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It has commonly been suggested that in modern cities individual or household deprivation (for example, low income or education) is amplified by area level deprivation (for example, lack of jobs or good schools), in ways which damage the health of the poorest and increase health inequalities. The aim of this study was to determine the location of a range of resources and exposures by deprivation in a UK city. We examined the location of 42 resources in Glasgow City, Scotland, in 2005-2006, by quintile of small area deprivation. Measures included number per 1000 population, network distance to nearest resource, and percentage of data zones containing at least one of each type of resource. Twelve resources had higher density in, and/or were closer to or more common in, more deprived neighbourhoods: public nurseries, public primary schools, police stations, pharmacies, credit unions, post offices, bus stops, bingo halls, public swimming pools, public sports centres, outdoor play areas, and vacant and derelict land/buildings. Sixteen had higher density in, and/or were closer to, or more common in, more affluent neighbourhoods: public secondary schools, private schools, banks, building societies, museums/art galleries, railway stations, subway stations, tennis courts, bowling greens, private health clubs, private swimming pools, colleges, A & E hospitals, parks, waste disposal sites, and tourist attractions. Private nurseries, Universities, fire stations, general, dental and ophthalmic practices, pawn brokers, ATMs, supermarkets, fast food chains, cafes, public libraries, golf courses, and cinemas showed no clear pattern by deprivation. Thus it appears that in the early 21st century access to resources does not always disadvantage poorer neighbourhoods in the UK. We conclude that we need to ensure that theories and policies are based on up-to-date and context-specific empirical evidence on the distribution of neighbourhood resources, and to engage in further research on interactions between individual and environmental factors in shaping health and health inequalities. [ABSTRACT FROM AUTHOR]

BACKGROUND: A number of different socio-economic classifications have been used in relation to health in the United Kingdom. The aim of this study was to compare the predictive power of different socio-economic classifications in relation to a range of health measures. METHODS: A postal questionnaire was sent to a random sample of adults in the West of Scotland (sampling from 1997 electoral roll, response rate 50 percent achieved sample 2,867). RESULTS: Associations between social position and health vary by socio-economic classification, health measure and gender. Limiting long-standing illness is more socially patterned than recent illness; income, Registrar General Social Class, housing tenure and car access are more predictive of health than the new National Statistics Socio Economic Classification; and men show steeper socio-economic gradients than women. CONCLUSION: Although there is a consistent picture of poorer health among more disadvantaged groups, however measured, in seeking to explain and reduce social inequalities in health we need to take a more differentiated approach that does not assume equivalence among social classifications and health measures. [ABSTRACT FROM AUTHOR]

It is frequently observed in contemporary industrialised societies that although women live longer than men, they are sicker than men in that they report higher rates of morbidity, disability and health care use. One common element of the explanation for women's higher rates of morbidity is that there are gender differences in the way that symptoms are perceived, evaluated and acted upon. It is widely assumed that women will be more ready to report illness and to seek help and that they have greater flexibility in their lives to accommodate illness. The few studies that have examined men and women with the same conditions or symptoms are contradictory, but lend little support to this hypothesised greater propensity, yet it is still widely believed. Here we compare men's and women's answers to a global, commonly used question about chronic illness and to a series of more specific prompts and classify the conditions reported by an externally defined categorisation of severity and International Classification of Disease chapter. Contrary to the common expectation that women report higher rates of morbidity and are more ready to report mental health problems, we found: no gender differences in the initial reporting of conditions; men reported a higher proportion of their conditions in response to the initial global question; and no evidence that women were more likely to report 'trivial' or mental health conditions in response to the initial question. [ABSTRACT FROM AUTHOR]

Objective: To explore associations between residents' perceptions of the local residential environment and the likelihood of their smoking. Design: Using data (n = 2615) from the West of Scotland Twenty-07 Study, separately by gender, cross- sectional associations between respondents' perceptions of neighbourhood (perceived absence of goods, incivilities and physical environmental problems) and the likelihood of being a current smoker and the amount smoked were examined. Results: Perceived neighbourhood problems are associated with the likelihood of smoking but mainly among those with the most negative view of the local neighbourhood. Perceptions of the provision of neighbourhood amenities seems to be more strongly associated with women's than men's smoking status, whereas the perceived quality of the local neighbourhood appears to be a better predictor of men's smoking. Conclusions: Efforts to reduce smoking levels among more deprived groups may need to pay more attention to the role of local environmental conditions in influencing smoking behaviour. [ABSTRACT FROM AUTHOR]

Provides a viewpoint on the difficulty in establishing the incidence of non-paternity. Prenatal carrier screening for recessively inherited disorders such as cystic fibrosis; Delicate social issues; Non-paternity rates; Consequences and conclusions.

