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All people (and some other animals) have aesthetic responses to sensory stimulation, responses of emotional pleasure or displeasure. These emotions vary from one person and culture to another, yet they share a common mechanism. To survive, an adaptive animal (as opposed to a tropic animal) needs to become comfortable with normality and to have slight abnormalities draw attention to themselves. Walking through a jungle you need to notice a tiger from a single stripe: if you must wait to see the whole animal, you are unlikely to survive. In Homo sapiens, the brain's adaptive neurochemistry does this naturally, partly because the brain's neuronal networks are structured to react efficiently to fractal structures, structures that shape much of nature. In addition, previous associations may turn a slight variation from normal into feelings of either pleasure or danger. The details of these responses—what is normal and what variations feel like—will depend upon an individual's experience, but the mechanism is the same, no matter whether a person is tasting a wine, seeing a face or landscape, or hearing a song. This article is part of the theme issue 'Sensing and feeling: an integrative approach to sensory processing and emotional experience'. [ABSTRACT FROM AUTHOR]

Objectives: To evaluate the advantages of adding acupuncture to standard postoperative pain management for open radical prostatectomy (RP). Materials and methods: A randomized controlled trial (1:1:1) comparing routine postoperative analgesic care (control [CON]) vs the addition of press tack needle acupuncture (ACU) or press tack placebo acupressure (SHAM) for pain management after open RP was performed. A total of 126 patients were enrolled between February 2020 and April 2021. After open RP, the CON group received standard postoperative analgesia, the ACU group received long‐term acupuncture with press tacks at specific points (P‐6, Shenmen and SP‐6) along with standard analgesia, and the SHAM group received placebo press tacks at the same acupuncture points alongside standard analgesia. The primary endpoint was postoperative pain measured on a numeric rating scale, the NRS‐11, calculated as the area under the curve. The cumulative use of routine postoperative analgesics, time to first defaecation, and quality of life were analysed using the Kruskal–Wallis rank sum test, Fisher's exact test, and Pearson's chi‐squared test. Results: The ACU group reported significantly less postoperative pain compared to the SHAM (P = 0.007) and CON groups (P = 0.02). There were no significant difference in median (interquartile range) cumulative pain medication usage, time to first defaecation (CON: 37 [33, 44] h; SHAM: 37 [33, 42] h; ACU: 37 [33, 41] h; P > 0.9), or health status at discharge (EuroQol five‐dimension, five‐level general health assessment questionnaire: CON: 70 [65–83]; SHAM: 70 [60–80]; ACU: 70 [50–80]). Conclusion: Incorporating acupuncture into postoperative pain management can improve patient postoperative outcomes. [ABSTRACT FROM AUTHOR]

Proton transport in aqueous systems occurs by making and breaking covalent bonds, a process that classical force fields cannot reproduce. Various attempts have been made to remedy this deficiency, by valence bond theory or instantaneous proton transfers, but the ability of such methods to provide a realistic picture of this fundamental process has not been fully evaluated. Here we compare an ab initio molecular dynamics (AIMD) simulation of an excess proton in water to a simulation of a classical H3O+ in TIP3P water. The energy gap upon instantaneous proton transfer from H3O+ to an acceptor water molecule is much higher in the classical simulation than in the AIMD configurations evaluated with the same classical potential. The origins of this discrepancy are identified by comparing the solvent structures around the excess proton in the two systems. One major structural difference is in the tilt angle of the water molecules that accept an hydrogen bond from H3O+. The lack of lone pairs in TIP3P produces a tilt angle that is too large and generates an unfavorable geometry after instantaneous proton transfer. This problem can be alleviated by the use of TIP5P, which gives a tilt angle much closer to the AIMD result. Another important factor that raises the energy gap is the different optimal distance in water-water vs H3O+-water H-bonds. In AIMD the acceptor is gradually polarized and takes a hydronium-like configuration even before proton transfer actually happens. Ways to remedy some of these problems in classical simulations are discussed. [ABSTRACT FROM AUTHOR]

Background: Chronic spontaneous urticaria (CSU) is both physically and emotionally stressful, and guideline recommendations are often not optimally implemented in clinical practice. The objective of this study was to provide an overview on the patient journey in CSU and to develop a mathematical model based on solid data. Methods: The journey of CSU patients in Germany was traced through literature review and expert meetings that included medical experts, pharmacists and representatives of patient organizations. The current situation's main challenges in the patient journey (education, collaboration and disease management) were discussed in depth. Then, a probabilistic model was developed in a co‐creation approach to simulate the impact of three potential improvement strategies: (1) patient education campaign, (2) medical professional education programme and (3) implementation of a disease management programme (DMP). Results: Chronic spontaneous urticaria patients are severely burdened by delays in diagnosis and optimal medical care. Our simulation indicates that in Germany, it takes on average of 3.8 years for patients to achieve disease control in Germany. Modelling all three optimization strategies resulted in a reduction to 2.5 years until CSU symptom control. On a population level, the proportion of CSU patients with disease control increased from 44.2% to 58.1%. Conclusions: In principle, effective CSU medications and a disease‐specific guideline are available. However, implementation of recommendations is lagging in practice. The approach of quantitative modelling of the patient journey validates obstacles and shows a clear effect of multiple interventions on the patient journey. The data generated by our simulation can be used to identify strategies for improving patient care. Our approach might helping in understanding and improving the management of patients beyond CSU. [ABSTRACT FROM AUTHOR]

In sociology, the question of what it means to explain social phenomena and how this relates to the purpose of the social sciences is important but nowadays rarely asked. This article elaborates on this question and provides an answer by outlining the program of “explanatory sociology” as a branch of the modern social science approach. It is shown that, in this framework, to explain means to uncover cause‐effect relationships based on models of individuals who are assumed the central force in social life. This idea is taken further to uncover specific challenges that individuals face in social life and how and why they establish and manage (or do not) social forms that help to organize the world from the viewpoint of their abilities and needs. Such action‐oriented explanations have been presented and developed in sociology since its very beginning. Two main forms or logics to construct action‐based explanations are outlined and developed due to the form and function of the used action theory or model. The article contributes to the discussion about the form and task of sociological theorizing by presenting action‐based explanations as a form of sociological theorizing that defines a clear task in exploring challenges in social life and assessing possible forms of coping with them from the perspective of individuals. By doing so, two main ways of broadening explanations are considered and compared in light of what the purpose of sociology might be. [ABSTRACT FROM AUTHOR]

Cellular senescence is associated with various age‐related disorders and is assumed to play a major role in the pathogenesis of osteoarthritis (OA). Based on this, we tested a senolytic combination therapy using Dasatinib (D) and Quercetin (Q) on aged isolated human articular chondrocytes (hACs), as well as in OA‐affected cartilage tissue (OARSI grade 1–2). Stimulation with D + Q selectively eliminated senescent cells in both, cartilage explants and isolated hAC. Furthermore, the therapy significantly promoted chondroanabolism, as demonstrated by increased gene expression levels of COL2A1, ACAN, and SOX9, as well as elevated collagen type II and glycosaminoglycan biosynthesis. Additionally, D + Q treatment significantly reduced the release of SASP factors (IL6, CXCL1). RNA sequencing analysis revealed an upregulation of the anabolic factors, inter alia, FGF18, IGF1, and TGFB2, as well as inhibitory effects on cytokines and the YAP‐1 signaling pathway, explaining the underlying mechanism of the chondroanabolic promotion upon senolytic treatment. Accordingly, stimulation of untreated hAC with conditioned medium of D + Q‐treated cells similarly induced the expression of chondrogenic markers. Detailed analyses demonstrated that chondroanabolic effects could be mainly attributed to Dasatinib, while monotherapeutical application of Quercetin or Navitoclax did not promote the chondroanabolism. Overall, D + Q therapy restored the chondrogenic phenotype in OA hAC most likely by creating a pro‐chondroanabolic environment through the reduction of SASP factors and upregulation of growth factors. This senolytic approach could therefore be a promising candidate for further testing as a disease‐modifying osteoarthritis drug. [ABSTRACT FROM AUTHOR]

