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Purpose: Improvements in outcomes for adolescent and young adult (AYA) oncology patients have lagged behind those of other age-specific cancer populations. Research has indicated that low availability of clinical trials, biological differences of this age-group, and several psychosocial factors including higher emotional distress impact outcomes. To improve care and survival rates for these patients, hospitals have implemented AYA oncology programs. The current study evaluated documentation of care in an AYA program housed in an academic medical center based on three areas emphasized in the National Comprehensive Cancer Network's Clinical Practice Guidelines in Oncology for AYAs: clinical trial enrollment, fertility, and psychosocial care. Methods: Retrospective chart reviews were conducted for 45 patients treated before the start of the AYA oncology program and 45 patients treated after program initiation. Patients aged 15–39 years with a diagnosis of a malignant tumor were included. Variables evaluated included documentation of clinical trial enrollment, fertility preservation and sexual health considerations, and behavioral health referrals. Results: Documentation of most clinical trial and fertility variables did not significantly improve from pre- to post-program, although a higher number of patients had these variables documented post-program. Behavioral health referrals increased significantly from 52.8% pre-program to 95.4% post-program. Conclusion: Access to behavioral health care improved the most following implementation of our AYA program, which is likely because of the integration of a dedicated psychologist for AYAs when the program began. The practice of guideline-based care for this population can be better assessed and improved with designated behavioral health providers and more systematic documentation processes. [ABSTRACT FROM AUTHOR]

Over the past 10 years, sexually transmitted infections (STIs) have seen a significant resurgence in the United States despite the availability of effective treatments and reliable prevention methods. Rhode Island has experienced a similar uptick in the incidence of syphilis, chlamydia and gonorrhea, with many cases occurring among gay, bisexual, men who have sex with men (GBMSM), which coincides with a recent concerning rise in congenital syphilis cases. We reviewed the most recent STI trends for the state of Rhode Island in 2022. During this year, 6,883 cases of STIs were reported to the Department of Health (N=5,199 chlamydia, 1,444 gonorrhea, and 240 infectious syphilis cases). Compared to 2012, this represented a 21%, 185%, and 253% increase in chlamydia, gonorrhea, and syphilis infections, respectively. Since 2020, eight cases of congenital syphilis have been reported. Prior to 2020, no cases of congenital syphilis were reported since 2009. This resurgence is mainly attributed to shifting social and behavioral trends, particularly among younger individuals and shared sexual networks across diverse groups.1 Further efforts and resources are needed to effectively address these concerning trends in STIs. [ABSTRACT FROM AUTHOR]

Simple Summary: Terrestrial animals, including humans and domestic dogs, naturally create cognitive maps in the horizontal plane in order to navigate; their navigation in the vertical plane is poorer, given their land-based locomotion. For humans, the development of multi-story buildings highlights this difficulty in mapping vertical space: for instance, on an elevator, humans typically rely on visual information about the height of the landing—floor numbers, e.g.,—to know where they are. However, human companions, domestic dogs, cannot rely on number cues, and do not appear to reliably know when the elevator has stopped on their home floor. In this study, we examined if dogs can learn what floor they are on based on a visual or odor cue on their floor, similar to humans' use of a number cue. The subject dogs were able to do so, with some caveats. Our results suggest that cues may help dogs navigate an anthropocentric environment. Spatial navigation allows animals to understand their environment position and is crucial to survival. An animal's primary mode of spatial navigation (horizontal or vertical) is dependent on how they naturally move in space. Observations of the domestic dog (Canis familiaris) have shown that they, like other terrestrial animals, navigate poorly in vertical space. This deficit is visible in their use of multi-story buildings. To date, no research has been conducted to determine if dogs can learn how to navigate in an anthropogenic vertical environment with the help of a landmark. As such, we herein investigate the effect of the addition of a visual or olfactory landmark on dogs' ability to identify when they are on their home floor. Subject behaviors toward their home door and a contrasting floor door were compared before and after exposure to a landmark outside of their home door. While subjects initially showed no difference in latency to approach an apartment door on their home or a wrong floor, we found a significant difference in latency to approach the doors in the test trials for subjects who approached the doors in every trial. Other findings are equivocal, but this result is consistent with the hypothesis that dogs can learn to navigate in vertical space. [ABSTRACT FROM AUTHOR]

Systems consolidation theories propose two mechanisms that enable the behavioral integration of related memories: coordinated reactivation between hippocampus and cortex, and the emergence of cortical traces that reflect overlap across memories. However, there is limited empirical evidence that links these mechanisms to the emergence of behavioral integration over time. In two experiments, participants implicitly encoded sequences of objects with overlapping structure. Assessment of behavioral integration showed that response times during a recognition task reflected behavioral priming between objects that never occurred together in time but belonged to overlapping sequences. This priming was consolidation-dependent and only emerged for sequences learned 24 hr prior to the test. Critically, behavioral integration was related to changes in neural pattern similarity in the medial prefrontal cortex and increases in post-learning rest connectivity between the posterior hippocampus and lateral occipital cortex. These findings suggest that memories with a shared predictive structure become behaviorally integrated through a consolidation- related restructuring of the learned sequences, providing insight into the relationship between different consolidation mechanisms that support behavioral integration. [ABSTRACT FROM AUTHOR]

