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The success of recent Spanish horror cinema must be understood in the context of a genre with a long tradition and popular acceptance. The films studied in this article, La abuela (Paco Plaza, 2021) and Malasaña 32 (Albert Pintó, 2020), are among the most remarkable of this new wave, and include recognizable features for horror film scholars. Specifically, both present queer characters and, through a terrifying representation of otherness, exploit the mechanisms of homophobia. This article places these films in the tradition of Spanish queer horror cinema and analyses the particularities of these new contributions. It focuses on how the representation of the queer, non-reproductive and non-normative body serves as the basis for the creation of a new horror. At the same time, it analyses how these films incorporate other contemporary anxieties, especially those caused by gentrification in large cities. [ABSTRACT FROM AUTHOR]

There is substantial evidence supporting the neuroprotective effects of the MIND diet in neurodegenerative diseases like Parkinson's and Alzheimer's. Our aim was to evaluate the impact of a nutritional intervention (NI) with this diet on multiple sclerosis (MS) patients. The study was conducted in two stages. In the first stage, two groups were included: MS patients before the NI (group A) and healthy control subjects (group B). In this stage, groups (A) and (B) were compared (case–control study). In the second stage, group (A) was assessed after the NI, with comparisons made between baseline and final measurements (before-and-after study). In the case–control stage (baseline evaluation), we found significant differences in fatigue scores (p < 0.001), adherence to the MIND diet (p < 0.001), the serum levels of brain-derived neurotrophic factor (BDNF) (p < 0.001), and higher oxidative status in the MS group, with lower levels of reduced glutathione (p < 0.001), reduced/oxidised glutathione ratio (p < 0.001), and elevated levels of lipoperoxidation (p < 0.002) and 8-hydroxy-2′-deoxyguanosine (p < 0.025). The before-and-after intervention stage showed improvements in fatigue scores (p < 0.001) and physical quality-of-life scores (MSQOL-54) (p < 0.022), along with decreases in the serum levels of glial-derived neurotrophic factor (GDNF) (p < 0.041), lipoperoxidation (p < 0.046), and 8-hydroxy-2′-deoxyguanosine (p < 0.05). Consumption of the MIND diet is linked to clinical and biochemical improvement in MS patients. [ABSTRACT FROM AUTHOR]

Around 50 years ago, molecular biology opened the path to understand changes in forms, adaptations, complexity, or the basis of human diseases through myriads of reports on gene birth, gene duplication, gene expression regulation, and splicing regulation, among other relevant mechanisms behind gene function. Here, with the advent of big data and artificial intelligence (AI), we focus on an elusive and intriguing mechanism of gene function regulation, RNA editing, in which a single nucleotide from an RNA molecule is changed, with a remarkable impact in the increase of the complexity of the transcriptome and proteome. We present a new generation approach to assess the functional conservation of the RNA-editing targeting mechanism using two AI learning algorithms, random forest (RF) and bidirectional long short-term memory (biLSTM) neural networks with an attention layer. These algorithms, combined with RNA-editing data coming from databases and variant calling from same-individual RNA and DNA-seq experiments from different species, allowed us to predict RNA-editing events using both primary sequence and secondary structure. Then, we devised a method for assessing conservation or divergence in the molecular mechanisms of editing completely in silico : the cross-testing analysis. This novel method not only helps to understand the conservation of the editing mechanism through evolution but could set the basis for achieving a better understanding of the adenosine-targeting mechanism in other fields. [ABSTRACT FROM AUTHOR]

Adeno-associated virus (AAV) gene therapy is making rapid strides owing to its wide range of therapeutic applications. However, development of serious immune responses to the capsid antigen or the therapeutic transgene product hinders its full clinical impact. Immune suppressive (IS) drug treatments have been used in various clinical trials to prevent the deleterious effects of cytotoxic T cells to the viral vector or transgene, although there is no consensus on the best treatment regimen, dosage, or schedule. Regulatory T cells (Tregs) are crucial for maintaining tolerance against self or nonself antigens. Of importance, Tregs also play an important role in dampening immune responses to AAV gene therapy, including tolerance induction to the transgene product. Approaches to harness the tolerogenic effect of Tregs include the use of selective IS drugs that expand existing Tregs, and skew activated conventional T cells into antigen-specific peripherally induced Tregs. In addition, Tregs can be expanded ex vivo and delivered as cellular therapy. Furthermore, receptor engineering can be used to increase the potency and specificity of Tregs allowing for suppression at lower doses and reducing the risk of disrupting protective immunity. Because immune-mediated toxicities to AAV vectors are a concern in the clinic, strategies that can enhance or preserve Treg function should be considered to improve both the safety and efficacy of AAV gene therapy. [ABSTRACT FROM AUTHOR]

Multiple sclerosis (MS) is characterized by a variety of symptoms that have a major impact on quality of life (QoL) even in early stages. In addition to individual motor, sensory, visual disturbances, and brainstem and sphincter disorders, which are expressed through the widely used Expanded Disability Status Scale (EDSS), other manifestations of MS have a detrimental effect on overall functioning and quality of life, such as cognitive impairment, depression, anxiety, fatigue, and pain. However, when talking about QoL, categorical definitions cannot be used because although the concept is generally understood, it is highly nuanced. Suffering from MS can significantly reduce QoL. Numerous research studies have focused on trying to identify and assess which are the elements that most affect the loss of QoL in MS people. However, in addition to the fact that the measurement of QoL can be subjective, it is very difficult to consider these elements in isolation, as they are interrelated. One such limiting factor of QoL that has been investigated is cognitive impairment (CI). This has been shown to have an impact on the lives of MS people, although the different approaches that have been taken to assess CI have evident limitations. [ABSTRACT FROM AUTHOR]

Flipped learning (FL) has positive effects on the teaching–learning process. Nevertheless, and given that it is a relatively new methodology, it still raises some misgivings. This work aims to highlight the potential of FL by the analysis of academic results in a subject in higher engineering education and, thus, to contribute to overcome possible misgivings. Methods were based on statistical analysis, using Pearson's correlation coefficient (PCC), and comparative analysis using graphs. Data from eight academic years were analysed, three with traditional methodology and five with FL. Influence of specific factors, such as participation in FL activities, on students' performance over time has been identified. FL has a very positive impact on students' academic performance and the active participation of students' results in a significant increase in the pass rate as well as in the quality of learning. These improvements have increased over time despite challenges such as the COVID‐19 pandemic. [ABSTRACT FROM AUTHOR]