Presents data suggesting the significance of socioeconomic position on car ownership in Great Britain. Importance of the correlation to the prediction of the health outcomes of car-owning individuals.

Observes the differing aspects of play areas that might influence their use as an activity arena by children. Key role of playgrounds in encouraging children to increase physical activity and reduce obesity cases among kids; Differences in the plat areas' attractiveness and potential to injure; Implications on community health.

Small lakes are likely to show considerable temporal variability in greenhouse gas emissions given their transient stratification and short residence time. To determine the extent that CO and CH emission and storage depends on surface meteorology, we studied a shallow lake during 2 years with contrasting rainfall and thermal stratification. Gas fluxes were estimated with wind-based and surface renewal models and compared to direct measurements obtained with floating chambers. The assessment of greenhouse gases storage revealed that the lake gained CO in association with rainfall in both the rainier (2011) and drier summer (2012). In 2011, stratification was less extensive and disrupted frequently. The lake was a source of CO and CH, and ebullition exceeded diffusive fluxes of CH. In 2012, stratification was more persistent, the lake was a sink for CO during dry periods, CO and CH accumulated in the hypolimnion later in the summer when rainfall increased, diffusive fluxes of CH were similar to those in 2011 mid-summer and over four times higher during overturn. Ebullition was lower in the drier summer. Fluxes measured with chambers were closer to estimations from the surface renewal model and about two times values estimated with wind-based models. [ABSTRACT FROM AUTHOR]

Multiple deprivation indicators are frequently used to capture the characteristics of an area. This is a useful approach for identifying the most deprived areas, and summary indices are good predictors of mortality and morbidity, but it remains unclear which aspects of the residential environment are most salient for health. A further question is whether the most important aspects vary for different types of residents. This paper focuses on whether associations with neighbourhood characteristics are different for men and women. The sociopolitical and physical environment, amenities, and indicators of economic deprivation and affluence were measured in neighbourhoods in the UK, and their relationship with self-rated health was investigated using multilevel regression models. Each of these contextual domains was associated with self-rated health over and above individual socioeconomic characteristics. The magnitude of the association was larger for women in each case. Statistically significant interactions between gender and residential environment were found for trust, integration into wider society, left-wing political climate, physical quality of the residential environment, and unemployment rate. These findings add to the literature indicating greater effects of non- work-based stressors for women and highlight the influence of the residential environment on women's health. [ABSTRACT FROM AUTHOR]

It is commonly asserted that while women have longer life expectancy than men, they have higher rates of morbidity, particularly for minor and psychological conditions. However, most research on gender and health has taken only limited account of the gendered distribution of social roles. Here we investigate gender differences in morbidity whilst controlling, as far as possible, for one major role, namely participation in paid employment. There is substantial segregation of the labour market by gender; men and women typically work different hours in different occupations which involve varying conditions and differing rewards and costs. Here, we examine men and women working full-time for the same employer. This paper reports on a postal survey of employees (1112 men and 1064 women) of a large British bank. It addresses three main questions: do gender differences in minor morbidity remain if we compare men and women who are employed in similar circumstances (same industry and employer)? What is the relative importance of gender, grade of employment within the organisation, perceived working conditions and orientation to gender roles for minor morbidity? Finally, are these factors related to health differentially for men and women? There were statistically significant gender differences amongst these full-time employees in recent experience of malaise symptoms, but not in physical symptoms or GHQ scores. Controlling for other factors did not reduce the gender differences in malaise scores and produced a weak, but significant, gender difference in GHQ scores. However, gender explained only a small proportion of variance, particularly in comparison with working conditions. Generally similar relationships between experience of work and occupational grade and morbidity were observed for men and women. Throughout the paper, we attempt to problematize gender, recognising that there are similarities between women and men and diversity amongst women and amongst men. However, we conclude that the gendered nature of much of adult life, including paid work, continues to shape the experiences and health of men and women at the end of the twentieth century. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To examine whether neighbourhood or residence is associated with body size and shape (height, weight, BMI, waist circumference and waist-hip ratio). DESIGN: Analysis of data collected in fact to face interviews at the second wave of longitudinal health survey of two adult age cohorts in the West of Scotland. SETTING: Four socially contrasting urban neighbourhoods in Glasgow City, Scotland. SUBJECTS: A total of 691 subjects: 142 males and 176 females aged 40 at interview; and 167 males and 206 females aged 60 at interview. All had been resident in their current neighbourhood for at least four years. MEASUREMENTS: height, weight, BMI, waist circumference and waist-hip ratio. RESULTS: Neighbourhood of residence was significantly associated with height, BMI, waist circumference and waisthip ratio after controlling for individual characteristics such as gender, age, social class, smoking behaviour and material deprivation (an index comprising income, housing tenure and car ownership). Individuals living in the most deprived neighbourhood were significantly shorter, and had bigger waist circumferences, waist-hip ratios and BMIs. CONCLUSIONS: If Health of the Nation targets on reducing the proportion of overweight individuals in the population are to be met, public health policy should focus on places as well as people. [ABSTRACT FROM AUTHOR]