AbstractThis study was conducted to monitor and evaluate the health risks of multiple organophosphorus pesticide residues in three characteristic fruits of Maragheh district, East Azerbaijan province. The Monte Carlo method was used to quantify the possible non-carcinogenic health risks associated with pesticide residues in adults and children. The residues of 17 pesticides in 36 samples were analysed using the QuEChERS extraction method coupled with gas chromatography-mass spectrometry (GC/MS). Residues of 13 pesticides (76.47%) were detected in grape samples and 15 pesticides (88.23%) in apricot and plum samples. The maximum level found in grape samples was due to chlorpyrifos with 1.2 mg/kg, and in apricot and plum samples to diazinon with 1.6 and 1.3 mg/kg, respectively. All grape, apricot and plum samples contained at least ten pesticides with levels exceeding the Iranian and EU Maximum Residue Limits (MRLs). The processing factor for washing treatment in grape, apricot and plum samples was less than 1, ranging from 0.53 to 0.69. Chlorpyrifos with values of 0.064 and 0.256 in the grape samples and diazinon with values of 0.0443 and 0.177 in the apricot samples and values of 0.0263 and 0.105 in the plum samples contain the highest hazard quotients (HQ) for adults and children, respectively. The cumulative risk assessment due to exposure to several pesticide residues suggests that there is no significant health risk for adults (HI < 1). However, consumption of unwashed grapes may cause adverse effects in children (HI = 1.48). However, for further research, a comprehensive longitudinal study is suggested to assess the long-term effects of exposure to pesticides especially for children. [ABSTRACT FROM AUTHOR]

Background: The World Health Organization is committed to strengthening access to pre-exposure prophylaxis (PrEP) for HIV prevention and its integration into primary care services. Unfortunately, the COVID-19 pandemic has disrupted the delivery of primary care, including HIV-related services. To determine the extent of this disruption, we conducted a systematic review and meta-analysis of the changes in access to PrEP services during the pandemic and the reasons for these changes. Methods: A search was conducted using PubMed, Scopus, Embase, PsycINFO, and Cinahl for studies published between January 2020 and January 2023. Selected articles described selfreported disruptions to PrEP service access associated with the COVID-19 pandemic or its responses. Pooled effect sizes were computed using a random-effects model. Results: Thirteen studies involving 12,652 PrEP users were included in our analysis. The proportion of participants reporting a disruption in access to PrEP services during the COVID-19 pandemic ranged from 3% to 56%, with a pooled proportion of 21% (95% confidence intervals: 8% to 38%). Social restrictions, financial constraints, and limited health insurance coverage were key factors affecting access to PrEP services during the pandemic. Conclusions: To our knowledge, this is the first meta-analysis to quantify the extent of disruptions to accessing PrEP services because of the COVID-19 pandemic. To increase the ability of primary care services to maintain PrEP services during public health crises, a mixture of strategies is worth considering. These include multimonth PrEP prescriptions, telehealth services, deployment of peer support groups to provide a community-based service or home delivery, and provision of financial support interventions. [ABSTRACT FROM AUTHOR]

Intervention programs for male intimate partner violence (IPV) perpetrators mostly use the group intervention modality. Notwithstanding, the literature has neglected the study of group-related variables and their possible association with these interventions' functioning and outcomes. This systematic review aimed to analyze group-related variables, their predictors, and their relation to the functioning and outcomes of intervention programs for IPV perpetrators. The systematic review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The following databases were searched from inception to November 2022: Web of Science, Scopus, PUBMED, and PsycINFO. Of the 5,941 identified studies, 13 were included in the review. The main predictors of group-related variables were: intervention stage, motivational strategies, and leadership (counseling approach). The group-related variables as predictors of intervention outcomes were: group management behaviors and support (facilitator behavior within the group); positive confrontation, protherapeutic behavior, active involvement, positive interaction with peers, and positive interaction with the facilitator (participant behavior within the group); and group cohesion and group climate (group dynamics). Group cohesion and participants' protherapeutic behavior stood out for their association with positive treatment outcomes (i.e., greater participation and working alliance, lower rates of violent behavior during follow-up). The findings from this review suggest that group processes are key factors in intervention programs for IPV perpetrators, and a better understanding of how these group processes are shaped, and how they can contribute to positive program outcomes, provides a new approach and insights to improve their effectiveness. [ABSTRACT FROM AUTHOR]

Autonomous agents are a critical factor for maintaining the well-being and health of astronaut teams in long duration spaceflight. As autonomous agents become more independent, and interdependent the need to understand how they can interact effectively with humans not only becomes more necessary, but will become the paradigm for future team research. In our paper, we describe a conceptual model that explains how autonomous agents and human team members can learn to implicitly coordinate through humorous social interaction and effective task interdependence. We argue that to build a shared mental model between autonomous agents and human team members, HATs need to develop trust with one another, albeit through different mechanisms, to work together effectively. • Autonomous agents can reduce stress and improve astronaut well-being in long space missions by being humorous. • Humor in human-autonomy teams enhances team cohesion and trust in isolated and confined environments. • Autonomous agents that use adaptive humor foster better team integration improving teamwork during critical periods. • Humorous interactions with autonomous agents can mitigate conflict and improve emotional management. • Autonomous agents' humor contributes to more effective teamwork and sustained well-being. [ABSTRACT FROM AUTHOR]

Amid imposed starvation and Israel's genocidal assault, Palestinians in Gaza return to their foremothers' ovens, practices, and recipes to survive. Ancestral food practices such as baking bread in a clay tabun oven in the absence of fuel and electricity, and foraging for edible and medicinal herbs, become practices of sumud and material survival. Through Palestine's foremothers, the seeds of steadfastness had long been planted. Gaza's food vloggers assert an Indigenous presence and a refusal to be erased even in the darkest hour of genocide. I argue that Gaza's digital storytellers provide the source material for Indigenous survival made possible by the creativity of the Gazan people and the lessons they carry from their foremothers. [ABSTRACT FROM AUTHOR]

At each cell division, nanometer-scale motors and microtubules give rise to the micron-scale spindle. Many mitotic motors step helically around microtubules in vitro, and most are predicted to twist the spindle in a left-handed direction. However, the human spindle exhibits only slight global twist, raising the question of how these molecular torques are balanced. Here, using lattice light sheet microscopy, we find that anaphase spindles in the epithelial cell line MCF10A have a high baseline twist, and we identify factors that both increase and decrease this twist. The midzone motors KIF4A and MKLP1 are redundantly required for left-handed twist at anaphase, and we show that KIF4A generates left-handed torque in vitro. The actin cytoskeleton also contributes to left-handed twist, but dynein and its cortical recruitment factor LGN counteract it. Together, our work demonstrates that force generators regulate twist in opposite directions from both within and outside the spindle, preventing strong spindle twist during chromosome segregation. [ABSTRACT FROM AUTHOR]