Nivolumab plus ipilimumab demonstrated promising clinical activity and durable responses in sorafenib-treated patients with advanced hepatocellular carcinoma (HCC) in the CheckMate 040 study at 30.7-month median follow-up. Here, we present 5-year results from this cohort. Patients were randomized 1 : 1 : 1 to arm A [nivolumab 1 mg/kg plus ipilimumab 3 mg/kg Q3W (four doses)] or arm B [nivolumab 3 mg/kg plus ipilimumab 1 mg/kg Q3W (four doses)], each followed by nivolumab 240 mg Q2W, or arm C (nivolumab 3 mg/kg Q2W plus ipilimumab 1 mg/kg Q6W). The primary objectives were safety, tolerability, investigator-assessed objective response rate (ORR), and duration of response (DOR) per RECIST version 1.1. A total of 148 patients were randomized across treatment arms. At 60-month minimum follow-up (62.6-month median follow-up), the ORR was 34% (n = 17), 27% (n = 13), and 29% (n = 14) in arms A, B, and C, respectively. The median DOR was 51.2 months [95% confidence interval (CI) 12.6 months-not estimable (NE)], 15.2 months (95% CI 7.1 months-NE), and 21.7 months (95% CI 4.2 months-NE), respectively. The median overall survival (OS) was 22.2 months (34/50; 95% CI 9.4-54.8 months) in arm A, 12.5 months (38/49; 95% CI 7.6-16.4 months) in arm B, and 12.7 months (40/49; 95% CI 7.4-30.5 months) in arm C; 60-month OS rates were 29%, 19%, and 21%, respectively. In an exploratory analysis of OS by response (6-month landmark), the median OS was meaningfully longer for responders versus nonresponders for all arms. No new safety signals were identified with longer follow-up. There were no new discontinuations due to immune-mediated adverse events since the primary analysis. Consistent with the primary analysis, the arm A regimen of nivolumab plus ipilimumab continued to demonstrate clinically meaningful responses and long-term survival benefit, with no new safety signals in patients with advanced HCC following sorafenib treatment, further supporting its use as a second-line treatment in these patients. • After 5 years, nivolumab plus ipilimumab continued to show clinically meaningful benefit in sorafenib-treated advanced HCC. • The ORR in arm A [nivolumab 1 mg/kg + ipilimumab 3 mg/kg Q3W (four doses), then nivolumab 240 mg Q2W] was 34%. • Responses were durable (median DOR 51.2 months) and long-term survival benefit was achieved (5-year OS rate 29%) in arm A. • No new safety signals were identified, and there were no additional discontinuations due to immune-mediated adverse events since primary analysis. • These results further support the use of the arm A regimen of nivolumab plus ipilimumab for sorafenib-treated advanced HCC. [ABSTRACT FROM AUTHOR]

Nestlings normally exhibit a mix of traits that attract parental care, such as postural and vocal begging and carotenoid‐based mouth colouration. These signals are hypothesised to be signs of nestling needs (vocal begging) and quality (mouth colouration). Therefore, we hypothesised that broods, where nestlings beg for less time and display more saturated carotenoid‐based mouth colouration, would have lower nestling mortality. We tested these predictions in two wild blue tit (Cyanistes caeruleus) populations. The breeding success (here defined as the proportion of eggs that produced fledglings) was related to nestling mouth flanges' carotenoid‐based colour saturation. This means that blue tits that raised nestlings with more coloured flanges had a higher within‐population breeding success. Time spent in vocal begging, by contrast, was not associated with breeding success. Hence, our findings reveal that some communication signals displayed by nestlings (carotenoid‐based colouration) predict breeding success, in our study mostly reflecting the proportion of eggs that hatched, while begging intensity does not, probably because the former reflects a better maternal pre‐laying condition and nestling physiological status in the mid‐term. [ABSTRACT FROM AUTHOR]

This study reports on a metal-free Covalent Triazine Framework (CTF) incorporating bithiophene structural units (TP-CTF) with a semicrystalline structure as an efficient heterogeneous photocatalyst under visible light irradiation. The physico-chemical properties and composition of this material was confirmed via different characterization solid-state techniques, such as XRD, TGA, CO2 adsorption and FT-IR, NMR and UV-Vis spectroscopies. The compound was synthesized through a solvothermal process and was explored as a heterogeneous photocatalyst for the oxidative coupling of amines to imines under visible light irradiation. TP-CTF demonstrated outstanding photocatalytic activity, with high conversion rates and selectivity. Importantly, the material exhibited exceptional stability and recyclability, making it a strong candidate for sustainable and efficient imine synthesis. The low bandgap of TP-CTF enabled the efficient absorption of visible light, which is a notable advantage for visible-light-driven photocatalysis. [ABSTRACT FROM AUTHOR]

Cardiorenal syndrome (CRS) involves joint dysfunction of the heart and kidney. Acute forms share biochemical alterations like hyperuricaemia (HU) with tumour lysis syndrome (TLS). The mainstay treatment of acute CRS with systemic overload is diuretics, but rasburicase is used in TLS to prevent and treat hyperuricaemia. An observational, retrospective study was performed to assess the effectiveness and safety of a single dose of rasburicase in hospitalized patients with cardiorenal syndrome, worsening renal function and uric acid levels above 9 mg/dL. Rasburicase improved diuresis and systemic congestion in the 35 patients included. A total of 86% of patients did not need to undergo RRT, and early withdrawal was possible in the remaining five. Creatinine (Cr) decreased after treatment with rasburicase from a peak of 3.6 ± 1.27 to 1.79 ± 0.83 mg/dL, and the estimated glomerular filtration rate (eGFR) improved from 17 ± 8 to 41 ± 20 mL/min/1.73 m2 (p = 0.0001). The levels of N-terminal type B Brain Natriuretic Peptide (Nt-ProBNP) and C-reactive protein (CRP) were also significantly reduced. No relevant adverse events were detected. Our results show that early treatment with a dose of rasburicase in patients with CRS and severe HU is effective to improve renal function and systemic congestion, avoiding the need for sustained extrarenal clearance, regardless of comorbidities and ventricular function. [ABSTRACT FROM AUTHOR]

Key message: A new OrAnom1 gene introgressed in cultivated sunflower from wild Helianthus anomalusconfers late post-attachment resistance toOrobanche cumana race G and maps to a target interval in Chromosome 4 where two receptor-like kinases (RLKs) have been identified in theH. anomalusgenome as putative candidates. Sunflower broomrape is a parasitic weed that infects sunflower (Helianthus annuus L.) roots causing severe yield losses. Breeding for resistance is the most effective and sustainable control method. In this study, we report the identification, introgression, and genetic and physiological characterization of a new sunflower source of resistance to race G of broomrape developed from the wild annual sunflower H. anomalus (accession PI 468642). Crosses between PI 468642 and the susceptible line P21 were carried out, and the genetic study was conducted in BC1F1, BC1F2, and its derived BC1F3 populations. A BC1F5 germplasm named ANOM1 was developed through selection for race G resistance and resemblance to cultivated sunflower. The resistant trait showed monogenic and dominant inheritance. The gene, named OrAnom1, was mapped to Chromosome 4 within a 1.2 cM interval and co-segregated with 7 SNP markers. This interval corresponds to a 1.32 Mb region in the sunflower reference genome, housing a cluster of receptor-like kinase and receptor-like protein (RLK-RLP) genes. Notably, the analysis of the H. anomalus genome revealed the absence of RLPs in the OrAnom1 target region but featured two RLKs as possible OrAnom1 candidates. Rhizotron and histological studies showed that OrAnom1 determines a late post-attachment resistance mechanism. Broomrape can establish a vascular connection with the host, but parasite growth is stopped before tubercle development, showing phenolic compounds accumulation and tubercle necrosis. ANOM1 will contribute to broadening the genetic basis of broomrape resistance in the cultivated sunflower pool and to a better understanding of the molecular basis of the sunflower-broomrape interaction. [ABSTRACT FROM AUTHOR]

