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This research aimed to analyse the partial mediating role of body satisfaction in the relationship between sport participation and depressive symptoms, as well as to examine the moderating role of gender in these associations. A cross-sectional study was conducted with a sample of 1810 adolescents aged 13-18 years old who completed self-report measures regarding sport participation, body satisfaction and depressive symptoms. The results indicated that a higher frequency of sport participation was associated with a lower presence of depressive symptoms, both directly and through greater body satisfaction, although gender differences were found in this partial mediation model. It was detected that sport participation had a greater effect on positive body satisfaction among boys, whereas body dissatisfaction indicated a greater presence of depressive symptoms among girls. The results emphasize the need to implement gender-specific programmes to improve psychological adjustment in adolescents by promoting sport practice and body acceptance. [ABSTRACT FROM AUTHOR]

During middle adolescence, elevated stress and a greater presence of psychological disorders have been documented. The research has paid little attention to the regulation of positive affective states. Fredrickson's broaden‐and‐build theory suggests that cultivating positive emotions helps to build resources that boost well‐being. The current research aimed to examine the longitudinal associations between responses to positive affect (emotion‐focused positive rumination, self‐focused positive rumination, and dampening) and psychological adjustment (self‐esteem and life satisfaction) during middle adolescence. A longitudinal study with two waves separated by one year was conducted, assessing 977 adolescents (M = 13.81, SD = 0.79; 51.5% boys) with self‐report measures. A cross‐lagged panel analysis was performed by including within the same model the relationships between all of the variables in the two assessment points. The results indicated cross‐lagged positive relationships of self‐focused positive rumination with both self‐esteem and life satisfaction, while dampening showed a negative cross‐lagged relationship with self‐esteem. Moreover, higher self‐esteem predicted more emotion‐focused positive rumination, and more dampening predicted lower life satisfaction. Thus, the use of adaptive responses to positive affect and a better psychological adjustment were found to be prospectively interrelated at the one‐year follow‐up during middle adolescence. The discussion argues for the need to implement programmes to promote more adaptive responses to positive affect to enhance psychological adjustment in the adolescent transition to adulthood. [ABSTRACT FROM AUTHOR]

This study aimed to analyze the prospective associations during adolescence between depressive symptoms and response styles to positive affect and to examine gender differences. A longitudinal study was conducted with three waves separated by 1 year each to assess a non-clinical sample of 622 Spanish adolescents who were 13 and 14 years old (50.2% boys, 49.8% girls). The participants completed self-report measures of depressive symptoms and responses to positive affect (emotion-focused positive rumination, self-focused positive rumination and dampening of positive emotion). The results showed that the increase in depressive symptoms was associated with an increase in dampening and decreases in emotion-focused and self-focused positive rumination. Furthermore, girls presented more depressive symptoms, as well as higher dampening and lower self-focused positive rumination, than boys. The conclusions highlight the need to consider responses to positive affect in explaining gender differences in depressive symptoms during mid-adolescence, as well as in designing prevention programs. [ABSTRACT FROM AUTHOR]

Consistent with Response Styles Theory, this study aimed to examine the prospective associations between changes in response styles and depressive symptoms during mid-adolescence, with a focus on gender differences. A 2-year longitudinal study was conducted consisting of three waves, each separated by 1 year. The participants were 663 Spanish adolescents ( M = 13.50, SD = .75) who individually completed the Children's Depression Inventory-Short and a short version of the Children's Response Styles Scale. Girls showed higher rumination and lower distraction than boys and more depressive symptoms. A multivariate latent growth curve model indicated that the increase in depressive symptoms during mid-adolescence in girls was associated with an increase in rumination and a decrease in distraction. After a 2-year follow-up, changes in response styles to negative affect (in rumination and distraction independently and in the ratio score) were interrelated with the changes in depressive symptoms in adolescent girls. [ABSTRACT FROM AUTHOR]

Current research has supported the role of perceived emotional intelligence as an important aspect of well-being and coping throughout the life span. This study aimed to analyse the association between changes in perceived emotional intelligence and changes in depressive symptoms during mid-adolescence, with a focus on gender differences. A two-year longitudinal study comprising three assessments separated by one year each was conducted. Self-report measures of perceived emotional intelligence and depressive symptoms were administered to 525 adolescents from 12 to 15 years of age who were enrolled in 18 secondary schools in Andalusia (Spain). The results showed a lower emotional intelligence and more depressive symptoms in girls and an increase in depressive symptoms and a decrease in perceived emotional intelligence, especially in girls. A latent growth curve model indicated that gender differences in emotional repair partially explained the gender differences in depressive symptoms at each study assessment, and gender differences in the rate of change in emotional clarity were related to gender differences in the rate of change in depressive symptoms. Thus, gender-focused interventions to improve self-perceptions of emotional skills could be needed to prevent depressive symptoms in adolescent girls. [ABSTRACT FROM AUTHOR]

