable performance. This information can then be used to develop strategies for improving sustainable performance by investing in digital transformation. The neutrosophic model was applied to measure and evaluate the role of digital transformation in improving sustainable performance using the balanced scorecard in some Egyptian universities. The results showed that the percentage of courses offered online and the percentage of students using digital learning platforms were the two digital transformation indicators that had the greatest impact on sustainable performance. The neutrosophic model is a powerful tool that can be used to measure and evaluate the role of digital transformation in improving sustainable performance in Egyptian universities, taking into account uncertainty, ambiguity, and incompleteness in the data. [ABSTRACT FROM AUTHOR]

Background Psoriasis is a common chronic, immune-mediated inflammatory skin disease. Despite the availability of several systemic therapeutic agents, treatment of psoriasis remains a challenge because of the associated adverse effects and/or the financial burden of these medications, given the chronicity of the disease. Objectives We aimed to compare the efficacy and safety of combined pulse azathioprine (AZA) and low-dose methotrexate (MTX) vs. a conventional dose of MTX in patients with chronic plaque psoriasis. Methods In this randomized controlled trial, 67 patients with moderate-to-severe plaque psoriasis were randomized into two groups, receiving either combined pulse AZA (300 mg weekly dose) and low-dose MTX (10 mg weekly) or conventional-dose MTX (0.3 mg kg−1 per week) for 16 weeks. Patients were assessed for treatment response using the Psoriasis Area and Severity Index (PASI) score and for the development of any adverse effects at weeks 12 and 16, and for a further 3 months after stopping treatment. Results A statistically significantly higher proportion of the patients receiving combined pulse AZA and low-dose MTX achieved ≥ 90% improvement in PASI and 100% improvement (PASI 100) at week 12, and PASI 100 at week 16, compared with those receiving the conventional dose of MTX as monotherapy. No serious adverse events were reported during the entire study period in the two groups. Conclusions Combination therapy using pulse AZA and low-dose MTX can be an efficacious treatment for moderate-to-severe plaque psoriasis, with a relatively good safety profile. [ABSTRACT FROM AUTHOR]

Anterior cruciate ligament (ACL) rehabilitation is a common intervention after ACL reconstruction. Since different types of exercise can influence muscle and kinematic parameters in diverse ways, the training order between the knee and ankle joints may also change gait parameters. This study aimed to investigate whether the training sequence of the knee and ankle joints (knee followed by ankle training or vice-versa) in an ACL reconstruction (ACLR) rehabilitation program has any effects on knee extension and flexion torques. Forty-two men (aged 20–30 years) with ACLR participated in this study. They were randomly allocated to receive one of two interventions: (A) knee joint training followed by ankle training or (B) ankle joint training followed by knee training. After five weeks (four weeks of intervention and one-week washout), participants crossed from one group to another for an additional four weeks. Knee extension and flexion torques were assessed during the stance phase of the gait cycle before and after the intervention program. Two-way Mixed-design MANOVA showed that knee extension torque improved significantly in both groups after training (p = 0.001, Cohen's D = 0.65), while the knee flexion torque increased significantly only in group B (p= 0.001, Cohen's D = 0.97). When comparing both groups, patients of group B presented significant improvements in the post-training mean values of all tested variables compared with group A. Starting a post-ACLR rehabilitation program with ankle training followed by knee training is better to improve knee flexion and extension torques during the stance phase of the gait cycle than starting the program by training the knee first, followed by the ankle. Future studies using a mixed-gender sample and different types of ACLR operations are necessary to examine whether similar improvements will happen as well as to test their effects on many sports activities. • Knee torques improves after ankle joint training in ACL. • Exercising ankle joint first then knee joint is better in ACLR. • Ankle joint training improves gait after ACLR. • Athletes get better recovery after ankle training. [ABSTRACT FROM AUTHOR]