LSD is a hallucinogen with complex neurobiological and behavioral effects. Underlying these effects are changes in brain neuroplasticity. This is the first study to follow the developmental changes in brain structure and function following LSD exposure in periadolescence. We hypothesized LSD given during a time of heightened neuroplasticity, particularly in the forebrain, would affect cognitive and emotional behavior and the associated underlying neuroanatomy and neurocircuitry. Female and male mice were given vehicle, single or multiple treatments of 3.3 µg of LSD by oral gavage starting on postnatal day 51. Between postnatal days 90–120 mice were imaged and tested for cognitive and motor behavior. MRI data from voxel-based morphometry, diffusion weighted imaging, and BOLD resting state functional connectivity were registered to a mouse 3D MRI atlas with 139 brain regions providing site-specific differences in global brain structure and functional connectivity between experimental groups. Motor behavior and cognitive performance were unaffected by periadolescent exposure to LSD. Differences across experimental groups in brain volume for any of the 139 brain areas were few in number and not focused on any specific brain region. Multiple exposures to LSD significantly altered gray matter microarchitecture across much of the brain. These changes were primary associated with the thalamus, sensory and motor cortices, and basal ganglia. The forebrain olfactory system and prefrontal cortex and hindbrain cerebellum and brainstem were unaffected. The functional connectivity between forebrain white matter tracts and sensorimotor cortices and hippocampus was reduced with multidose LSD exposure. Does exposure to LSD in late adolescence have lasting effects on brain development? The bulk of our significant findings were seen through changes is DWI values across 74 brain areas in the multi-dose LSD group. The pronounced changes in indices of anisotropy across much of the brain would suggest altered gray matter microarchitecture and neuroplasticity. There was no evidence of LSD having consequential effects on cognitive or motor behavior when animal were evaluated as young adults 90–120 days of age. Neither were there any differences in the volume of specific brain areas between experimental conditions. The reduction in connectivity in forebrain white matter tracts with multidose LSD and consolidation around sensorimotor and hippocampal brain areas requires a battery of tests to understand the consequences of these changes on behavior. [ABSTRACT FROM AUTHOR]

LSD is a hallucinogen with complex neurobiological and behavioral effects. Underlying these effects are changes in brain neuroplasticity. This is the first study to follow the developmental changes in brain structure and function following LSD exposure in periadolescence. We hypothesized LSD given during a time of heightened neuroplasticity, particularly in the forebrain, would affect cognitive and emotional behavior and the associated underlying neuroanatomy and neurocircuitry. Female and male mice were given vehicle, single or multiple treatments of 3.3 µg of LSD by oral gavage starting on postnatal day 51. Between postnatal days 90–120 mice were imaged and tested for cognitive and motor behavior. MRI data from voxel-based morphometry, diffusion weighted imaging, and BOLD resting state functional connectivity were registered to a mouse 3D MRI atlas with 139 brain regions providing site-specific differences in global brain structure and functional connectivity between experimental groups. Motor behavior and cognitive performance were unaffected by periadolescent exposure to LSD. Differences across experimental groups in brain volume for any of the 139 brain areas were few in number and not focused on any specific brain region. Multiple exposures to LSD significantly altered gray matter microarchitecture across much of the brain. These changes were primary associated with the thalamus, sensory and motor cortices, and basal ganglia. The forebrain olfactory system and prefrontal cortex and hindbrain cerebellum and brainstem were unaffected. The functional connectivity between forebrain white matter tracts and sensorimotor cortices and hippocampus was reduced with multidose LSD exposure. Does exposure to LSD in late adolescence have lasting effects on brain development? The bulk of our significant findings were seen through changes is DWI values across 74 brain areas in the multi-dose LSD group. The pronounced changes in indices of anisotropy across much of the brain would suggest altered gray matter microarchitecture and neuroplasticity. There was no evidence of LSD having consequential effects on cognitive or motor behavior when animal were evaluated as young adults 90–120 days of age. Neither were there any differences in the volume of specific brain areas between experimental conditions. The reduction in connectivity in forebrain white matter tracts with multidose LSD and consolidation around sensorimotor and hippocampal brain areas requires a battery of tests to understand the consequences of these changes on behavior. [ABSTRACT FROM AUTHOR]

Across the seventeenth and eighteenth centuries, Atlantic African leaders confronted new challenges as the European demand for captive African labour transformed the political economy of the region and the experience of living within it. Among a range of new and remodelled strategies designed to protect their polities, West African leaders used alcohol diplomacy to facilitate political alliance, cross-cultural communication and economic exchange. This article draws on warehouse registers, European travelogues and joint-stock company correspondence to uncover Queen Tituba of Agona (c. 1638–1707) in her efforts to manage the English Royal African Company. By tracing her adroit use of alcohol, it reveals how West Africans repurposed English commodities to fit their own patterns of consumption and exchange. From funnelling diplomatic gifts of brandy into Akan-speaking political hierarchies to resolving disputes over rum, the queen drew on alcohol to fortify her rule against other coastal powers and navigate the demands of her own officials, subjects and enslaved labourers. She deployed alcohol in these ways despite, and because of, the pressures placed on her as a woman political leader. Essential to trade and ritual, yet morally fraught, Queen Tituba's use of alcohol upended the European hierarchies of race and gender that consigned West African women to the status of commodity rather than recognized them as strategic consumers. Following alcohol offers a way of unravelling the intersection between gender, consumption and authority in a period when the trafficking of enslaved African peoples fundamentally transformed Atlantic political economy. [ABSTRACT FROM AUTHOR]