Lower self-esteem in adolescent girls than boys confers greater vulnerability to numerous risks in their development towards social adulthood. This research aimed to study the role of perceived emotional intelligence in self-esteem's gender differences. An anonymous questionnaire was applied to 1791 Spanish adolescents aged between 12 and 17 years old, composed of the Rosenberg self-esteem scale and a reduced version of the Trait Meta-Mood Scale. The results showed that girls presented lower overall self-esteem than boys, as well as lower perceived emotional intelligence. On the one hand, it was found that high perceived emotional attention was related to lower self-esteem in girls; on the other hand, results detected that high perceived emotional attention was linked to higher perceived emotional clarity and repair in boys, which were associated with higher self-esteem. These results suggest the need to design programmes to improve self-esteem in adolescent girls by reducing perceived emotional attention. [ABSTRACT FROM AUTHOR]

Feline leukemia virus (FeLV) is still a major cause of morbidity and mortality in domestic cats and some wild cats despite the availability of relatively effective vaccines against the virus. FeLV subgroup A (FeLV-A) is transmitted in natural infections, and FeLV subgroups B, C, and T can evolve directly from FeLV-A by mutation and/or recombination with endogenous retroviruses in domestic cats, resulting in a variety of pathogenic outcomes. The cell surface entry receptor for FeLV-A is a putative thiamine transporter (THTR1). Here, we have addressed whether FeLV-A infection might disrupt thiamine uptake into cells and, because thiamine is an essential nutrient, whether this disruption might have pathological consequences. First, we cloned the cat ortholog of the other of the two known thiamine transporters in mammals, THTR2, and we show that feline THTR1 (feTHTR1) and feTHTR2 both mediate thiamine uptake, but feTHTR2 does not function as a receptor for FeLV-A. We found that feTHTR1 is widely expressed in cat tissues and in cell lines, while expression of feTHTR2 is restricted. Thiamine uptake mediated by feTHTR1 was indeed blocked by FeLV-A infection, and in feline fibroblasts that naturally express feTHTR1 and not feTHTR2, this blockade resulted in a growth arrest at physiological concentrations of extracellular thiamine. The growth arrest was reversed at high extracellular concentrations of thiamine. Our results show that FeLV-A infection can indeed disrupt thiamine uptake with pathological consequences. A prediction of these experiments is that raising the plasma levels of thiamine in FeLV-infected cats may ameliorate the pathogenic effects of infection. [ABSTRACT FROM AUTHOR]

Background: XMRV (xenotropic murine leukemia virus-related virus) was initially discovered in association with prostate cancer and later with chronic fatigue syndrome (CFS). Its association with CFS is now largely discredited, and current results support a laboratory origin for XMRV with no reproducible evidence for infection of humans. However, some results indicating the presence of XMRV in prostate cancer are difficult to attribute to sample contamination. Here we have sought biological evidence that might confirm the presence of XMRV in prostate cancer samples previously having tested positive. Methods and Results: We have tested for infectious XMRV and neutralizing antibodies against XMRV in blood plasma from 29 subjects with prostate cancer, and for infectious XMRV in prostate secretions from another five prostate cancer subjects. Nine of these subjects had previously tested positive for XMRV by PCR or by virus assay. We did not detect XMRV or related retroviruses in any sample, and the neutralizing activities of the plasma samples were all very low, a result inconsistent with XMRV infection of the plasma donors. Conclusions: We find no evidence for XMRV infection of any human subject tested, either by assay for infectious virus or for neutralizing antibodies. Our results are consistent with the majority of published studies on XMRV, which find that XMRV is not present in humans. The observed low to undetectable XMRV neutralization by human plasma indicates a lack of innate restriction of XMRV replication by soluble factors in human blood. [ABSTRACT FROM AUTHOR]

Addresses the statistical mechanics of fluctuating metrics in two, simple, one-dimensional manifolds, the unit interval and the unit circle. Geometry of space-time; Quantization of gravity; Exact computation of the partition function.

There is ample evidence of the teratogenic effects of prenatal alcohol exposure, with long-term consequences throughout the entire life cycle. Nevertheless, research on risk perception of alcohol consumption among pregnant women is scarce. In order to analyze risk perception of alcohol consumption during pregnancy, a cross-sectional study was conducted with a random sample of 426 pregnant women (in their 20th week of gestation) receiving care at the outpatient clinics of a public university hospital in the southern European city of Seville (Spain). Data were collected through structured face-to-face interviews conducted by trained health professionals using a customized questionnaire. Data analysis included structural equation modeling. Only 48.1% of the sample indicated that the sequelae from alcohol consumption during pregnancy were life-long. The structural equation model showed that a lower risk perception about beer and wine consumption, and a lower educational level, were related to more frequent alcohol consumption. Younger participants showed lower risk perception concerning beer consumption. Higher levels of education were related to a greater risk perception of beer. Healthcare institutions should articulate programs that facilitate health advice regarding alcohol consumption during pregnancy, particularly when providing care for women with low educational levels. [ABSTRACT FROM AUTHOR]

An abstract of the article "Xpr1 Is an Atypical G-Protein-Coupled Receptor That Mediates Xenotropic and Polytropic Murine Retrovirus Neurotoxicity," by Andrew E. Vaughan and colleagues is presented.

