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Respiratory motion can blur the tomographic reconstruction of positron emission tomography or single-photon emission computed tomography (SPECT) images, which subsequently impair quantitative measurements, e.g. in the upper abdomen area. Respiratory signal phase-based gated reconstruction addresses this problem, but deteriorates the signal-to-noise ratio (SNR) and other intensity-based quality measures. This paper proposes a 3D reconstruction method dedicated to micro-SPECT imaging of mice. From a 4D acquisition, the phase images exhibiting motion are identified and the associated list-mode data are discarded, which enables the reconstruction of a 3D image without respiratory artefacts. The proposed method allows a motion free reconstruction exhibiting both satisfactory count statistics and accuracy of measures. With respect to standard 3D reconstruction (non-gated 3D reconstruction) without breathing motion correction, an increase of 14.6% of the mean standardized uptake value has been observed, while, with respect to a gated 4D reconstruction, up to 60% less noise and an increase of up to 124% of the SNR have been demonstrated. [ABSTRACT FROM AUTHOR]

Medical images are of great importance in radiotherapy, which became a privileged application field for image processing techniques. Moreover, because of the progression of the computers’ performances, these techniques are also in full expansion. Today, the recent developments of the radiotherapy (3DCR, IMRT) offer a huge place to them. Effectively, they can potentially answer to the precision requirements of the modern radiotherapy, and may then contribute to improve the delivered treatments. The purpose of this article is to present the different image processing techniques that are currently used in radiotherapy (including image matching and segmentation) as they are described in the literature. [Copyright &y& Elsevier]

Abstract: Purpose: Manual delineation of dental structures is too time-consuming to be feasible in routine practice. Information on dose risk levels is crucial for dentists following irradiation of the head and neck to avoid postextraction osteoradionecrosis based on empirical dose-effects data established on bidimensional radiation therapy plans. Material and methods: We present an automatic atlas-based segmentation framework of the dental structures, called Dentalmaps, constructed from a patient image-segmentation database. Results: This framework is accurate (within 2Gy accuracy) and relevant for the routine use. It has the potential to guide dental care in the context of new irradiation techniques. Conclusion: This tool provides a user-friendly interface for dentists and radiation oncologists in the context of irradiated head and neck cancer patients. It will likely improve the knowledge of dose-effect correlations for dental complications and osteoradionecrosis. [Copyright &y& Elsevier]

Abstract: Highly conformal irradiation techniques are associated with steep gradient doses. Accuracy and reproducibility of delineation are required to avoid geometric misses and to properly report dose–volume effects on organs at risk. Guidelines of the International Commission on radiation units have largely contributed to high quality treatments. The ICRU endeavors to collect and evaluate the latest data and information pertinent to the problems of radiation measurement and dosimetry. There remains a need for delineation guidelines and automatic segmentation tools in routine practice. Among these tools, atlas-based segmentation has been shown to provide promising results. The methodology used for head and neck cancer patients is illustrated. [Copyright &y& Elsevier]

Abstract: Purpose: The aim of the present study was to quantitatively assess the performance of a block matching-based automatic registration algorithm integrated within the commercial treatment planning system designated ISOgray™ from Dosisoft. The accuracy of the process was evaluated by a phantom study on computed tomography (CT), magnetic resonance (MR) and positron emission tomography (PET) images. Materials and methods: Two phantoms were used to carry out this study: the cylindrical Jaszczak® phantom and the anthropomorphic Liqui-Phil™ Head Phantom (the Phantom Laboratory), containing fillable spheres. External fiducial markers were used to quantify the accuracy of 41 CT/CT, MR/CT and PET/CT automatic registrations with images of the rotated and tilted phantoms. Results: The study first showed that a cylindrical phantom was not adapted for the evaluation of the performance of a block matching-based registration software. Secondly, the Liqui-Phil™ Head Phantom study showed that the algorithm was able to perform automatic registrations of CT/CT and MR/CT images with differences of up to 40° in phantom rotation and of up to 20–30° for PET/CT with accuracy below the image voxel size. Conclusion: The study showed that the block matching-based automatic registration software under investigation was robust, reliable and yielded very satisfactory results. This phantom-based test can be integrated into a periodical quality assurance process and used for any commissioning of image registration software for radiation therapy. [Copyright &y& Elsevier]