Background Chikungunya is a serious and debilitating viral infection with a significant disease burden. VLA1553 (IXCHIQ®) is a live-attenuated vaccine licensed for active immunization for prevention of disease caused by chikungunya virus (CHIKV). Methods Immunogenicity following a single dose of VLA1553 was evaluated in healthy adults aged ≥18 years in two Phase 3 trials [ N  = 656 participants (per protocol analysis set)]. Immunogenicity data to 180 days post-vaccination [geometric mean titres (GMTs), seroresponse rate, seroconversion rate] were pooled for the two trials. A comparison of subgroups based on age, sex, body mass index (BMI), race and baseline seropositivity was included. All analyses were descriptive. Results Most participants were aged 18–64 years (N  = 569/656 [86.7%]), there were slightly more females (N  = 372/656 [56.7%]), most were not Hispanic/Latino (N  = 579/656 [88.3%]), and most were White (N  = 517/656 [78.8%]). In baseline seronegative participants, GMT peaked at Day 29 post-vaccination, and subsequently declined slightly but remained elevated until Day 180. At Days 29, 85 and 180, seroresponse rate was 98.3, 97.7 and 96.4% and seroconversion rate was 98.5, 98.4 and 98.2%. There were no differences in seroresponse rate in participants aged 18–64 years or ≥65 years at Day 29 (98.1 vs 100%), Day 85 (97.4 vs 100%) and Day 180 (96.3 vs 96.5%) nor based on sex, BMI, ethnicity or race. An immune response was shown in a small heterogenous population of baseline seropositive participants, with GMTs showing the same trend as baseline seronegative participants. Conclusions A single dose of VLA1553 elicited a very strong immune response by Day 29 that remained elevated at Day 180 in both baseline seronegative and seropositive participants in a combined evaluation of two Phase 3 trials. The vaccine was similarly immunogenic in participants aged ≥65 years and 18–64 years, and there were no differences based on subgroup analyses for sex, BMI, ethnicity or race. [ABSTRACT FROM AUTHOR]

Metastatic uveal melanoma (mUM) is associated with poor prognosis. Ipilimumab/nivolumab has shown antitumor efficacy in phase II studies. Tebentafusp resulted in longer overall survival (OS) compared to investigator's choice in a phase III study. We sought to describe the radiological response patterns of mUM patients treated with immunotherapy. Patients with mUM treated with ipilimumab/nivolumab and tebentafusp between July 2018 and December 2022, with available radiological assessment per RECISTv1.1 and/or imPERCIST5, were retrospectively identified and included. Progression-free survival (PFS) and OS rates, liver-specific response and pathological assessment in available liver biopsies were evaluated. In the ipilimumab/nivolumab group, median PFS (mPFS) was 2.9 months (95% CI 2.2–28.6) and mOS 28.9 months (95% CI 12.7-NR). Complete (CMR) and partial (PMR) metabolic response per imPERCIST5, and partial response (PR) per RECISTv1.1 were associated with longer PFS and OS by trend, compared to morphologically and metabolically stable or progressive disease. In the tebentafusp group, mPFS was 2.7 months (95% CI 2.2–3) and mOS 18.6 months (95% CI 11.5-NR). PMR and PR were associated with longer PFS by trend. In both treatments, the overall treatment response was associated with the radiological response at the liver site. In available liver tumor biopsies, differences in pathological and radiological responses were noted. ImPERCIST5 and RECIST v1.1 are valuable tools in the radiological response assessment, but both methods display limitations. Accurate biomarkers to stratify patients at risk for disease progression and future translational studies to investigate mechanisms of response and resistance are required. [ABSTRACT FROM AUTHOR]

Background: Neuroendocrine tumors of the small bowel (small intestine neuroendocrine neoplasms, SI-NEN) are the most frequent tumors of the small intestine and approximately 30–40% are still surgically treatable with curative intent at the time of diagnosis. Certain surgical principles must be followed for optimal oncological outcomes and good postoperative quality of life. Methods: Based on international guidelines and own experiences, the locoregional surgical treatment of SI-NENs is presented. Results: Locoregional SI-NENs should always be resected if technically feasible, as only this approach can achieve a long-term cure and even small primary tumors (< 10 mm) often already show lymphatic metastasis. The resectability of SI-NENs and their difficulty depend on the extent of lymphatic metastasis, which should be assessed based on preoperative imaging of the extent around the superior mesenteric artery. Currently, the surgical gold standard for SI-NENs is open surgery with bidigital palpation of the entire small intestine followed by primary tumor resection via small bowel segment resection, right hemicolectomy or ileocecal resection and vessel-sparing, and therefore organ-preserving lymphadenectomy (≥ 8 lymph nodes). The guidelines consider that laparoscopic or robotic approaches are justified only for early stages of SI-NENs. Conclusion: Guideline-compliant surgical treatment of locoregional SI-NEN enables recurrence-free long-term survival with good quality of life. [ABSTRACT FROM AUTHOR]

Pediatric residents care for dying children during training. Few educational efforts focus on helping trainees better understand their own grief process and the supports available to them and their patients' families. This work aims to assess pediatric residents' needs and preferences for content included in a curriculum on grief and bereavement. Pediatric residents, at a single institution, completed an electronic survey in Spring 2023 on how they cope with patient deaths and their preferences on content in a proposed grief and bereavement curriculum. The survey was emailed to 165 current or recent trainees; 71 surveys were fully completed (43% response rate). Most respondents (63/71, 89%) indicated that a formalized bereavement curriculum for pediatric residents is important. The resources most frequently utilized by residents following a pediatric death included peer support (59/71, 83%), attending a debrief coordinated by residency leadership or the supportive care division (38/71, 54%), and reading a patient's obituary (23/71, 32%). The most desired content areas were institutional services provided to bereaved families (66/71, 93%), unique aspects of healthcare professional grief (58/71, 82%), and experiences of bereaved families hearing from providers after their child's death (56/71, 79%). Pediatric residents indicate a strong desire for structured curricula on grief and bereavement focusing on resources that exist for families, approaches to grieving as a healthcare professional, and better understanding the experiences of bereaved families. These data may inform educators on priorities in training and support of pediatric residents on grief and bereavement. [ABSTRACT FROM AUTHOR]

Bimetallic PtRu/C catalysts have been prepared by depositing Ru onto a commercial Pt/C catalyst and subsequent thermal annealing. Different Pt : Ru ratios of 1 : 1, 2 : 1, 4 : 1, 8 : 1, and 16 : 1 have been investigated with annealing temperatures of 350 and 500 °C. Using X‐ray diffraction (XRD), synchrotron powder X‐ray diffraction (SPXRD) combined with pair distribution function (PDF) analysis and scanning transmission electron microscopy with energy dispersive X‐ray spectrum imaging (STEM‐EDXS), we show that diffusion of Ru into the fcc crystal structure of the Pt nanoparticles takes place during thermal annealing. Partial segregation and the formation of Pt nanoclusters on the bimetallic surface was observed depending on the Pt : Ru ratio. The annealing process does not only cause a high Pt dispersion but also affects the electronic structure of the Pt surface by broadening the d‐band thus facilitating the product's desorption from the surface of the bimetallic particle. These beneficial effects have been exemplified for the catalytic dehydrogenation of dicyclohexylmethanol, a promising hydrogen carrier compound with 7.2 wt% hydrogen capacity. The most active catalyst material among the tested supported alloys and monometallic reference materials was Pt4Ru1/C after annealing at 500 °C, which increased the hydrogen release productivity by 65 % compared to the unmodified Pt/C catalyst. [ABSTRACT FROM AUTHOR]

