1. Epidemiology of Candidemia in Swiss Tertiary Care Hospitals: Secular Trends, 1991--2000.
- Author
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Marchetti, Oscar, Bille, Jacques, Fluckiger, Ursula, Eggimann, Philippe, Ruef, Christian, Garbino, Jorge, Calandra, Thierry, Glauser, Michel-Pierre, Täuber, Martin George, and Pitter, Didier
- Subjects
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CANDIDA , *PATHOGENIC microorganisms , *NOSOCOMIAL infections , *CANDIDIASIS , *MYCOSES - Abstract
Candida species are among the most common bloodstream pathogens in the United States, where the emergence of azoleresistant Candida glabrata and Candida krusei are major concerns. Recent comprehensive longitudinal data from Europe are lacking. We conducted a nationwide survey of candidemia during 19912000 in 17 university and university-affiliated hospitals representing 79% of all tertiary care hospital beds in Switzerland. The number of transplantations and bloodstream infections increased significantly (P<.001). A total of 1137 episodes of candidemia were observed: Candida species ranked seventh among etiologic agents (2.9% of all bloodstream isolates). The incidence of candidemia was stable over a 10-year period. C. albicans remained the predominant Candida species recovered (66%), followed by C. glabrata (15%). Candida tropicalis emerged (9%), the incidence of Candida parapsilosis decreased (1%), and recovery of C. krusei remained rare (2%). Fluconazole consumption increased significantly (P<.001). Despite increasing high-risk activities, the incidence of candidemia remained unchanged, and no shift to resistant species occurred. [ABSTRACT FROM AUTHOR]
- Published
- 2004