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The African penguin population has declined precipitously in recent decades, and if current rates of decline persist, this species could become extinct in the wild by 2035. Resource extraction of small pelagic fish prey by the purse-seine fishery around African penguin breeding colonies has been identified as a demographically meaningful threat to African penguins. Consequently, long-term, effective no-take zones around breeding colonies have been endorsed by an expert panel of scientists constituted by the South African government. Here, we consider the six largest South African penguin colonies that currently hold 76% of the global population. We evaluate the adequacy of different no-take zone options using a trade-off mechanism recommended by the expert panel. For all six colonies except Bird Island, Algoa Bay, which is subject to the least fishing pressure, the current no-take zone delineations are assessed as having little benefit to the African penguin and little to no cost to the purse-seine fishery. Four of the six current no-take zones include ≤50% of the African penguins' core foraging areas. Alternative no-take zones that approximate a more balanced trade-off offer more impactful alternatives to the current fisheries restrictions. Given the urgent need to implement evidence-based conservation interventions for the endangered African penguin, we recommend the substitution of the current no-take zones with those proposed herein. [ABSTRACT FROM AUTHOR]

Parkinson's disease (PD) is typically a sporadic late-onset disorder, which has made it difficult to model in mice. Several transgenic mouse models bearing mutations in SNCA, which encodes alpha-Synuclein (a-Syn), have been made, but these lines do not express SNCA in a physiologically accurate spatiotemporal pattern, which limits the ability of the mice to recapitulate the features of human PD. Here, we generated knock-in mice bearing the G51D SNCA mutation. After establishing that their motor symptoms begin at 9 mo of age, we then sought earlier pathologies. We assessed the phosphorylation at Serine 129 of a-Syn in different tissues and detected phospho-a-Syn in the olfactory bulb and enteric nervous system at 3 mo of age. Olfactory deficit and impaired gut transit followed at 6 mo, preceding motor symptoms. The SncaG51D mice thus parallel the progression of human PD and will enable us to study PD pathogenesis and test future therapies. [ABSTRACT FROM AUTHOR]

The Exascale Computing Project (ECP) Software Technology and Co-Design teams addressed the growing complexities in high-performance computing (HPC) by developing scalable software libraries and tools that leverage exascale system capabilities. As we enter the exascale era, the need for reusable, optimized software solutions that can handle the unique challenges posed by these systems becomes increasingly important. The primary challenges the ECP teams faced were to create software libraries and tools that are performant on exascale architectures and portable and usable across diverse hardware platforms. Efforts addressed issues related to concurrent execution, memory management, and the integration of heterogeneous computing resources, such as GPUs from multiple vendors. The ECP's strategy involved a structured development process encompassing the creation, optimization, and deployment of software in collaboration with industry, academia, and national laboratories. The project was organized into several technical areas: co-design of domain-specific suites with target applications, programming models and runtimes, development tools, mathematical libraries, data and visualization tools, and software ecosystem and delivery mechanisms. ECP has successfully developed a large portfolio of software libraries and tools that demonstrate significant improvements in performance and scalability on exascale systems. These products have been integrated into the Department of Energy's computing facilities, supporting various scientific applications and ensuring robust performance across different hardware setups. ECP advancements in software development for exascale computing highlight the importance of a collaborative and adaptive approach to handling next-generation HPC systems complexities. The lessons learned emphasize the need for continuous engagement with end-users and vendors, and the importance of maintaining a balance between innovation and practical implementation. Future efforts will focus on ensuring scalability, keeping pace with rapid hardware advancements, and further enhancing the interoperability and usability of the software ecosystem. Subsequent articles in this special issue provide in-depth discussions and case studies into specific library and tool efforts. [ABSTRACT FROM AUTHOR]

Over the past decade, militaries have been highly visible elements in the response to health emergencies and in particular disease outbreaks. Although there has been a long tradition of civil–military collaboration in health, COVID–19 saw an unprecedented worldwide use of militaries which occurred within a permissive environment established by narratives of global health, humanitarian intervention and multi-sectorality. This creates a dilemma: militaries will likely be an important element in responding to a major health emergency and this risks not only militarizing health emergencies, but affects the balance between society and the military more generally. Moreover, the response to the COVID pandemic suggested that current emergency planning is often poorly prepared for the use of militaries in health crises, thereby reducing the effectiveness of a response. This article engages with how concerns over the securitization of health have evolved into concerns over militarization, and the question of how militaries might be used effectively in future health emergencies without risking the militarization of health or damaging civil–military relations more widely. [ABSTRACT FROM AUTHOR]

Introduction: Matching-adjusted indirect comparisons (MAIC) were used to assess the relative efficacy of bimekizumab 160 mg every 4 weeks (Q4W) compared to guselkumab 100 mg Q4W or every 8 weeks (Q8W) at 48/52 weeks in patients with psoriatic arthritis (PsA) who were biologic disease-modifying antirheumatic drug-naïve (bDMARD-naïve) or with previous inadequate response or intolerance to tumor necrosis factor inhibitors (TNFi-IR). Methods: Relevant trials were identified as part of a systematic literature review. For patients who were bDMARD-naïve, individual patient data (IPD) from BE OPTIMAL (N = 431) was matched to summary data from DISCOVER-2 (Q4W, n = 245; Q8W, n = 248). For patients who were TNFi-IR, IPD from BE COMPLETE (n = 267) and summary data from COSMOS (Q8W, N = 189). Trial populations were re-weighted using propensity scores. Unanchored comparisons of recalculated bimekizumab and guselkumab 48- or 52-week non-responder imputation outcomes for 20/50/70% improvement in American College of Rheumatology score (ACR20/50/70) and minimal disease activity (MDA) index were analyzed. Results: In patients who were bDMARD-naïve, bimekizumab was associated with a greater likelihood of ACR50 (odds ratio [95% confidence interval] 1.62 [1.07, 2.44]; p = 0.021), ACR70 (2.20 [1.43, 3.38]; p < 0.001), and MDA (1.82 [1.20, 2.76]; p = 0.005) compared to guselkumab Q4W at week 52. Bimekizumab also had a greater likelihood of ACR70 response (2.08 [1.34, 3.22]; p = 0.001) and MDA (2.07 [1.35, 3.17]; p < 0.001) compared to guselkumab Q8W at week 52. In patients who were TNFi-IR, bimekizumab had a greater likelihood in achieving all evaluated outcomes compared to guselkumab Q8W at week 48/52 (ACR20, 1.77 [1.15, 2.72]; p = 0.010; ACR50, 1.56 [1.03, 2.36]; p = 0.037; ACR70, 1.66 [1.05, 2.61]; p = 0.028; and MDA, 1.95 [1.27, 3.02]; p = 0.003). Conclusions: According to MAICs, bimekizumab demonstrated greater or comparable efficacy on ACR50/70 and MDA outcomes than guselkumab in patients with PsA who were bDMARD-naïve and TNFi-IR at week 48/52. Bimekizumab had a more favorable likelihood than guselkumab in achieving more stringent treatment outcomes. Trial Registrations: NCT03895203, NCT03896581, NCT04009499, NCT03158285, NCT03796858. [ABSTRACT FROM AUTHOR]