The United States emerged as a naval competitor of Great Britain after the First World War. American naval ambitions exasperated Winston Churchill, who saw this challenge threatening Britain's position as the world's leading sea power. Faced by America's growing economy and navy, Churchill lamented Britain's decline as a world power. He confided to his wife Clementine: 'Poor old England – she is being slowly but surely forced into the shade'. Despite America's undoubted economic strength, Churchill was determined that Britain stay ahead of the United States in the naval arms race. My article examines Churchill's views about America's growing naval power and Britain's ability to compete against the United States. Examining Churchill's views in this period provides an opportunity to explore the question of how the leading world power responded to a rising international great-power challenger. [ABSTRACT FROM AUTHOR]

The article in Diplomacy & Statecraft honors the life and work of Brian McKercher, a scholar in international history. McKercher's research focused on themes such as great powers, diplomacy, and the impact of leaders on history. His contributions to understanding British-American relations during the interwar period have been significant, and he has also made a mark as an editor and teacher in the field. The article serves as a tribute to McKercher's dedication to the study of war and peace, acknowledging his influence as a mentor and colleague in the academic community. [Extracted from the article]

Purpose: The evaluation of treatment success and progression in oncology patient-reported outcomes (PROs) is playing an increasingly important role. Meanwhile, PROs are a component of the certification requirements of the German Cancer Society for oncology centers. PROs are used to provide supportive therapy. There is currently no instrument that fully covers the requirements. At the University Hospital Regensburg (UKR), a digital ONCOlogical-ROUTinE-Screening (ONCO-ROUTES) procedure was developed in order to assess the need for supportive therapy in a standardized way and to provide patients with supportive interventions tailored to their needs. Methods: On the basis of current requirements and guidelines, the development of ONCO-ROUTES was supported by experts in focus groups and interviews, and digitalization was carried out in connection with the IT infrastructure. Results: A Needs-based, Quality-of-life (QoL) and Symptoms Screening (NQS2) tool already established in the routine at the UKR was further developed into ONCO-ROUTES, which is made up of the domains therapy phase, nutrition, tobacco use, alcohol use, quality of life, general condition/functional status, physical activity, psychooncology, social services, and further support needs. By linking the digitized questionnaire to the hospital information system, the results are available for immediate use in routine operations and thus for the referral of patients for further supportive therapy. Conclusion: The digital PRO application ONCO-ROUTES is designed to involve patients in monitoring additional supportive needs and thus, improves supportive interdisciplinary treatment. [ABSTRACT FROM AUTHOR]

This article examines the interplay of the maturation of the EU's identity as an international foreign and security actor with the institutionalisation of its foreign and security architecture. While the formal policy- and decision-making modes within the CFSP/CSDP have changed little during the past 25 years, the EU's international identity did still change over time, potentially indicating a "coming of age". How can we explain this maturation of the EU's foreign and security identity despite the critique of the EU's inefficiency and lack of adequateness in security policy? By means of re-interpreting existing scholarship, we argue that the relative maturation of the EU's foreign and security identity since the Lisbon Treaty is not so much linked to formal institutional change ("maturation by design"), but rather to changing informal institutional practice and the selection and use of respective instruments ("maturation by practice"). This dynamic, we argue, is due to an interplay of internal and external factors, accompanied by ongoing socialisation of member states in how they perceive the nature of the CFSP/CSDP and the EU as an international foreign and security actor. [ABSTRACT FROM AUTHOR]

The Russian invasion of Ukraine has brought war back to the European continent and led to considerable change in EU member states' foreign policies. The consequential degree of EU foreign policy unity, as well as shifts in long-lasting national and collective security and defence taboos, has represented a significant departure from past practices. We use these processes of change as a starting point to set the scene for this special issue and to inform its main research question: in what manner, if at all, has the EU come of age as a foreign and security actor during Russia's war on Ukraine? This introduction situates the main question of the special issue into the wider scholarly debates on actorness and the EU's geopolitical ambitions. It conceptually develops the analogy of "coming of age" to examine a prospective maturation process of the EU as a foreign and security actor. In doing so, it not only interrogates what the EU as a mature foreign and security actor would look like, but it also develops the framework, identifies four maturation processes and reflects on necessary caveats for drawing inferences about the state of maturation of the EU as foreign and security actor. [ABSTRACT FROM AUTHOR]

Recent agenda-setting studies have increasingly replaced survey data with readily available, nonreactive data that at first glance might serve as indicators of the public agenda to the same extent: the amount of online search queries regarding an issue and the volume of donations for non-profit organizations that are collecting money for problem solving related to an issue. This raises the question of whether the results of agenda-setting studies depend on which of these indicators is used to measure the public agenda. In this study, we compare the agenda-setting effect of media coverage of migration on the public salience of this issue in Germany between 2015 and 2020 as measured by three different indicators of the public agenda on a monthly basis: survey data, Google Trends data, and fundraising data. Our analyses show significant simultaneous correlations between the media agenda and all three indicators of the public agenda, with a smaller influence of the media agenda on fundraising data than in the other two cases. However, when Granger causality is used to identify causal relationships, a positive influence of the media agenda on the public agenda is only found when the public agenda is measured with survey data. [ABSTRACT FROM AUTHOR]

Introduction: In chronic spontaneous urticaria (CSU), interleukin (IL)-4 and IL-13 may promote mast cell activation directly via IL-4 receptor expression, or indirectly via upregulated immunoglobulin E (IgE) production. Dupilumab significantly improved CSU signs and symptoms in the phase 3, randomized, placebo-controlled LIBERTY-CSU CUPID Study A. This analysis explores the impact of dupilumab on CSU signs and symptoms and serum IgE levels in patients from LIBERTY-CSU CUPID Study A with serum total IgE above and below 100 IU/mL at baseline. Methods: Patients with H1-antihistamine-refractory CSU received dupilumab (n = 70) or placebo (n = 68) for 24 weeks. Efficacy endpoints were change from baseline to weeks 12 and 24 in serum total IgE levels, Itch Severity Score over 7 days (ISS7), Urticaria Activity Score over 7 days (UAS7), and Hives Severity Score over 7 days (HSS7) in dupilumab- or placebo-treated patients with serum total IgE above and below 100 IU/mL at baseline. Results: Dupilumab treatment significantly reduced median (interquartile range) IgE levels at week 12 [dupilumab: −31.9% (−41.9; −22.6); placebo: −6.3% (−21.3; 14.9)] and week 24 [dupilumab: −48.2% (−56.8; − 39.5); placebo: − 6.3% (−34.5; 14.8)]. Similar IgE reductions relative to baseline were observed in dupilumab-treated patients regardless of baseline IgE level. Dupilumab treatment improved ISS7, UAS7, and HSS7 over 12 and 24 weeks, regardless of baseline serum IgE level (interaction p ≥ 0.59 for all treatment by subgroup comparisons), with weak correlations (r < 0.2) observed between IgE level changes and ISS7, UAS7, and HSS7 outcomes. Conclusions: Dupilumab significantly improved CSU signs and symptoms and reduced serum IgE, regardless of baseline IgE levels. In the current analysis, baseline total IgE had no predictive value as a dupilumab treatment response biomarker in CSU. Downregulation of IgE, a key mediator of mast cell activation and histamine release, may at least partially explain the effectiveness of dupilumab in reducing CSU signs and symptoms. Trial Registration: ClinicalTrials.gov Identifier: NCT04180488. [ABSTRACT FROM AUTHOR]

