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The South African fruit export industry is a key contributor to the country's economy, and must be managed efficiently to that ensure its vital role is maintained. Significant increases in reefer freight rates have placed substantial pressure on the fruit export industry to find new and innovative ways of improving the space / volume use of fruit in these reefer containers. Improvements must adhere to key constraints to ensure that fruit quality and shelf life are not compromised. This paper analyses the current potential for increasing the mass of stone and pome fruit that is exported in reefer containers. The study indicates that pome fruit has the greatest opportunity for improvement, whereas stone fruit has less room for improving the use of space / volume. Proposed improvement methods are: optimal packing arrangements of fruit; improved packaging and pallet dimensions (special pallet sizes); improved stacking arrangements of cartons on pallets and pallets in reefers; and lastly, the use of slip sheets instead of pallets. [ABSTRACT FROM AUTHOR]

The concepts of Industry 4.0 and closed loop supply chains are becoming popular as logistics management evolves. Industry 4.0, through its instruments such as cloud manufacturing and the Internet of Things, has been known to improve operations management significantly. At the same time, closed loop supply chains have gained momentum with the increase in environmental sustainability issues. However, closed loop supply chains are often associated with uncertainties in the timing, quality, and quantity of returns. For these and other reasons, most organisations employ third parties to perform most reverse logistics activities. This paper systematically reviews the literature on the entry and use of third parties in reverse logistics with the objective of providing researchers with future research directions for this fast-emerging topic. The results show that there is a need to expand on the literature and on managerial issues such as performance measurement of reverse logistics networks with third parties. The literature also needs to consider how third parties use technological aspects such as Industry 4.0 to manage and operate reverse supply chains successfully. [ABSTRACT FROM AUTHOR]

Successful innovation projects require an adequate innovation management capability in organisations. This means a sufficiently rigorous, continuous, and goal-oriented management of innovation processes. The literature research demonstrates that an integrated innovation methodology requires highly qualitative processes that are both flexible and customer-specific in their design. This work focuses on the FuGle® innovation process model, which is applied at the Industrial Engineering Department of Stellenbosch University. The enhanced FuGle® innovation process model presents flexible processes that are supported by methods and techniques that guide the user to drive innovation projects. This paper presents an innovation approach that enables organisations proactively to manage customer needs and trends. Thus the enhanced FuGle® innovation process model aims to turn an innovation project into a marketable product. [ABSTRACT FROM AUTHOR]

In today's competitive environment, organisations cannot afford to focus only on effectiveness and efficiencies - they also need to innovate. This is evident from most literature sources on innovation. Innovation topics, such as the innovation process and the drivers, barriers, principles, and success factors for innovation, have received a lot of attention in the literature. What is still lacking, however, is a consolidated view of the core requirements for building an innovation capability within an organisation. This paper lays the foundation for an innovation capability reference architecture by identifying those innovation success factors or requirements described in the literature, and consolidating and structuring it within an easy-to-use enterprise architecture framework. [ABSTRACT FROM AUTHOR]

The objective of this study was to determine the effect of ripeness and of different tannin extraction methods on the sensory properties of wine, with a specific focus on mouthfeel properties. Quantitative descriptive analysis (QDA) was performed to evaluate the sensory properties of 20 young Shiraz wines in two phases. In Phase 1, wines from a cool area were evaluated and, in Phase 2, wines from a warm area were evaluated. Clear differences were found between the wines from the two regions. Wines from the cooler region were generally associated with higher levels of total non-flavonoids and total anthocyanins, and more intense numbing and puckering sensations. In contrast, the wines from the warmer region as a group were associated with a more drying and grippy mouthfeel, as well as less total anthocyanins and total non-flavonoids. In the set of wines from the cooler region, the effect of ripeness was more pronounced than in the set of wines from the warmer region. In both cases, riper grapes resulted in a coarser surface smoothness, a more numbing sensation, a bitter aftertaste and less adhesive mouthfeel. The wines from the cooler region that were harvested at a riper stage were associated with many of the anthocyanins/ anthocyanin derivatives and were negatively associated with hydroxycinnamate, procyanidin B1 and delphinidin-3-glucoside-p-coumaric acid. In the warmer area, the riper grapes were again associated with anthocyanins/anthocyanin derivatives, but this time were strongly associated with procyanidin B2, caffeic acid, p-coumaric acid, catechin, coutaric acid and total non-flavonoids. The effect of tannin extraction method on the sensory properties of the wines from the warmer region was more pronounced than in the wines from the cooler region. Unfortunately, the differentiation between treatments was not consistent from one ripeness level to the next. However, it appeared that the cold soak treatment differed the least from the control, regardless of region or ripeness, whereas the post-maceration treatment differed the most based on mouthfeel and phenolic composition. Although some mouthfeel attributes and phenolic compounds were consistently associated with region and ripeness, it is not clear if mouthfeel can be manipulated consistently by tannin extraction methods. [ABSTRACT FROM AUTHOR]

