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The article reports on research conducted to determine the effects strength training had on physical function and to determine its impact on strength, power, muscle volume, body composition and physical function. Researchers evaluated 50 inactive adults over the age of 65. They found that strength training improves performance in functional tasks important for activities of daily living and led to changes in strength, power, and fat free mass.

Background:Approximately 5% of patients administered gentamicin (GM), an aminoglycoside antibiotic, experience vestibular ototoxicity resulting in balance dysfunction. In the present study, we sought to identify susceptibility genes associated with GM-induced vestibular dysfunction using a case/control design. Methods: White cases (n = 137; 55 men, 82 women) were recruited based on physician-confirmed unilateral or bilateral vestibular dysfunction attributed to GM administration. Controls (n = 126; 54 men, 72 women) were healthy, age-matched individuals without vestibular dysfunction or balance impairment. Buccal cell samples were obtained from all subjects and DNA was genotyped for 15 polymorphisms in 9 genes. Candidate genes were identified primarily for their roles in oxidative stress based on predicted mechanisms of gentamicin-induced ototoxicity. Statistical analyses included the multi-dimensionality reduction (MDR) method for identifying gene x gene interactions across multiple candidate genes. Results: Both single gene and MDR analyses revealed the NOS3 (ENOS) p.Glu298Asp polymorphism as significantly associated with GM-induced vestibular dysfunction (both p ⩽ 0.03). MDR analysis revealed a three-gene combination, consisting of NOS3 (p.Glu298Asp), GSTZ1 (p.Lys32Glu), and GSTP1 (p.Ile105Val), that provided the highest predictive model for GM-induced vestibular dysfunction (64% accuracy; p = 0.009). Conclusions: The results indicate that carriers of risk alleles at three oxidative stress-related genes have increased susceptibility to GM-induced vestibular dysfunction. [ABSTRACT FROM AUTHOR]

PURPOSE: To identify susceptibility genes associated with gentamicin-(GM; an aminoglycoside antibiotic) induced vestibular dysfunction. METHODS: A case/control analysis was performed. White cases (n=137; 55 men, 82 women) were recruited based on physician-confirmed unilateral or bilateral vestibular dysfunction attributed to GM administration. Controls (n=126; 54 men, 72 women) were healthy, age-matched individuals without vestibular dysfunction or balance impairment. Buccal cell samples were obtained from all subjects and DNA was genotyped for 15 polymorphisms in 9 genes. Statistical analyses included the multi-dimensionality reduction (MDR) method for identifying gene x gene interactions across multiple candidate genes. RESULTS: Both single gene and MDR analyses revealed that the ENOS Glu298Asp polymorphism was significantly associated with GM-induced vestibular dysfunction (both P<0.05). MDR analysis revealed a three-gene combination, consisting of ENOS (Glu298Asp), GSTZ1 (Lys32Glu), and GSTP1 (Ile105Val), that provided the highest predictive model for GM-induced vestibular dysfunction (64% accuracy; p=0.001). CONCLUSION: The results indicate that carriers of risk alleles at three oxidative stress-related genes have increased susceptibility to GM-induced vestibular dysfunction. [ABSTRACT FROM AUTHOR]