Chronic inducible urticaria (CIndU) is a condition characterized by the formation of itchy wheals and/or angioedema in response to specific triggers. It accounts for 20-30% of all cases of chronic urticaria. The triggers for CIndU can be physical or non-physical, such as mechanical friction, exposure to cold or heat, pressure, or specific agents. The diagnosis of CIndU is based on a thorough patient history and provocation testing. Treatment options include antihistamines and, in some cases, off-label use of omalizumab. Managing CIndU involves measuring and monitoring disease activity, mitigating triggers, and using medication. [Extracted from the article]

Chronic spontaneous urticaria (CSU) is a debilitating, inflammatory skin condition characterized by infiltrating immune cells. Available treatments are limited to improving the signs and symptoms. There is an unmet need to develop therapies that target disease‐driving pathways upstream of mast cell activation to inhibit or delay the progression of CSU and associated comorbidities. Here, we aim to define disease modification due to a treatment intervention and criteria that disease‐modifying treatments (DMTs) must meet in CSU. We have defined disease modification in CSU as a favorable treatment‐induced change in the underlying pathophysiology and, therefore, the disease course, which is clinically beneficial and enduring. A DMT must fulfil the following criteria: (1) prevents or delays the progression of CSU, (2) induces long‐term, therapy‐free clinical remission, which is the sustained absence of CSU signs and symptoms without the need for treatment, and (3) affects the underlying mechanism of CSU, as demonstrated by an effect on disease‐driving signals and/or a biomarker. DMTs in CSU should slow disease progression, achieve long‐lasting disease remission, target disease‐driving mechanisms, reduce mast cell‐activating IgE autoantibodies, target cytokine profile polarization, and normalize the gut microbiome and barrier. Treating CSU at the immune system level could provide valuable alternatives to pharmacotherapy in CSU management. Specific DMTs in CSU are yet to be developed, but some show potential benefits, such as inhibitors of Bruton's Tyrosine Kinase, IL‐4 and IL‐13. Future therapies could prevent CSU signs and symptoms, achieve long‐term clinical benefits after discontinuing treatment, and prevent associated concomitant disorders. [ABSTRACT FROM AUTHOR]

Aim: Global change, especially landscape simplification, is a main driver of species loss that can alter ecological interaction networks, with potentially severe consequences to ecosystem functions. Therefore, understanding how landscape simplification affects the rate of loss of plant–pollinator interaction diversity (i.e., number of unique interactions) compared to species diversity alone, and the role of persisting abundant pollinators, is key to assess the consequences of landscape simplification on network stability and pollination services. Location: France, Germany, and Switzerland. Methods: We analysed 24 landscape‐scale plant–pollinator networks from standardised transect walks along landscape simplification gradients in three countries. We compared the rates of species and interaction diversity loss along the landscape simplification gradient and then stepwise excluded the top 1%–20% most abundant pollinators from the data set to evaluate their effect on interaction diversity, network robustness to secondary loss of species, and flower visitation frequencies in simplified landscapes. Results: Interaction diversity was not more vulnerable than species diversity to landscape simplification, with pollinator and interaction diversity showing similar rates of erosion with landscape simplification. We found that 20% of both species and interactions are lost with an increase of arable crop cover from 30% to 80% in a landscape. The decrease in interaction diversity was partially buffered by persistent abundant generalist pollinators in simplified landscapes, which were nested subsets of pollinator communities in complex landscapes, while plants showed a high turnover in interactions across landscapes. The top 5% most abundant pollinator species also contributed to network robustness against secondary species loss but could not prevent flowers from a loss of visits in simplified landscapes. Main Conclusions: Although persistent abundant pollinators buffered the decrease in interaction diversity in simplified landscapes and stabilised network robustness, flower visitation frequency was reduced, emphasising potentially severe consequences of further ongoing land‐use change for pollination services. [ABSTRACT FROM AUTHOR]

This meta-analysis synthesizes 49 standardized mean-change differences between control and treatment groups as effect sizes from 28 independent studies, investigating the efficacy of existing reading interventions on literacy skills for Chinese children. Six potentially important moderators were considered in this study. These moderators included intervention outcome, intervention method, intervention timing, participant type, intervention form, and intervention implementer. Overall, the existing reading intervention significantly impacted Chinese children’s literacy achievement (g = 0.68). Different intervention methods showed somehow different effects on literacy outcomes. Specifically, fluency training (g = 1.78) appeared as the most effective intervention method with a large effect. Working memory training (g = 0.80), phonological training (g = 0.69), orthographic training (g = 0.70), and morphological training (g = 0.66) had significant and medium effects on improving literacy skills of Chinese children. In addition, reading intervention improved literacy skills of older children (g = 0.90) and younger children (g = 0.63) comparably. However, children with dyslexia (g = 0.87) seemed to benefit more than typically developing children (g = 0.49) from reading interventions. Reading interventions seemed to have a better effect on word spelling (g = 0.93) than word reading (g = 0.63). Interventions delivered in group (g = 0.78) seemed to be more effective than interventions delivered individually (g = 0.45). Children gained more from interventions administered by researchers (g = 0.85) or combined implementers (g = 1.11) than by parents (g = 0.27). These findings suggest that appropriate reading interventions are effective and essential for improving the literacy outcomes of Chinese children, but the efficacy might be different depending on the intervention methods, children’s literacy status, outcome measures, and intervention settings. [ABSTRACT FROM AUTHOR]

Attempts to create a novel Mg−Be bond by reaction of [(DIPePBDI*)MgNa]2 with Be[N(SiMe3)2]2 failed; DIPePBDI*=HC[(tBu)C=N(DIPeP)]2, DIPeP=2,6‐Et2C‐phenyl. Even at elevated temperatures, no conversion was observed. This is likely caused by strong steric shielding of the Be center. A similar reaction with the more open Cp*BeCl gave in quantitative yield (DIPePBDI*)MgBeCp* (1). The crystal structure shows a Mg−Be bond of 2.469(4) Å. Homolytic cleavage of the Mg−Be bond requires ΔH=69.6 kcal mol−1 (cf. CpBe−BeCp 69.0 kcal mol−1 and (DIPPBDI)Mg−Mg(DIPPBDI) 55.8 kcal mol−1). Natural‐Population‐Analysis (NPA) shows fragment charges: (DIPePBDI*)Mg +0.27/BeCp* −0.27. The very low NPA charge on Be (+0.62) compared to Mg (+1.21) and the strongly upfield 9Be NMR signal at −23.7 ppm are in line with considerable electron density on Be and the formal oxidation state assignment of MgII−Be0. Despite this Mgδ+−Beδ− polarity, 1 is extremely thermally stable and unreactive towards H2, CO, N2, cyclohexene and carbodiimide. It reacted with benzophenone, azobenzene, phenyl acetylene, CO2 and CS2. Reaction with 1‐adamantyl azide led to reductive coupling and formation of an N6‐chain. The azide reagent also inserted in the Cp*−Be bond. The inertness of 1 is likely due to bulky ligands protecting the Mg−Be unit. [ABSTRACT FROM AUTHOR]