Climbing plants, such as common beans (Phaseolus vulgaris L.), exhibit complex motion patterns that have long captivated researchers. In this study, we introduce a stereo vision machine system for the in-depth analysis of the movement of climbing plants, using image processing and computer vision. Our approach involves two synchronized cameras, one lateral to the plant and the other overhead, enabling the simultaneous 2D position tracking of the plant tip. These data are then leveraged to reconstruct the 3D position of the tip. Furthermore, we investigate the impact of external factors, particularly the presence of support structures, on plant movement dynamics. The proposed method is able to extract the position of the tip in 86–98% of cases, achieving an average reprojection error below 4 px, which means an approximate error in the 3D localization of about 0.5 cm. Our method makes it possible to analyze how the plant nutation responds to its environment, offering insights into the interplay between climbing plants and their surroundings. [ABSTRACT FROM AUTHOR]

Mental health disorders are one of the most common causes that limit the ability of mothers to care for themselves and for their children. Recent data suggest high rates of distress among women in charge of young children in Zambia. Nevertheless, Zambia's public healthcare offers very limited treatment for common mental health distress. To address this treatment gap, this study aims to test the feasibility, acceptability, and potential efficacy of a context-adapted psychosocial intervention. A total of 265 mothers with mental health needs (defined as SRQ-20 scores above 7) were randomly assigned with equal probability to the intervention or control group. The intervention group will receive a locally adapted version of the Problem-Management Plus and "Thinking Healthy" interventions developed by the World Health Organization (WHO), combined with specific parts of the Strong Minds-Strong Communities intervention. Trained and closely supervised wellbeing-community health workers will provide the psychosocial intervention. Mental health distress and attendance to the intervention will be assessed at enrollment and 6 months after the intervention. We will estimate the impact of the intervention on mental health distress using an intention-to-treat approach. We previously found that there is a large necessity for interventions that aim to address mother anxiety/depression problems. In this study, we tested the feasibility and efficacy of an innovative intervention, demonstrating that implementing these mental health treatments in low-income settings, such as Zambia, is viable with an adequate support system. If successful, larger studies will be needed to test the effectiveness of the intervention with increased precision. Trial registration: This study is registered at clinicaltrials.gov as NCT05627206. [ABSTRACT FROM AUTHOR]

This article aims to reflect on how the current changes in the context of domesticity are the result of multiple contributions from women working in different fields. It is a collective effort that began to bear fruit in the second half of the 20th century, when an open war against former traditional standards already existed. In that respect, there is a reference to female artists, writers and architects from the last two centuries which calls that notion into question: from artists present at the Women House exhibition celebrated in 2018 at the National Museum of Women in the Arts (Washington D.C., USA), where many described the domestic realm as a trap to female writers and architects who equally defy and revise previous conceptions of domesticity. All in all, it seems clear that the theoretical approach that supports the need to reshape old domesticity standards works in conjunction with many hands-on efforts, some of which will be shown below. [ABSTRACT FROM AUTHOR]

Background: Veiled chameleon (Chamaeleo calyptratus) and panther chameleon (Furcifer pardalis) are two of the most popular pet chameleons, and consequently, these species are frequently evaluated in veterinary practices. According to our review of the literature, normal computed tomography (CT) anatomy of these lizards has not been previously described. Aim: The purposes of this prospective study were to describe the normal CT anatomy of the coelomic organs in healthy patients and to provide normal reference values in these species. Methods: Seventeen clinically healthy veiled chameleons and 15 clinically healthy panther chameleons were included. All CT studies were performed with the chameleons under light anesthesia and positioned in sternal recumbency. Studies were performed with a 16-slice helical CT scanner with a slice thickness of 0.625 mm. The authors recorded qualitative and quantitative CT characteristics of the coelomic structures. Macroscopic cross-sectional anatomy was performed for comparison of the CT findings. Results: Heart, lungs, liver, including caudal vena cava, hepatic vessels, gallbladder, esophagus, stomach, intestines, gonads, fat bodies, kidneys, and urinary bladder could be visualized with CT. The spleen, pancreas, and adrenal glands could not be identified. Conclusion: This study provides a guide to the normal cross-sectional and computed tomographic anatomy of the coelomic cavity in veiled and panther chameleons. Our results could be used as a reference for future research studies or comparison of clinically ill patients. [ABSTRACT FROM AUTHOR]

Open review is one of the components of open science that scientific journals are incorporating in their editorial processes. In contrast to open access to literature and research data, open review still raises many doubts and concerns among the involved parties (editors, reviewers and authors). This article aims to analyze the perception of editors of Brazilian academic journals on open peer review. To achieve this, a questionnaire was sent to 3,208 editors, out of which 351 responded to the full set of 42 questions. The editors expressed satisfaction with the current model of scientific communication, the double-blind model, and disagreed with any type of identification of reviewers. However, they perceived an advantage in open review, as it allows for mutual interaction between authors and reviewers with the goal of improving the quality of content. As barriers, they pointed out conflicts of interest and rivalries that open review might generate and the difficulty in finding reviewers willing to accept this review model. The overall conclusion points to a conservative profile among editors regarding the introduction of open peer review practices. [ABSTRACT FROM AUTHOR]

The paper presents a novel solution to the issue of incomplete regions in 3D meshes obtained through digitization. Traditional methods for estimating the surface of missing geometry and topology often yield unrealistic outcomes for intricate surfaces. To overcome this limitation, the paper proposes a neural network-based approach that generates points in areas where geometric information is lacking. The method employs 2D inpainting techniques on color images obtained from the original mesh parameterization and curvature values. The network used in this approach can reconstruct the curvature image, which then serves as a reference for generating a polygonal surface that closely resembles the predicted one. The paper's experiments show that the proposed method effectively fills complex holes in 3D surfaces with a high degree of naturalness and detail. This paper improves the previous work in terms of a more in-depth explanation of the different stages of the approach as well as an extended results section with exhaustive experiments. [Display omitted] • We perform 3D surface reconstructions using generative inpainting techniques. • 2D representation of a 3D surface geometry based on its curvature. • Application of a general purpose neural network for inpainting. • Our approach does not require dataset nor training time. • Results outperform state-of-the-art quality and naturalness of the reconstructions. [ABSTRACT FROM AUTHOR]

