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In setting the scene for the articles featured in the special issue, the Introduction provides a brief overview of the literature on the Axis between Fascist Italy and Nazi Germany from its origins until the present day. While traditionally the historiography has overlooked culture as a point of contact between the two regimes, there is a small, but growing, body of recent research on the topic, which is often inspired by transnational, comparative, and global history. Thus, the introduction presents the cultural entanglements of Fascism and National Socialism as fertile ground for new research. [ABSTRACT FROM AUTHOR]

In recent years, the architectural legacy and so-called 'difficult heritage' of Fascist Italy has become a flourishing field of research. These topics have also begun to make their way into the undergraduate classroom. To date, however, there has been little research carried out into the methods we use to teach the history of Fascism in particular. In this short article, we outline how we have applied problem-based learning and scenario-based learning approaches to tackle this topic. After presenting three assignments, we explain the benefits associated with a PBL/SBL approach, summarised under the headings of interdisciplinarity, creativity and authenticity, before highlighting some aspects on which colleagues may wish to reflect if they are considering adopting a similar approach in their teaching. [ABSTRACT FROM AUTHOR]

This article aims to dissect the nature of exemplarity in Italian Fascism. The social and political structures that emerged in Fascist Italy were highly reliant on a sense of morality, largely because of the degree of violence inherent in those structures. Under Fascism, morality was founded on concrete examples rather than on abstract principles. Exemplars were idealized sources of moral strength, and figures with the capacity to inspire or persuade. In particular, the fallen soldier and those who died for the nation constituted a major category of Fascist exemplars. Thus, soldiers who fell in the First World War were awarded exemplary status in order to encourage behaviors favorable to the regime. With the goal to demonstrate the importance awarded to exemplars, this paper focuses on a group of ossuaries, or bone depositaries, that were built under Mussolini's dictatorship, and within which the regime reburied the remains of soldiers who fell in the First World War. The main purpose of the ossuaries was to present the dead as role models that might boost support for a program of nationalism, militarism, and imperialism. Thus, while their creation drew on factors such as Romantic literature and Italy's religious and political traditions, the ossuaries represent an ideal case study of how Fascist morality was aided by and expressed through the use of exemplars. [ABSTRACT FROM AUTHOR]

This essay presents a critical overview of recent literature in English on the modern cultural history of death. In order to locate new developments, it charts the evolution of the field from the 1970s until today and distinguishes between French and Anglophone strands in the historiography. A selection of studies published between 2005 and 2015 exemplifies a revival in recent scholarship that hangs on four main innovations: the abandonment of grand narratives of modernization and secularization; an interdisciplinary integration of political, cultural, and intellectual history; greater attention to the individual; and the expansion of the field beyond Europe and North America. Thus, today, the history of death is both local and global, public and private, personal and universal. [ABSTRACT FROM AUTHOR]

The military ossuaries (sacrari militari) that were built to house the remains of fallen soldiers of the First World War offer a striking example of how Italy has dealt with the legacy of Fascism. Located along former frontlines in north-eastern Italy, the ossuaries occupy an ambiguous position in Italian heritage as both national monuments and the remnants of a difficult past. Whereas originally they functioned as instruments of Fascist propaganda, they have been reinvented as monuments of Republican Italy. Thus, while challenging the notion of Fascist remains as 'difficult heritage', this article suggests that the ossuaries might be seen as palimpsests that have been overlaid with different and ever-changing memories. To this end, the article traces the afterlives of ossuaries from 1945 to the present in search of evidence of evolving attitudes towards the Fascist period. It also examines a recent resurgence of public interest in the ossuaries in conjunction with the centenary of the First World War. [ABSTRACT FROM AUTHOR]

This article examines how Italy has dealt with the physical remains of the Fascist regime, as a window onto Italian attitudes to the past. The ventennio left indelible marks on Italy’s cities in the form of urban projects, individual buildings, monuments, plaques and street names. In effect, the survival of physical traces contrasts with the hazy memories of Fascism that exist within the Italian collective consciousness. Conspicuous, yet mostly ignored, Italy’s Fascist heritage is hidden in plain sight. However, from the 1990s, buildings associated with the regime have sparked a number of debates regarding the public memory of Fascism. Although these debates present an opportunity to re-examine history, they may also be symptomatic of a crisis in the Italian polity and of attempts to rehabilitate Fascism through historical revisionism. [ABSTRACT FROM PUBLISHER]