Measurements of nutrient concentrations and physicochemical parameters were carried out monthly between March 2005 and March 2006 along a transect between the Nyanza Gulf and the open waters of Lake Victoria to evaluate spatial and seasonal variations in nutrient fluxes and ecosystem metabolism. Nutrient concentration gradients were observed between the deep and seasonally stratifying main lake basin and the large, shallow river-influenced Nyanza Gulf, which are connected by the relatively deep and narrow Rusinga Channel. Nutrient gradients were steepest in the Rusinga Channel where there was always a strong gradient in electrical conductivity. A mixing-box model used to quantify nutrient fluxes and ecosystem metabolism along the gulf and the channel showed that nutrients entering the gulf through river inflows and municipal sources were largely retained in the gulf, with only a small fraction transferred into the main lake. In contrast, the main lake was a net exporter of dissolved inorganic phosphorus to the gulf (110 mg P m-2 yr-1), which is in contrast to the paradigm that the gulf is a major contributor to the increasing nutrient enrichment and, hence, eutrophication of the greater Lake Victoria. The channel had net regeneration of dissolved nutrients indicating net heterotrophy; whereas in the gulf, there was net consumption of dissolved nutrients, resulting in high estimates of net ecosystem production (570 mg C m-2 d-1) and, hence, net autotrophy. Nitrogen balance ranged from +3 to +15 mg N m-2 d-1, indicating dominance of nitrogen fixation over denitrification in both the gulf and the channel, which are both well-oxygenated. [ABSTRACT FROM AUTHOR]

Background The relationship between childhood residential mobility and health in the UK is not well established; however, research elsewhere suggests that frequent childhood moves may be associated with poorer health outcomes and behaviours. The aim of this paper was to compare people in the West of Scotland who were residentially stable in childhood with those who had moved in terms of a range of health measures. Methods A total of 850 respondents, followed-up for a period of 20 years, were included in this analysis. Childhood residential mobility was derived from the number of addresses lived at between birth and age 18. Multilevel regression was used to investigate the relationship between childhood residential mobility and health in late adolescence (age 18) and adulthood (age 36), accounting for socio-demographic characteristics and frequency of school moves. The authors examined physical health measures, overall health, psychological distress and health behaviours. Results Twenty per cent of respondents remained stable during childhood, 59% moved one to two times and 21% moved at least three times. For most health measures (except physical health), there was an increased risk of poor health that remained elevated for frequent movers after adjustment for socio-demographic characteristics and school moves (but was only significant for illegal drug use). Conclusions Risk of poor health was elevated in adolescence and adulthood with increased residential mobility in childhood, after adjusting for sociodemographic characteristics and school moves. This was true for overall health, psychological distress and health behaviours, but physical health measures were not associated with childhood mobility. [ABSTRACT FROM AUTHOR]

Data from the longitudinal West of Scotland Twenty-07 STUDY: Health in the Community was used to examine whether, over a 20 year period, the self-reported health of people living in deprived areas became poorer faster compared to those living in more affluent areas. Three cohorts (born in the early 1930s, 1950s and 1970s) are included, covering 60 years of the life span. Using multilevel growth curve models, a 40% probability of reporting poor health was predicted among residents of more deprived areas at an earlier age (66) compared to those living in more affluent areas (83). Wider area differences were seen for men than for women. Our findings indicate that attempts to reduce area differences in health should start young but also continue throughout the lifespan. [ABSTRACT FROM AUTHOR]