Introduction: To evaluate the effect of guselkumab on work productivity and nonwork daily activity impairment and general health status through 2 years in patients who were biologic-naïve with active psoriatic arthritis (PsA) in the phase 3 DISCOVER-2 clinical trial. Methods: Adult patients with PsA were randomized to subcutaneous injections of guselkumab 100 mg every 4 weeks (Q4W); at weeks 0, 4, then every 8 weeks (Q8W); or placebo (through week 24 with crossover to guselkumab Q4W). Work productivity and nonwork daily activity impairment were assessed using the Work Productivity and Activity Impairment Questionnaire for PsA (WPAI-PsA) and patient-reported general health status using the EuroQol 5-Dimension 5-Level (EQ-5D-5L) Index and EQ-Visual Analog Scale (EQ-VAS). Least-squares (LS) mean changes from baseline in WPAI-PsA domains and EQ-5D-5L/EQ-VAS were assessed through week 100. Changes in employment status were utilized to estimate potential indirect savings from improved work productivity. Results: Of 739 randomized patients, 738 had available baseline data for the analyses (Q4W 245; Q8W 248; placebo 245). At week 24, greater improvements in work productivity, nonwork daily activity, and EQ-5D-5L/EQ-VAS were observed in the Q4W and Q8W groups versus the placebo group. At week 100, LS mean reductions in work productivity impairment (− 23.8% to − 28.0%) and nonwork daily activity impairment (– 26.6% to − 29.2%) and improvements in EQ-5D-5L/EQ-VAS (0.14 to 0.15/21.2 to 25.0) were maintained in patients receiving guselkumab. Among patients employed at baseline, 12.1–16.4% were not employed at week 100, and 20.0–25.3% shifted from not employed at baseline to employed at week 100. Potential yearly indirect cost savings (USD) from improved work productivity at week 100 ranged from $16,529 to $19,409. Conclusion: Patients with active PsA treated with guselkumab demonstrated reduced impairment in work productivity and nonwork daily activity, together with improvement in general health status and substantial potential cost savings, over a 2-year period. Trial Registration: Clinicaltrials.gov identifier: NCT03158285. [ABSTRACT FROM AUTHOR]

Orbiting solar reflectors (OSRs) are flat, thin and lightweight reflective structures that are proposed to enhance terrestrial solar energy generation by illuminating large terrestrial solar power plants locally around dawn/dusk and during night hours. The incorporation of OSRs into terrestrial energy systems may offset the daylight-only limitation of terrestrial solar energy. However, the quantity of solar energy delivered to the Earth's surface remains low due to short duration of orbital passes and the low density of the reflected solar power due to large slant ranges. To compensate for these, this paper proposes a constellation of multiple reflectors in low-Earth orbit for scalable enhancement of the quantity of energy delivered. Circular near-polar orbits of 1000 km altitude in the terminator region are considered in a Walker-type constellation for a preliminary analysis. Starting from a simplified approach, the equations of Walker constellations describing the distribution of the reflectors are first modified by introducing a phasing parameter to ensure repeating pass-geometry over solar power farms. This approach allows for a single groundtrack optimisation to define the constellation, which was carried out by a genetic algorithm for single and two reflectors per orbit with an objective function defined as the total quantity of energy delivered per day, to existing and hypothetical solar power projects around the Earth. When full-scale constellations are considered with a number of reflectors, the quantity of solar energy delivered is substantial in the broader context of global terrestrial solar energy generation. • Terrestrial solar energy enhancement by constellation of orbiting reflectors is proposed. • Scalable, predictable and continuous solar energy from space is aimed. • Walker constellation equations are modified for repeating reflector passes. • Groundtrack optimised by genetic algorithm to maximise daily energy delivery. • Quantity of daily solar energy delivered is considerable in the global context. [ABSTRACT FROM AUTHOR]

This Reflections essay considers antiracist theory and practice and its impact on Romantic Studies today as displayed in a master's-level module aimed at introducing the use of theory to postgraduate students of nineteenth-century studies. Alongside these concerns, the reflection considers what it means to feel "Romantic" today, as well as the role and usefulness of discomfort in postgraduate pedagogy. [ABSTRACT FROM AUTHOR]

Transient killer whales have been documented hunting marine mammals across a variety of habitats. However, relatively little has been reported about their predatory behaviours near deep submarine canyons and oceanic environments. We used a long-term database of sightings and encounters with these predators in and around the Monterey Submarine Canyon, California to describe foraging behaviour, diet, seasonal occurrence, and habitat use patterns. Transient killer whales belonging to the outer coast subpopulation were observed within the study area 261 times from 2006–2021. Occurrences, behaviours, and group sizes all varied seasonally, with more encounters occurring in the spring as grey whales migrated northward from their breeding and calving lagoons in Mexico (March-May). Groups of killer whales foraged exclusively in open water, with individuals within the groups following the contours of the submarine canyon as they searched for prey. Focal follows revealed that killer whales spent 51% of their time searching for prey (26% of their time along the shelf-break and upper slope of the canyon, and 25% in open water). The remainder of their time was spent pursuing prey (10%), feeding (23%), travelling (9%), socializing (6%), and resting (1%). Prey species during 87 observed predation events included California sea lions, grey whale calves, northern elephant seals, minke whales, common dolphins, Pacific white-sided dolphins, Dall's porpoise, harbour porpoise, harbour seals, and sea birds. The calculated kill rates (based on 270 hours of observing 50 predation events) were 0.26 California sea lions per killer whale over 24 hours, 0.11 grey whale calves, and 0.15 for all remaining prey species combined. These behavioural observations provide insights into predator-prey interactions among apex predators over submarine canyons and deep pelagic environments. [ABSTRACT FROM AUTHOR]

The article discusses a study on the evidence for an oceanic population of killer whales (Orcinus orca) in offshore waters of California and Oregon conducted by Josh D. McInnes et al., published in the journal ". The study attempts to determine the ecotype of killer whales observed far from the coastlines based on their foraging behaviors, prey species consumed, morphologies, and the prevalence of cookiecutter shark bite scars.

Background: Variation in hospital stroke care is problematic. The Quality in Acute Stroke (QASC) Australia trial demonstrated reductions in death and disability through supported implementation of nurse-led, evidence-based protocols to manage fever, hyperglycaemia (sugar) and swallowing (FeSS Protocols) following stroke. Subsequently, a pre-test/post-test study was conducted in acute stroke wards in 64 hospitals in 17 European countries to evaluate upscale of the FeSS Protocols. Implementation across countries was underpinned by a cascading facilitation framework of multi-stakeholder support involving academic partners and a not-for-profit health organisation, the Angels Initiative (the industry partner), that operates to promote evidence-based treatments in stroke centres..We report here an a priori qualitative process evaluation undertaken to identify factors that influenced international implementation of the FeSS Protocols using a cascading facilitation framework. Methods: The sampling frame for interviews was: (1) Executives/Steering Committee members, consisting of academics, the Angels Initiative and senior project team, (2) Angel Team leaders (managers of Angel Consultants), (3) Angel Consultants (responsible for assisting facilitation of FeSS Protocols into multiple hospitals) and (4) Country Co-ordinators (senior stroke nurses with country and hospital-level responsibilities for facilitating the introduction of the FeSS Protocols). A semi-structured interview elicited participant views on the factorsthat influenced engagement of stakeholders with the project and preparation for and implementation of the FeSS Protocol upscale. Interviews were recorded, transcribed verbatim and analysed inductively within NVivo. Results: Individual (n = 13) and three group interviews (3 participants in each group) were undertaken. Three main themes with sub-themes were identified that represented key factors influencing upscale: (1) readiness for change (sub-themes: negotiating expectations; intervention feasible and acceptable; shared goal of evidence-based stroke management); (2) roles and relationships (sub-themes: defining and establishing roles; harnessing nurse champions) and (3) managing multiple changes (sub-themes: accommodating and responding to variation; more than clinical change; multi-layered communication framework). Conclusion: A cascading facilitation model involving a partnership between evidence producers (academic partners), knowledge brokers (industry partner, Angels Initiative) and evidence adopters (stroke clinicians) overcame multiple challenges involved in international evidence translation. Capacity to manage, negotiate and adapt to multi-level changes and strategic engagement of different stakeholders supported adoption of nurse-initiated stroke protocols within Europe. This model has promise for other large-scale evidence translation programs. [ABSTRACT FROM AUTHOR]