The genus Persicaria (Polygonaceae) comprises about 150 species found in temperate regions. and subtropical region of Africa, India, and South America This review aims to provide an overview of the current status of Persicaria species native to the North African region in terms of their ethnobotanical uses, phytochemistry, and biological activity alongside the main botanical characteristics. This review includes comprehensive information that identified seven species from the genus Persicaria traditionally used to treat several ailments, namely P. amphibia, P. decipiens, P. hydropiper, P. lapathifolia, P. maculosa, P. lanigera , and P. senegalensis. A considerable number of secondary metabolites, such as phenolic glycosides and derivatives, flavonoids (aglycone and glycosides), terpenoids, and numerous fatty acids have been identified in this genus, which are responsible for their diverse pharmacological activities. Their extracts and pure compounds have been reported for their astringent, antipyretic, styptic, laxative, antibacterial, diuretic, and tonic properties. The information gathered in this review might be of help for future studies in terms of the current knowledge on the link between the phytochemical components and medicinal uses of Persicaria species native to North Africa. This could facilitate more discoveries on its potential particularly in the pharmacological characteristics and consequently be developed into modern medicines. [Display omitted] • Seven Persicaria species native to North Africa were selected and reviewed. • All reviewed species grow near water and exhibit common botanical characteristics. • These species are enriched with phenolic compounds; some contain terpenoids as essential oils. • A wide spectrum of folk medicinal and biological activities was reported for Persicaria species. [ABSTRACT FROM AUTHOR]

Objective: This randomized controlled clinical trial compared the clinical efficacy of self‐adhesive bulk‐fill Surefil One with a traditional bulk‐fill composite in class II restorations. Materials and Methods: Sixty‐four direct class II composite restorations were categorized into two groups. Group I, control group (n = 32): cavities were restored by Filtek One bulk‐fill composite with Scotchbond Universal (SBU) adhesive in self‐etch mode, Group II, test group (n = 32): cavities were restored by Surefil One self‐adhesive bulk‐fill composite. The study involved a follow‐up period of 1 year, during which restorations were assessed at baseline (BL), 6 months, and 12 months using Federation Dentaire Internationale (FDI) criteria. Data analysis was performed using nonparametric tests. A comparison of restoration characteristics was performed utilizing the chi‐square test (X2). The significance level was set at 0.05. Results: Filtek One and Surefil One bulk‐fill composites revealed clinically acceptable FDI scores over 12‐month recalls. Thirty‐two patients (64 restorations) were available for all follow‐up visits; 100% of the restorations survived. For esthetic properties, Filtek One was far better than Surefil One at all time points. However, in terms of functional and biological properties, both restorations demonstrated comparable performances. Conclusions: Filtek One bulk‐fill restorations were superior in terms of surface luster, surface staining, color match, and translucency, but Surefil One restorations performed well and were similar to Filtek One restorations; however, additional advancements and research are needed to obtain better esthetics. Furthermore, longitudinal studies with extended follow‐up periods are needed to assess the clinical potential of both materials. Clinical Significance: Both Filtek One and Surefil One met the FDI criteria, with Filtek One demonstrating superior esthetic and functional qualities and similar performance regarding biological criteria. Both innovative restorative materials show potential for clinical use. Trial registered on ClinicalTrials.gov under registration number; NCT06120868:07/11/2023. [ABSTRACT FROM AUTHOR]

Purpose: Exogenous melatonin has been proven to have beneficial effects on sleep. A good sleep quality promotes recovery and improves physical performance. In this sense, the present study aimed to explore the potential effect of nocturnal melatonin ingestion on psycho-cognitive and short-term maximal performances, in the following morning. Method: Twelve professional soccer players (22.9 ± 1.3 years, 1.80 ± 0.05 m, and 72.0 ± 8.8 kg) volunteered to perform two separate testing sessions after either nocturnal melatonin or placebo ingestion. The next morning, participants performed the following psycho-cognitive and physical tests: Hooper's index, reaction time, vigilance, handgrip strength (HG), squat jump (SJ), modified agility T-test (MAT) and Wingate anaerobic test (WanT). Rating of perceived exertion (RPE) and blood lactate [La] were recorded, respectively, immediately and 3 min after the WanT. Blood glucose [GL] was measured before and 3 min after WanT. Results: Compared with placebo, melatonin improved subjective sleep quality, short-term maximal performances (HG and SJ), reaction-time, as well as peak and mean WanT powers and decreased fatigue index and RPE scores. However, [La] and [GL] were not affected by melatonin ingestion. Conclusion: Nocturnal melatonin intake before sleep has beneficial effects on cognitive and physical performances the following day. [ABSTRACT FROM AUTHOR]