Abstract: Deprived and declining areas in Scotland have poorer health than other areas in the rest of Scotland. Using data from the Scottish Longitudinal Study, this paper examines whether differential migration over a one year period can explain these differences. Compared with migrants to and from deprived and declining areas, stable residents in those areas were generally older, less well educated and less affluent. Continued disproportionate loss of more affluent and better educated individuals could result in deprived and declining areas becoming even more deprived over time. Migrants appeared to be in better health; however, this finding was reversed on adjustment for age. It may be that while the relationship between migration and socio-economic status is immediately apparent, the relationship between migration and health could take longer to develop. [Copyright &y& Elsevier]

Abstract: There is growing evidence that childhood IQ is inversely associated with mortality in later life. However, the specificity of this association in terms of causes of death, whether it is continuous over the whole range of IQ scores and whether it is the same according to age and sex is not clear. In a large cohort (N =11,603) of a complete population of children born in one city in the UK in the early 1950s, IQ measured at age 7 years (using a routinely administered picture test) was found to be inversely associated with mortality between the ages of 15 and 57 years. For every 1 SD increase in IQ at 7, the all cause mortality hazard ratio was 0.79 (95% CI 0.73, 0.85). On adjustment for a range of perinatal factors, father''s social class at birth, number of sibs in the household and childhood height and weight, this was attenuated slightly to 0.81 (0.74, 0.88). Almost identical associations of IQ with mortality were seen for men and women as well as at younger (15–39) and older (40+) ages. These associations were across the entire IQ range, although some of the high mortality in the lowest category of IQ (<70) was accounted for by causes associated with congenital disorders. Overall, external causes of death showed the strongest association, with weaker associations being seen for cancer. Further work is required to understand the mechanisms whereby childhood IQ has such a robust association with mortality in later life. [Copyright &y& Elsevier]

Abstarct: Aim: To determine the effectiveness of serial influenza vaccination. Scope: Studied in a Scottish GP population, the overall seroresponse rate increased with annual influenza vaccinations and after 5 years it increased from 45.1% to 93.3% for influenza virus A (H1) and from 48.4% to 98.3% for influenza virus A (H3). However, there was little boosting effect with further doses after becoming a seroresponder. The pre-vaccination titres were significantly higher in previous year''s seroresponders compared to non-responders. Conclusions: The policy of annual vaccination is supported by our data in order to increase the disappointing response rate after one dose. However, the lack of a boosting response with subsequent doses and the significant residual immunity after becoming a seroresponder suggests a prior serological immunity check in order to better direct the vaccine supply (in the years of no antigenic drift), to those who need it most. [Copyright &y& Elsevier]

Parasites are integral parts of most ecosystems, yet attention has only recently focused on how community structure and abiotic factors impact host-parasite interactions. In lakes, both factors are influenced by habitat morphology. To investigate the role of habitat structure in mediating parasitism in the plankton, we quantified timing and prevalence of a common microparasite (Metschnikowia bicuspidata) in its host, Daphnia dentifera, in 18 lakes that vary in basin size and shape. Over three years, we found substantial spatial and temporal variation in the severity of epidemics. Although infection rates reached as high as 50% in some lakes, they did not occur in most lakes in most years. Host density, often considered to be a key determinant of disease spread, did not explain a significant amount of variation in the occurrence of epidemics. Furthermore, host resistance does not fully explain this parasite's distribution, since we easily infected hosts in the laboratory. Rather, basin shape predicted epidemics well; epidemics occurred only in lakes with steep-sided basins. In these lakes, the magnitude of epidemics varied with year. We suggest that biological (predation) and physical (turbulence) effects of basin shape interact with annual weather patterns to determine the regional distribution of this parasite. [ABSTRACT FROM AUTHOR]