Background: Variation in hospital stroke care is problematic. The Quality in Acute Stroke (QASC) Australia trial demonstrated reductions in death and disability through supported implementation of nurse-led, evidence-based protocols to manage fever, hyperglycaemia (sugar) and swallowing (FeSS Protocols) following stroke. Subsequently, a pre-test/post-test study was conducted in acute stroke wards in 64 hospitals in 17 European countries to evaluate upscale of the FeSS Protocols. Implementation across countries was underpinned by a cascading facilitation framework of multi-stakeholder support involving academic partners and a not-for-profit health organisation, the Angels Initiative (the industry partner), that operates to promote evidence-based treatments in stroke centres..We report here an a priori qualitative process evaluation undertaken to identify factors that influenced international implementation of the FeSS Protocols using a cascading facilitation framework. Methods: The sampling frame for interviews was: (1) Executives/Steering Committee members, consisting of academics, the Angels Initiative and senior project team, (2) Angel Team leaders (managers of Angel Consultants), (3) Angel Consultants (responsible for assisting facilitation of FeSS Protocols into multiple hospitals) and (4) Country Co-ordinators (senior stroke nurses with country and hospital-level responsibilities for facilitating the introduction of the FeSS Protocols). A semi-structured interview elicited participant views on the factorsthat influenced engagement of stakeholders with the project and preparation for and implementation of the FeSS Protocol upscale. Interviews were recorded, transcribed verbatim and analysed inductively within NVivo. Results: Individual (n = 13) and three group interviews (3 participants in each group) were undertaken. Three main themes with sub-themes were identified that represented key factors influencing upscale: (1) readiness for change (sub-themes: negotiating expectations; intervention feasible and acceptable; shared goal of evidence-based stroke management); (2) roles and relationships (sub-themes: defining and establishing roles; harnessing nurse champions) and (3) managing multiple changes (sub-themes: accommodating and responding to variation; more than clinical change; multi-layered communication framework). Conclusion: A cascading facilitation model involving a partnership between evidence producers (academic partners), knowledge brokers (industry partner, Angels Initiative) and evidence adopters (stroke clinicians) overcame multiple challenges involved in international evidence translation. Capacity to manage, negotiate and adapt to multi-level changes and strategic engagement of different stakeholders supported adoption of nurse-initiated stroke protocols within Europe. This model has promise for other large-scale evidence translation programs. [ABSTRACT FROM AUTHOR]

Hill's approximation models the motion of two small masses gravitationally interacting with each other and perturbed by a large central body. An application of the model is employed in this paper to manoeuvre the relative motion of two asteroids by a small impulse to capture them in bound binary motion in Earth's orbit. The initial conditions prior to the capture manoeuvre are restricted in a parameter space termed the gateway region. The gateway region is produced by applying the constraint that the capture impulse is a real-valued function, and the zero-velocity curve closes, enveloping both asteroids. A full mission scenario is designed with three impulses. The first impulse transfers one asteroid from a far field region to the gateway region, where there is mutual interaction with the second asteroid, which is assumed to be the origin of the relative motion. The second impulse changes the trajectory of the asteroid in the gateway region to a linear drift approaching the second asteroid. The third impulse is calculated by means of increasing the Jacobi integral to reach the critical value required to close the zero-velocity curve. It is demonstrated in principle that the triple impulses enable the candidate asteroids to be captured in a bound pair in Earth's orbit. It is also shown that the thruster on-time for the capture impulse as applied for the different small asteroids considered is short relative to the natural time-scale of the orbital dynamics of the problem, which shows the feasibility of the impulse approximation with the typical thruster forces applied. This strategy could provide a basis for parking small captured near-Earth asteroids in Earth's orbit. • A three-impulse scenario is proposed to form an asteroid pair in bound motion. • Hill's equations are modified with capture impulse to the transverse relative velocity. • An analytical investigation for position and velocity constraints is applied to the capture impulse. • A gateway map is generated to provide possible initial conditions for the capture impulse scenario. • The scenario is illustrated by forming an artificial binary pair in high Earth orbit. [ABSTRACT FROM AUTHOR]

Previous work indicated that the incidence of travellers' diarrhoea (TD) is higher in soldiers of British origin, when compared to soldiers of Nepalese descent (Gurkhas). We hypothesise that the composition of the gut microbiota may be a contributing factor in the risk of developing TD in soldiers of British origin. This study aimed to characterise the gut microbial composition of Gurkha and non-Gurkha soldiers of the British Army. Recruitment of 38 soldiers (n = 22 Gurkhas, n = 16 non-Gurkhas) and subsequent stool collection, enabled shotgun metagenomic sequencing-based analysis of the gut microbiota. The microbiota of Gurkhas had significantly (P < 0.05) lower diversity, for both Shannon and Simpson diversity indices, using species level markers than the gut microbiota of non-Gurkha soldiers. Non-metric Multidimensional Scaling (NMDS) of the Bray-Curtis distance matrix revealed a significant difference in the composition of the gut microbiota between Gurkhas and non-Gurkha soldiers, at both the species level (P = 0.0178) and the genus level (P = 0.0483). We found three genera and eight species that were significantly enriched in the non-Gurkha group and one genus (Haemophilus) and one species (Haemophilus parainfluenzae) which were enriched in the Gurkha group. The difference in the microbiota composition between Gurkha soldiers and soldiers of British origin may contribute to higher colonization resistance against diarrhoeal pathogens in the former group. Our findings may enable further studies into interventions that modulate the gut microbiota of soldiers to prevent TD during deployment. [ABSTRACT FROM AUTHOR]

The COVID‐19 pandemic created unprecedented demands and additional stress for nurses in mental health settings. There is no prior evidence on nurses' experience of building and maintaining resilience in the context of work during COVID‐19. The aim of this study was to explore the experience and impacts of the COVID‐19 pandemic on the resilience of nurses in mental health settings. Data from semi‐structured interviews with 20 nurses from an Australian mental health service were analysed using reflexive thematic analysis. Four main themes were generated: experiencing significant disruptions; making sense of shared chaos; having professional commitment; and growing through the challenges. Nurses' practice and teamwork were disrupted by COVID‐19 related changes to care models and infection prevention policies. They successfully adjusted by having awareness of self and others' emotions, using mental and emotional self‐regulatory strategies, engaging in self‐care, using 'bricolage' to create different ways to provide care, and having mutually supportive relationships. Nurses connected to their sense of purpose and professional commitment to fuel their therapeutic work and sustain care delivery. They experienced personal and professional growth with an increased understanding of their strengths and resilience. In the post‐pandemic period, although the challenges presented by the pandemic have lessened, there are ongoing negative impacts on nurses' wellbeing. To maintain and strengthen their wellbeing and practice, the findings indicate the importance of professional development in emotional regulation skills, and strategies to strengthen self‐care and build collegial relationships in teams. Resilience education can be implemented to support nurses' resilient practice skills. [ABSTRACT FROM AUTHOR]

The general three-body problem is investigated with the addition of a fixed external force applied to one of the masses. It is firstly demonstrated that the centre-of-mass of the three-body system accelerates. Then, it is demonstrated that only a single, unstable, collinear equilibrium solution exits in the accelerating frame. While unstable, it is also demonstrated that this single equilibrium configuration is in principle controllable using additional control accelerations distributed between the masses. Potential applications of such an accelerated collinear equilibrium configuration are discussed for the active manoeuvring of chains of small asteroids for space resource utilisation. [ABSTRACT FROM AUTHOR]