This article presents research designed to support teachers in the promotion of learning practical citizenship through the provision of appropriate guidelines and strategies. Practical citizenship refers to critical participation in democratic processes for social transformation. The authors recognise schools' transformative capacity, despite their hierarchical structure and the prevalence of individuality. They contend that the analysis of how people learn and exercise practical citizenship in diverse contexts generates useful knowledge to be applied in schools.They have analysed the experiences and discourses of the stakeholders involved in participatory movements and practices: those generally located in informal and open contexts. Their interpretation of the results has drawn practical guidelines for helping teachers to make school the most democratic environment possible. [ABSTRACT FROM AUTHOR]

This study explores workplace gender bias in images generated by DALL-E 2, an application for synthesising images based on artificial intelligence (AI). To do this, we used a stratified probability sampling method, dividing the sample into segments on the basis of 37 different professions or prompts, replicating the study by Farago, Eggum-Wilkens and Zhang (2020) on gender stereotypes in the workplace. The study involves two coders who manually input different professions into the image generator. DALL-E 2 generated 9 images for each query, and a sample of 666 images was collected, with a confidence level of 99% and a margin of error of 5%. Each image was subsequently evaluated using a 3-point Likert scale: 1, not stereotypical; 2, moderately stereotypical; and 3, strongly stereotypical. Our study found that the images generated replicate gender stereotypes in the workplace. The findings presented indicate that 21.6% of AI-generated images depicting professionals exhibit full stereotypes of women, while 37.8% depict full stereotypes of men. While previous studies conducted with humans found that gender stereotypes in the workplace exist, our research shows that AI not only replicates this stereotyping, but reinforces and increases it. Consequently, while human research on gender bias indicates strong stereotyping in 35% of instances, AI exhibits strong stereotyping in 59.4% of cases. The results of this study emphasise the need for a diverse and inclusive AI development community to serve as the basis for a fairer and less biased AI. [ABSTRACT FROM AUTHOR]

Oxidative stress (OS) is a relevant intermediate mechanism involved in Type 2 Diabetes Mellitus (T2D) development. To date, the interaction between OS parameters and variations in genes related to T2D has not been analyzed. To study the genetic interaction of genes potentially related to OS levels (redox homeostasis, renin-angiotensin-aldosterone system, endoplasmic stress response, dyslipidemia, obesity and metal transport) and OS and T2D risk in a general population from Spain (the Hortega Study) in relation to the risk of suffering from T2D. One thousand five hundred and two adults from the University Hospital Rio Hortega area were studied and 900 single nucleotide polymorphisms (SNPs) from 272 candidate genes were analyzed. There were no differences in OS levels between cases and controls. Some polymorphisms were associated with T2D and with OS levels. Significant interactions were observed between OS levels and two polymorphisms in relation to T2D presence: rs196904 (ERN1 gene) and rs2410718 (COX7C gene); and between OS levels and haplotypes of the genes: SP2 , HFF1A , ILI8R1 , EIF2AK2 , TXNRD2 , PPARA , NDUFS2 and ERN1. Our results indicate that genetic variations of the studied genes are associated with OS levels and that their interaction with OS parameters may contribute to the risk of developing T2D in the Spanish general population. These data support the importance of analyzing the influence of OS levels and their interaction with genetic variations in order to establish their real impact in T2D risk. Further studies are required to identify the real relevance of interactions between genetic variations and OS levels and the mechanisms involved in them. [Display omitted] • Oxidative stress (OS) is an intermediate mechanism involved in Type 2 Diabetes Mellitus (T2D) development. • Hyperglycemia contribute to increased reactive oxygen species (ROS) generation and ROS can lead to insulin resistance. • Many genetic systems have been related to OS and T2D development • Studied SNPs and haplotypes are associated with OS. Their interaction with OS contribute to T2D in spanish population. [ABSTRACT FROM AUTHOR]

Propolis is a natural bee-produced substance with antimicrobial, anti-inflammatory, and wound-healing properties, containing some components from the leaves, buds and resins of plants. It has been used for centuries for various health benefits. In this manuscript, our group reviewed the radioprotective effect of propolis using PubMed and Embase, and our review was conducted according to the PRISMA statement. Finally, 27 articles were included in this review, which includes the radioprotective effect of propolis from cell-based studies (n = 8), animal models (n = 14), and human trials (n = 5). Results reflected that the dosage forms of propolis extracted in the scientific literature were ethanolic extracts of propolis, a water-soluble derivate of propolis, or capsules. The efficacy of the radioprotective properties from propolis is extracted from the bibliography, as several compounds of this resinous mixture individually or synergistically are possible candidates that have the radioprotective effect. In fact, studies prior to 2011 lacked a comprehensive characterization of propolis due to the variability in active compounds among different batches of propolis and were limited to analytical techniques. Furthermore, in this manuscript, we have selected studies to include primarily propolis types from Brazil, Croatia, Egypt, European countries, and those commercialized in Spain. They all contained ethanolic extract of propolis (EEP) and were influenced by different dosage forms. EEP showed a significant presence of lipophilic bioactive compounds like flavones, flavonols, and flavanones. [ABSTRACT FROM AUTHOR]

Mediterranean endorheic wetlands are strongly affected by local meteorological events, so they undergo frequent unpredictable disturbances, such as episodes of high salinity or desiccation. In this context, salinity and temperature may be crucial for determining the structure of zooplankton communities and regional biodiversity, since they may trigger the hatching of egg bank in different ways. The goal of this study is to assess the combined role of these two variables on the zooplankton assemblage emerging from the egg bank. We hypothesize that temperature and salinity affect the community structure in a non-linear way, that is, both factors interact and modify the magnitude of their effects. We performed a laboratory factorial design where the same sediment was incubated under different thermal and salinity conditions, reducing the potential effects of other possible confusion factors. Community structure was described by measuring cumulative abundances, species composition, richness, and diversity. Our results showed that the community structure was strongly determined by salinity at all experimental temperatures. In contrast, the magnitude of the temperature effect depended on salinity. The high variability among replicates when salinity and temperature increased suggests that climate change might lead to unpredictable patterns of the community emerging from the egg bank. [ABSTRACT FROM AUTHOR]

Mediterranean temporary ponds are a priority habitat according to the Natura 2000 network of the European Union, and complete inventories of these ecosystems are therefore needed. Their small size, short hydroperiod, or severe disturbance make these ponds undetectable by most remote sensing systems. Here we show, for the first time, that the distributed hydrologic model IBER+ detects ephemeral and even extinct wetlands by fully exploiting the available digital elevation model and resolving many microtopographic features at drainage basin scales of about 1000 km2. This paper aims to implement a methodology for siting flood-prone areas that can potentially host a temporary wetland, validating the results with historical orthophotos and existing wetlands inventories. Our model succeeds in dryland endorheic catchments of the Upper Guadalquivir Basin: it has detected 89% of the previously catalogued wetlands and found four new unknown wetlands. In addition, we have found that 24% of the detected wetlands have disappeared because of global change. Subsequently, environmental managers could use the proposed methodology to locate wetlands quickly and cheaply. Finding wetlands would help monitor their conservation and restore them if needed. [ABSTRACT FROM AUTHOR]