HIV voluntary counselling and testing (VCT) is now an integral part of many HIV care and control programmes. However, very little work has been done to assess the quality of VCT services. An evaluation of VCT services for mineworkers in Welkom, South Africa was conducted to assess client and counsellor satisfaction, the quality of the services and to identify barriers to uptake of VCT. A cross-sectional survey was carried out using tools developed by UNAIDS, consisting of semi-structured interviews and observation of counselling sessions. Twenty-two nurse counsellors and six community volunteers were interviewed. Twenty-four counselling sessions were observed and 24 client exit interviews were conducted. Although nine of the 22 nurse counsellors had only in-service rather than formal training for HIV counselling whereas all community volunteers had been formally trained, nurse counsellors demonstrated better interpersonal skills than did community volunteers. Both clients and counsellors identified fear of a positive result as a major barrier to HIV testing. Clients also raised concerns about confidentiality. UNAIDS evaluation tools were a feasible and an acceptable method of assessing VCT in this operational setting. The study identified areas where training needs to be strengthened and suggested ways of improving the services, and changes to the service have now been implemented in line with these recommendations. [ABSTRACT FROM AUTHOR]

Summary The F1 antigen of Yersinia pestis belongs to a class of non-pilus adhesins assembled via a classical chaperone–usher pathway. Such pathways consist of PapD-like chaperones that bind subunits and pilot them to the outer membrane usher, where they are assembled into surface structures. In a recombinant Escherichia coli model system, chaperone–subunit (Caf1M:Caf1 n ) complexes accumulate in the periplasm. Three inde-pendent methods showed that these complexes are rod- or coil-shaped linear arrays of Caf1 subunits capped at one end by a single copy of Caf1M chaperone. Deletion and point mutagenesis identified an N-terminal donor strand region of Caf1 that was essential for polymerization in vitro , in the periplasm and at the cell surface, but not for chaperone–subunit interaction. Partial protease digestion of periplasmic complexes revealed that this region becomes buried upon formation of Caf1:Caf1 contacts. These results show that, despite the capsule-like appearance of F1 antigen, the basic structure is assembled as a linear array of subunits held together by intersubunit donor strand complementation. This example shows that strikingly different architectures can be achieved by the same general principle of donor strand complementation and suggests that a similar basic polymer organization will be shared by all surface structures assembled by classical chaperone–usher pathways. [ABSTRACT FROM AUTHOR]

Since their inception in the 1970s, the NOAA Geostationary Operational Environmental Satellite (GOES) system has monitored the sources of space weather on the sun and the effects of space weather at Earth. These observations are important for providing forecasts, warnings and alerts to many customers, including satellite operators, the power utilities, and NASA's human activities in space. The GOES magnetometer provides observations of the geomagnetic field, which can be the first indication that significant space weather has reached Earth. In addition, the magnetic field observations are used to identify and forecast the severity of the space weather activity. This paper reviews the capabilities of the GOES-16 magnetometer (MAG) and presents initial post-launch calibration/validation results including issues found in the data. The GOES-16 MAG requirements and capabilities are similar to those for previously flown instruments, measuring three components of the geomagnetic field but with an improved sampling rate of 10 samples/second. The MAG data are low-pass filtered with a 2.5 Hz cutoff compared to the 0.5 Hz cutoff of previous GOES magnetometers. The MAG is composed of two magnetometers, an inboard (closer to spacecraft bus) and outboard (on tip of boom) magnetometer. Presented are the science and instrument requirements, ground and initial on-orbit instrument calibration and data validation. The on-orbit analysis found magnetic contamination along with temperature dependency effects that resulted in unexpected instrument noise and decreased accuracy, with the issues generally more significant on the inboard magnetometer. The outboard sensor was used for initial analysis of MAG performance. Preliminary comparison, excluding arcjet firing periods, between the outboard magnetometer and the GOES-14 magnetometer found a statistical difference of 5 nT at 3 σ for the total field. This comparison does not consider inaccuracies in the GOES-14 magnetometer. Future studies will focus on optimizing the outboard sensor performance. [ABSTRACT FROM AUTHOR]