Purpose: The role of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in managing cardiovascular outcomes in patients with type 2 diabetes mellitus (T2DM) is evolving. This meta-analysis seeks to explore the influence of SGLT2i on the recurrence of atrial fibrillation (AF) following catheter ablation (CA) in individuals with T2DM qualitatively and quantitatively. Methods: A comprehensive literature search was conducted in electronic databases. Studies meeting predefined criteria were included. Individual patient data (IPD) were used from reconstructed time-to-event data to estimate hazard ratios (HRs) and 95% confidence intervals for AF recurrence. IPD meta-analysis was followed by a direct meta-analysis to assess the risk of AF recurrence. Results: A total of five studies [one randomized controlled trial (RCT) and four cohort studies] were included in this study, and five studies were included in the qualitative analysis, while four studies comprising 1043 patients with T2DM were included in the quantitative analysis. The pooled Kaplan–Meier curve based on reconstructed data showed a significantly lower risk of AF recurrence in the SGLT2i group compared with all antidiabetic drugs (log-rank P = 0.00011) and dipeptidyl-peptidase IV inhibitors (DPP4i) (log-rank P = 0.01). Cox regression analysis showed consistent results. Direct meta-analysis showed that SGLT2i, compared with all antidiabetic medications (HR 0.57, 95% CI [0.44, 0.73], I2) and DPP4i (HR 0.41, 95% CI [0.24, 0.70], I2), was associated with a lower risk of AF recurrence. Conclusions: SGLT2i are associated with a reduced risk of AF recurrence after CA in patients with T2DM. These results suggest that SGLT2i is promising in improving clinical outcomes for this population. [ABSTRACT FROM AUTHOR]

Diaspis echinocacti (Bouché), a globally distributed cochineal scale insect, poses a significant threat to Opuntia spp. in Morocco and worldwide. This study explores the ecological dynamics of D. echinocacti across different Opuntia spp. varieties, employing antixenosis and antibiosis tests in a controlled greenhouse environment (25.3 ºC). In the antixenosis test, Opuntia spp. varieties displayed varying levels of resistance at 6–24 h post-infestation. Marjana and Belara exhibited early resistance with significantly lower numbers of insects (6 h: 4.4, 9.8; 12 h: 3.2, 5.1; 24 h: 2.3, 4.4), while Aakria, Ghalia, and Karama sustained higher susceptibility (6 h: 71.3, 82.1, 85.6; 12 h: 75.2, 89.6, 105.6; 24 h: 105.6, 110.3, 118.0). In the antibiosis test, the life cycle, behavior, and reproductive parameters of D. echinocacti were assessed. Marjana and Belara exhibited longer early nymphal stages compared to Aakria, Ghalia, and Karama. Longevity in both females and males was highest in Ghalia and Karama, while Marjana and Belara showed the shortest duration. Female life cycles ranged from 63.4 to 88.2 days, with Marjana and Belara having the shortest durations and Karama the longest. Fecundity was highest in Karama (152.80 eggs) and lowest in Marjana (12.60 eggs). Population growth parameters highlighted that Karama (r = 0.09, λ = 1.10, R0 = 61.73) and Ghalia (r = 0.09, λ = 1.09, R0 = 56.54) exhibited the highest intrinsic rate of increase, finite rate of increase, and total reproduction per generation. This study offers essential insights into D. echinocacti dynamics, informing pest management and advancing our understanding of ecological interactions in cactus ecosystems, particularly for breeding programs targeting Opuntia spp. resistance to scale insects. [ABSTRACT FROM AUTHOR]

Loss and absence of melanocytes due to a number of factors is responsible for vitiligo; known to be the commonest disorder of pigmentation. The aim of the current work was to compare the efficacy and safety of excimer light with topical tacrolimus ointment 0.1% versus excimer light with topical bimatoprost gel 0.01% in treatment of facial vitiligo. The study was carried out on 48 patients presented with facial vitiligo. The patients were divided randomly using sealed envelope method into two groups (24 patients each). Group 1 were treated with excimer light plus topical tacrolimus ointment 0.1% and group 2 treated with excimer light plus topical bimatoprost gel 0.01%. Clinical improvement based on the quartile grading scale at the end of treatment did not show any statistically significant difference between groups. The majority of subjects in both groups experienced good to excellent improvement. Only 20.9% of patients in group 1 and 33.3% of subjects in group 2 achieved less than 50% repigmentation (p = 0.889). Our study demonstrated that 0.01% topical bimatoprost gel in combination with excimer light is considered safe and effective as treatment of nonsegmental facial vitiligo with comparable results to 0.1% tacrolimus. [ABSTRACT FROM AUTHOR]