Background. The efficacy and safety of esketamine nasal spray (ESK) were established in registration trials in patients with treatment‐resistant depression (TRD). This French real‐world study aimed to describe the treatment patterns, effectiveness, and safety of ESK in TRD patients over a 12‐month follow‐up. Materials and Methods. This study used secondary data from patient files of hospital‐based psychiatrists and started during the first French patient early access to ESK. The response and remission rates with ESK were analyzed using the total score of the Montgomery–Åsberg Depression Rating Scale (MADRS). The time to first treatment response and work resumption were described (Kaplan–Meier method). Adverse events (AEs) were analyzed. Results. Prior to ESK initiation, the 157 analyzed patients (age ≤ 65 years, 82.8%; female, 66.2%) had depression for 10.5 years (median, IQR, 4.2–21.2) and received a median of 6 (3–8) previous treatment lines. At ESK initiation, the mean ± SD total MADRS score was 32.1 ± 7.7. At that time, ESK was combined with antidepressants (93.6% of patients; SNRI, 65.0%; SSRI, 57.3%) and/or other potentiation strategy (63.1%; atypical antipsychotics, 36.3%; lithium, 25.6%; antiepileptics, 21.7%). During the 12‐month follow‐up, 125 patients (79.6%) discontinued ESK. The median duration of ESK treatment was 19.4 weeks (IQR, 4.4–40.1). At 1 month after ESK initiation, 40.2% of still treated patients met criteria for clinical response and 19.7% for remission (median time to response, 5.7 weeks; 95% CI (4.1–8.4)). 82.6% of active patients were on sick leave at ESK initiation; the work resumption rate was 24% (13%–40%) 12 weeks later. AEs were reported in 68.6% of patients, serious AEs in 17.2%, and AEs leading to ESK discontinuation in 14.6%. Conclusion. These real‐world effectiveness and safety data were consistent with findings from previous clinical trials, describing the real‐life clinical experience of patients receiving ESK and confirming that ESK has its place in therapy for the treatment of TRD. [ABSTRACT FROM AUTHOR]

Anticipatory coarticulation is a highly informative cue to upcoming linguistic information: listeners can identify that the word is ben and not bed by hearing the vowel alone. The present study compares the relative performances of human listeners and a self-supervised pre-trained speech model (wav2vec 2.0) in the use of nasal coarticulation to classify vowels. Stimuli consisted of nasalized (from CVN words) and non-nasalized (from CVCs) American English vowels produced by 60 humans and generated in 36 TTS voices. wav2vec 2.0 performance is similar to human listener performance, in aggregate. Broken down by vowel type: both wav2vec 2.0 and listeners perform higher for non-nasalized vowels produced naturally by humans. However, wav2vec 2.0 shows higher correct classification performance for nasalized vowels, than for non-nasalized vowels, for TTS voices. Speaker-level patterns reveal that listeners' use of coarticulation is highly variable across talkers. wav2vec 2.0 also shows cross-talker variability in performance. Analyses also reveal differences in the use of multiple acoustic cues in nasalized vowel classifications across listeners and the wav2vec 2.0. Findings have implications for understanding how coarticulatory variation is used in speech perception. Results also can provide insight into how neural systems learn to attend to the unique acoustic features of coarticulation. [ABSTRACT FROM AUTHOR]

A multi-crystalline specimen of gadolinium zirconate (Gd 2 Zr 2 O 7) has been synthesized by solid-state reaction method (un-milled sample). The sample underwent high-energy ball-milling for 6 h, 12 h, 18 h, and 24 h durations (milled samples). An investigation has been conducted to examine the effects of mechanical attrition on structural, microstructural, vibrational, and dielectric properties. Notably, the elemental analysis of the samples reveals a substantial increase in the atomic percentage of oxygen. This indicates the partial development of an oxygen-enriched phase during the milling process. The Rietveld refinement of X-ray diffraction profiles indicates that all the samples have a disordered fluorite structure however, in the 18 h and 24 h milling samples in addition to this main phase, a minor ordered phrochlore-phase has been formed. The nano-phasic character of all the milled samples has been confirmed by the SEM, TEM, and BET surface area analysis. The BET isotherms displayed a type –II hysteresis loop, indicating that all the samples are macro-porous with a pore diameter exceeding 50 nm. The FTIR and Raman spectrum studies indicate the presence of both defect fluorite and pyrochlore phases in the samples. An in-depth investigation has been conducted on the impact of mechanical milling-induced reduction in particle size and micro-strain on conduction mechanism, dielectric relaxation, and variation of various dielectric properties with frequency. [ABSTRACT FROM AUTHOR]

The importance of psychopathy for perpetration and maintenance of intimate partner violence (IPV) has been speculated. However, less is known about whether psychopathy would explain a psychophysiological response (cardiorespiratory and electrodermal) of IPV perpetrators dealing with acute stressors. Therefore, we first aimed to assess whether IPV perpetrators (n = 58) showed differences in psychopathic traits and their psychophysiological response to acute stress compared to nonviolent men (n = 53). Second, we examined in both groups whether psychopathic traits would explain a psychophysiological response when dealing with acute laboratory stress. Our results revealed that IPV perpetrators differed from controls in all the psychopathic traits, scoring higher on all psychopathy scales. Moreover, IPV perpetrators showed lower total respiratory sinus arrhythmia (RSA) levels than controls. Finally, regarding high total psychopathy scores, factor 1 and affective facet entailed low RSA levels in both groups and scoring high in lifestyle facet of factor 2 explained reduced heart rate (HR) changes in response to acute stress in both groups. All these results highlighted that a reduced vagal tone could be characteristic of psychopathic traits, especially for the affective facet of psychopathy. Therefore, it would be important to incorporate biological markers in combination with psychological measurements to clearly diagnose IPV perpetrators before starting intervention programs. This would increase our ability to improve IPV intervention therapeutic targets and reduce risk of recidivism. [ABSTRACT FROM AUTHOR]