At large scales, the mechanisms underpinning stability in natural communities may vary in importance due to changes in species composition, mean abundance, and species richness. Here we link species characteristics (niche positions) and community characteristics (richness and abundance) to evaluate the importance of stability mechanisms in 156 butterfly communities monitored across three European countries and spanning five bioclimatic regions. We construct niche‐based hierarchical structural Bayesian models to explain first differences in abundance, population stability, and species richness between the countries, and then explore how these factors impact community stability both directly and indirectly (via synchrony and population stability). Species richness was partially explained by the position of a site relative to the niches of the species pool, and species near the centre of their niche had higher average population stability. The differences in mean abundance, population stability, and species richness then influenced how much variation in community stability they explained across the countries. We found, using variance partitioning, that community stability in Finnish communities was most influenced by community abundance, whereas this aspect was unimportant in Spain with species synchrony explaining most variation; the UK was somewhat intermediate with both factors explaining variation. Across all countries, the diversity–stability relationship was indirect with species richness reducing synchrony which increased community stability, with no direct effects of species richness. Our results suggest that in natural communities, biogeographical variation observed in key drivers of stability, such as population abundance and species richness, leads to community stability being limited by different factors and that this can partially be explained due to the niche characteristics of the European butterfly assemblage. [ABSTRACT FROM AUTHOR]

The CC chemokine receptor 6 (CCR6) is a G protein-coupled receptor (GPCR) involved in a wide range of biological processes. When CCR6 binds to its sole ligand CCL20, a signaling network is produced. This pathway is implicated in mechanisms related to many diseases, such as cancer, psoriasis, multiple sclerosis, HIV infection or rheumatoid arthritis. The CCR6/CCL20 axis plays a fundamental role in immune homeostasis and activation. Th17 cells express the CCR6 receptor and inflammatory cytokines, including IL-17, IL-21 and IL-22, which are involved in the spread of inflammatory response. The CCL20/CCR6 mechanism plays a crucial role in the recruitment of these pro-inflammatory cells to local tissues. To date, there are no drugs against CCR6 approved, and the development of small molecules against CCR6 is complicated due to the difficulty in screenings. This review highlights the potential as a therapeutic target of the CCR6 receptor in numerous diseases and the importance of the development of antibodies against CCR6 that could be a promising alternative to small molecules in the treatment of CCR6/CCL20 axis-related pathologies. [ABSTRACT FROM AUTHOR]

SciELO promotes open access and cooperative publication of scholarly journals, based mainly in Latin America, the Caribbean, Spain and Portugal. SciELO was created to offer solutions to increase the visibility of participating journals and facilitate free access to their full texts. This work aims to analyse the open access editorial policies implemented by the health sciences journals of the SciELO network (411 journals at the time of this study) in terms of authors' rights, copyright issues, self-archiving policies and openness. From SciELO health sciences journals network, 92% of the 411 journals use a Creative Commons licence, 89% require transfer of author copyright and 14% apply author processing charges. According to the past SHERPA/RoMEO taxonomy of self-archiving policies, 8.5% of the journals were classified as white, 81.5% blue and 10% green. The openness of journals calculated through the Open Access Spectrum approach was higher than 60% in more than 80% of the total journals. Out of the 411 journals in SciELO portals, 380 have their own website. Discrepancies were found between licences stated in SciELO compared with the ones used in their websites, mainly due to the lack of declared licences in either of the two sources or because the licences did not match. The licences used on the websites and in SciELO were also compared with their corresponding records in the Directory of Open Access Journals and Crossref, and again the differences were narrowly related to the data supplier. [ABSTRACT FROM AUTHOR]

In the last few years, the importance of neoantigens in the development of personalized antitumor vaccines has increased remarkably. In order to study whether bioinformatic tools are effective in detecting neoantigens that generate an immune response, DNA samples from patients with cutaneous melanoma in different stages were obtained, resulting in a total of 6048 potential neoantigens gathered. Thereafter, the immunological responses generated by some of those neoantigens ex vivo were tested, using a vaccine designed by a new optimization approach and encapsulated in nanoparticles. Our bioinformatic analysis indicated that no differences were found between the number of neoantigens and that of non-mutated sequences detected as potential binders by IEDB tools. However, those tools were able to highlight neoantigens over non-mutated peptides in HLA-II recognition (p-value 0.03). However, neither HLA-I binding affinity (p-value 0.08) nor Class I immunogenicity values (p-value 0.96) indicated significant differences for the latter parameters. Subsequently, the new vaccine, using aggregative functions and combinatorial optimization, was designed. The six best neoantigens were selected and formulated into two nanoparticles, with which the immune response ex vivo was evaluated, demonstrating a specific activation of the immune response. This study reinforces the use of bioinformatic tools in vaccine development, as their usefulness is proven both in silico and ex vivo. [ABSTRACT FROM AUTHOR]

Pillars of open science are often included within the editorial policies of scholarly journals, including policies on open access publication, availability of underlying research data, preprints and open peer review. The aim of this paper is to examine and analyse perceptions and editorial practices related to open access, preprints, open research data and open peer review, from the perspective of editors of scientific journals published in Spain, to gain an insight into editorial policies related to open science. Results and data were obtained by a combined method of online interviews and an online questionnaire. The online survey was sent to editors from journals indexed in the Dulcinea directory, which at the time of the study included 1875 academic journals. A total of 420 responses (22.4%) were obtained. The results indicated that 92% of the journals were open access journals, 2% of the journals conducted open peer review, 15% of the journals had instructions to allow archiving preprints, and out of 375 responses, only 59 journals (16%) reported having a policy on underlying research data. Based on these results, there is a trend in favour of open access, but the perceived barriers to open peer review outweighed the advantages. There is also some reluctance to allow preprints to be made available. This concern might be because editors want authors and readers to read and cite the contents published in their journals, rather than their preprint versions. [ABSTRACT FROM AUTHOR]

Photovoltaic (PV) energy development has increased in the last years mainly based on large utility-scale plants. These plants are characterised by a huge number of panels connected to high-power inverters occupying a large land area. An accurate estimation of the power production of the PV plants is needed for failure detection, identifying production deviations, and the integration of the plants into the power grid. Various studies have used Machine Learning estimation techniques developed on very small PV plants. This paper deals with large utility-scale plants and uses all the available information to represent the non-uniform radiation over the whole studied solar field. Variables measured in up to four meteorological stations and distributed across the plant are used. Three PV plants with 1, 2 and 4 meteorological stations have been used to develop Machine Learning models. The hyperparameters were systematically optimised, demonstrating the improvements by comparing with a simple model based on Multiple Linear Regression. The best results were obtained with the Random Forest technique for the three PV plants, providing a RMS error value ranging from 1.9% to 5.4%. The final models were compared with those found in the literature for tiny PV plants showing in general much better performance. • Use of distributed met-station data improves production estimations in large PV plants. • Systematic optimisation of hyperparameters of ML models is a must for improving performance. • The estimations obtained with tree-based models outperform those provided by ANN. [ABSTRACT FROM AUTHOR]