Background Previous studies have shown that making multiple residential moves in childhood leads to an increased risk of emotional and behavioural problems in early adulthood and to poorer self-reported health in midlife. Such studies tend to focus on one or two health variables, measured at one time point. This study examines health status in early adulthood and midlife across a wider range of measures. Aim To compare subjects who were residentially stable in childhood with those who had moved more often in terms of a wide range of health measurements at 18 and 36. Methods Analysis of the 1970s cohort of the West of Scotland Twenty-07 Study. In total, 850 respondents who participated in waves 1 (1987/88), 2 (1990/92) and 5 (2007/8) of the study, and whose childhood residential history was available, were included in regression analyses. Residential stability was derived from the number of addresses at which the respondent had lived between birth and age 15 and 18. We considered directly measured health variables (BMI, waist-hip ratio and lung function), self-reported health, psychological wellbeing (GHQ12) and self-reported health behaviours (smoking, drinking and trying drugs). Results Twenty percent of respondents remained residentially stable during childhood, 59% had moved 1-2 times and 21% had moved at least 3 times. Directly measured health variables were not associated with number of residential moves made at 18 or 36. Odds of scoring at least 3 on the GHQ12 questionnaire were significantly increased at age 18 for those moving 1-2 times (OR 2.01 (1.36–2.96)) and those moving 3 times or more (OR 2.04 (1.3, 3.22)) compared to those who remained stable. Similarly, odds of reporting a long-standing illness at 18 were increased for 1-2 moves (OR 1.88 (1.11, 3.18)) and at least 3 moves (OR=2.03 (1.11, 3.69)). Odds were elevated, but not significant, at 36 for these health variables. Odds of trying drugs and smoking at 18 were significantly increased but only for those moving at least 3 times. Although elevated, odds for these health behaviours were not significant at 36. Conclusions Increased mobility during childhood is independently associated with adverse health status. At 18, the relationships between residential mobility and self-reported health outcomes, psychological wellbeing and some health behaviours were significant; however, by 36 findings were no longer significant. Directly measured health variables, at 18 and 36, do not appear to be associated with childhood mobility. [ABSTRACT FROM AUTHOR]

Background Previous studies have shown that making multiple residential moves in childhood leads to an increased risk of emotional and behavioural problems in early adulthood and to poorer self-reported health in midlife. Such studies tend to focus on one or two health variables, measured at one time point. This study examines health status in early adulthood and midlife across a wider range of measures. Aim To compare subjects who were residentially stable in childhood with those who had moved more often in terms of a wide range of health measurements at 18 and 36. Methods Analysis of the 1970s cohort of the West of Scotland Twenty-07 Study. In total, 850 respondents who participated in waves 1 (1987/88), 2 (1990/92) and 5 (2007/8) of the study, and whose childhood residential history was available, were included in regression analyses. Residential stability was derived from the number of addresses at which the respondent had lived between birth and age 15 and 18. We considered directly measured health variables (BMI, waist-hip ratio and lung function), self-reported health, psychological wellbeing (GHQ12) and self-reported health behaviours (smoking, drinking and trying drugs). Results Twenty percent of respondents remained residentially stable during childhood, 59% had moved 1-2 times and 21% had moved at least 3 times. Directly measured health variables were not associated with number of residential moves made at 18 or 36. Odds of scoring at least 3 on the GHQ12 questionnaire were significantly increased at age 18 for those moving 1-2 times (OR 2.01 (1.36–2.96)) and those moving 3 times or more (OR 2.04 (1.3, 3.22)) compared to those who remained stable. Similarly, odds of reporting a long-standing illness at 18 were increased for 1-2 moves (OR 1.88 (1.11, 3.18)) and at least 3 moves (OR=2.03 (1.11, 3.69)). Odds were elevated, but not significant, at 36 for these health variables. Odds of trying drugs and smoking at 18 were significantly increased but only for those moving at least 3 times. Although elevated, odds for these health behaviours were not significant at 36. Conclusions Increased mobility during childhood is independently associated with adverse health status. At 18, the relationships between residential mobility and self-reported health outcomes, psychological wellbeing and some health behaviours were significant; however, by 36 findings were no longer significant. Directly measured health variables, at 18 and 36, do not appear to be associated with childhood mobility. [ABSTRACT FROM PUBLISHER]

Modeling studies examining the effect of lakes on regional and global climate, as well as studies on the influence of climate variability and change on aquatic ecosystems, are surveyed. Fully coupled atmosphere-land surface-lake climate models that could be used for both of these types of study simultaneously do not presently exist, though there are many applications that would benefit from such models. It is argued here that current understanding of physical and biogeochemical processes in freshwater systems is sufficient to begin to construct such models, and a path forward is proposed. The largest impediment to fully representing lakes in the climate system lies in the handling of lakes that are too small to be explicitly resolved by the climate model, and that make up the majority of the lake-covered area at the resolutions currently used by global and regional climate models. Ongoing development within the hydrological sciences community and continual improvements in model resolution should help ameliorate this issue. [ABSTRACT FROM AUTHOR]