Health and social care workers (HSCWs) have an essential role in the uptake of the COVID-19 vaccine. Vaccination is an emotionally charged issue and perceptions of risk associated with COVID19 can contribute towards vaccine hesitancy (VH). The aim of this study was to explore the role of emotion and risk perception associated with HSCWs' uptake of the COVID-19 vaccine during the initial mass roll-out of the vaccine in Scotland. A cross-sectional online survey with a correlational design was used. An online survey was conducted with HSCWs (N = 1189) aged 18 to 67 years (M = 44.09 yrs, SD = 11.48) working in Scotland during the third lockdown period (26 December – 31 March 2021) of the COVID-19 pandemic. The survey collected data relating to sociodemographic characteristics, vaccine uptake and VH, emotions associated with the COVID-19 vaccine, and risk perception. Open-ended free text data were also collected on HSCWs' main reasons for VH. Most participants (83.96%) felt positively about the roll-out of the COVID-19 vaccine, stating it would be beneficial for themselves and others to receive it. Nonetheless, 16.04% of HSCWs expressed VH. Occupational group, age, gender and risk perceptions did not affect variance in VH, but positive emotions associated with the COVID-19 vaccine and years of experience did. We emphasise the importance of future interventions to increase COVID-19 vaccine uptake by enhancing positive emotions and reducing ambivalent emotions associated with the COVID-19 vaccine particularly among less experienced HSCWs. [ABSTRACT FROM AUTHOR]

• A generic energy delivery model is presented for mirrors in circular orbits. • Model includes Earth's oblateness, rotation, shadow and orbit around the Sun. • Detailed analytical insights are provided for pass duration over a solar farm. • Earlier results for simple polar orbits are extended to a range of different orbits. • The model can in principle be extended to other planetary bodies. Orbiting solar reflectors may be a useful assets to illuminate solar power farms to enhance their utility when direct sunlight is not available. The assessment of their feasibility for a variety of applications requires accurate calculations of how much solar energy can be delivered from a variety of orbits. This paper presents a generic, three-dimensional semi-analytical model that outputs the quantity of solar energy for a given circular orbit and solar power farm position at the beginning of a pass. The model extends previous studies by including new phenomena such as the Earth's oblateness, rotation, shadow on the reflector and orbit around the Sun, in addition to time-dependent geometric and atmospheric losses. These additions provide new analytical insights into the delivery of reflected solar energy delivery and demonstrate the importance of high-fidelity modelling. The strengths of the model are illustrated for a 1000 km altitude Sun-synchronous orbit throughout, as well as a range of other orbits and solar power farms located at different latitudes and longitudes. [ABSTRACT FROM AUTHOR]

Aim: Non‐surgical options for inducing type 2 diabetes remission are limited. We examined whether remission can be achieved by combining lifestyle approaches and short‐term intensive glucose‐lowering therapy. Methods: In this trial, 160 patients with type 2 diabetes on none to two diabetes medications other than insulin were randomised to (a) an intervention comprising lifestyle approaches, insulin glargine/lixisenatide and metformin, or (b) standard care. Participants with glycated haemoglobin (HbA1c) <7.3% (56 mmol/mol) at 12 weeks were asked to stop diabetes medications and were followed for an additional 52 weeks. The primary outcome was diabetes relapse defined as HbA1c ≥6.5% (48 mmol/mol) at 24 weeks or thereafter, capillary glucose ≥10 mmol/L on ≥50% of readings, or use of diabetes medications, analysed as time‐to‐event. Main secondary outcomes included complete or partial diabetes remission at 24, 36, 48 and 64 weeks defined as HbA1c <6.5% (48 mmol/mol) off diabetes medications since 12 weeks after randomisation. A hierarchical testing strategy was applied. Results: The intervention significantly reduced the hazard of diabetes relapse by 43% (adjusted hazard ratio 0.57, 95% confidence interval 0.40‐0.81; p =.002). Complete or partial diabetes remission was achieved in 30 (38.0%) intervention group participants versus 16 (19.8%) controls at 24 weeks and 25 (31.6%) versus 14 (17.3%) at 36 weeks [relative risk 1.92 (95% confidence interval 1.14‐3.24) and 1.83 (1.03‐3.26), respectively]. The relative risk of diabetes remission in the intervention versus control group was 1.88 (1.00‐3.53) at 48 weeks and 2.05 (0.98‐4.29) at 64 weeks. Conclusions: A 12‐week intensive intervention comprising insulin glargine/lixisenatide, metformin and lifestyle approaches can induce remission of diabetes. [ABSTRACT FROM AUTHOR]

UV-B radiation regulates numerous morphogenic, biochemical and physiological responses in plants, and can stimulate some responses typically associated with other abiotic and biotic stimuli, including invertebrate herbivory. Removal of UV-B from the growing environment of various plant species has been found to increase their susceptibility to consumption by invertebrate pests, however, to date, little research has been conducted to investigate the effects of UV-B on crop susceptibility to field pests. Here, we report findings from a multi-omic and genetic-based study investigating the mechanisms of UV-B-stimulated resistance of the crop, Brassica napus (oilseed rape), to herbivory from an economically important lepidopteran specialist of the Brassicaceae, Plutella xylostella (diamondback moth). The UV-B photoreceptor, UV RESISTANCE LOCUS 8 (UVR8), was not found to mediate resistance to this pest. RNA-Seq and untargeted metabolomics identified components of the sinapate/lignin biosynthetic pathway that were similarly regulated by UV-B and herbivory. Arabidopsis mutants in genes encoding two enzymes in the sinapate/lignin biosynthetic pathway, CAFFEATE O-METHYLTRANSFERASE 1 (COMT1) and ELICITOR-ACTIVATED GENE 3–2 (ELI3-2), retained UV-B-mediated resistance to P. xylostella herbivory. However, the overexpression of B. napus COMT1 in Arabidopsis further reduced plant susceptibility to P. xylostella herbivory in a UV-B-dependent manner. These findings demonstrate that overexpression of a component of the sinapate/lignin biosynthetic pathway in a member of the Brassicaceae can enhance UV-B-stimulated resistance to herbivory from P. xylostella. [ABSTRACT FROM AUTHOR]

Background: The critical role that middle managers play in enacting organisational culture change designed to address unprofessional co-worker behaviours has gone largely unexplored. We aimed to explore middle managers' perspectives on i) whether they speak up when they or their team members experience unprofessional behaviours (UBs); ii) how concerns are handled; iii) the outcomes; and iv) the role of a professional accountability culture change program (known as Ethos) in driving change. Methods: Qualitative, constructivist approach. Five metropolitan hospitals in Australia which had implemented Ethos. Purposive sampling was used to invite middle-level managers from medicine, nursing, and non-clinical support services. Semi-structured interviews conducted remotely. Inductive, reflexive thematic and descriptive thematic analyses undertaken using NVivo. Results: Thirty interviews (approximately 60 min; August 2020 to May 2021): Nursing (n = 12), Support Services (n = 10), and Medical (n = 8) staff, working in public (n = 18) and private (n = 12) hospitals. One-third (n = 10) had a formal role in Ethos. All middle managers (hearers) had experienced the raising of UBs by their team (speakers). Themes representing reasons for ongoing UBs were: staying silent but active; history and hierarchy; and double-edged swords. The Ethos program was valued as a confidential, informal, non-punitive system but required improvements in profile and effectiveness. Participants described four response stages: i) determining if reports were genuine; ii) taking action depending on the speaker's preference, behaviour factors (type, frequency, impact), if the person was known/unknown; iii) exploring for additional information; and iv) addressing either indirectly (e.g., change rosters) or directly (e.g., become a speaker). Conclusions: Addressing UBs requires an organisational-level approach beyond supporting staff to speak up, to include those hearing and addressing UBs. We propose a new hearer's model that details middle managers' processes after a concern is raised, identifying where action can be taken to minimise avoidant behaviours to improve hospital culture, staff and patient safety. [ABSTRACT FROM AUTHOR]