Objective: ESKALE is a French, multicentre, observational study of adults with treatment-resistant depression (TRD) treated with esketamine. This interim analysis describes baseline demographic and clinical characteristic evolution in patients included and treated from early access program to post-marketing launch. Methods: Data were collected from medical records and included patient characteristics, disease history at esketamine initiation, use of neurostimulation, the patient's care pathway, and the number of antidepressant treatment lines prescribed prior to esketamine initiation. Descriptive statistics were used for each cohort: the early access program 'Temporary Authorisation for Use' (ATU), post-ATU, and post-launch cohorts. Results: The overall ESKALE cohort (N = 160 included; n = 157 treated with esketamine; average age 49.0 years; 66.2% female) demonstrated moderate-to-severe depression according to clinical assessment and a mean Montgomery-Åsberg Depression Rating Scale score of 32.6 (8.0); however, severity, subtype, and comorbidities were heterogeneous across the cohorts. Earlier use of esketamine and prior to alternative treatments occurred during the later cohorts. Conclusion: These findings demonstrated a high burden of TRD in these patients and that esketamine is used in TRD treatment regardless of their disease severity, subtype, or existing comorbidities. These results also suggest that esketamine is potentially a clinically useful alternative treatment, particularly with healthcare professionals gaining greater familiarity with and easier access to esketamine. KEY POINTS: ESKALE is a long-term, French, multicentre, observational study based on secondary data in adult patients with treatment-resistant depression (TRD) who initiated esketamine treatment in one of three mutually exclusive cohorts: the Temporary Authorisation for Use (ATU), post-ATU, and post-launch cohorts. ESKALE is one of the largest European real-world studies investigating the profiles of more than 150 patients and their treatment with esketamine before and after marketing authorisation. A majority of patients had moderate to severe TRD, with multiple treatment failures with medications and/or neurostimulation prior to esketamine initiation. Esketamine nasal spray administration was undertaken more frequently in an outpatient setting, with the post-administration period monitoring being undertaken mostly by nurses. Esketamine was used in patients with TRD in real-world conditions regardless of their disease severity and subtype or existing comorbidities. These results highlight both the need for an effective treatment for TRD and the adoption of esketamine by multidisciplinary teams that are involved in esketamine prescription and administration. [ABSTRACT FROM AUTHOR]

The 18th century was a period in which the practice of gedik increased visibly in Ottoman tradesmen. In this period, the introduction of the inhisar method in Ottoman tradesmen gave a new meaning to the concept of gedik. In this context, in the secondary literature, the concept of gedik has been mostly defined on the basis of the new meaning it has gained as of the 18th century. Therefore, it is possible to draw an indirect conclusion from the definitions of the gedik in the literature, prevents the increase in employment in tradesmen. At this point, the question arises whether the gediks prevent the increase in employment in the tradesmen. Although there are studies in the literature on various branches of tradesmen and the number of shops in these sectors over the years, there is no study that deals with the subject in the context of gedik and its effect on employment. Since the effect of gedik on the employment rate is not the same in every period and in every sector, it was deemed appropriate to select a certain period and sector within the scope of the study. In this context, the aim of the study is to determine to what extent and in which direction the gedik system affects the employment rate and quality of bakery tradesmen. The 18th century, which was the period when the inhisar method was adopted by the state, was preferred as the period. The reason why bakery tradesmen are preferred as a sector is that bakery is one of the sectors that met the gedik system in the earliest and most intense way. Thus, it is aimed to evaluate the policy pursued by the state regarding the production of compulsory foodstuffs and the connection of this policy with the gediks. [ABSTRACT FROM AUTHOR]

This paper provides an educational tool to help the public better understand the greenhouse gas (GHG) emissions from the food they choose to eat on a daily basis. Using balloons filled with the representative volume of GHGs emitted through the growth, harvest, production, and transportation of various food choices, participants are able to visualize the impact of their food choices without the burden of analyzing a graph or table. Additionally, displaying the typical GHG metric of equivalent kilograms of carbon dioxide (kg CO2e) in the volume this gas would occupy at standard pressure and temperature allows for greater clarity in these results. Distribution methods for this visualization tool described herein range from science classrooms to Science, Technology, Engineering, and Mathematics (STEM) outreach events and to restaurants and grocery stores. Several tools are provided as part of this research, including a spreadsheet that incorporates these calculations, presentation slides, a worksheet for the in-class method, and poster images for eateries. For each method, participants are asked to select a protein, vegetable, and starch option to fill their plate and the resulting GHG volume is then calculated based on their selections. This provides context and allows for discussion and reshaping of our contributions to climate change. [ABSTRACT FROM AUTHOR]

Words that describe sensory perception give insight into how language mediates human experience, and the acquisition of these words is one way to examine how we learn to categorize and communicate sensation. We examine the differential predictions of the typological prevalence hypothesis and embodiment hypothesis regarding the acquisition of perception verbs. Studies 1 and 2 examine the acquisition trajectories of perception verbs across 12 languages using parent questionnaire responses, while Study 3 examines their relative frequencies in English corpus data. We find the vision verbs see and look are acquired first, consistent with the typological prevalence hypothesis. However, for children at 12–23 months, touch—not audition—verbs take precedence in terms of their age of acquisition, frequency in child‐produced speech, and frequency in child‐directed speech, consistent with the embodiment hypothesis. Later at 24–35 months old, frequency rates are observably different and audition begins to align with what has previously been reported in adult English data. It seems the initial orientation to verbalizing touch over audition in child–caregiver interaction is especially related to the control of physically and socially appropriate behaviors. Taken together, the results indicate children's acquisition of perception verbs arises from the complex interplay of embodiment, language‐specific input, and child‐directed socialization routines. [ABSTRACT FROM AUTHOR]

It is well established that the integration of behavioral healthcare into the medical home model improves patient outcomes, reduces costs, and increases resident learning. As academic health centers increasingly integrate behavioral healthcare, targeted training for interprofessional collaboration around behavioral healthcare is needed. Simulation educational approaches potentially can provide this training. Health service psychologists are well-poised to support this because of their specialized training in integrated healthcare. The present exploratory study aimed to evaluate existing simulation programs and develop recommendations for integrated behavioral health training and evaluation. Directors of ACGME accredited residency programs that are high utilizers of the medical home model (Pediatrics, Internal Medicine, Medicine/Pediatrics, Family Medicine) as well as Psychiatry residencies and medical schools with membership in the Society for Simulation in Healthcare were recruited to complete a 26-item survey to assess program usage of psychologists as part of simulation training for integrated behavioral healthcare services. Of 79 participants who completed initial items describing their training program, only 32 programs completed the entire survey. While many academic health centers offered integrated team and behavioral health simulations, few utilized psychology faculty in design, implementation, and evaluation. Other behavioral health providers (psychiatrists, social workers) were often involved in medical school and pediatric residency simulations. Few institutions use standardized evaluation. Qualitative feedback and faculty-written questionnaires were often used to evaluate efficacy. Survey responses suggest that psychologists play limited roles in integrated behavioral healthcare simulation despite their expertise in interdisciplinary training, integrated behavioral healthcare, and program evaluation. [ABSTRACT FROM AUTHOR]