Background:Cholesteatoma is considered a benign, gradually expanding and destructive epithelial lesion of the temporal bone. The pathogenesis of different classifications of cholesteatoma is marked by similar underlying cellular and molecular processes. Stepwise explanations of the histopathogenesis have been described previously. The current paper focuses on expounding the molecular events of cholesteatoma.Method and results:Cholesteatoma pathogenesis encompasses a complex network of signalling pathways during: epidermal hyperplasia, perimatrix–matrix interactions and mucosal disease. This paper presents a review of the molecular events driven by inflammatory mediators and enzymes during: cholesteatoma growth (cell proliferation and apoptosis); maintenance and deterioration (angiogenesis and hypoxia, oxidative stress and toxicity); and complications (bone erosion and hearing loss). The cascade of molecular events applicable to atelectasis and cholesteatoma that coexist with chronic otitis media and bone erosion as sequelae is summarised.Conclusion:The role of lipids in this disease is relatively unexplored, but there is evidence in support of fatty acid role-players that needs confirmation. Future directions in lipid research to delineate molecular mechanisms are proposed. [ABSTRACT FROM PUBLISHER]

Background: Since Virchow's first, 1855 publication on cholesteatoma, this disease has been the subject of extensive debate. The pathogenesis of acquired cholesteatoma is repeatedly explained on the premises of the migration, hyperplasia and metaplasia theories, but proof for the latter theory remains limited. In retrospect, there is progress toward better understanding of all the pathological mechanisms involved, as expounded in this review. Discussion: The triggers for cholesteatoma onset are diverse, and may involve tympanic membrane trauma (i.e. perforation, displacement, retraction or invagination), tympanic membrane disease, and/or tympanic cavity mucosa disease. Research has revealed that cell migration is replaced under inflammatory conditions by hyperplasia, which triggers the onset of cholesteatoma. Lately, the hyperplasia theory gained prominence and circumscription of the papillary cone formation concept provided insight into cholesteatoma progression (growth and expansion). Diseased mucosa can contribute to the development of retraction pockets and cholesteatoma. The type of cholesteatoma trigger and the role of chronic inflammation during disease progression and recurrence are important in guiding clinical intervention. [ABSTRACT FROM AUTHOR]

Human papilloma virus (HPV)-induced recurrent laryngeal papillomatosis (RLP) is a chronic debilitating disease often encountered among children of poor socio-economic South African groups. There are a few studies and limited evidence as to what extent nutrition may contribute to this disease. To our knowledge this is the first study that gives an account of dietary FA and micronutrient intakes in RLP patients, according to food frequency questionnaires. The dietary FA profile revealed an excessive linoleic acid (LA) intake syndrome and is also marked by high palmitic acid (PA), oleic acid (OA) and SFA intakes. Research revealed that enhanced LA and PA drive, respectively, mitogenic stimuli and apoptotic resistance during tumorigenesis, whist SFAs are associated with lipid rafts, the Th1 immune response and immunosuppression. Low folate intake, a risk for HPV-infection, and low Zn intake, detrimental for lipid metabolism and immunocompetence, occurred in, respectively, 70% and 20% RLP patients. The poor correlations that were found in RLP patients between essential fatty acids (EFAs) and micronutrients, namely, Mg, Zn and Se, involved in lipid metabolism and immune responses, need proper clarification. Overall, it is plausible that the diet (poor nutrition), a shift in lipid metabolism caused by HPV- infection, environmental smoke and oxidative stress, as well as extra-esophageal acid reflux with secondary inflammation in the larynx are co-factors in the etiology of laryngeal papillomatosis, and that immunocompromised patients are subjected to recurrence. It is imperative to ensure that children with RLP receive proper nutrition and follow a healthy lifestyle to prevent disease recurrence after treatment. [ABSTRACT FROM AUTHOR]

