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This study aimed to assess the mediating role of anthropometric parameters in the relation of education and inflammation in the elderly. Cross-sectional data from the population-based CARdio-vascular Disease, Living and Ageing in Halle study were used after excluding subjects with a plasma level of high-sensitive C-reactive protein ( hsCRP) above 10 mg L−1 (916 men/760 women remaining). Education was categorized in accordance with International Standard Classification of Education. As inflammation parameters, the soluble tumour necrosis factor type 1 ( sTNF- R1), hsCRP and interleukin 6 ( IL-6) were taken into account. Anthropometric parameters were the body mass index ( BMI), waist-to-hip ratio ( WHR) and waist-to-height ratio ( WHeR). We used covariate adjusted mixed models to assess associations. Effect measures were the natural indirect effect ( NIE), controlled direct effect and total effect ( TE). Education was associated with sTNF- R1, hsCRP and IL-6 in men, and sTNF- R1 and hsCRP in women. Anthropometric parameters correlated with all inflammation parameters after covariate adjustment. BMI and WHeR were strong mediators of educational differences in sTNF- R1 (percentage of NIE of TE: 28% in men; 33% in women) and hsCRP (percentage of NIE of TE: 35% in men; 52% in women), while WHR was the weakest mediator. General obesity mediates roughly one-third of the association of education with chronic inflammation in the elderly. [ABSTRACT FROM AUTHOR]

Background There is inconsistent evidence on population mortality, especially cardiovascular disease mortality, on match days of national soccer teams during particular international tournaments. This study examines the number of deaths in Germany on match days of the national soccer team during a long-term period including several tournaments. Methods We analysed all registered daily deaths in Germany from 1995 to 2009 (11 225 966 cases) using time series analysis methods. Following the Box/Jenkins approach, we applied a seasonal autoregressive integrated moving average model. To assess the effect of match days, we performed an intervention analysis by including a transfer function model representing match days of the national team in the statistical analyses. We conducted separate analyses for all matches and for matches during international tournaments (European and World Championships) only. Time series and results were stratified in terms of sex, age (<50 years, 50–70 years, >70 years) and cause of death (cardiovascular deaths, injuries, others). We performed a further independent analysis focusing only on the effect of match results (victory, loss, draw) and kind of tournament (international championships, qualifications, friendly matches). Results Most of the results did not indicate a distinct effect of matches of the national team on general mortality. Moreover, all null value deviations were small when compared with the average number of daily deaths (n=2270). Conclusions There is no relevant increase or decrease in mortality on match days of the German national soccer team. [ABSTRACT FROM AUTHOR]

Poster: Clinical track: Health services research / health economics PO-1283: Public health predictors of the geographical variation of prostatectomy or radiotherapy in Germany D. Medenwald, K. Medenwald, A. Glowka, D. Vordermark. [Extracted from the article]

To investigate patterns of care and prognostic benefits of MRI, FDG-PET/CT and image-guidance in re-irradiation of locoregionally recurrent or second primary head-and-neck squamous cell carcinomas (r/s HNSCCs) within a multicenter cohort study. Patients receiving re-irradiation for r/s HNSCC between 2009 and 2020 at 16 tertiary cancer centers in Germany were retrospectively analyzed in terms of MRI and FDG-PET/CT usage for treatment planning and regarding image-guidance frequency during re-irradiation. Patterns of use of these modalities over time were analyzed by binary logistic regression analysis, and the association between the usage of these modalities and best locoregional treatment response was analyzed with chi-square tests. Cumulative incidence analyses of locoregional failures with death as competing event were performed. In the total cohort of 297 patients, 226 (76%) were male, median age was 62 years (IQR, 56-70), and median ECOG was 1 (IQR, 1-2). There were 260 locoregionally recurrent HNSCCs, and 37 second primary HNSCCs; 44 patients (15%) had distant metastases at the time of re-irradiation. MRI and FDG-PET/CT was used for re-irradiation planning in 117 (39%) and 71 patients (24%), respectively. In median, image guidance (IGRT) was performed twice weekly (IQR, 1-5), usually with cone beam CTs or megavolt-CTs, and 85 patients (29%) received daily IGRT during re-irradiation. Usage of MRI (OR = 0.967; 95% CI, 0.892-1.048; p =.416), FDG-PET/CT (OR = 1.053; 95% CI, 0.960-1.156; p =.274), or daily IGRT (OR = 1.057; 95% CI, 0.968-1.115; p =.218) did not increase in frequency over time within the analyzed time span but was significantly dependent on the treatment center (χ2(15), P <.001 for all modalities). Daily IGRT was associated with a higher rate of at least stable disease after re-irradiation as assessed by RECIST criteria (χ2(1) = 4.011, p <.05). There was a trend towards better RECIST-assessed treatment response for MRI (χ2(1) = 3.223, p =.073) and FDG-PET/CT (χ2(1) = 2.792, p =.095) as part of the re-irradiation planning process. Incidence of locoregional failures was not dependent on MRI (SHR = 0.94; 95% CI, 0.67-1.33; p = 0.741, Fine-Gray), FDG-PET/CT (SHR = 0.88; 95% CI, 0.59-1.33; p = 0.552) or daily IGRT (SHR = 0.76; 95% CI, 0.51-1.14, p = 0.182), There was a trend towards lower acute grade 3/4-toxicities in patients receiving daily IGRT (χ2(1) = 3.354, p = 0.067). Our data suggest that daily IGRT may increase disease control and should be regularly applied for re-irradiation of r/s HNSCCs. MRI and FDG-PET/CT usage were not associated with the incidence of locoregional failures after re-irradiation. However, prospective trials with multiparametric MRI and/or FDG-PET/CT for optimal re-irradiation planning are warranted. [ABSTRACT FROM AUTHOR]

Poster: Clinical track: Palliation PO-1262: Treatment effects of palliative care consultation and patient satisfactionâ a monocentric study L. Flöther, B. Pötzsch, K. Medenwald, M. Jung, R. Jung, A. Glowka, M. Bucher, D. Vordermark, D. Medenwald, PO-1262: Treatment effects of palliative care consultation and patient satisfaction- a monocentric study. [Extracted from the article]