CeO2‐supported noble metal clusters are attractive catalytic materials for several applications. However, their atomic dispersion under oxidizing reaction conditions often leads to catalyst deactivation. In this study, the noble metal cluster formation threshold is rationally adjusted by using a mixed CeO2‐Al2O3 support. The preferential location of Pd on CeO2 islands leads to a high local surface noble metal concentration and promotes the in situ formation of small Pd clusters at a rather low noble metal loading (0.5 wt %), which are shown to be the active species for CO conversion at low temperatures. As elucidated by complementary in situ/operando techniques, the spatial separation of CeO2 islands on Al2O3 confines the mobility of Pd, preventing the full redispersion or the formation of larger noble metal particles and maintaining a high CO oxidation activity at low temperatures. In a broader perspective, this approach to more efficiently use the noble metal can be transferred to further systems and reactions in heterogeneous catalysis. [ABSTRACT FROM AUTHOR]

CeO2‐supported noble metal clusters are attractive catalytic materials for several applications. However, their atomic dispersion under oxidizing reaction conditions often leads to catalyst deactivation. In this study, the noble metal cluster formation threshold is rationally adjusted by using a mixed CeO2‐Al2O3 support. The preferential location of Pd on CeO2 islands leads to a high local surface noble metal concentration and promotes the in situ formation of small Pd clusters at a rather low noble metal loading (0.5 wt %), which are shown to be the active species for CO conversion at low temperatures. As elucidated by complementary in situ/operando techniques, the spatial separation of CeO2 islands on Al2O3 confines the mobility of Pd, preventing the full redispersion or the formation of larger noble metal particles and maintaining a high CO oxidation activity at low temperatures. In a broader perspective, this approach to more efficiently use the noble metal can be transferred to further systems and reactions in heterogeneous catalysis. [ABSTRACT FROM AUTHOR]

Attempts to create a novel Mg−Be bond by reaction of [(DIPePBDI*)MgNa]2 with Be[N(SiMe3)2]2 failed; DIPePBDI*=HC[(tBu)C=N(DIPeP)]2, DIPeP=2,6‐Et2C‐phenyl. Even at elevated temperatures, no conversion was observed. This is likely caused by strong steric shielding of the Be center. A similar reaction with the more open Cp*BeCl gave in quantitative yield (DIPePBDI*)MgBeCp* (1). The crystal structure shows a Mg−Be bond of 2.469(4) Å. Homolytic cleavage of the Mg−Be bond requires ΔH=69.6 kcal mol−1 (cf. CpBe−BeCp 69.0 kcal mol−1 and (DIPPBDI)Mg−Mg(DIPPBDI) 55.8 kcal mol−1). Natural‐Population‐Analysis (NPA) shows fragment charges: (DIPePBDI*)Mg +0.27/BeCp* −0.27. The very low NPA charge on Be (+0.62) compared to Mg (+1.21) and the strongly upfield 9Be NMR signal at −23.7 ppm are in line with considerable electron density on Be and the formal oxidation state assignment of MgII−Be0. Despite this Mgδ+−Beδ− polarity, 1 is extremely thermally stable and unreactive towards H2, CO, N2, cyclohexene and carbodiimide. It reacted with benzophenone, azobenzene, phenyl acetylene, CO2 and CS2. Reaction with 1‐adamantyl azide led to reductive coupling and formation of an N6‐chain. The azide reagent also inserted in the Cp*−Be bond. The inertness of 1 is likely due to bulky ligands protecting the Mg−Be unit. [ABSTRACT FROM AUTHOR]

Introduction: Accidental caustic burns of the esophagus in children represent a significant global health challenge, often necessitating esophageal reconstruction. The aim of this study is to compare the efficacy and morbidity related to esophagus replacement with colonic and gastric tube transplants in a pediatric population followed for caustic stenosis. Methods: This retrospective study was conducted at a tertiary pediatric surgery unit for children treated from January 1989 to December 2022. We compared colonic and gastric tube esophageal replacement. Short term (within 30 days) and mid-term outcomes and complications were reviewed. Statistical evaluation was considered using a Chi-square test for categorical data analysis. Results: A total of 124 children with caustic esophageal burns were included. Among them, 23 (18.5%) had a gastric tube transplant for esophagus replacement and 101 (81.5%) a colonic transplant. During surgical intervention, we found a significantly higher risk of complications when using a colonic transplant (34%, p < 0.001). There was no significant statistical difference in postoperative short term and mid-term complications between the two techniques. Twenty-six (26%) of the children required a reoperation, with a higher risk in the gastric tube transplant group (p < 0.001). Endoscopic dilatation after surgery was also performed on a higher number of children who had received a gastric tube transplant (p = 0.005). Overall, 97.6% recovered full normal oral feeding. Conclusions: We found that colonic and gastric tube replacement are both good options for pediatric esophageal replacement after a caustic injury and show effectiveness over time. Gastric tube transplants carried a slightly higher risk of reoperations and a higher number of dilatations post-surgery. However, our groups are not really comparable, due to the much higher number of colonic transplants. Both surgical options have to be considered during surgery, and the choice depends on the anatomy of the patient. Our future research will focus on assessing long term quality of life and the potential risk of neoplastic complications. [ABSTRACT FROM AUTHOR]

This article examines historical institutionalism as a means to overcome the theoretical deficit in comparative vocational education and training (VET) research. While contributions to this field of research have extensively analysed changes in VET systems, they have often not adequately explained such processes. The article therefore argues that historical institutionalism has significantly contributed to a broader theoretical discussion within comparative VET research. However, it also points out that the application of this approach encounters clear limitations, as long as the role of educational actors and institutions at various implementation levels are not more systematically integrated into the comparative analysis of VET systems. [ABSTRACT FROM AUTHOR]

In this pilot study, the authors investigated the preliminary effectiveness of the digital lifestyle intervention, actensio (mementor DE GmbH), in treating arterial hypertension. Adults with arterial hypertension were randomly assigned to an intervention group (actensio + standard care) or a control group (waiting list + standard care) in a 1:1 ratio. Primary and secondary endpoints were assessed at baseline (t0) and 3 months post‐randomization (t1). The primary endpoint was average systolic blood pressure, measured at home for 1 week. Secondary endpoints included patient engagement (measured using the "patient activation measure"; PAM‐13), average diastolic blood pressure, and heart rate. All endpoints were analyzed using ANCOVA models, following an intention‐to‐treat approach, while adjusting for baseline values. Missing data were estimated using multiple imputation models. A total of N = 102 participants (f = 59, age = 52.94 ± 9.01) were randomized to either the intervention (IG; N = 52) or the control group (CG; N = 50), of which N = 80 completed the blood pressure diary, and N = 81 the PAM‐13 at t1. Between‐group comparisons showed an average group difference in systolic blood pressure of −5.06 mm Hg (95% CI = −8.71 to −1.41, p =.013) between the intervention group (M = 137.37 ± 10.13) and the control group (M = 142.35 ± 11.23). Average group difference for patient engagement was 3.35 points with a trend towards statistical significance (95% CI = −018 to 6.89, p =.064), favoring the intervention group (MIG = 79.38 ± 9.44 vs. MCG = 75.45 ± 10.62). There were no group differences in diastolic blood pressure (−1.78 mm Hg; 95% CI = −4.50 to 0.95, p =.402) and heart rate (−0.684; 95% CI = −3.73 to 2.36, p = 0.683). The results of the present pilot study confirm the preliminary effectiveness of the digital lifestyle intervention, actensio, in reducing high blood pressure in patients with hypertension. [ABSTRACT FROM AUTHOR]