Nail psoriasis is a chronic, inflammatory condition which is difficult to treat, linked with greater psoriasis severity, and may be associated with anxiety and significant functional impairment of the quality of life. The 1064 nm Nd: YAG laser was reported to yield satisfactory results in the treatment of nail psoriasis. The aim of the study was to assess the clinical and ultrasonographic efficacy of long-pulsed 1064 nm Nd: YAG laser in the treatment of fingernail psoriasis and compare its effect to control fingernails. This intra-patient randomized controlled trial analyzed 86 fingernails collected from 13 patients suffering from cutaneous and nail psoriasis. The nails were randomized into two groups. Group A was treated with Nd: YAG laser once monthly for three sessions while group B served as control. Assessment took place at baseline, 1 and 3 months after the last treatment session. For scoring, the 32-points target NAPSI scoring systems was used. Additionally, two blinded dermatologists' score of improvement, patients' pain assessment by visual analogue score and ultrasonographic assessment were all performed. At the end of follow up, the medians of tNAPSI score, plate definition, matrix thickness, bed thickness and bed vascularity decreased significantly in the Nd: YAG laser treated group in comparison to baseline (p = 0.001, 0.006, 0.039, < 0.001 and 0.010, respectively). While, there was a non-significant reduction in median tNAPSI score in the control group at last follow up, however, ultrasonography recorded a significant reduction in the medians of plate definition, bed thickness and vascularity (p = 0.002, 0.011 and 0.033, respectively) from the baseline. Comparison of the Nd: YAG laser and the control groups showed no significant difference from baseline regarding the medians of tNAPSI, tNAPSI percentile improvement, pits count, blinded evaluation of photographs and ultrasonographic assessments. In conclusion, Nd: YAG laser showed clinical and ultrasonographic improvement in fingernail psoriasis. Ultrasonography is a useful noninvasive tool in diagnosing and monitoring the clinical and even the subclinical changes in nail psoriasis. Nail psoriasis although difficult to treat, may show spontaneous improvement. [ABSTRACT FROM AUTHOR]

This paper proposes a complete model for simulating and controlling particle distribution in the final part manufactured by the resin transfer molding (RTM) process. This model combines (i) a numerical model to simulate the injection of a particle-filled resin through the fibrous medium and (ii) the integration of the genetic optimization algorithm to control the final particle distribution in the composite. Firstly, the numerical model is validated by comparing its numerical results with experimental measurements from the literature. Next, global sensitivity analysis methods were applied to identify the parameters (material and process) with the most significant influence on final particle distribution. As a result, it was found that the injected particle concentration is the most influential parameter compared to the injection pressure and the initial volume fraction of the preform, which has negligible effects. Finally, optimization applications were carried out to test the proposed approach's robustness. Four different and interesting profiles in the final distribution of particles in the composite were targeted: uniform distribution (UD) and functionally graded (FG) reinforcements (FG-O, FG-X, and FG-NI). The last three profiles are based on functionally graded materials (FGMs) with a substantial property gradient. In all cases, an optimal solution for the evolution of the initial concentration is reached, and the final particle distribution obtained after the injection simulation with this optimized initial concentration leads quite precisely to the desired profile. [ABSTRACT FROM AUTHOR]