Viruses are obligate pathogens that entirely rely on their hosts to complete their infectious cycle. The outcome of viral infections depends on the status of the host. Host developmental stage is an important but sometimes overlooked factor impacting host-virus interactions. This impact is especially relevant in a context where climate change and human activities are altering plant development. To better understand how different host developmental stages shape virus evolution, we experimentally evolved turnip mosaic virus (TuMV) on Arabidopsis thaliana at three different developmental stages: vegetative (juvenile), bolting (transition) and reproductive (mature). After infecting plants with an Arabidopsis-naive or an Arabidopsis-well-adapted TuMV isolate, we observed that hosts in later developmental stages were prone to faster and more severe infections. This observation was extended to viruses belonging to different genera. Thereafter, we experimentally evolved lineages of the naive and the well-adapted TuMV isolates in plants from each of the three developmental stages. All evolved viruses enhanced their infection traits, but this increase was more intense in viruses evolved in younger hosts. The genomic changes of the evolved viral lineages revealed mutation patterns that strongly depended on the founder viral isolate aswell as on the developmental stage of the host wherein the lineages were evolved. [ABSTRACT FROM AUTHOR]

The Sustainable Development Goals of the 2030 Agenda have set a new horizon for higher education institutions. Universities must guarantee an inclusive and quality education for all. Far from this objective, in the Spanish university system, the expansion of participation seems to have come to a halt, generating obvious situations of inequality. From a qualitative approach, this work gathers the contributions of 119 faculty members who reflected on how to advance toward more inclusive universities. The results show the barriers to inclusion that Spanish universities must overcome and the strategies that would allow them to progress toward more inclusive university culture, policies and practices. It concludes with the invitation to a cultural and organisational change based on a broader conception of inclusion. Moreover, it suggests an institutional commitment translated into a greater economic investment that enables the improvement of learning conditions and the training of faculty members in inclusive pedagogies. [ABSTRACT FROM AUTHOR]

Simple Summary: Maternal adipose tissue grows during pregnancy to secure the fetus's nutritional supply, and too much visceral adipose tissue at the start of pregnancy can increase metabolic risk and gestational problems. The distribution of fat, and more particularly the rise in visceral fat or central obesity, has been found to be more closely linked to the onset of cardiovascular disease and metabolic syndrome than obesity itself. Our goal is to examine the association between the thickness of the mother's visceral fat, as determined by a first trimester ultrasound exam, and the risk of poor pregnancy outcomes. We observed that women who experienced complications during pregnancy had greater levels of maternal visceral fat, especially gestational diabetes, which was linked to metabolic risk factors including insulin resistance and arterial blood pressure. This fact may imply that the risk of complications would increase more when the distribution of visceral fat (associated with metabolic risk) is greater than expected for a given degree of obesity/body mass index. Obese women are more likely to experience pregnancy complications. The distribution of fat, and more particularly the rise in visceral fat, is well established to be more closely linked to the onset of cardiovascular disease and metabolic syndrome than obesity itself. We aim to examine the relationship between maternal visceral fat assessment in the first trimester and the appearance of adverse pregnancy outcomes. A prospective cohort study including 416 pregnant women was conducted. During the first trimester scan (11–13 + 6 weeks), all individuals had their visceral fat and subcutaneous thicknesses measured by ultrasonography. Blood samples were obtained, and maternal demographics and clinical information were documented. After delivery, the obstetric outcomes were evaluated. We contrasted two groups: one with healthy pregnancies and the other with adverse pregnancy outcomes (APO), defined as the development of at least one of the following complications: gestational diabetes mellitus, hypertensive disorders of pregnancy, abnormal fetal growth, preterm delivery or preterm premature rupture of membranes. Median maternal age was 33 and 34 years old for the uncomplicated and adverse pregnancy outcomes groups, respectively. We found that women with adverse pregnancy outcomes had higher VFT (median 30 vs. 26.5 mm, p = 0.001) and SFT (median 18.9 vs. 17.1 mm, p = 0.03). However, the visceral/subcutaneous fat ratio was not statistically different between groups. Finally, we performed a subanalysis for metabolic and placental vascular dysfunction complications. After performing a multivariate logistic regression analysis adjusted for maternal age, smoking, and mean arterial pressure, both the VFT (aOR 1.03, p < 0.001) and the ratio of visceral/subcutaneous fat (aOR 1.37, p = 0.04) were significantly associated with the development of adverse pregnancy outcomes; however, the associations of VFT and the VFT-to-SFT ratio were higher for the occurrence of gestational diabetes (aOR 1.07, p < 0.001; aOR 2.09, p = 0.001; respectively) and showed no relationships with placental complications. When conducting a first-trimester ultrasound assessment, sonographers may measure VFT without additional time or cost involved. Identification of pregnant women with increased VFT (>37 mm) may benefit from a close follow-up, especially for the development of gestational diabetes, independent of BMI. [ABSTRACT FROM AUTHOR]

Introduction: Left bundle branch pacing (LBBP) has emerged in recent years as a new pacing modality, providing patients with a narrower paced QRS than conventional pacing and stable pacing parameters. At the same time, there is a growing concern about the use of fluoroscopy in pacemaker implantations, given its harmful effects on both patients and operators. However, there are no prior experiences of zero‐fluoroscopy in LBBP procedure. Methods: We conducted an observational prospective study recruiting consecutive patients that underwent zero‐fluoroscopy LBBP pacemaker implantation. A 6‐month follow‐up visit was programmed for every patient. The main goal of our study was to assess the efficacy, feasibility, and safety of the procedure. Results: From January 2021 to February 2022, we included 10 patients, 8 males. The average age was 63 ± 4 years. The procedure was successful in all patients. We observed a significant reduction in paced QRS width compared with basal QRS width (149 ± 31.9 vs. 116 ± 15.6 ms, p =.02). All device parameters remained stable at 6‐month follow‐up: no significant differences in mean impedance (700.5 ± 136.4 vs. 494 ± 72.7 Ohm, p =.09), capture threshold (0.67 ± 0.2 vs. 0.83 ± 0.2 V @ 0.4 ms, p =.27) or endocardial V‐wave amplitude (10.6 ± 5.2 vs. 13.9 ± 6.3 mV, p =.19). No complications were reported in any case. Conclusion: Zero‐fluoroscopy LBBP is feasible and safe, and it may be considered in cases where radiation exposure is contraindicated or especially undesirable. Future randomized clinical trials are needed for the widespread use of this new technique. [ABSTRACT FROM AUTHOR]

The article "The Linguistics of Love: From the Passion of Words" is a book edited by M.ª Mar Galindo and M.ª del Carmen Méndez that compiles various studies on how affective relationships are constructed through language. Specialists address topics such as the concepts of love and conversation, verbal behavior in seduction rituals, stages of love through the study of voice, the use of metaphors to express love, the language of desire in the LGBTQ+ community, the language of couples, and the differences in sexual lexicon between men and women. It also analyzes how the topic of eroticism is approached in translations of erotic novels and how to address transgender individuals without offending them. The text presents a summary of a book that addresses the topic of love from different perspectives, such as linguistics, psychology, and music. Several chapters are mentioned that explore metaphors about love in songs, translations of romantic relationships in teenage series, the use of dating apps like Tinder, the phenomenon of ghosting, and the lexicon of love in pop and rock songs. It is emphasized that love is not limited to language, but is also expressed through images, gestures, and movements. Additionally, it is mentioned that there are differences in how men and women express love and that gender-related myths related to the topic still persist. It is also noted that the language of love in the LGBTQ+ community remains a taboo topic in society. [Extracted from the article]