This article examines the monumental cemeteries of nineteenth-century Italy with regard to their role as platforms for the tensions between Church and state. In that burial grounds were publically owned yet administered by the clergy, they represented a space where conflicts between secular and clerical powers might be played out – conflicts that reached a peak in the final decades of the Ottocento following the annexation of the Papal State to unified Italy. Particular attention is given to the adoption of cremation as a practice that was advocated by anticlerical, liberal and radical factions in opposition to the Catholic Church. That opposition was manifested in the design and layout of Italian burial grounds and in construction of new crematoria. [ABSTRACT FROM PUBLISHER]

We found that blood vitronectin (VTN) leaks into the brain and exacerbates tissue loss after stroke by increasing pro-inflammatory IL-6 expression in female, but not male, mice. VTN signals through integrins and downstream focal adhesion kinase (FAK). Here, a two day systemic treatment with a small molecule FAK inhibitor starting 6 h after middle cerebral artery occlusion reduced ipsilateral brain injury size by ∼40–45% at 7 and 14 d, as well as inflammation and motor dysfunction in wild-type female, but not male, mice. FAK inhibition also reduced IL-6 expression in the injured female striatum at 24 h by 62%. Inducible selective gene deletion of FAK in astrocytes also reduced acute IL-6 expression by 72% only in females, and mitigated infarct size by ∼80% and inflammation at 14 d after stroke. Lastly, VTN−/− females had better outcomes, but FAK inhibitor treatment had no additional protective or anti-inflammatory effects. Altogether, this suggests that VTN is detrimental in females primarily through FAK and that FAK inhibition provides neuroprotection (cerebroprotection) by reducing VTN-induced IL-6 expression in astrocytes. Thus, VTN signaling can be targeted to mitigate harmful inflammation with relevance to treatments for women with ischemic stroke, who often have worse outcomes than men. [ABSTRACT FROM AUTHOR]

Highlights • CNTF plays a sex-specific role in depressive-like behavior. • CNTF is pro-depressive in female mice but anti-depressive in male mice. • The anti-depressant effect of progesterone is through inhibition of CNTF in the amygdala. Abstract Ciliary neurotrophic factor (CNTF) is produced by astrocytes and promotes neurogenesis and neuroprotection. Little is known about the role of CNTF in affective behavior. We investigated whether CNTF affects depressive- and anxiety-like behavior in adult mice as tested in the forced swim, sucrose preference and elevated-T maze tests. Female wild type CNTF+/+ mice more readily developed behavioral despair with increased immobility time and decreased latency to immobility in the forced swim test than male CNTF+/+ littermates. The lack of CNTF in CNTF-/- mice had an opposite effect on depressive-like behavior in female mice (reduced immobility time and increased sucrose preference) vs. male mice (increased immobility time). Female wildtype mice expressed more CNTF in the amygdala than male mice. Ovariectomy increased CNTF expression, as well as immobility time, which was significantly reduced in CNTF-/- mice, suggesting that CNTF mediates overiectomy-induced immobility time, possibly in the amygdala. Progesterone but not 17-β estradiol inhibited CNTF expression in cultured C6 astroglioma cells. Progesterone treatment also reduced CNTF expression in the amygdala and decreased immobility time in female CNTF+/+ but not in CNTF-/- mice. Castration did not alter CNTF expression in males nor their behavior. Lastly, there were no effects of CNTF on the elevated T-maze, a behavioral test of anxiety, suggesting that a different mechanism may underlie anxiety-like behavior. This study reveals a novel CNTF-mediated mechanism in stress-induced depressive-like behavior and points to opportunities for sex-specific treatments for depression, e.g. progesterone in females and CNTF-stimulating drugs in males. [ABSTRACT FROM AUTHOR]