Designing scaffolds to fit with essential requirements for wound dressings is still a challenge. A material with high antibacterial activity and biocompatibility is targeted. In this case, the electrospinning technique is used to fabricate a nanofiber scaffold of polylactic acid (PLA) embedded with ginger and/or molybdenum trioxide (MoO3) and cupric oxide (CuO). The nanofiber scaffolds were examined using SEM, TEM, Raman, XRD, FTIR, and EDX. In addition, the surface topography of the nanofiber scaffold of MoO3/ginger@PLA showed that the nanofiber diameters differ from 0.085 to 0.34 µm. Furthermore, the contact angle of the water drop on the surface of the pure PLA and MoO3/CuO/GO/ginger@PLA is remarkably changed from 32.3° to 18.9°. Moreover, the cell viability test of the composition MoO3/CuO/GO/ginger@PLA is above the IC50 at all concentrations. Meanwhile, the antibacterial test exhibited antibacterial activity against E. coli and S. aureus for the scaffolds, with an inhibition zone of 23 ± 0.816 mm and 16.33 ± 0.942 mm for MoO3/CuO/ginger@PLA and 20.3 ± 0.471 mm and 15.33 ± 0.943 mm for MoO3/CuO/GO/ginger@PLA. The obtained results are appropriate to aid the cells to grow and proliferate. As a result of that, the fabricated scaffolds could be utilized in biomedical applications. [ABSTRACT FROM AUTHOR]

This paper addresses the null controllability of an abstract boundary control systems in Hilbert spaces where the system operator is of Riesz type. Consequently, this document establishes a criterion for null controllability in such systems based on initial data, utilizing the moment problem. Furthermore, this criterion is formulated by employing a null controllability criterion that is applicable to a corresponding linear system with internal control. Finally, we apply our approach to the heat equation and the Mullins equation, demonstrating the practicality of our methodology. [ABSTRACT FROM AUTHOR]

Background Patients and Methods Results Conclusion The cortical shell technique is frequently associated with technical drawbacks, such as the lack of anatomical guidance during shell harvest and graft. This study aims to assess the horizontal bone gain and accuracy of a digitalized protocol that incorporates two interlocking patient‐specific stackable guides (PSSGs) to control the shell harvest, positioning, and fixation.Twenty patients with deficient anterior mandibles were randomly allocated; 10 patients received freehand symphyseal shell harvest and fixation (the control group), whereas the other 10 received fully guided harvest and graft (study group) using (PSSGs), the first aided an accurate shell harvest, whereas the second conveyed shell fixation. The interposition gap among both groups was loaded with an equal mix of xenogeneic and autogenous particulates. The mean radiographic bone gain among both groups was calibrated 6 months postoperatively, and the accuracy of the digital plan was assessed by superimposing and comparing the virtually planned horizontal bone dimensions with the immediate postoperative actual bone dimensions.The mean 6‐month postoperative horizontal bone gain value of the study group was recorded as (4.97 ± 0.73) mm versus (4.45 ± 0.61) mm for the control group, with a statistically insignificant mean gain difference of (0.52) mm, (p = 0.101). The mean virtual preplanned horizontal bone gain was recorded (5.4 ± 0.6) versus (5.4 ± 0.6) for the immediate postoperative actual bone gain, which was also statistically insignificant (p = 0.9).The (PSSGs) provided a precise method for graft harvest, position, and fixation, resulting in satisfactory alveolar ridge dimensions with intimate accuracy. [ABSTRACT FROM AUTHOR]

Background Aim Study design Results Conclusions Relevance to Clinical Practice Patient–ventilator asynchrony (PVA) is a condition that commonly affects patients who are mechanically ventilated. PVA happens when the patient's own breathing effort and the ventilator preset settings are out of sync. Ventilator waveform monitoring is viewed as a difficult undertaking, even for experienced practitioners, despite being a non‐invasive and reliable tool for diagnosing PVA.To assess the knowledge levels and attitudes of critical care nurses (CCNs) regarding the use of ventilator waveform monitoring to detect PVA.A cross‐sectional online survey was conducted in three intensive care units (ICUs) in Alexandria, Egypt. The questionnaire consisted of four parts to evaluate CCNs’ level of knowledge and attitude regarding ventilator waveform monitoring and assess their ability to detect PVA.Of the 137 CCNs approached, 101 CCNs completed the survey, resulting in a 73.7% response rate. Most nurses (88.1%) demonstrated poor knowledge levels and negative attitudes (93.1%) towards using waveform monitoring to detect PVA. A significant relationship was found between nurses' knowledge of ventilator waveform monitoring and their participation in previous training programmes on mechanical ventilation (MV; p = .031). Additionally, nurses' attitudes towards ventilator waveform monitoring were significantly associated with their level of education (p = .002) and attendance in previous courses on waveform analysis (p = .020).A majority of CCNs have poor knowledge and negative attitudes regarding ventilator waveform monitoring. Previous training in MV and attendance courses on ventilator waveform analysis showed a significant correlation between nurses' level of knowledge and attitudes regarding ventilator waveform monitoring.Assessment of CCNs’ knowledge and attitudes regarding ventilator waveform monitoring for detecting patient–ventilator asynchrony (PVA) informs the development of future educational programmes, ultimately aiding in the delivery of prompt and high‐quality care. [ABSTRACT FROM AUTHOR]