Abstract: Intra-subject and inter-subject nonlinear registration based on dense transformations requires the setting of many parameters, mainly for regularization. This task is a major issue, as the global quality of the registration will depend on it. Setting these parameters is, however, very hard, and they may have to be tuned for each patient when processing data acquired by different centers or using different protocols. Thus, we present in this article a method to introduce more coherence in the registration by using fewer degrees of freedom than with a dense registration. This is done by registering the images only on user-defined areas, using a set of affine transformations, which are optimized together in a very efficient manner. Our framework also ensures a smooth and coherent transformation thanks to a new regularization of the affine components. Finally, we ensure an invertible transformation thanks to the Log-Euclidean polyaffine framework. This allows us to get a more robust and very efficient registration method, while obtaining good results as explained below. We performed a qualitative and quantitative evaluation of the obtained results on two applications: first on atlas-based brain segmentation, comparing our results with a dense registration algorithm. Then the second application for which our framework is particularly well suited concerns bone registration in the lower-abdomen area. We obtain in this case a better positioning of the femoral heads than with a dense registration. For both applications, we show a significant improvement in computation time, which is crucial for clinical applications. [Copyright &y& Elsevier]

Abstract: Saccular aneurisms illustrate usefulness and possible techniques of image-based modeling of flow in diseased vessels. Aneurism flow is investigated in order to estimate the rupture risk, assuming that the pressure is the major factor and that high-pressure zones are correlated to within-wall strong-stress concentrations. Computational flow is also aimed at providing additional arguments for the treatment strategy. Angiographies of aneurismal vessels of large and medium size are processed to provide three-dimensional reconstruction of the vessel region of interest. Different reconstruction techniques are used for a side and a terminal aneurisms. Reconstruction techniques may lead to different geometries especially with poor input data. The associated facetisation is improved to get a computation-adapted surface triangulation, after a treatment of vessel ends and mesh adaptation. Once the volumic mesh is obtained, the pulsatile flow of an incompressible Newtonian blood is computed using in vivo non-invasive flowmetry and the finite element method. High pressure zones are observed in the aneurism cavity. The pressure magnitude in the aneurism, the location and the size of high pressure zones depend mainly on the aneurism implantation on the vessel wall and its orientation with respect to the blood flux in the upstream vessel. The stronger the blood impacts on the aneurismal wall the higher the pressure. The state of the aneurism neck, where a high-pressure zone can occur, and the location of the aneurism, with an easy access or not, give arguments for the choice between coiling and surgical clipping. Mesh size and 3D reconstruction procedure affect the numerical results. Helpful qualitative data are provided rather than accurate quantitative results in the context of multimodeling. [Copyright &y& Elsevier]

Although numerous methods to register brains of different individuals have been proposed, no work has been done, as far as we know, to evaluate and objectively compare the performances of different nonrigid (or elastic) registration methods on the same database of subjects. In this paper, we propose an evaluation framework, based on global and local measures of the relevance of the registration. We have chosen to focus more particularly on the matching of cortical areas, since intersubject registration methods are dedicated to anatomical and functional normalization, and also because other groups [7] have shown the relevance of such registration methods for deep brain structures. Experiments were conducted using 6 methods on a database of 18 subjects. The global measures used show that the quality of the registration is directly related to the transformation's degrees of freedom. More surprisingly, local measures based on the matching of cortical sulci did not show significant differences between rigid and non rigid methods. [ABSTRACT FROM AUTHOR]

This paper presents a 4D (3D+time) echocardiographic image anisotropic filtering and a 3D model-based segmentation system. To improve the extraction of left ventricle boundaries, we rely on two preprocessing stages. First, we apply an anisotropic filter that reduces image noise. This 4D filter takes into account the spatial and temporal nature of echocardiographic images. Second, we adapt the usual gradient filter estimation to the cylindrical geometry of the 3D ultrasound images. The reconstruction of the endocardium takes place by deforming a deformable simplex mesh having an a priori knowledge of left ventricle shape and that is guided by a region-based data attraction force. The external force formulation improves the segmentation robustness against noise and outliers. We illustrate our method by showing experimental results on very challenging sparse and noisy ultrasound images of the heart and by computing quantitative measurements of the left ventricle volume. [Copyright &y& Elsevier]