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Evolutionary Algorithms (EAs) have been widely employed to solve water resources problems for nearly two decades with much success. However, recent research in hyperheuristics has raised the possibility of developing optimisers that adapt to the characteristics of the problem being solved. In order to select appropriate operators for such optimisers it is necessary to first understand the interaction between operator and problem. This paper explores the concept of EA operator behaviour in real world applications through the empirical study of performance using water distribution networks (WDN) as a case study. Artificial networks are created to embody specific WDN features which are then used to evaluate the impact of network features on operator performance. The method extracts key attributes of the problem which are encapsulated in the natural features of a WDN, such as topologies and assets, on which different EA operators can be tested. The method is demonstrated using small exemplar networks designed specifically so that they isolate individual features. A set of operators are tested on these artificial networks and their behaviour characterised. This process provides a systematic and quantitative approach to establishing detailed information about an algorithm's suitability to optimise certain types of problem. The experiment is then repeated on real-world inspired networks and the results are shown to fit with the expected results. [ABSTRACT FROM AUTHOR]

The present study explores the ability of intracellular bacteria within the renal-inter-renal tissue of the winter skate Leucoraja ocellata to metabolize steroids and contribute to the synthesis of the novel elasmobranch corticosteroid, 1α-hydroxycorticosterone (1α- OH-B). Despite the rarity of C1 hydroxylation noted in the original identification of 1α- OH-B, literature provides evidence for steroid C1 hydroxylation by micro-organisms. Eight ureolytic bacterial isolates were identified in the renal-inter-renal tissue of L. ocellata, the latter being the site of 1α- OH-B synthesis. From incubations of bacterial isolates with known amounts of potential 1α- OH-B precursors, one isolate UM008 of the genus Rhodococcus was seen to metabolize corticosteroids and produce novel products via HPLC analysis. Cations Zn2+ and Fe3+ altered metabolism of certain steroid precursors, suggesting inhibition of Rhodococcus steroid catabolism. Genome sequencing of UM008 identified strong sequence and structural homology to that of Rhodococcus erythropolis PR4. A complete enzymatic pathway for steroid-ring oxidation as documented within other Actinobacteria was identified within the UM008 genome. This study highlights the potential role of Rhodococcus bacteria in steroid metabolism and proposes a novel alternative pathway for 1α- OH-B synthesis, suggesting a unique form of mutualism between intracellular bacteria and their elasmobranch host. [ABSTRACT FROM AUTHOR]

An abstract of the article "The efficacy and safety of tight blood glucose control during heart surgery: a systematic review and meta-analysis," by K. Ng and colleagues is presented.