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1. Novel Small Molecule Inhibitorsof Activated ThrombinActivatable Fibrinolysis Inhibitor (TAFIa) from Natural Product Anabaenopeptin.

Author

Nis Halland, Mark Brönstrup, Jörg Czech, Werngard Czechtizky, Andreas Evers, Markus Follmann, Markus Kohlmann, Matthias Schiell, Michael Kurz, Herman A. Schreuder, and Christopher Kallus

Subjects
*SMALL molecules, *ANTITHROMBINS, *ENZYME inhibitors, *ANTIFIBRINOLYTIC agents, *CYANOBACTERIA
Abstract

Anabaenopeptins isolated from cyanobacteriawere identified asinhibitors of carboxypeptidase TAFIa. Cocrystal structures of thesemacrocyclic natural product inhibitors in a modified porcine carboxypeptidaseB revealed their binding mode and provided the basis for the rationaldesign of small molecule inhibitors with a previously unknown centralurea motif. Optimization based on these design concepts allowed fora rapid evaluation of the SAR and delivered potent small moleculeinhibitors of TAFIa with a promising overall profile. [ABSTRACT FROM AUTHOR]

Published
2015
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