Enucleation and exenteration are widely utilized ophthalmic procedures in veterinary field. Enucleation in camels is like other large animals, typically performed under the influence of heavy sedation and loco-regional analgesia. The aim of the current study was to introduce a new surgical approach to enucleate the eye of camels through supraorbital fossa approach. for that purpose, the technique was applied to seven camels referred to the King-fisal teaching veterinary hospital for unilateral enucleation. Assessment of applicability, safety and feasibility of this technique was done. All procedures were performed in the kush (sitting) position under the influence of heavy sedation with Xylazine HCl in combination with retrobulbar nerve block. A "C" shaped skin incision was made in the skin and fascia of the supraorbital fossa to enter the orbital cavity, after which the periorbital fat was gripped, dissected and removed. Bleeding controlled by electrocautery and visible large blood vessels were ligated. After ligation the optic nerve and ophthalmic blood vessels, the eyeball was dissected sharply and freed from the orbital bony attachment. Finally, the orbital fascia and skin were sutured with simple interrupted pattern separately. The approach proved successful in all camels, with the enucleation procedure being both feasible and easily performed. The mean surgical time was approximately 46.6±12.4 minutes. The minimal occurrence of short and long-term complications was encouraging, and the cosmetic outcomes were notably improved. The supraorbital approach is a safe and effective technique for camel ophthalmic surgery, showing advantages in exposure and minimal complications. Further research is needed for validation and broader clinical applications. [ABSTRACT FROM AUTHOR]

Postharvest decay caused by Botrytis cinerea (gray mold) and Fusarium solani (fruit decay) negatively affects strawberry fruits during handling and marketing.The effect of cinnamon oil, sodium benzoate, potassium sorbate and/or pomegranate peel powder were estimated on the growth of the two pathogenic fungi and their fruit decay incidence under in vitro and in vivo conditions.The isolated fungi from decayed strawberry fruits were identified as Botrytis cinerea and Fusarium sp. The isolated Fusarium sp. was identified molecularly as Fusarium solani and registered in GenBank under accession number ON248575.1 (https://www.ncbi.nlm.nih.gov/nuccore/ON248575.1).Complete fungal growth suppression was observed at a concentration of 3% for all tested materials, Additionally the same (100%) effect was achieved at 2% of a combination of essential oil, salts and pomegranate peel powder. Significant reduction in decay incidence and severity was observed in inoculated strawberry fruits treated with the same concentrations of the tested materials after 10 and 15 days of storage.The results demonstrate that cinnamon oil, sodium benzoate, potassium sorbate and/or pomegranate peel powder have potency as eco-friendly products, for safe postharvest treatments against strawberry fruit rots during storage. They could be recommended for use in packing-houses due to their wide utilization as safe food preservatives. [ABSTRACT FROM AUTHOR]