Differential search trees can be used for selection with replacement and for a form of selection without replacement. We show that they can be extended to many different types of selection, both with and without replacement. In addition, virtually every aspect of a differential search tree can be modified dynamically. We provide algorithms for making these modifications. Virtually all differential search tree algorithms are straightforward and easy to implement, especially with our preferred implementation, which is both simple and efficient. Differential search tree operations are virtually all logarithmic with the exception of building the tree and dynamically adding leaves to the tree, which are both linear. [ABSTRACT FROM AUTHOR]

2‐tetrelavinylidenes (C=EH2; E=Si, Ge) are according to quantum chemical studies the least stable isomers on the [E,C,2H] potential energy hypersurface isomerizing easily via the trans‐bent tetrelaacetylenes HE≡CH to the thermodynamically most stable 1‐tetrelavinylidenes (E=CH2). Consequently, experimental studies on 2‐tetrelavinylidenes (C=ER2) and their derivatives are lacking. Herein we report experimental and theoretical studies of the first N‐heterocyclic carbene (NHC) supported 2‐silavinylidene (NHC)C=SiBr(Tbb) (1‐Si: NHC=C[N(Dipp)CH]2, Dipp=2,6‐diisopropylphenyl, Tbb=2,6‐bis[bis(trimethylsilyl)methyl]‐4‐tert‐butylphenyl) and the isovalent 2‐germavinylidenes (NHC)C=GeBr(R) (1‐Ge, 1‐GeMind: R=Tbb, Mind (1,1,3,3,5,5,7,7‐octamethyl‐s‐hydrindacene‐4‐yl)). The NHC‐supported 2‐tetrelavinylidenes were obtained selectively from the 1,2‐dibromoditetrelenes (E)‐(R)BrE=EBr(R) using the diazoolefin (NHC)CN2 as vinylidene transfer reagent. 1‐E (E=Si, Ge) have a planar vinylidene core, a bent‐dicoordinated vinylidene carbon atom (CVNL), a very short E=CVNL bond and an almost orthogonal orientation of the NHC five‐membered ring to the vinylidene core. Quantum chemical analysis of the electronic structures of 1‐E suggest a significantly bent 1‐tetrelaallene and tetrelyne character. NMR studies shed light into the dynamics of 1‐E involving NHC‐rotation around the CVNL−CNHC bond with a low activation barrier. Furthermore, the synthetic potential of 1‐E is demonstrated by the synthesis and full characterization of the unprecedented NHC‐supported bromogermynes BrGe=C(EBr2Tbb)(NHC) (2‐SiGe: E=Si; 2‐GeGe: E=Ge). [ABSTRACT FROM AUTHOR]

2‐tetrelavinylidenes (C=EH2; E=Si, Ge) are according to quantum chemical studies the least stable isomers on the [E,C,2H] potential energy hypersurface isomerizing easily via the trans‐bent tetrelaacetylenes HE≡CH to the thermodynamically most stable 1‐tetrelavinylidenes (E=CH2). Consequently, experimental studies on 2‐tetrelavinylidenes (C=ER2) and their derivatives are lacking. Herein we report experimental and theoretical studies of the first N‐heterocyclic carbene (NHC) supported 2‐silavinylidene (NHC)C=SiBr(Tbb) (1‐Si: NHC=C[N(Dipp)CH]2, Dipp=2,6‐diisopropylphenyl, Tbb=2,6‐bis[bis(trimethylsilyl)methyl]‐4‐tert‐butylphenyl) and the isovalent 2‐germavinylidenes (NHC)C=GeBr(R) (1‐Ge, 1‐GeMind: R=Tbb, Mind (1,1,3,3,5,5,7,7‐octamethyl‐s‐hydrindacene‐4‐yl)). The NHC‐supported 2‐tetrelavinylidenes were obtained selectively from the 1,2‐dibromoditetrelenes (E)‐(R)BrE=EBr(R) using the diazoolefin (NHC)CN2 as vinylidene transfer reagent. 1‐E (E=Si, Ge) have a planar vinylidene core, a bent‐dicoordinated vinylidene carbon atom (CVNL), a very short E=CVNL bond and an almost orthogonal orientation of the NHC five‐membered ring to the vinylidene core. Quantum chemical analysis of the electronic structures of 1‐E suggest a significantly bent 1‐tetrelaallene and tetrelyne character. NMR studies shed light into the dynamics of 1‐E involving NHC‐rotation around the CVNL−CNHC bond with a low activation barrier. Furthermore, the synthetic potential of 1‐E is demonstrated by the synthesis and full characterization of the unprecedented NHC‐supported bromogermynes BrGe=C(EBr2Tbb)(NHC) (2‐SiGe: E=Si; 2‐GeGe: E=Ge). [ABSTRACT FROM AUTHOR]

Modern analytical techniques enable researchers to study heterogeneous catalytic systems at extended length scales and with local probing methods which were previously impractical. Such spatially–resolved analyses are ideal for exploring the complex dynamics governing catalytic activity, and more specifically, deactivation. Here we highlight significant experimental concepts and milestones in the spatially–resolved analysis of technical catalysts, where it is now possible to study catalyst behavior even up to industrially relevant scale. At such extended length scales and in contrast to many model systems, spatial heterogeneities in solid catalyst bodies may play a crucial role in controlling catalytic properties and may be closely linked to catalyst deactivation. Spatially–resolved studies can therefore provide a unique source of information about such local phenomena. Researchers can gain a deeper insight into the operational life of a catalyst by understanding deactivation patterns, which are one of many factors influencing the dynamics of catalytic reactions. In turn, this information promotes the design of more robust and sustainable catalytic systems. We therefore outline the current state of spatially–resolved characterization, together with its role in deconvoluting the complexity of technical catalysts and their deactivation. [ABSTRACT FROM AUTHOR]

AbstractAs part of the German site selection procedure for deep geological disposal of high-level radioactive waste (HLW), an investigation, according to federal regulations, must be undertaken into whether potential sites for HLW are also suitable for the additional disposal of low- and intermediate-level radioactive waste (L/ILW) at the same site in a separate repository area. In order to assess this option, the mutual influences that could emanate from the two different repository areas need to be examined.To this end the GemEnd research project has investigated the identification and assessment of processes that could arise from a repository at the same site for both HLW and L/ILW. The research project was carried out on behalf of the Federal Office for the Safety of Nuclear Waste Management (BASE).The present paper provides a brief overview of international concepts for a combined repository and their findings on potential safety-relevant processes and the resulting minimum safety distances between the repository areas in the respective host rock. These potentially safety-relevant thermal, hydraulic, mechanical, chemical, and biological processes are compared with the results of the GemEnd research project for the three host rock types permitted in Germany, namely, rock salt, clay rock, and crystalline rock.Finally, similarities and differences in the joint disposal concepts and the international investigations into the extent of the identified processes are analyzed in order to assess the transferability of the obtained findings to the site selection procedure in Germany. [ABSTRACT FROM AUTHOR]

