1. A randomized, double‐blind, placebo‐controlled pilot study of the comparative effects of dienogest and the combined oral contraceptive pill in women with endometriosis.
- Author
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Mehdizadeh Kashi, Abolfazl, Niakan, Gelareh, Ebrahimpour, Majid, Allahqoli, Leila, Hassanlouei, Babak, Gitas, Georgios, and Alkatout, Ibrahim
- Abstract
Objective: To compare the effects of dienogest and a combined oral contraceptive pill (COCP) after laparoscopic surgery on pain and quality of life in women with severe endometriosis. Methods: A randomized double‐blind pilot study was conducted from March 2018 to March 2020 in women with severe endometriosis confirmed by laparoscopic surgery. A total of 108 patients who had undergone laparoscopic surgery received dienogest, COCP, or placebo daily for 6 months. Primary and secondary outcomes were compared between the three groups. Results: Treatment with dienogest or COCP was associated with improved self‐reported pain after 6 months of treatment, as evidenced by significantly lower scores for pelvic pain and dyspareunia compared with placebo (P < 0.05). Significant differences in overall quality of life score were observed over 6 months in the dienogest, COCP, and placebo groups (mean difference 22.00, 23.45, and 6.45 points, respectively; P < 0.001). Post‐hoc analysis revealed a significant difference in overall quality of life score between the placebo group and the dienogest (P < 0.001) and COCP groups (P = 0.004). Conclusion: Postoperative administration of dienogest or COCP reduced endometriosis‐associated pain and improved quality of life in women with severe endometriosis. Clinical trials registration: https://en.irct.ir/trial/43070. Synopsis: Postoperative administration of dienogest or the combined oral contraceptive pill is an effective treatment with few adverse effects, reduced endometriosis‐associated pain, and improved quality of life. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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