Feline leukemia virus (FeLV) is a horizontally transmitted virus that causes a variety of proliferative and immunosuppressive diseases in cats. There are four subgroups of FeLV, A, B, C, and T, each of which has a distinct receptor requirement. The receptors for all but the FeLV-A subgroup have been defined previously. Here, we report the identification of the cellular receptor for FeLV-A, which is the most transmissible form of FeLV. The receptor cDNA was isolated using a gene transfer approach, which involved introducing sequences from a feline cell line permissive to FeLV-A into a murine cell line that was not permissive. The feline cDNA identified by this method was approximately 3.5 kb, and included an open reading frame predicted to encode a protein of 490 amino acids. This feline cDNA conferred susceptibility to FeLV-A when reintroduced into nonpermissive cells, but it did not render these cells permissive to any other FeLV subgroup. Moreover, these cells specifically bound FeLV-A-pseudotyped virus particles, indicating that the cDNA encodes a binding receptor for FeLV-A. The feline cDNA shares∼93% amino acid sequence identity with the human thiamine transport protein 1 (THTR1). The human THTR1 receptor was also functional as a receptor for FeLV-A, albeit with reduced efficiency compared to the feline orthologue. On the basis of these data, which strongly suggest the feline protein is the orthologue of human THTR1, we have named the feline receptor feTHTR1. Identification of this receptor will allow more detailed studies of the early events in FeLV transmission and may provide insights into FeLV pathogenesis. [ABSTRACT FROM AUTHOR]

Declining oxygen is one of the most drastic changes in the ocean, and this trend is expected to worsen under future climate change scenarios. Spatial variability in dissolved oxygen dynamics and hypoxia exposures can drive differences in vulnerabilities of coastal ecosystems and resources, but documentation of variability at regional scales is rare in open-coast systems. Using a regional collaborative network of dissolved oxygen and temperature sensors maintained by scientists and fishing cooperatives from California, USA, and Baja California, Mexico, we characterize spatial and temporal variability in dissolved oxygen and seawater temperature dynamics in kelp forest ecosystems across 13° of latitude in the productive California Current upwelling system. We find distinct latitudinal patterns of hypoxia exposure and evidence for upwelling and respiration as regional drivers of oxygen dynamics, as well as more localized effects. This regional and small-scale spatial variability in dissolved oxygen dynamics supports the use of adaptive management at local scales, and highlights the value of collaborative, large-scale coastal monitoring networks for informing effective adaptation strategies for coastal communities and fisheries in a changing climate. [ABSTRACT FROM AUTHOR]

The human retrovirus XMRV (xenotropic murine leukemia virus-related virus) is associated with prostate cancer, but a causal relationship has not been established. Here, we have used cultured fibroblast and epithelial cell lines to test the hypothesis that XMRV might have direct transforming activity but found only rare transformation events, suggestive of indirect transformation, even when the target cells expressed the human Xpr1 cell entry receptor for XMRV. Characterization of cells from three transformed foci showed that all were infected with and produced XMRV, and one produced a highly active transforming virus, presumably generated by recombination between XMRV and host cell nucleic acids. Given the sequence similarity of XMRV to mink cell focus-forming (MCF) viruses and the enhanced leukemogenic activity of the latter, we tested XMRV for related MCF-like cytopathic activities in cultured mink cells but found none. These results indicate that XMRV has no direct transforming activity but can activate endogenous oncogenes, resulting in cell transformation. As part of these experiments, we show that XMRV can infect and be produced at a high titer from human HT-1080 fibrosarcoma cells that express TRIM5α (Ref1), showing that XMRV is resistant to TRIM5α restriction. In addition, XMRV poorly infects NIH 3T3 cells expressing human Xpr1 but relatively efficiently infects BALB 3T3 cells expressing human Xpr1, showing that XMRV is a B-tropic virus and that its infectivity is regulated by the Fv1 mouse locus. [ABSTRACT FROM AUTHOR]

The predictive capabilities of computational materials science today derive from overlapping advances in simulation tools, modeling techniques, and best practices. We outline this ecosystem of molecular simulations by explaining how important contributions in each of these areas have fed into each other. The combined output of these tools, techniques, and practices is the ability for researchers to advance understanding by efficiently combining simple models with powerful software. As specific examples, we show how the prediction of organic photovoltaic morphologies have improved by orders of magnitude over the last decade, and how the processing of reacting epoxy thermosets can now be investigated with million-particle models. We discuss these two materials systems and the training of materials simulators through the lens of cognitive load theory. For students, the broad view of ecosystem components should facilitate understanding how the key parts relate to each other first, followed by targeted exploration. In this way, the paper is organized in loose analogy to a coarse-grained model: The main components provide basic framing and accelerated sampling from which deeper research is better contextualized. For mentors, this paper is organized to provide a snapshot in time of the current simulation ecosystem and an on-ramp for simulation experts into the literature on pedagogical practice. [ABSTRACT FROM AUTHOR]