Silver nanowires (AgNW) find use in transparent conductive electrodes with applications in solar cells, touch screens, and wearables. Unprotected AgNW are prone to atmospheric corrosion and lose conductivity over time. Known passivation techniques either require submersion of pre‐deposited AgNW in liquid compounds or the modification of AgNW inks prior to deposition, which alters viscosity and complicates deposition. Here, new possibilities for stabilization of pre‐deposited AgNW networks without need for submersion are explored. It is demonstrated that AgNW networks can be stabilized either by argon or hydrogen plasma treatment or by solvent vapor annealing with ethanol, methanol, or ethyl acetate. These treatments yielded stable electrical resistance over at least nine weeks, whereas untreated or thermally annealed AgNW layers quickly lost conductivity. The potential of solvent vapor annealing is further explored by demonstrating a new processing technique for stable polymer matrix composites containing AgNW. Co‐deposited layers of AgNW with polystyrene microbeads are annealed in ethyl acetate vapor to stabilize the AgNW while at the same time merging polymer beads into a closed film around the AgNW. The resulting composites maintained stable resistance and transmittance for at least seven weeks. [ABSTRACT FROM AUTHOR]

EU foreign policy is highly dependent on EU member states, but we still lack a coherent conceptual framework that does justice to the interdependences and co-constitutive relations between EU countries. Building on relational theory and social psychology, we develop a social relational model about group emotions in the Council that conceptualises under what conditions emotions play a role in EU foreign policy decision-making. We formulate scope conditions detailing when the performance of emotions might allow member states to accumulate relational power (e.g. process power), which can in turn allow for the emergence of group emotions and even drive policy changes. Most notably, we shed light on group dynamics within the Council, determining if and how group emotions inform the EU´s policy response to norm contestation. Our framework helps understand why processes of emotional appraisal, contagion, and emergence might sometimes help propel the EU into action, whereas other times they seem to have little or no effect. [ABSTRACT FROM AUTHOR]

While rising geopolitical competition poses significant political challenges for future arms control negotiations, it also complicates national arms control verification by making on-site inspections unlikely. One way to verify future arms control agreements without on-site inspections would be to rely on counting rules verified by national technical intelligence. American policymakers should consider how they might combine on-site inspections and counting rules in future arms control agreements. By allowing each party to choose its verification modality, future arms control agreements could cater to different security preferences while also preserving areas of American military advantage. [ABSTRACT FROM AUTHOR]

Research has shown that leached plant toxins negatively impact the growth and development of larval amphibians. However, tadpoles may encounter these same toxins in food material, and differential exposure routes and distribution of toxic chemicals can yield variable downstream effects on animals. To date, most research understanding the interactions between dietary plant toxins and herbivores has been conducted in terrestrial systems. Despite the abundance of plant toxins in food and water sources, the effects of dietary plant toxins on larval amphibians have not been studied, and tannins could negatively affect these species. Here, green frog tadpoles (Lithobates clamitans) were fed diets with or without 2% tannic acid to test how their growth, development, behavior, and gut microbiome respond to dietary tannins. At the end of the trial, we conducted a behavioral assay to measure tadpole activity and boldness and inventoried the gut microbiome using 16S rRNA sequencing. Dietary tannins significantly decreased body mass by 66% and length by 28%, without influencing tadpole developmental stage. We found significant differences in exploratory behavior and boldness during the first minute of our behavioral assay, demonstrating that tannins have the potential to influence behavior during novel or stressful events. Finally, tannins significantly sculpted the gut microbiome, with an increase in the measurement of Shannon entropy. We observed 7 microbial phyla and 153 microbial genera that exhibited significantly differential abundances differences between control and tannic acid‐fed tadpoles. Collectively, our results demonstrate that dietary tannins have the potential to alter amphibian growth, behavior, and microbiome. [ABSTRACT FROM AUTHOR]

Summary Dissemination of digital cognitive behavioural therapy is a promising approach for treating insomnia in the broad population. Current evidence supports the effectiveness of the digital format, but clinical findings are often limited by the choice of control group and lack of in‐depth therapeutic measures. This study was designed to investigate the specific effects of digital cognitive behavioural therapy in comparison to a self‐monitoring application. Participants meeting criteria for insomnia were randomly allocated (1:1) to 8 weeks of digital cognitive behavioural therapy or 8 weeks of digital sleep monitoring (control application). The primary outcome, insomnia severity, was assessed at baseline, 8‐ and 16‐weeks post‐randomisation. Secondary outcomes included the assessment of sleep via application‐integrated sleep diaries and actigraphy. Linear‐mixed models were fitted to assess between‐group differences. Fifty‐six participants (48 females, mean age: M = 45.55 ± 13.70 years) were randomised to either digital cognitive behavioural therapy (n = 29) or digital sleep monitoring (n = 27). At 8‐ and 16‐weeks post‐randomisation, large treatment effects (d = 0.87–1.08) indicated robust reductions (−3.70 and −2.97, respectively; p ≤ 0.003) in insomnia severity in the digital cognitive behavioural therapy arm, relative to digital sleep monitoring. Treatment effects in favour of digital cognitive behavioural therapy were also found for self‐reported and actigraphy‐derived sleep continuity variables, indicating that sleep improved throughout the 8‐week intervention period. Our study reinforces the role of digital cognitive behavioural therapy in achieving clinical improvements for patients with insomnia, affirming previous findings and supporting the specific effects of cognitive behavioural therapy. [ABSTRACT FROM AUTHOR]

Rapid eye movement sleep (REMs) is characterized by activated electroencephalogram (EEG) and muscle atonia, accompanied by vivid dreams. REMs is homeostatically regulated, ensuring that any loss of REMs is compensated by a subsequent increase in its amount. However, the neural mechanisms underlying the homeostatic control of REMs are largely unknown. Here, we show that GABAergic neurons in the preoptic area of the hypothalamus projecting to the tuberomammillary nucleus (POAGAD2→TMN neurons) are crucial for the homeostatic regulation of REMs in mice. POAGAD2→TMN neurons are most active during REMs, and inhibiting them specifically decreases REMs. REMs restriction leads to an increased number and amplitude of calcium transients in POAGAD2→TMN neurons, reflecting the accumulation of REMs pressure. Inhibiting POAGAD2→TMN neurons during REMs restriction blocked the subsequent rebound of REMs. Our findings reveal a hypothalamic circuit whose activity mirrors the buildup of homeostatic REMs pressure during restriction and that is required for the ensuing rebound in REMs. [ABSTRACT FROM AUTHOR]

High-energy photon interrogation is a nondestructive technique that is used to detect special nuclear materials and characterize nuclear waste. The development of such systems is complex and requires Monte Carlo simulations to optimize system performance. Monte Carlo simulations rely on various scattering, absorption, and photonuclear cross-section data. While the scattering and absorption cross-section data have been extensively studied and validated with experiments, the results obtained from photonuclear simulations are often found to underpredict measured results, indicating uncertainties in the photonuclear cross sections themselves. Thus, there is a need for new measured results that can be used to quantify underpredictions in simulations using photonuclear cross-section data. In the present work, we interrogated depleted uranium with a 9-MV electron linac and detected photoneutrons with trans-stilbene organic scintillators. The measurement of photoneutrons with organic scintillators is challenging due to the presence of the intense photon flux, which causes issues such as pulse pile-up, detector saturation, and poor signal-to-background ratio. To mitigate these challenges, we used iron and polyethylene shielding of varying thicknesses around the depleted uranium target and a neural network–based digital pulse processing algorithm to recover neutron and photon information from piled-up events. Our goal was to compare the measured photoneutron count rate with the simulated rate obtained using the MCNPX-PoliMi transport code. For a light output window of 0.28 to 2.67 MeVee (1.66- to 6.85-MeV proton recoil energy), we found that the simulated count rate obtained using the ENDF/B-VII photonuclear cross-section library underpredicts the measured rate by 32.8% $$ \pm $$ ± 3.2%. Additionally, we compared the simulated and measured photoneutron light output distributions. For the least thicknesses of shielding, the simulation was found to underpredict measurements in the 0.70- to 2.67-MeVee light output window. For the greatest thicknesses of shielding, the simulation was found to underpredict the measurement across the entire light output window of 0.28 to 2.67 MeVee. [ABSTRACT FROM AUTHOR]