This work examines how the dependence structures between energy futures asset prices differ in two periods identified before and after the 2008 global financial crisis. These two periods were characterized by a difference in the number of extraordinary meetings of OPEC countries organized to announce a change of oil production. In the period immediately following the global financial crisis, the decrease in oil prices and oil and gas demand forced OPEC countries to make frequent adjustments to the production of oil, while, since the first quarter of 2010, the recovery led to more regular meetings, with only three organized extraordinary meetings. We propose to use a copula model to study how the dependence structure among energy prices changed among the two periods. The use of copula models allows to introduce flexible and realistic models for the marginal time series; once marginal parameters are estimated, the estimates are used to fit several copula models for all asset combinations. Model selection techniques based on information criteria are implemented to choose the best models both for the univariate asset prices series and for the distribution of co-movements. The changes in the dependence structure of couple of assets are investigated through copula functionals and their uncertainty estimated through a bootstrapping method. We find the strength of dependence between asset combinations considerably differ between the two periods, showing a significant decrease for all the pairs of assets. [ABSTRACT FROM AUTHOR]

Ketamine intravenous therapy (KIT) appears effective for treating depression in controlled trials testing a short series of infusions. A rapidly proliferating number of clinics offer KIT for depression and anxiety, using protocols without a strong evidence basis. Controlled comparison of mood and anxiety from real-world KIT clinics, and the stability of outcomes, is lacking. We performed a retrospective controlled analysis on patients treated with KIT in ten community clinics across the US, between 08/2017‐03/2020. Depression and anxiety symptoms were evaluated using the Quick Inventory of Depressive Symptomatology-Self Report 16-item (QIDS) and the Generalized Anxiety Disorder 7-item (GAD-7) scales, respectively. Comparison data sets from patients who did not undergo KIT were obtained from previously published real-world studies. Of 2758 patients treated, 714 and 836 met criteria for analysis of KIT induction and maintenance outcomes, respectively. Patients exhibited significant and concordant reduction in both anxiety and depression symptoms after induction (Cohen's d = -1.17 and d = -1.56, respectively). Compared to two external datasets of KIT-naive depressed patients or patients starting standard antidepressant therapy, KIT patients experienced a significantly greater reduction in depression symptoms at eight weeks (Cohen's d = -1.03 and d = -0.62 respectively). Furthermore, we identified a subpopulation of late-responders. During maintenance, up to a year post-induction, increases in symptoms were minimal. Due to the retrospective nature of the analyses, interpreting this dataset is limited by incomplete patient information and sample attrition. KIT treatment elicited robust symptomatic relief that remained stable up to one year of follow-up. • Depression and anxiety outcomes data for KIT are highly concordant and stable over time. • Eighty percent of the patients had SI pretreatment and 50% had no SI at all after KIT induction. [ABSTRACT FROM AUTHOR]

Mental health nursing work is challenging, and workplace stress can have negative impacts on nurses' well‐being and practice. Resilience is a dynamic process of positive adaptation and recovery from adversity. The aims of this integrative review were to examine and update understandings and perspectives on resilience in mental health nursing research, and to explore and synthesize the state of empirical knowledge on mental health nurse resilience. This is an update of evidence from a previous review published in 2019. Using integrative review methodology, 15 articles were identified from a systematic search (July 2018–June 2022). Data were extracted, analysed with constant comparison method, synthesized narratively and then compared with the findings from the original review. As an update of evidence, mental health nurse resilience was moderate to high across studies, was positively associated with psychological well‐being, post‐traumatic growth, compassion satisfaction and negatively associated with burnout, mental distress and emotional labour. Lack of support and resources from organizations could negatively impact nurses' ability to maintain resilience and manage workplace challenges through internal self‐regulatory processes. A resilience programme improved mental health nurses' awareness of personal resilience levels, self‐confidence, capacity to develop coping skills and professional relationships. Some studies continue to lack contemporary conceptualizations of resilience, and methodological quality varied from high to low. Further qualitative and interventional research is needed to investigate the role of resilience in mental health nursing practice, personal well‐being, workforce sustainability and the ongoing impacts of the COVID‐19 pandemic. [ABSTRACT FROM AUTHOR]

The article analyzes the period romantic comedy film "EMMA" directed by Autumn de Wilde, adapted from Jane Austen's 1815 novel "Emma." Topics discussed include the portrayal of the film's heroine as a sadist, land shark and reptile, the engagement of the film with Austen and pop culture, and the opposing characters of Emma and Mr. George Knightley.

A model of the spatiotemporal evolution of urban areas is developed that simultaneously includes the effects on household utility of geography, population density, income distribution, and household preference for characteristics of dwellings and neighbors. The result is a utility function whose structure is similar to that of the energy of interacting spin systems in external fields. Spatiotemporal housing market evolution then results via transactions driven by increases in utility and changes in numbers of households and dwellings. It is shown that the model successfully predicts formation of monocentric and polycentric urban areas, stratification by wealth, segregation due to preferences for housing or neighbors, and the balance of supply and demand. These results go well beyond those of prior models that each dealt with subsets of these phenomena, and do so within a single, unified framework. Potential generalizations are discussed and further applications are suggested. [ABSTRACT FROM AUTHOR]

This paper presents an inexhaustive but thorough review of the evidence of violence against persons with disabilities that came before, or ought to have been known to, the prosecutors of the international criminal tribunals for the former Yugoslavia, Rwanda and Sierra Leone. This research demonstrates that despite significant and compelling evidence from investigators, journalists and witnesses, gross violations against persons with disabilities were largely ignored by the prosecution or treated merely as aggravating factors at sentencing. These crimes could instead have been characterized as an "other inhumane act" prosecutable as a crime against humanity, which would have emphasized the gravity of the crimes, provided recognition of the victims' suffering, imposed criminal sanctions on those responsible, and unequivocally condemned violence against persons with disabilities during armed conflict. [ABSTRACT FROM AUTHOR]

Objective The IL-23 p19-subunit inhibitor guselkumab has been previously compared with other targeted therapies for PsA through network meta-analysis (NMA). The objective of this NMA update was to include new guselkumab COSMOS trial data, and two key comparators: the IL-23 inhibitor risankizumab and the Janus kinase (JAK) inhibitor upadacitinib. Material and methods A systematic literature review was conducted to identify randomized controlled trials up to February 2021. A hand-search identified newer agents up to July 2021. Bayesian NMAs were performed to compare treatments on ACR response, Psoriasis Area and Severity Index (PASI) response, modified van der Heijde–Sharp (vdH-S) score, and serious adverse events (SAEs). Results For ACR 20, guselkumab 100 mg every 8 weeks (Q8W) and every 4 weeks (Q4W) were comparable (i.e. overlap in credible intervals) to most other agents, including risankizumab, upadacitinib, subcutaneous TNF inhibitors and most IL-17A inhibitors. For PASI 90, guselkumab Q8W and Q4W were better than multiple agents, including subcutaneous TNF and JAK inhibitors. For vdH-S, guselkumab Q8W was similar to risankizumab, while guselkumab Q4W was better; both doses were comparable to most other agents. Most agents had comparable SAEs. Conclusions Guselkumab demonstrates better skin efficacy than most other targeted PsA therapies, including upadacitinib. For vdH-S, both guselkumab doses are comparable to most treatments, with both doses ranking higher than most, including upadacitinib and risankizumab. Both guselkumab doses demonstrate comparable ACR responses to most other agents, including upadacitinib and risankizumab, and rank favourably in the network for SAEs. [ABSTRACT FROM AUTHOR]