Background: Pediatric cancer patients' oncology teams regularly take on a primary care role, but due to the urgent nature of cancer treatment, developmental screenings may be deprioritized. This leaves patients at risk of developmental diagnoses and referrals being delayed. Aims: Clarify the current developmental surveillance and screening practices of one pediatric oncology team. Materials and methods: Researchers reviewed charts for patients (n = 66) seen at a pediatric oncology clinic in a suburban academic medical center to determine engagement in developmental screening (including functioning around related areas such as speech, neurocognition, etc.) and referrals for care in these areas. Results: Developmental histories were collected from all patients through admission history and physical examination (H&P), but there was no routinized follow‐up. Physicians did not conduct regular developmental screening per American Academy of Pediatrics guidelines for any patients but identified n = 3 patients with needs while the psychology team routinely surveilled all patients seen during this time (n = 41) and identified n = 18 patients as having delays. Discussion: Physicians did not routinely screen for development needs beyond H&P and were inconsistent in developmental follow‐up/referrals. Integrated psychologists were key in generating referrals for developmental‐based care. However, many oncology patients were not seen by psychologists quickly or at all, creating a significant gap in care during a crucial developmental period. Conclusion: The case is made for further routinization of ongoing developmental screening in pediatric oncology care. Key points: For pediatric oncology patients, oncology providers may take on a primary care role to surveil, screen, and refer for developmental concerns per guidelines issued by the American Academy of Pediatrics.This quality improvement study sought to explore the developmental monitoring practices of one pediatric oncology clinic.Only a portion of pediatric oncology patients diagnosed with cancer between 6 months and 5 years 11 months received developmental surveillance, screenings, and/or referrals from the oncology team beyond patients' initial history and physical.Patients who were seen by the integrated psycho‐oncology team were the most likely to have received developmental surveillance, screening, and referrals. Integrated psycho‐oncology providers may serve to address gaps in developmental monitoring practices in pediatric oncology clinics. [ABSTRACT FROM AUTHOR]

Glucocorticoid resistance syndrome is a rare disorder with no genetically proven cases reported from India; in addition, there are no descriptions available regarding its management during pregnancy. A 27-year-old woman, hypertensive since the age of 17 years, presented with hypokalemic paresis. She reported regular menses and acne. On investigation, she had elevated serum cortisol that remained unsuppressed after a low-dose dexamethasone suppression test. Genetic analysis revealed a novel, homozygous missense variant in exon 5 of the NR3C1 gene confirming glucocorticoid resistance syndrome. She was managed with oral dexamethasone followed by tapering of antihypertensive drugs. A year later, she conceived with assisted reproductive techniques when dexamethasone was replaced with prednisolone, necessitating the reintroduction of antihypertensive drugs to maintain normotension and potassium supplements to manage hypokalemia. She presented with acute abdomen at 36 weeks of gestation; evaluation revealed right adrenal hemorrhage, which was managed conservatively. Postpartum, the right adrenal lesion reduced in size and an underlying right adrenal myelolipoma was unveiled. [ABSTRACT FROM AUTHOR]

Background: Colorectal cancer (CRC) and liver cancer are two of the leading causes of cancer death in the United States and persistent disparities in CRC and liver cancer incidence and outcomes exist. Chronic hepatitis C virus (HCV) infection is one of the main contributors to liver cancer. Effective screening for both CRC and HCV exist and are recommended for individuals based upon age, regardless of gender or sex assigned at birth. Recommendations for both screening behaviors have been recently updated. However, screening rates for both CRC and HCV are suboptimal. Targeting adoption of multiple screening behaviors has the potential to reduce cancer mortality and disparities. Objective: To examine psychosocial factors associated with completion of CRC and HCV screenings in order to inform a multi-behavioral educational intervention that pairs CRC and HCV screening information. Methods: A cross-sectional survey was conducted with participants (N = 50) recruited at two community health centers in Florida (United States). Kruskal-Wallis and Fisher's exact tests were used to examine associations between completion of both CRC and HCV screening, CRC and HCV knowledge, Preventive Health Model constructs (e.g., salience and coherence, response efficacy, social influence), and sociodemographic variables. Results: Most participants were White (84%), female (56%), insured (80%), and reported a household income of $25,000 or less (53%). 30% reported ever previously completing both CRC and HCV screenings. Prior completion of both screening behaviors was associated with higher educational attainment (p =.014), having health insurance (p =.022), being U.S.-born (p =.043), and higher salience and coherence scores for CRC (p =.040) and HCV (p =.004). Conclusions: Findings demonstrate limited uptake of both CRC and HCV screenings among adults born between 1945 and 1965. Uptake was associated with multiple sociodemographic factors and health beliefs related to salience and coherence. Salience and coherence are modifiable factors associated with completion of both screening tests, suggesting the importance of incorporating these health beliefs in a multi-behavioral cancer education intervention. Additionally, health providers could simultaneously recommend and order CRC and HCV screening to improve uptake among this age cohort. [ABSTRACT FROM AUTHOR]