Background: The proposed research study introduces independent concentration extraction (ICE) as a novel UV–Vis spectrophotometric approach. The approach can be used for extracting the concentration of two analytes with severely overlapped spectra from their binary mixtures. ICE is based on spectral extraction platform involving simple smart successive methods that can directly extract the original zero order spectra of the analytes at their characteristic (λmax). Chlorpheniramine maleate (CPM) and Levocloperastine fendizoate (LCF) are two commonly co-formulated drugs in cough preparations. The combined mixture was used to confirm the validity of the developed ICE tool. Another less green HPTLC was developed for the first time to separate both drugs and help also in confirming the proposed tool. Methods: For the simultaneous determination of CPM and LCF, two ecologically friendly techniques were employed. The first approach encompasses the use of the ICE spectrophotometric method that could be successively applied for extracting the concentration of two analytes with severely overlapped unresolved spectra in their binary mixtures. Other complementary methods aiming at original spectral extraction; including spectrum subtraction (SS) and unity subtraction (US) were also successfully employed to resolve the zero order spectra of the combined drugs with all their characteristic features and peaks. The second technique used, a high-performance TLC-densitometric one, was performed on silica plates with silica plates F254 and a mobile phase with a ratio of 3:3:3:1 by volume of toluene, ethanol, acetone, and ammonia as a developing system at 230 nm. Results: The presented extraction approach was executed without any optimization steps or sample pretreatment for the simultaneous determination of CPM and LCF. The method was found to be valid for their determination within concentration range of 3.0–30.0 μg mL−1 for both drugs. For HPTLC method, the resulting Rf values of CPM and LCF were 0.37 and 0.78, within concentration ranges of 0.3–4.0 μg/spot and 0.8–10.0 μg/spot, respectively. Greenness assessment of both developed methodologies showed that the HPTLC method is less green than the spectrophotometric method, yet with comparable sustainability when it comes to the used technique. Conclusion: The procedures were found to be selective, accurate, and precise for analysis of the studied binary mixture. Furthermore, the environmental impact of the introduced methods was assessed using novel greenness metrics, namely AGREE and Green Analytical Procedure Index (GAPI) to prove their ecological safety. In addition, white analytical chemistry (WAC) evaluation metric was employed to ensure the synergy and coherence of analytical, practical, and ecological attributes. [ABSTRACT FROM AUTHOR]

Background: Spondylolisthesis is a prevalent condition in the lumbar spine that can cause low back pain, leg pain, neurogenic claudication, and impact health-related quality of life in symptomatic individuals. Aim: to assess the results of minimally invasive TLIF (MIS-TLIF) versus open-TLIF and the impact of correcting spino-pelvic parameters on the Health-Related Quality of Life (HRQoL) in patients with low-grade isthmic spondylolisthesis. The primary objective was to compare the effectiveness of both methods in correcting spinopelvic parameters. The secondary objectives involved comparing clinical improvement, operating time, blood loss, complications, and postoperative hospital stays between the two procedures. Patients and methods: Seventy-two patients with low-grade isthmic spondylolisthesis were enrolled in this retrospective cohort-control study, with a minimum follow-up period of 18 months. Disability was assessed using the Oswestry Disability Index (ODI), while back and leg discomfort were rated using the Visual Analogue Scale (VAS) for each patient. The measurements comprised the sacral slope (SS), pelvic tilt (PT), pelvic incidence (PI), and Meyerding slip grades. We measured lumbar lordosis (LL), and segmental lordosis. Results: The seventy-two patients were 60 female and 12 males. There was no statistically significant difference in the duration of operation between the two groups. In the MIS group, there was a notable reduction in blood loss, higher radiation exposure, and a shorter hospital stay (P < 0.001). The back VAS showed more favorable outcomes in the MIS-TLIF, while the leg VAS showed better results in the Open-TLIF in the early outcome. Both procedures significantly reduced leg and back pain VAS scores and ODI, with no notable difference between the two groups at the final follow-up. Post-surgery, the pelvic incidence (PI) and lumbar lordosis (LL) matched properly in all patients, showing a rise in LL and sacral slope along with a decrease in pelvic tilt. Conclusion: Both open-TLIF and MIS-TLIF are effective methods for correcting spino-pelvic parameters and improving HRQoL in patients with low-grade isthmic spondylolisthesis. The rapid improvement in back pain experienced by these patients favored the use of MIS-TLIF. However, the cost-effectiveness of this approach must be carefully evaluated. [ABSTRACT FROM AUTHOR]

AbstractThe elbow is presented in pressurized tubular structures as a connecting element, generally subjected to bending moments either out-of-plane or in-plane, in closure or opening. Another mode of bending moment that can also occur in these tubular structures is the combined bending moment between out-of-plane and in-plane in closure, or out-of-plane and in-plane in opening. In this work, to better present the potential severity caused by this loading mode, an elbow structure attached by straight tubular sections made of X60 steel is analyzed and its damage under this combined bending moment with orientations between the plane and out-of-plane of the structure is discussed. A reinforcement proposal will be made in the second part of this work. Indeed, the structure is pretreated thermally at the elbow, resulting in a graded structure along the thickness with two different material constituents: the base metal and the thermally affected zone (HAZ). Based on the concept of Functionally Graded Materials (FGM), the gradation is by volume fraction between the base metal and the HAZ, following a power law function of a volume fraction index (n). This graded property is introduced along the thickness by finite element layers. The elastic-plastic behavior of the HAZ-base metal mixture is modeled using the Voce model and the Von Mises equivalent stress flow theory. Using the XFEM technique(extended finite element method), the damage of the pressurized and thermally treated structure under a combined out-of-plane bending moment shows that these parameters condition the response and the level of damage. [ABSTRACT FROM AUTHOR]