Objectives: The objective of this study was to examine international literature to identify best practices for treatment of opioid dependence in Indigenous contexts. Methods: We utilized a systematic search to identify relevant literature. The literature was analysed using a realist review methodology supported by a two-step knowledge contextualization process, including a Knowledge Holders Gathering to initiate the literature search and analysis, and five consensus-building meetings to focus and synthesize relevant findings. A realist review methodology incorporates an analysis of the complex contextual factors in treatment by identifying program mechanisms, namely how and why different programs are effective in different contexts. Results: A total of 27 sources were identified that met inclusion criteria. Contextual factors contributing to opioid dependence described in the literature often included discussions of a complex interaction of social determinants of health in the sampled community. Twenty-four articles provided evidence of the importance of compassion in treatment. Compassion was evidenced primarily at the individual level, in interpersonal relationships based on nonjudgmental care and respect for the client, as well as in more holistic treatment programs beyond biophysical supports such as medically assisted treatment. Compassion was also shown to be important at the structural level in harm reduction policies. Twenty-five articles provided evidence of the importance of client self-determination in treatment programs. Client self-determination was evidenced primarily at the structural level, in community-based programs and collaborative partnerships based in trust and meaningful engagement but was also shown to be important at the individual level in client-directed care. Identified outcomes moved beyond a reduction in opioid use to include holistic health and wellness goals, such as improved life skills, self-esteem, feelings of safety, and healing at the individual level. Community-level outcomes were also identified, including more families kept intact, reduction in drug-related medical evacuations, criminal charges and child protection cases, and an increase in school attendance, cleanliness, and community spirit. Conclusions: The findings from this realist review indicate compassion and self-determination as key program mechanisms that can support outcomes beyond reduced incidence of substance use to include mitigating systemic health inequities and addressing social determinants of health in Indigenous communities, ultimately healing the whole human being. [ABSTRACT FROM AUTHOR]

Seed dormancy is the key driver regulating seed germination, hence is fundamental to the seedling recruitment life‐history stage and population persistence. However, despite the importance of physical dormancy (PY) in timing post‐fire germination, the mechanism driving dormancy‐break within seed coats remains surprisingly unclear. We suggest that seed coat chemistry may play an important role in controlling dormancy in species with PY. In particular, seed coat fatty acids (FAs) are hydrophobic, and have melting points within the range of seed dormancy‐breaking temperatures. Furthermore, melting points of saturated FAs increase with increasing carbon chain length. We investigated whether fire could influence seed coat FA profiles and discuss their potential influence on dormancy mechanisms.Seed coat FAs of 25 species within the Faboideae, from fire‐prone and fire‐free ecosystems, were identified and quantified through GC–MS. Fatty acid profiles were interpreted in the context of species habitat and interspecific variation.Fatty acid compositions were distinct between species from fire‐prone and fire‐free habitats. Fire‐prone species tended to have longer saturated FA chains, a lower ratio of saturated to unsaturated FA, and a slightly higher relative amount of FAs compared to fire‐free species.The specific FA composition of seed coats of fire‐prone species indicated a potential role of FAs in dormancy mechanisms. Overall, the distinct FA composition between fire‐prone and fire‐free species suggests that chemistry of the seed coat may be under selection pressure in fire‐prone ecosystems. [ABSTRACT FROM AUTHOR]

[Display omitted] • Arrhenius plots with three or four data points underestimate the error of E a. • Minimum five data points are essential to avoid underestimating the error of E a. • R 2 values alone do not give information on the error of E a. • A graphic correlation between E a ± Δ E and the R 2 value was constructed for easy use. • The R 2 together with the number of data points enables the statistical analysis of E a. Arrhenius plots estimate the apparent activation energy (E a) of catalytic reactions. The R -squared value (r 2) often accompanies the Arrhenius plot to support its validity. However, no paper has quantitatively presented the minimum data points and the minimum r 2 to validate the E a. In this study, statistical analysis quantitatively visualized the relationship between the number of data points (n p), r 2, and the reliability of E a. When n p ≧ 5, the risk of underestimating the variance of E a is suppressed significantly, making the E a and its variance more reliable. Furthermore, to claim that two values of E a are statistically different, the minimum required r 2 was formulated and plotted as a function of E a and n p. The proposed formulas couple n p and r 2 to validate E a quantitatively. This method is superior to the empirical method using r 2 alone. This study produces tangible and quantitative guidance to control the reliability of the Arrhenius plot. [ABSTRACT FROM AUTHOR]

Introduction: Efficacy and safety of the Janus kinase (JAK) inhibitor upadacitinib (UPA) was evaluated in patients with psoriatic arthritis (PsA) through week 104 of the ongoing long-term extension of the phase 3 trial SELECT-PsA 1. Methods: Exploratory analyses of all primary and secondary endpoints (non-responder imputation and as observed for binary endpoints; mixed-effect model repeated measures and as observed for continuous endpoints), and summary of treatment-emergent adverse events, in patients receiving UPA 15 mg (UPA15) or 30 mg (UPA30) once daily, or adalimumab 40 mg (ADA) every other week, through week 104 are reported. Results: Of 1704 patients, 25.4% discontinued the study drug by week 104. Proportions of patients achieving ≥ 20%/50%/70% improvement in American College of Rheumatology criteria (ACR20/50/70), ≥ 75%/90%/100% improvement in Psoriasis Area and Severity Index (PASI75/90/100), or minimal disease activity (MDA) were maintained through week 104; greater responses by nominal P value were observed with UPA15 and UPA30 versus ADA for ACR20/50/70 and MDA. Mean change from baseline in modified total Sharp/van der Heijde Score (mTSS) was similar across groups and to week 56 results. The safety profile of UPA was generally comparable to ADA and not altered from week 56 data. Rates of serious infection, herpes zoster, anemia, neutropenia, lymphopenia, and elevated creatine phosphokinase remained numerically higher with UPA15 and/or UPA30 versus ADA. Rates of malignancies excluding non-melanoma skin cancer (NMSC), major adverse cardiovascular events, and venous thromboembolism were similar across groups; rates of NMSC were higher with UPA versus ADA. Two deaths were reported with UPA15, one with UPA30, and one with ADA. Conclusions: In PsA patients, efficacy responses were similar or greater with UPA15 or UPA30 versus ADA through week 104, and inhibition of radiographic progression was maintained. No new safety risks were identified with exposure to UPA through 2 years (week 104). Clinical Trial Registration: ClinicalTrials.gov, NCT03104400. [ABSTRACT FROM AUTHOR]

In response to the unprecedented refugee crisis around the world, a growing body of research has focused on psychological distress among individuals and families forced to flee their homelands. Less attention has been directed toward understanding resilience, adaptation, and growth among this population. This grounded theory study explored the posttraumatic growth experiences of Middle Eastern and Afghan refugees resettled in the United States. The principal researcher conducted 23 interviews with seven couples and 16 individuals aged 25 to 67 years, from Afghanistan, Iraq, Iran, and Syria. This study aimed to explore how refugees understand, process, overcome, and grow from the trauma and adversity they have experienced. Findings were used to delineate a model of the process through which refugees experience posttraumatic growth. The overarching theme of moving forward had five specific growth themes: increased awareness of context; tolerating uncertainty; spiritual/religious attunement; consideration of others; and integrating into society. Findings shed light on the complex process of growth and adaptation in the aftermath of war and forced migration. The model can serve as a tool for clinicians to facilitate more empowering posttraumatic narratives with refugee clients rooted in growth experiences. [ABSTRACT FROM AUTHOR]

It is well known that an asymptotically flat four-dimensional Kerr black hole has a smaller (specific) entropy than a Schwarzschild black hole of the same mass. We show here that the same is true if the temperature, rather than the mass, is held fixed; and we also show that an asymptotically AdS5-Kerr black hole has a smaller specific entropy than an AdS5-Schwarzschild black hole of the same temperature, except in a negligibly small class of special examples. The AdS5-Kerr case is particularly interesting, because here the gauge-gravity duality applies; if we further accept that there is a useful analogy between the strongly coupled field theories dual to AdS black holes and the best-understood example of a strongly coupled fluid (the Quark-Gluon Plasma), then we can apply QGP theory to predict the behaviour of black hole entropy in this case. The prediction agrees with our study of AdS5-Kerr entropy. The hope is that such results might lead ultimately to an identification of black hole microstates. [ABSTRACT FROM AUTHOR]