Academic journals have been incorporating several elements of open science: open access (since 2000), later, the deposit of research data of the articles published, the dissemination of preprints before the publication of the paper and, finally, the open peer review (OPR). While open access is well-established and the inclusion of research data is increasingly widespread, the OPR is just at the beginning of its incorporation as a real alternative to the double-blind model, which is the most widespread and consolidated. The objective of our article is to analyse the opinion of the editors of Spanish scientific journals about the advantages and disadvantages or barriers for the implementation of the OPR. This is a qualitative study that has been carried out from the open answers of a questionnaire sent to the 1875 editors of the Spanish academic journals that appear in the database Dulcinea and that obtained a response of 22.4%. Regarding the limitations, the study is based on the opinions and experience of the editors of Spanish scientific journals, which are mostly published by academic institutions and are in the field of social sciences and humanities. The results focus on delving into the advantages and disadvantages. Among the encouraging factors, the editors point out that to have open reports is very useful for the scientific community, that it recognizes the role of the reviewer, makes it possible to control the arbitrariness of some reviewers, and that it promotes the reviewer-author dialogue. The main barriers discussed are the following: a possible lack of objectivity and rigor, resistance to change a consolidated system (“double-blind”), knowing the author benefits established authors and harms novices, more difficulties for finding reviewers, increases costs and can lengthen the review process. [ABSTRACT FROM AUTHOR]

Due to the high number of people requesting psychological help and the scarcity of professional resources available to many psychological assistance services, it is necessary to promote the implementation of therapeutic modalities that optimize these resources; a promising alternative is the group adaptation of Barlow's unified protocol (Barlow et al., 2018). However, it is necessary to identify the patients who can most likely benefit from this group protocol, and which are the variables that characterize those with a higher risk of abandoning this type of intervention. This study was carried out on a total sample of 54 people who initiated a group adaptation of Barlow's Unified Protocol, in the Psychological Assistance Service of the Pontifical University of Salamanca. A group of patients who completed the treatment (n = 37) was compared with a group who abandoned it at some point (n = 17). Measures of anxiety, depression, personality variables, quality of life, interference and self-compassion were taken. The results indicate the presence of statistically significant differences in anxiety symptoms and the level of interference of the problem in daily life, these being more severe in the group that abandoned treatment; patients who complete the treatment, score significantly higher in the shared humanity variable, involved in the processes of empathy and belonging to the group; likewise, differences are observed, at the limit of statistical significance, in the depression and quality of life variables, with the patients in the group that abandoned treatment obtaining the highest scores in depression and the lowest in quality of life. These preliminary results show some characteristics that can be used to identify, in an initial assessment, the possible beneficiaries of this format and optimize the therapeutic alternatives offered. [ABSTRACT FROM AUTHOR]

Critical for tungsten alloys' use as plasma-facing component materials are their thermal response and their evolution under irradiation. Utilising Transient Grating Spectroscopy, TEM, and Molecular Dynamics, this study sought to probe these changes in W, W6Ta, and W11Ta alloys. Irradiation with 12.25 MeV W 6 + ions was carried out in the CLASS facility at MIT at a temperature of 500 °C for doses of 0.1, 0.3, and 1.0 dpa. The alloys' thermal diffusivity was found to degrade less than that of the pure counterpart. Molecular Dynamics simulation revealed that this was due to a reduced defect population below TEM resolution. Despite these alloys showing enhanced resilience to thermal property degradation, it was found that the absolute values of their thermal diffusivity remained below that of pure tungsten. This study highlighted a key interplay between enhancing radiation tolerance with alloying additions and the alloy additions' initial negative effect on the thermal response and thus in-service behaviour. • The thermal diffusivity of tungsten–tantalum alloys under W-ion irradiation was measured at 500 ° C up to a dose of 1.0 dpa. • Tantalum addition showed reduced degradation of thermal diffusivity. • The absolute value of the thermal diffusivity of tungsten remained higher than the alloys at all doses. [ABSTRACT FROM AUTHOR]

Heart failure is the most common disease among elderly people, and the risk increases with age. The use of smart Internet of Things (IoT) systems for monitoring patients with chronic heart failure (CHF) in a non-intrusive manner can result in better control of the disease, improving proactive healthcare through real-time and historical patient's data, promoting self-care in patients, reducing unneeded interaction between patients and doctors, reducing the number of hospitalizations and saving healthcare costs. This work presents an active assisted living (AAL) solution based on the IoT to provide a tele-assistance platform for CHF patients from the public health service of the region of Murcia in Spain, with formal and informal caregivers and health professionals also as key actors. In this article, we have detailed the methodology, results, and conclusions of the prevalidation phase for the set of IoT technologies to be integrated in the AAL platform, the first mandatory step before the deployment of a large-scale pilot that will lead to improving the innovation of the system from its current technology readiness level to the market. The work presented, in the framework of the H2020 Pharaon project, aims to serve as inspiration to the R&D community for the design, development, and deployment of AAL solutions based on heterogeneous IoT technologies, or similar approaches, for smart healthcare solutions in real healthcare institutions. [ABSTRACT FROM AUTHOR]

Background: Excessive inflammation is pathogenic in the pneumonitis associated with severe COVID-19. Neutrophils are among the most abundantly present leukocytes in the inflammatory infiltrates and may form neutrophil extracellular traps (NETs) under the local influence of cytokines. NETs constitute a defense mechanism against bacteria, but have also been shown to mediate tissue damage in a number of diseases.Research Question: Could NETs and their tissue-damaging properties inherent to neutrophil-associated functions play a role in the respiratory failure seen in patients with severe COVID-19, and how does this relate to the SARS-CoV-2 viral loads, IL-8 (CXCL8) chemokine expression, and cytotoxic T-lymphocyte infiltrates?Study Design and Methods: Sixteen lung biopsy samples obtained immediately after death were analyzed methodically as exploratory and validation cohorts. NETs were analyzed quantitatively by multiplexed immunofluorescence and were correlated with local levels of IL-8 messenger RNA (mRNA) and the density of CD8+ T-cell infiltration. SARS-CoV-2 presence in tissue was quantified by reverse-transcriptase polymerase chain reaction and immunohistochemistry analysis.Results: NETs were found in the lung interstitium and surrounding the bronchiolar epithelium with interindividual and spatial heterogeneity. NET density did not correlate with SARS-CoV-2 tissue viral load. NETs were associated with local IL-8 mRNA levels. NETs were also detected in pulmonary thrombi and in only one of eight liver tissues. NET focal presence correlated negatively with CD8+ T-cell infiltration in the lungs.Interpretation: Abundant neutrophils undergoing NETosis are found in the lungs of patients with fatal COVID-19, but no correlation was found with viral loads. The strong association between NETs and IL-8 points to this chemokine as a potentially causative factor. The function of cytotoxic T-lymphocytes in the immune responses against SARS-CoV-2 may be interfered with by the presence of NETs. [ABSTRACT FROM AUTHOR]