Summary: Background: Laparoscopic herniorrhaphy using staples or smooth suture has been shown to be safe and effective for the surgical treatment of congenital inguinal hernia in colts and gives the possibility to spare the testicles. An automated laparoscopic suturing device combined with barbed suture reduces the technical challenges of laparoscopic suturing. Objectives: The objective of the study was to describe the application of the Endo Stitch™ automated suturing device in combination with V‐Loc™ unidirectional barbed suture for laparoscopic herniorrhaphy in foals with congenital inguinal hernia, share experiences and provide long‐term follow‐up regarding the outcome. Study design: Retrospective case series. Methods: Medical records of all foals that had laparoscopic herniorrhaphy using the Endo Stitch™ combined with V‐Loc™ unidirectional barbed suture at two equine referral hospitals between May 2015 and July 2022 were reviewed. Long‐term follow‐up was conducted by telephone interviews with the owners using a standardised questionnaire. Results: Nine foals aged 0.5–13 weeks suffering from unilateral (seven cases) or bilateral (two cases) indirect inguinal hernia underwent unilateral (two cases) or bilateral (seven cases) laparoscopic herniorrhaphy using the described technique. In two animals, the testicles were spared, five animals were bilaterally castrated, and two were unilaterally castrated at the time of herniorrhaphy. No major intraoperative complications occurred. Postoperatively, foals were bright and alert and none of them had significant complications attributable to the surgery. Median long‐term follow‐up was 8 months. No re‐herniation was observed in any of the cases at any time postoperatively. Main limitations: Retrospective study design and follow‐up period of less than 6 months in three cases. Conclusions: Laparoscopic herniorrhaphy using the Endo Stitch™ laparoscopic suturing device and V‐Loc™ barbed suture is technically less demanding than previously described laparoscopic techniques and effective in preventing re‐herniation in foals suffering from congenital inguinal hernia. A fast and uncomplicated postoperative recovery can be expected. [ABSTRACT FROM AUTHOR]

The protozoan parasite Plasmodium, the causative agent of malaria, undergoes an obligatory stage of intra‐hepatic development before initiating a blood‐stage infection. Productive invasion of hepatocytes involves the formation of a parasitophorous vacuole (PV) generated by the invagination of the host cell plasma membrane. Surrounded by the PV membrane (PVM), the parasite undergoes extensive replication. During intracellular development in the hepatocyte, the parasites provoke the Plasmodium‐associated autophagy‐related (PAAR) response. This is characterized by a long‐lasting association of the autophagy marker protein, and ATG8 family member, LC3B with the PVM. LC3B localization at the PVM does not follow the canonical autophagy pathway since upstream events specific to canonical autophagy are dispensable. Here, we describe that LC3B localization at the PVM of Plasmodium parasites requires the V‐ATPase and its interaction with ATG16L1. The WD40 domain of ATG16L1 is crucial for its recruitment to the PVM. Thus, we provide new mechanistic insight into the previously described PAAR response targeting Plasmodium liver stage parasites. [ABSTRACT FROM AUTHOR]

The detection of specific biological macromolecules in cryogenic electron tomography data is frequently approached by applying cross‐correlation‐based 3D template matching. To reduce computational cost and noise, high binning is used to aggregate voxels before template matching. This remains a prevalent practice in both practical applications and methods development. Here, the relation between template size, shape and angular sampling is systematically evaluated to identify ribosomes in a ground‐truth annotated data set. It is shown that at the commonly used binning, a detailed subtomogram average, a sphere and a heart emoji result in near‐identical performance. These findings indicate that with current template‐matching practices macromolecules can only be detected with high precision if their shape and size are sufficiently different from the background. Using theoretical considerations, the experimental results are rationalized and it is discussed why primarily low‐frequency information remains at high binning and that template matching fails to be accurate because similarly shaped and sized macromolecules have similar low‐frequency spectra. These challenges are discussed and potential enhancements for future template‐matching methodologies are proposed. [ABSTRACT FROM AUTHOR]

Background There has been a fivefold increase of neurosurgeons over the last three decades in Germany, despite a lesser increase in operations. Currently, there are approximately 1,000 neurosurgical residents employed at training hospitals. Little is known about the overall training experience and career opportunities for these trainees. Methods In our role as resident representatives, we implemented a mailing list for interested German neurosurgical trainees. Thereafter, we created a survey including 25 items to assess the trainees' satisfaction with their training and their perceived career prospects, which we then distributed through the mailing list. The survey was open from April 1 until May 31 2021. Results Ninety trainees were enrolled in the mailing list and we received 81 completed responses to our survey. Overall, 47% of the trainees were very dissatisfied or dissatisfied with their training. Sixty-two percent of the trainees reported a lack of surgical training. Fifty-eight percent of trainees found it difficult to attend courses or classes and only 16% had consistent mentoring. There was an expressed desire for a more structured training program and mentoring projects. In addition, 88% of trainees were willing to relocate for fellowships outside their current hospitals. Conclusions Half of the responders were dissatisfied with their neurosurgical training. There are various aspects that require improvement, such as the training curriculum, structured mentoring, and reduction of the amount of administrative work. We propose the implementation of a modernized structured curriculum, which addresses the mentioned aspects, in order to improve neurosurgical training and, consecutively, patient care. [ABSTRACT FROM AUTHOR]

The article focuses on nineteenth-century moon imaginaries in popular visual culture and their connection to planetary critique. Topics include the overlooked abundance of lunar imaginaries in various media forms such as dioramas, panoramas, and early films, examining how these representations interpreted the moon through scientific investigation, commodification as entertainment spectacle, and imaginative narratives of lunar life.

The COVID-19 pandemic was a major challenge for journalism. In the case of Germany, critics very early on voiced concerns over the quality of mainstream media coverage. Mainstream media were attacked for the intensity of their coverage, for reporting too much and unnecessarily frightening audiences, for not presenting a diversity of viewpoints on the pandemic and the measures taken to mitigate it, and for being one-sided and too close to the government. Against this background, this paper examines the intensity and viewpoint diversity of the coverage of 13 mainstream and two alternative media in Germany in 2020 and 2021. Based on a comprehensive manual content analysis of almost 9000 news stories, we conclude that the mainstream media did not cover the pandemic in a fundamentally exaggerated or one-sided way. However, they did not always report intensively when the pandemic was particularly severe, and they tended to warn against the pandemic rather than criticize the measures taken. In contrast, alternative media coverage tended to be more one-sided and generally biased against government measures. [ABSTRACT FROM AUTHOR]

Early modern paper, formed from the fibers of recycled linen rags, captured the imagination of early modern writers, translators, and readers. Drawing on paper's material properties and history, seventeenth‐century chymists — including Thomas Tymme, Michael Maier, and Otto Tachenius — repeatedly imagine papermaking as a chymical purification in order to claim paper as a chymical invention. In doing so, these chymists seek to demonstrate their art's centrality to early modern knowledge production, circulation, and preservation. At the same time, by imagining papermaking as chymistry, these writers probe the boundaries of art and nature, the mechanical and liberal arts, and the ordinary and alchemical. Further, because of readers' familiarity and proximity to linen and paper, the material book offered proof of chymistry's usefulness, grounded in the tacit knowledge of daily experience. [ABSTRACT FROM AUTHOR]