The current COVID-19 pandemic emphasises the dramatic consequences of emerging zoonotic pathogens and stimulates the need for an assessment of the evolution and natural cycle of such microbes in a "One Health" framework. A number of recent studies have revealed an astonishing diversity of bat-borne coronaviruses, including in insular environments, which can be considered as simplified biological systems suited for the exploration of the transmission cycles of these viruses in nature. In this work, we present two new lineages of Alphacoronaviruses detected by screening the only two extant New Zealand bat species: the lesser short-tailed bat (Mystacina tuberculata) and the long-tailed bat (Chalinolobus tuberculatus). Infection prevalence reaching 60% in long-tailed bats makes this host-pathogen model relevant for the investigation of maintenance mechanisms in a bat reservoir with peculiar physiological adaptations to temperate climates. A phylogenetic analysis shows that these viral lineages do cluster with coronaviruses hosted by bat sister species from Australia, supporting co-diversification processes. These patterns provide an interesting framework for further research aiming at elucidating the natural history and biological cycles of bat-borne coronaviruses. [ABSTRACT FROM AUTHOR]

Bimekizumab is a monoclonal IgG1 antibody that selectively inhibits interleukin (IL)-17A and IL-17F. We assessed the efficacy and safety of bimekizumab in patients with active psoriatic arthritis who were naive to biologic disease-modifying antirheumatic drugs (DMARDs). BE OPTIMAL was a 52-week, phase 3, multicentre, randomised, double-blind, placebo-controlled, active reference (adalimumab) trial done at 135 sites (hospitals, clinics, doctors' offices, and research centres) in 14 countries. Eligible patients were 18 years or older with a documented diagnosis of adult-onset psoriatic arthritis that met the Classification Criteria for Psoriatic Arthritis for at least 6 months before screening. Participants were randomly assigned with an interactive-voice and web-response system on the basis of a predetermined randomisation schedule (3:2:1, stratified by region and bone erosion number at baseline) to bimekizumab 160 mg every 4 weeks, placebo every 2 weeks, or the reference group (adalimumab 40 mg every 2 weeks), all administered subcutaneously. At week 16, patients randomly assigned to placebo switched to bimekizumab 160 mg every 4 weeks. The primary endpoint was the proportion of patients reaching 50% or greater improvement in American College of Rheumatology criteria (ACR50) at week 16 (non-responder imputation). Efficacy analyses included all patients who were randomly assigned (intention-to-treat population); the safety analysis set comprised patients who received one or more doses of treatment. Data are presented to week 24 (preplanned analysis). This trial is registered at ClinicalTrials.gov , NCT03895203. Between April 3, 2019, and Oct 25, 2021, 1163 patients were screened and 852 were randomly assigned to bimekizumab (n=431), placebo (n=281), and reference (adalimumab; n=140) groups. At week 16, significantly more patients receiving bimekizumab (189 [44%] of 431) reached ACR50 response versus placebo (28 [10%] of 281; odds ratio 7·1 [95% CI 4·6–10·9], p<0·0001; adalimumab 64 [46%] of 140). All secondary hierarchical endpoints were met. Treatment-emergent adverse events up to week 16 were reported in 258 [60%] of 431 patients receiving bimekizumab, 139 [49%] of 281 patients receiving placebo, and 83 [59%] of 140 patients receiving adalimumab. No deaths occurred. Bimekizumab treatment had superior improvements in joint, skin, and radiographic efficacy outcomes at week 16 compared with placebo in patients with psoriatic arthritis who were naive to biologic DMARDs. The safety profile of bimekizumab, including the occurrence of fungal infections, was consistent with previous phase 3 studies in patients with plaque psoriasis, and with IL-17A inhibitors. UCB Pharma. [ABSTRACT FROM AUTHOR]

The rapid evolution of in-orbit manufacturing will enable the fabrication of low-cost, large-scale space structures. In particular, the use of 3D printing technologies will remove traditional payload constraints associated with launch vehicles, due to fairing size and launch loads, thus allowing the construction of larger and lighter structures, such as orbiting solar reflectors. These structures will require efficient attitude control systems, able to provide the necessary torque for maneuvers and to counteract perturbations, such as gravity gradient and solar radiation pressure. In this paper, a top-level overview of actuator performances for orbiting solar reflectors is provided, and scaling laws associated with the required actuator mass and input power are developed. For each class of actuator, upper bounds on the maximum size of the structure which can be effectively controlled are presented. The results can also be extended to other classes of large planar Earth-pointing structures such as solar power satellites, solar sails, or large antennae. [ABSTRACT FROM AUTHOR]

Objective: To assess the long‐term safety, tolerability, and efficacy of bimekizumab in active psoriatic arthritis (PsA). Methods: Adult patients with active PsA who completed the double‐ and dose‐blind periods of the BE ACTIVE randomized controlled trial were eligible to enroll in the open‐label extension (OLE) study at week 48, after which patients received 160 mg of bimekizumab every 4 weeks. Safety and efficacy results are presented through 152 weeks. Results: At week 152, 161 of 206 patients (78.2%) remained in the study. From weeks 0–152, 184 of 206 patients experienced ≥1 treatment‐emergent adverse event (126.4 per 100 patient‐years). The most frequent events were nasopharyngitis (7.6 per 100 patient‐years), upper respiratory tract infection (6.8 per 100 patient‐years), bronchitis (3.5 per 100 patient‐years), and oral candidiasis (3.5 per 100 patient‐years). Additionally, 47 of 206 patients had mild to moderate localized fungal infections (9.7 per 100 patient‐years), including 24 of 206 patients who had Candida infections (4.6 per 100 patient years) and 19 of 206 patients who had oral candidiasis (3.5 per 100 patient years). Four patients had serious infections (0.7 per 100 patient‐years); there were no reported cases of active tuberculosis, adjudicated major adverse cardiac events, or deaths. Efficacy demonstrated at week 48 was sustained in the OLE study. At week 152, nonresponder imputation analysis showed that 52.9% of patients (69.4% of observed cases) achieved the American College of Rheumatology criteria for 50% improvement, 57.7% (73.8% of observed cases) achieved 100% skin clearance per the Psoriasis Area and Severity Index, and 51.5% (67.5% of observed cases) achieved minimal disease activity. Patients also maintained improvements in pain, physical function, and health‐related quality of life. Conclusion: The safety profile of bimekizumab was consistent with previous reports, with no new safety signals identified. Sustained joint and efficacy responses were observed over 3 years. Video Abstract [ABSTRACT FROM AUTHOR]

Despite persistent criticism from international human rights bodies and experts, Queensland continues to permit the 'lawful correction' of children as a defence to criminal offences committed against them. The recent introduction of a human rights framework in Queensland further highlights the disconnect between the State's correction defence, contemporary understandings of the deleterious effects of physically punishing children, and children's human rights principles. This article examines that disconnect and the consistency of the Queensland defence with the Human Rights Act 2019 (Qld). To this end, it outlines the current position in the medical and psychological literature that corporal punishment has severe consequences for children. It also explains the scope of the Queensland defence and compares it to other Australian jurisdictions. The article then turns to an analysis of the consistency of the defence with the Human Rights Act. It concludes that the defence offends against human rights guarantees in Queensland, as well as the international framework for children's rights, and identifies avenues for reform. [ABSTRACT FROM AUTHOR]

The article presents the discussion on NASSR/BARS conference, “New Romanticisms,” eventually held at Edge Hill University in August 2022. Topics include exploring the relationship between Wordsworth’s elegiac practice and ecological interests in two poems probing the natural world’s resistance; and creating an inclusive and activist classroom through making links between international experiences of injustice and revolution.