Human papilloma virus-induced recurrent laryngeal papillomatosis is considered a troublesome and dangerous disease, because it can cause airway obstruction. Better understanding of metabolic pathways followed under pathological conditions can contribute to improved therapies by which growth and recurrence may be obviated. Part I of this study presents a clinically relevant total lipid fatty acid profile for papilloma cells, analyzed by gas liquid chromatography and a phosholipid red blood cell profile for RLP patients, analyzed by thin layer chromatography. In the papilloma cells virus interference with delta-6 and delta 5- desaturase activities is prevalent and the n-9 FA metabolic pathway is followed. It is plausible that up-regulated fatty acid synthase and 9 desaturase activities occur, since enhanced saturated fatty acids and monounsaturated fatty acid levels are also prevalent. High saturated fatty acid levels are known for their propensity to interfere with delta-6 and delta-5 desaturase activities and this is reflected in the blood profile of the RLP patients. It is also known that enhanced saturated fatty acid levels can contribute to enhanced cyclooxygenase-2 activity. Furthermore, cumulative oxidative stress with an oxidative burst is responsible for complete exhaustion of exogenous dietary arachidonic acid intake in these patients. The role of linoleic acid needs to be defined. The dietary intakes of lipids and micronutrients in RLP patients and a rationale for adjuvant FA therapy in the management of these patients are discussed in parts II and III of the study. [ABSTRACT FROM AUTHOR]

"Instead of being really good at doing some particular thing, companies must be really good at learning how to do new things" [1]. This ability to do new things involves both the identification and the mastery of the next 'new thing' as well as the ability to align the rest of the company with this new direction. This paper focuses on the alignment of innovation activities with the overall business strategy and infrastructure. An innovation strategic alignment model is presented that supports alignment in a company by identifying the driver of change and its impact on other areas of the business. [ABSTRACT FROM AUTHOR]

Abstract: Cervical cancer is a leading cause of death in developing countries and is the second highest occurring cancer in women all over the world. The progression of cancer is a multistep process affecting aspects of cellular function such as proliferation, differentiation and apoptosis. Mitogen activated protein kinases (MAPKs), which include p38-MAPK, c-Jun NH2-terminal kinase (JNK) and extracellular signal-regulated kinases (ERKs) are closely associated with cell proliferation and apoptosis and the balance between them could determine a cell''s fate. Despite the expanding research effort in vitro, little is known about MAPK activation in clinical specimens of cervical cancer. Therefore, the aim of this ex vivo study was to correlate the phosphorylation status (activity) of MAPKs (p38-MAPK, JNK and ERK), as well as poly (ADP-ribose) polymerase (PARP) and caspase-3 (two cellular markers of apoptosis), during the different stages of cervical carcinogenesis, to observe whether correlations between MAPK activities and apoptosis during the disease process exist. Decreased p38-MAPK phosphorylation was found in the carcinoma (Ca) group) compared to the normal tissues, as well when the low grade squamous intraepithelial lesion—LSIL) group and high grade squamous intraepithelial lesion—HSIL) group were compared with the Ca group. Interestingly, a significant decrease in ERK44 phosphorylation was observed in Ca when compared to LSIL and HSIL. There was also a significant decrease in JNK phosphorylation in Ca when compared with normal tissue and HSIL. As expected, caspase-3 activation and PARP cleavage was significantly lower in Ca when compared with normal tissue. Our results present the first evidence of in vivo involvement of MAPKs in cervical cancer and indicate a possible correlation between MAPK activities and apoptosis in the disease process. [Copyright &y& Elsevier]

We analyse the impact of failing to control invasive alien plants (IAPs) on the water supply to the Berg River and De Hoop Dams, in other words, the opportunity cost of not clearing IAPs in these two catchments. To do this we used models to assess and compare the impact of current and future invasions on inflows into the dams. Although the clearing of current invasions would only provide a modest increase in the amount of water compared to, for example, the construction of another dam, failure to clear the invasion will have a negative impact on water security in the long term. We estimated that the Berg River Dam could lose up to 51% of its mean annual inflows to IAPs over a 45-year period, and the De Hoop Dam catchment could lose up to 44%. These impacts would continue to increase over time, and the costs of control could become very high as the plants invade rugged terrain. Major infrastructural development requires Ministerial approval, supported by advice from senior officials. We suggest that such advice should substantively take sufficient account of the benefits of clearing existing invasions, or at least of preventing further invasions. Our results suggest that serious consequences arise from insufficient investment in catchment management. An integrated approach to the management of the supply of and demand for water, that ensures long-term sustainability, is essential in informed decision-making and the early control of IAPs is a key component of that approach. [ABSTRACT FROM AUTHOR]