Comorbidity between anxiety and depression symptoms is often high in children. Person-oriented statistical approaches are useful to detect heterogeneity of individuals and diverse patterns of response to treatment. This study aimed to explore the different profiles in a sample of Spanish children who received the Super Skills for Life (SSL) transdiagnostic program, to identify which profile of individuals benefited most from the intervention and the likelihood of transition of symptom patterns over time. Participants were 119 children (42.9% were female) aged 8–12 years old (M = 9.39; SD = 1.26). Children completed anxiety and depression measures at the baseline, postintervention, and 12-months follow-up. Results from latent transition analysis (LTA) revealed two groups depending on the severity of the anxiety and depression symptoms: low symptoms (LS) and high symptoms (HS). LS group remained stable and HS decreased by 25%, switching to the LS group. Children with greater social anxiety benefited most from the program over time. Furthermore, older children were more likely to improve rapidly one year after the intervention compared to younger children. This study provides information to consider when implementing preventive interventions for schoolchildren and to tailor them according to the target population characteristics to increase their effectiveness. [ABSTRACT FROM AUTHOR]

Aim: It is important to understand the factors affecting community stability because ecosystem function is increasingly at risk from biodiversity loss. Here, we evaluate how a key factor, the position of local environmental conditions within the thermal range of the species, influences the stability of butterfly communities at a continental scale. Location: Spain, UK and Finland. Time period: 1999–2017. Major taxa studied: Butterflies. Methods: We tested the following hypotheses about how species responses to temperature anomalies aggregate to influence stability: Hypothesis 1, species have contrasting responses to local temperature anomalies at opposing edges of their thermal range; hypothesis 2, communities with central thermal range positions have higher community stability; and the impacts of thermal range position on community stability are driven by hypothesis 3, population asynchrony, or hypothesis 4, additive population stability. Data were analysed at 876 sites for 157 species. Results: We found some support for hypothesis 1, because there were interactions between thermal range and response to temperature anomalies such that species at different range edges could provide weak compensatory dynamics. However, responses were nonlinear, suggesting strong declines with extreme anomalies, particularly at the hot range edge. Hypothesis 2 was supported in part, because community stability increased with central thermal range positions and declined at the edges, after accounting for species richness and community abundance. Thermal range position was weakly correlated with asynchrony (hypothesis 3) and population stability (hypothesis 4), although species richness and population abundance had larger impacts. Main conclusions: Future extreme heat events will be likely to impact species negatively across their thermal range, but might be particularly impactful on populations at the hottest end of the thermal range. Thermal range position influenced community stability because range edge communities were stable. However, the prediction of community stability from thermal range position is challenging because of nonlinear responses to temperature, with small temperature anomalies producing weak compensatory dynamics, but large extreme events synchronizing dynamics. [ABSTRACT FROM AUTHOR]

An increasing interest in regenerative medicine has been an approach with natural products used for assorted skin treatments. Propolis from Apis mellifera species of bees have shown high acceptance due to antimicrobial and anti-inflammatory properties. However, just a few propolis types presents stronger effects in controlling inflammation. The current work describes an organic propolis recently isolated, named as OP6, that presented strong anti-inflammatory influences in vivo when associated with EDTA cross-linked hydrogel, used as a curative device in second-degree burns in a murine model. We developed a cellulose acetate hydrogel cross-linked with ethylenediaminetetraacetic dianhydride (HAC-EDTA) as a polymeric matrix for a bandage based on an ethanolic extract of propolis at 15%, 30%, and 60% (w/v) for treating second-degree burns. In vivo studies were carried out in Wistar rats divided into three groups: negative control (only lesion), positive control (lesion with HAC-EDTA film), and treatment group (lesion with the HAC-EDTA + OP6 at 15%, 30%, and 60%). Each group was randomized and equally subdivided into two subgroups according to the period of bandage wearing (7 and 14 days). Previous work of this research group selected the propolis OP6 sample source as the best candidate for the in vivo study. HAC-EDTA + OP6 15%, 30%, and 60% films demonstrated a concentration-dependent release rate, with the highest amount of propolis released after tests (484.3 mg) by HAC-EDTA enriched with the highest concentrated extract of propolis. HAC-EDTA + OP6 films were efficient in preventing infections, promoting lesion retraction, and tissue regeneration. The HAC-EDTA + OP6 30% treatment was more efficient, revealing a reduced inflammatory process and stimulating skin regeneration. The designed HAC-EDTA + propolis films were shown as promising tools for second-degree burns treatment, accelerating healing process to a full recovery tissue repair after 14 days. [ABSTRACT FROM AUTHOR]

Rosmarinic acid (RA), a caffeic acid derivative, has been loaded in polymeric nanoparticles made up of poly(lactic-co-glycolic acid) (PLGA) through a nano-emulsion templating process using the phase-inversion composition (PIC) method at room temperature. The obtained RA-loaded nanoparticles (NPs) were colloidally stable exhibiting average diameters in the range of 70–100 nm. RA was entrapped within the PLGA polymeric network with high encapsulation efficiencies and nanoparticles were able to release RA in a rate-controlled manner. A first-order equation model fitted our experimental data and confirmed the prevalence of diffusion mechanisms. Protein corona formation on the surface of NPs was assessed upon incubation with serum proteins. Protein adsorption induced an increase in the hydrodynamic diameter and a slight shift towards more negative surface charges of the NPs. The radical scavenging activity of RA-loaded NPs was also studied using the DPPH·assay and showed a dose–response relationship between the NPs concentration and DPPH inhibition. Finally, RA-loaded NPs did not affect the cellular proliferation of the human neuroblastoma SH-SY5Y cell line and promoted efficient cellular uptake. These results are promising for expanding the use of O/W nano-emulsions in biomedical applications. [ABSTRACT FROM AUTHOR]

Anxious children report a more negative perception of their social performance and increased nervous behaviors. The video-feedback with cognitive preparation allows children to contrast and modify their negative social self-image, increasing their self-confidence and decreasing anxiety behaviors. This study aimed to examine the effectiveness of the Super Skills for Life (SSL) program in improving social performance in a sample of children with emotional symptoms. Results indicated that both objective and subjective evaluation showed positive effects of the SSL program on the children's social performance, enhancing their social skills and reducing anxiety behaviors in social situations, both during the program and in the last session. Girls felt more comfortable and showed better speech and social performance than boys. Our findings increase the evidence about the short-term effects of the video-feedback with cognitive preparation of the SSL program and provide a useful transdiagnostic protocol for application in the clinical setting. [ABSTRACT FROM AUTHOR]