This article offers an underexplored resistance strategy to gender norms, based on a feminist and queer reading of the work of French thinker Roland Barthes. Building on Barthes's peculiar conception of what he calls "the Neutral" and revisiting his work in light of feminist and queer scholarship on sexual (in)difference, my main goal is to reshape our understanding of what it means to be gender neutral. In opposition to classical conceptions of neutrality associated with passivity, indifference, and blandness, I show that Barthes's Neutral can be conceived as an active gesture, which alters common systems of meanings and power, including the gender binary. But this conception of the Neutral, I argue, neither refers to a call for an androgynous, queer, or nonbinary gender experience. It does not target gender embodiments but gender regulations—that is, the social enforcement of gender categories (by way, for instance, of administrative forms, single-sex bathrooms, or normalizing attitudes toward others). A gender-neutral arrangement, therefore, refers to an ethical, administrative, social, or spatial relation in which subjects are not assigned based on gender categories. This practice of gender suspension, I show, has two main transformative effects. First, it opens a space of freedom and livability for gender-nonconforming subjects. Second, it contributes to lessening the significance of sexual difference in social life and therefore alleviating its symbolic and normative weight for everyone. [ABSTRACT FROM AUTHOR]

The mitotic spindle is the bipolar, microtubule-based structure that segregates chromosomes at each cell division. Aberrant spindles are frequently observed in cancer cells, but how oncogenic transformation affects spindle mechanics and function, particularly in the mechanical context of solid tumors, remains poorly understood. Here, we constitutively overexpress the oncogene cyclin D1 in human MCF10A cells to probe its effects on spindle architecture and response to compressive force. We find that cyclin D1 overexpression increases the incidence of spindles with extra poles, centrioles, and chromosomes. However, it also protects spindle poles from fracturing under compressive force, a deleterious outcome linked to multipolar cell divisions. Our findings suggest that cyclin D1 overexpression may adapt cells to increased compressive stress, possibly contributing to its prevalence in cancers such as breast cancer by allowing continued proliferation in mechanically challenging environments. [ABSTRACT FROM AUTHOR]

Nitrogen-vacancy (NV) centers in diamond are a promising platform for nanoscale NMR sensing. Despite significant progress toward using NV centers to detect and localize nuclear spins down to the single spin level, NV-based spectroscopy of individual, intact, arbitrary target molecules remains elusive. Such sensing requires that target molecules are immobilized within nanometers of NV centers with long spin coherence. The inert nature of diamond typically requires harsh functionalization techniques such as thermal annealing or plasma processing, limiting the scope of functional groups that can be attached to the surface. Solution-phase chemical methods can be readily generalized to install diverse functional groups, but they have not been widely explored for single-crystal diamond surfaces. Moreover, realizing shallow NV centers with long spin coherence times requires highly ordered single-crystal surfaces, and solution-phase functionalization has not yet been shown with such demanding conditions. In this work, we report a versatile strategy to directly functionalize C--H bonds on single-crystal diamond surfaces under ambient conditions using visible light, forming C--F, C--Cl, C--S, and C--N bonds at the surface. This method is compatible with NV centers within 10 nm of the surface with spin coherence times comparable to the state of the art. As a proof-of-principle demonstration, we use shallow ensembles of NV centers to detect nuclear spins from surface-bound functional groups. Our approach to surface functionalization opens the door to deploying NV centers as a tool for chemical sensing and single-molecule spectroscopy. [ABSTRACT FROM AUTHOR]

Background: Spinal cord tumors present a challenge in diagnosis and treatment due to their varied histopathological characteristics. While Ewing sarcoma is a rare malignant tumor typically originating from skeletal bone, cases of primary intradural extraskeletal Ewing sarcoma are exceptionally rare. The similarity of its presentation to other spinal tumors further complicates its identification and management. Case presentation: We report a case of a 58-year-old Palestinian male with intradural extraskeletal lumbar Ewing sarcoma. The patient initially presented with lower back pain and bilateral S1 radiculopathy, with more severe symptoms on the left side. Magnetic resonance imaging revealed a 7 cm oval-shaped mass with homogeneous contrast enhancement, obstructing the spinal canal from L3/L4 to L5/S1 levels. Initially, a myxopapillary ependymoma was suspected, but the patient's sensory and motor functions suddenly deteriorated during hospitalization. Repeat magnetic resonance imaging indicated heterogeneous contrast enhancement, indicating acute intratumoral hemorrhage. Consequently, the patient underwent emergent L3–L5 laminotomy, with successful gross total resection of the tumor. Histopathological and immunohistochemical analyses confirmed the diagnosis of intradural extraskeletal Ewing sarcoma. Adjuvant therapy was administered to minimize the risk of local recurrence or distant metastasis. A systematic review of relevant literature, along with retrospective analysis of medical records, operative reports, radiological studies, and histopathological findings of similar cases, was also conducted. Conclusions: Intradural extraskeletal Ewing sarcoma is an infrequently encountered condition in adult patients, emphasizing the importance of considering it in the differential diagnosis of spinal tumors. Surgeons must possess a comprehensive understanding of this rare entity to ensure accurate staging and optimal management, particularly in the early stages when prompt intervention may improve prognosis. [ABSTRACT FROM AUTHOR]