Borosilicate glasses possess excellent melting properties and high stability against chemical attack by aqueous solutions, enabling this glass family to be used in various fields. In this article, we design a novel glass network in order to achieve a chemically robust glass with a low melting temperature. Therefore, the substitution effect of Na2O by MgO, Al2O3, Li2O, and K2O on the chemical durability and melting properties of sodium aluminosilicate glass (i.e., 80SiO2‒5Al2O3‒15Na2O [mol%]) was examined using a standard hydrolytic resistance test and viscosity measurement. Interestingly, we found that the partial replacement of Na2O by Al2O3, Li2O, and K2O (i.e., 80SiO2‒5Al2O3‒15Na2O → 80SiO2‒6.5Al2O3‒9Li2O‒2.25Na2O‒2.25K2O) makes the glass network with chemical durability and melting properties comparable to those of the commercial borosilicate network, resulting in a low HCl consumption of 0.04 mL/g and working temperature of 1238°C (i.e., temperature at viscosity 104 dPa s). The structural characterizations indicate that the high chemical stability of this glass composition originates from the abundance of SiO4 tetrahedrons with three and four bridging oxygen in the glass network as well as the increase in cationic field strength of mixed alkali ions. These excellent melting properties and superior chemical durability of glass imply the possibility of using the mixed alkali metal oxides aluminosilicate glass together with the commercial borosilicate glass in the markets for numerous practical applications. [ABSTRACT FROM AUTHOR]

AbstractThis study investigates the dynamic response of an infinite structure comprising two coaxial cylinders employing the one-relaxation-time generalized thermoelastic diffusion model. The inner cylinder, serving as a cavity, possessing a radius a, while the outer cylinder has radius b. The inner cylinder is insulated and experiencing a localized thermal load with thickness 2 h. The outer cylinder, with radius b, is also experiencing to a localized thermal load with width 2 h, and its surface exhibits no traction. Additionally, the structure experiences the influence of a solenoidal body force. The analysis of this problem employs a combination of Laplace transform, inverse Laplace transform, and exponential Fourier transform techniques. Numerical analysis of the resulting solutions reveals the variations in temperature, displacement, radial stress, concentration, and potential fields as a function of the radial coordinate. Results indicate a minimal impact of the time interval on the temperature distribution, while displacement and radial stress exhibit significant time-dependent behavior. These findings highlight the significance of incorporating thermoelastic diffusion theory in the analysis of real-world engineering problems. [ABSTRACT FROM AUTHOR]

This study provides a critical review of Underground Hydrogen Storage (UHS), emphasizing its potential as a viable energy storage option despite several associated challenges. These challenges include microbial degradation, chemical reactivity, unique thermophysical characteristics, and geomechanics considerations. Effective and secure UHS operation requires careful site selection, management, and a thorough understanding of hydrogen's behavior under various geological and operational conditions. Our review examines the significance of hydrogen's physical properties, H 2 -fluid-rock dynamics, redox-driven geochemical interactions, microbial activities, and geomechanical risks influencing UHS performance, safety, and containment. Additionally, we discuss the importance of optimal material selection and operational strategic development to maximize UHS efficiency and minimize associated risks. While global projects and ongoing research form a solid foundation for UHS development, ensuring UHS effectiveness and safety requires further investigation. This article also identifies the main knowledge gaps and future research directions for effective deployment of UHS projects. [Display omitted] • Assessment of geological formations suitable for UHS, including salt caverns, depleted reservoirs, and saline aquifers. • Insights derived from global UHS projects inform best practices. • H 2 physical properties and the complex H 2 -fluid-rock dynamics are crucial for ensuring UHS efficiency and safety. • Geochemical reactions, microbial activities, and geomechanics may affect UHS performance and integrity. • Geologic and operational parameters are keys to achieving optimal UHS performance. [ABSTRACT FROM AUTHOR]