Abstract Vitronectin (VTN) is a glycoprotein in the blood and affects hemostasis. VTN is also present in the extracellular matrix of various organs but little is known about its function in healthy adult tissues. We show, in adult mice, that VTN is uniquely expressed by approximately half of the pericytes of subventricular zone (SVZ) where neurogenesis continues throughout life. Intracerebral VTN antibody injection or VTN knockout reduced neurogenesis as well as expression of pro-neurogenic CNTF, and anti-neurogenic LIF and IL-6. Conversely, injections of VTN, or plasma from VTN+/+, but not VTN−/− mice, increased these cytokines. VTN promoted SVZ neurogenesis when LIF and IL-6 were suppressed by co-administration of a gp130 inhibitor. Unexpectedly, VTN inhibited FAK signaling and VTN−/− mice had increased FAK signaling in the SVZ. Further, an FAK inhibitor or VTN increased CNTF expression, but not in conditional astrocytic FAK knockout mice, suggesting that VTN increases CNTF through FAK inhibition in astrocytes. These results identify a novel role of pericyte-derived VTN in the brain, where it regulates SVZ neurogenesis through co-expression of CNTF, LIF and IL-6. VTN-integrin-FAK and gp130 signaling may provide novel targets to induce neurogenesis for cell replacement therapies. Graphical abstract Unlabelled Image Highlights • Vitronectin (VTN) is uniquely expressed in perivascular pericytes of the brain where they interact with astrocytes. • VTN promotes cytokine expression to regulate subventricular zone neurogenesis, identifying new roles in healthy tissues. • VTN increases CNTF to promote neurogenesis when IL-6 and LIF are reduced by gp130 inhibition. • VTN stimulates CNTF expression entirely through inhibition of focal adhesion kinase in astrocytes. • VTN-integrin-FAK and gp130 signaling are novel targets to promote neurogenesis with implications for cell replacement. [ABSTRACT FROM AUTHOR]

Vitronectin (VTN) is a blood protein produced mainly by the liver. We show that VTN leaks from the bloodstream into the injury site and neighboring subventricular zone (SVZ) following ischemic stroke (middle cerebral artery occlusion, MCAO) in adult mice. MCAO is known to increase neurogenesis after stroke. VTN inhibits this response in females, but not in males, as shown by ~70% more stroke-induced SVZ neurogenesis in female VTN−/− mice at 14 d. In female VTN−/− mice, stroke-induced expression of interleukin-6 (IL-6) at 24 h was reduced in the SVZ. The closely related leukemia inhibitory factor (LIF) or pro-neurogenic ciliary neurotrophic factor (CNTF) were not affected. The female-specific effect of VTN on IL-6 expression was not due to sex hormones, as shown by ovariectomy and castration. IL-6 injection next to the SVZ reversed the MCAO-induced increase in neurogenesis seen in VTN−/− mice. Our in vitro and vivo data suggest that plasma VTN activates focal adhesion kinase (FAK) in the SVZ following MCAO, which reduces IL-6 expression in astrocytes but increases it in other cells such as microglia/macrophages. Inducible conditional astrocytic FAK deletion increased MCAO-induced IL-6 expression in females at 24 h and blocked MCAO-induced neurogenesis at 14 d, confirming a key detrimental role of IL-6. Collectively, these data suggest that leakage of VTN into the SVZ reduces the neurogenic response to stroke in female mice by promoting IL-6 expression. Reducing VTN or VTN signaling may be an approach to promote neurogenesis for neuroprotection and cell replacement after stroke in females. Unlabelled Image • Vitronectin (VTN) leaks from blood into the subventricular zone (SVZ) of adult mice after ischemic stroke. • VTN inhibits stroke-induced SVZ neurogenesis in females, but not males, by promoting acute expression of SVZ IL-6. • The female-specific VTN-induced IL-6 was through activation of FAK signaling but not due to gonadal hormones. • Astrocytic FAK plays a role in repressing stroke-induced IL-6 in females only. • VTN or VTN signaling may be a good targets for promoting neurogenesis for neuroprotection and cell replacement in females. [ABSTRACT FROM AUTHOR]

Sea levels are projected to rise in response to climate change, causing the intrusion of sea water into land. In flat coastal regions, this would generate an increase in shallow water covered areas with limited circulation. This scenario raises a concern about the consequences it could have on human health, specifically the possible impacts on disease transmission. In this review paper we identified three categories of diseases which are associated with water and whose transmission can be affected by sea level rise. These categories include: mosquitoborne diseases, naturalized organisms ( Vibrio spp. and toxic algae), and fecal-oral diseases. For each disease category, we propose comprehensive adaptation strategies that would help minimize possible health risks. Finally, the City of Key West, Florida is analyzed as a case study, due to its inherent vulnerability to sea level rise. Current and projected adaptation techniques are discussed as well as the integration of additional recommendations, focused on disease transmission control. Given that sea level rise will likely continue into the future, the promotion and implementation of positive adaptation strategies is necessary to ensure community resilience. [ABSTRACT FROM AUTHOR]