Genetic variants in SLC22A5, encoding the membrane carnitine transporter OCTN2, cause the rare metabolic disorder Carnitine Transporter Deficiency (CTD). CTD is potentially lethal but actionable if detected early, with confirmatory diagnosis involving sequencing of SLC22A5. Interpretation of missense variants of uncertain significance (VUSs) is a major challenge. In this study, we sought to characterize the largest set to date (n = 150) of OCTN2 variants identified in diverse ancestral populations, with the goals of furthering our understanding of the mechanisms leading to OCTN2 loss-of-function (LOF) and creating a protein-specific variant effect prediction model for OCTN2 function. Uptake assays with 14C-carnitine revealed that 105 variants (70%) significantly reduced transport of carnitine compared to wild-type OCTN2, and 37 variants (25%) severely reduced function to less than 20%. All ancestral populations harbored LOF variants; 62% of green fluorescent protein (GFP)-tagged variants impaired OCTN2 localization to the plasma membrane of human embryonic kidney (HEK293T) cells, and subcellular localization significantly associated with function, revealing a major LOF mechanism of interest for CTD. With these data, we trained a model to classify variants as functional (>20% function) or LOF (<20% function). Our model outperformed existing state-of-the-art methods as evaluated by multiple performance metrics, with mean area under the receiver operating characteristic curve (AUROC) of 0.895 ± 0.025. In summary, in this study we generated a rich dataset of OCTN2 variant function and localization, revealed important disease-causing mechanisms, and improved upon machine learning-based prediction of OCTN2 variant function to aid in variant interpretation in the diagnosis and treatment of CTD. [ABSTRACT FROM AUTHOR]

Substantial amounts of money have been invested in peatland restoration over the last decades to address the current challenges of global changes and to enhance biodiversity. Given the magnitude of financial investments and the pressing societal needs, it is essential that appropriate decisions are made about the restoration techniques employed to avoid negative consequences and to optimise the benefits to human society.Based on the knowledge and expertise that has been developed over recent decades, three approaches to peatland restoration are discussed regarding their implications for climate change, nutrient fluxes and biodiversity: peatland inundation, topsoil removal and slow rewetting.Considered over the long term, for instance tens or hundreds of years, rewetted peatlands have the potential to fulfil multiple restoration goals, including those targeting climate change mitigation, water quality protection and species conservation. In short term, ill‐informed decisions on the approach to peatland restoration can generate negative impacts, for instance on the downstream water quality or radiative forcing gas emissions.Synthesis and application. The restoration of peatlands, and the trajectory that any restorative action may take, is a matter of societal choice; however, it is essential that society understands the broad potential benefits and disadvantages that such restoration may have so that evidence‐based choices can be made. [ABSTRACT FROM AUTHOR]

Vaginal lavage cytology is commonly used in rodents to determine oestrous cyclicity and is a requirement for regulatory reproductive toxicity studies. While rats are the preferred species for these studies, where scientifically justified, the mouse is an alternative species. The current study sought to evaluate the utility of day 21 vaginal lavage cytology in the CD-1 mouse for assessment of changes in the murine oestrous cycle. It compared the vaginal lavage technique, using either fresh or fixed and stained cytology smears, with the histological evaluation of the vagina on day 21 of a murine study and examined the results in the context of interpreting data from reproductive toxicity studies conducted in mice. On day 21, concordance between methanol-fixed, Wright-Giemsa-stained vaginal lavage cytology slides and histological examination of the vagina was recorded in 17/24 animals (70.83%). The results also show that vaginal lavage cytology in mice yields variable data with the stages of the oestrous cycle being less clearly discernible. Compared with vaginal lavage cytology, terminal histological examination of the vagina was found to be the most accurate method for determining stage of oestrous. Routine assessment of oestrous cyclicity in mice by vaginal lavage cytology is of questionable value and has animal welfare implications. [ABSTRACT FROM AUTHOR]

This article revisits a paper and from an autoethnographic/critical reflective biographical approach re-examines seven cultural notions or myths, which may encourage ageism. It is framed within my experiential knowledge of caring for my ageing parents, with the tensions and challenges around problematising the value of expertise based on experience, communication, grief, and autonomy and freedom versus safety. The commentary emphasises that by analysing the impact of our personal life experiences, we can start to understand both the intended and unintended consequences of policy and practice affecting those in the fourth age. As a social work educator, I wanted to reflect upon how my tacit experiential knowledge, if made explicit, could impact upon my own and others' learning. The recent death of my father has allowed for a period of reflection on my own caring and indeed my professional social work experience, knowledge, skills and practice. It is argued that the ageing process is unequal as class and socio-economic factors, i.e. geography, age, gender, religion and ethnicity, all play parts in determining how someone ages, and indeed upon the care an individual older person receives. A fuller understanding of negotiating the role of one stakeholder, that of a family carer in the ageing process, is elicited in this paper. [ABSTRACT FROM AUTHOR]

Neuroinflammation has a major role in several brain disorders including Alzheimer's disease (AD), yet at present there are no effective anti-neuroinflammatory therapeutics available. Copper(II) complexes of bis(thiosemicarbazones) (CuII(gtsm) and CuII(atsm)) have broad therapeutic actions in preclinical models of neurodegeneration, with CuII(atsm) demonstrating beneficial outcomes on neuroinflammatory markers in vitro and in vivo. These findings suggest that copper(II) complexes could be harnessed as a new approach to modulate immune function in neurodegenerative diseases. In this study, we examined the anti-neuroinflammatory action of several low-molecular-weight, charge-neutral and lipophilic copper(II) complexes. Our analysis revealed that one compound, a thiosemicarbazone–pyridylhydrazone copper(II) complex (CuL5), delivered copper into cells in vitro and increased the concentration of copper in the brain in vivo. In a primary murine microglia culture, CuL5 was shown to decrease secretion of pro-inflammatory cytokine macrophage chemoattractant protein 1 (MCP-1) and expression of tumor necrosis factor alpha (Tnf), increase expression of metallothionein (Mt1), and modulate expression of Alzheimer's disease-associated risk genes, Trem2 and Cd33. CuL5 also improved the phagocytic function of microglia in vitro. In 5xFAD model AD mice, treatment with CuL5 led to an improved performance in a spatial working memory test, while, interestingly, increased accumulation of amyloid plaques in treated mice. These findings demonstrate that CuL5 can induce anti-neuroinflammatory effects in vitro and provide selective benefit in vivo. The outcomes provide further support for the development of copper-based compounds to modulate neuroinflammation in brain diseases. [ABSTRACT FROM AUTHOR]

Reducing the use of solvents is an important aim of green chemistry. Using micelles self-assembled from amphiphilic molecules dispersed in water (considered a green solvent) has facilitated reactions of organic compounds. When performing reactions in micelles, the hydrophobic effect can considerably accelerate apparent reaction rates, as well as enhance selectivity. Here, we review micellar reaction media and their potential role in sustainable chemical production. The focus of this review is applications of engineered amphiphilic systems for reactions (surface-active ionic liquids, designer surfactants, and block copolymers) as reaction media. Micelles are a versatile platform for performing a large array of organic chemistries using water as the bulk solvent. Building on this foundation, synthetic sequences combining several reaction steps in one pot have been developed. Telescoping multiple reactions can reduce solvent waste by limiting the volume of solvents, as well as eliminating purification processes. Thus, in particular, we review recent advances in "one-pot" multistep reactions achieved using micellar reaction media with potential applications in medicinal chemistry and agrochemistry. Photocatalyzed reactions in micellar reaction media are also discussed. In addition to the use of micelles, we emphasize the process (steps to isolate the product and reuse the catalyst). [ABSTRACT FROM AUTHOR]