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Zirconia is one of the strongest porcelain materials used in indirect posterior restorations. However, lithium disilicate is also used as an alternative with good esthetics. One of the aspects that is often neglected when producing restorations is the marginal fit; hence, restorations will easily leak and will not be durable. The purpose of this experiment was to evaluate the differences in the marginal fit of zirconia and lithium disilicate onlays. Experimental research with twenty-six CAD/CAM onlay restorations were divided into two groups: zirconia and lithium disilicate. A light body impression material was inserted between the restoration and typodont. Marginal fit was tested using an analytical balance and a micrometre screw gauge to weigh and measure the thickness of the light body impression material, respectively. Using the Mann-Whitney test showed a significant difference of the mean weight of the lightbody between Monolithic Zirconia (15.1+ 2.22 mg) and Lithium Disilicate (21.6+ 6.87 mg) (p = 0.002), while the marginal fit between these groups showed no significant difference (p>0.05). In comparison, lightbody monolithic zirconia appears to be lighter than lithium disilicate; however, both materials exhibit equivalent marginal fit for CAD/CAM onlay restorations. [ABSTRACT FROM AUTHOR]