Background There are various recommendations for third-line treatment in mCRC, however, there is no consensus on who is more suitable for particular strategy. Chemotherapy re-use in third-line setting is a common option in clinical practice. This study aimed to investigate the efficacy of third-line chemotherapy re-use by the comparison with that of anti-angiogenic monotherapy, and further find the population more suitable for third-line chemotherapy. Methods Using electronic medical records of patients with mCRC, a retrospective cohort study was conducted. A total of 143 patients receiving chemotherapy and 40 patients receiving anti-angiogenic monotherapy in third-line setting as control group were retrospectively collected. Baseline characteristics were analyzed using the χ² test or the Fisher’s exact test. ROC curve and surv_cutpoint function of ‘survminer’ package in R software were used to calculate the cut-off value. Survival curves were plotted with the Kaplan-Meier method and were compared using the log-rank test. The Cox proportional hazard regression model was used to analyze the potential risk factors. Results A total of 143 patients receiving chemotherapy and 40 patients receiving anti-angiogenic monotherapy in third-line setting were retrospectively collected. Chemotherapy rechallenge was recorded in 93 patients (93/143, 65.0%), and the remaining patients chose new chemotherapeutic drugs that had not been previously used, including irinotecan-based (22/50), oxaliplatin-based (9/50), raltitrexed (9/50), gemcitabine (5/50) and other agents (5/50). The ORR and DCR of third-line chemotherapy reached 8.8%, 61.3%, respectively (anti-angiogenic monotherapy group: ORR 2.6%, DCR 47.4%). The mPFS and mOS of patients receiving chemotherapy were 4.9 and 12.0 m, respectively (anti-angiogenic monotherapy group: mPFS 2.7 m, mOS 5.2 m). Subgroup analyses found that patients with RAS/RAF mutation, longer PFS (greater than 10.6 m) in front-line treatment or larger tumor burden had better prognosis with third-line chemotherapy rather than anti-angiogenic monotherapy. Conclusions Third-line chemotherapy re-use was effective in mCRC. Those with more aggressive characteristics (RAS/RAF mutant, larger tumor burden) or better efficacy of previous chemotherapy (longer PFS) were more appropriate for third-line chemotherapy, rather than anti-angiogenic monotherapy. [ABSTRACT FROM AUTHOR]

Everyday life is composed of events organized by changes in contexts, with each event containing an unfolding sequence of occurrences. A major challenge facing our memory systems is how to integrate sequential occurrences within events while also maintaining their details and avoiding over-integration across different contexts. We asked if and how distinct hippocampal subfields come to hierarchically and, in parallel, represent both event context and subevent occurrences with learning. Female and male human participants viewed sequential events defined as sequences of objects superimposed on shared color frames while undergoing high-resolution fMRI. Importantly, these events were repeated to induce learning. Event segmentation, as indexed by increased reaction times at event boundaries, was observed in all repetitions. Temporal memory decisions were quicker for items from the same event compared to across different events, indicating that events shaped memory. With learning, hippocampal CA3 multivoxel activation patterns clustered to reflect the event context, with more clustering correlated with behavioral facilitation during event transitions. In contrast, in the dentate gyrus (DG), temporally proximal items that belonged to the same event became associated with more differentiated neural patterns. A computational model explained these results by dynamic inhibition in the DG. Additional similarity measures support the notion that CA3 clustered representations reflect shared voxel populations, while DG's distinct item representations reflect different voxel populations. These findings suggest an interplay between temporal differentiation in the DG and attractor dynamics in CA3. They advance our understanding of how knowledge is structured through integration and separation across time and context. [ABSTRACT FROM AUTHOR]

The article details the efforts of the online resource known as the Internet Archive to preserve Internet news web sites as well as digitizing and archiving physical newspaper collections from around the world.

Human consumption of sea turtles remains prevalent throughout Mexico even though laws restricting trade and take of threatened and endangered species have been in place for several decades. The illegal consumption of sea turtles represents a risk to animal conservation, and the pathogens in the meat can adversely affect human health. In 2017, we surveyed 201 adult residents of 22 coastal communities about their diets, health, and attitudes about the environment, and we collected hair samples that were tested for heavy metals. A large percentage of the samples had high levels of mercury (87%), arsenic (81%), lead (65%), aluminum (57%), and cadmium (31%). Odds ratios suggested that the 28% of participants who reported recent sea turtle consumption had an increased likelihood of high metal levels even after adjusting for sex, age, and consumption of fish that bioaccumulate heavy metals. Conservation efforts may be more successful when they appeal to people's self‐interest rather than merely focusing on ecological benefits. Concerns about toxins in sharks, tuna, and other types of deep‐sea fish have reduced human consumption of some species. Both sea turtle conservation and human health may benefit from awareness campaigns that emphasize the adverse outcomes associated with eating sea turtles while continuing to affirm the economic benefits of healthy ecosystems. Transdisciplinary research that draws on ecology, epidemiology, toxicology, law, and public policy provides a valuable foundation for solving complex health issues. Creative reframing of biodiversity concerns will be necessary for promoting planetary health in a time of accelerating environmental change. Key points: Human consumption of endangered sea turtles remains prevalent throughout Mexico even though laws restricting trade in threatened and endangered species have been in place for several decades.Sea turtle consumption by residents of communities in northwestern Mexico was associated with high hair metal levels even after adjusting for sex, age, and consumption of fish that bioaccumulate heavy metals.Sea turtle conservation efforts may benefit from awareness campaigns that emphasize the adverse health outcomes associated with eating turtle meat while continuing to affirm the economic benefits of healthy ecosystems. [ABSTRACT FROM AUTHOR]

Maria Sibylla Merian, a remarkable woman born in 1647, made significant contributions to the field of entomology through her study of insects and their interactions with other living creatures. Her observations and illustrations challenged widely accepted scientific beliefs, particularly Aristotle's theory of spontaneous generation. Merian's research took her to Suriname, where she studied the diverse species of insects and plants. Despite facing obstacles as a woman in the 17th century, Merian's privileged background and access to resources played a role in her success. The story of Bobbi Wilson, a young Black girl with a passion for entomology, highlights the racial and gender inequalities that persist in science today. Both Merian and Wilson demonstrate the importance of breaking down structural inequities in scientific education to create a more inclusive space for scientific discovery. [Extracted from the article]

Attention in the contemporary educational environment has acquired a fundamental importance for the academic performance and integral development of students. This study set out to design and evaluate a Gamification Activity System specifically conceived for fifth-year elementary school students with attention deficit. The research was carried out at the fiscomisional school of basic education Mercedes Navarrete, with a sample of 20 students and three teachers. A quasiexperimental experimental design of a single pretest-posttest group was implemented, complemented with teacher interviews and validation by expert criteria. The standardized instruments used included the Test of Concentrated Attention and the Attention and Concentration Scale. The results revealed significant improvements in student attention, supporting the effectiveness of the Gamification Activity System. Despite the positive reception, areas for improvement were identified in the variety of activities and the integration of multimedia elements. These findings underscore the relevance of adaptive pedagogical strategies, especially in the context of attentional deficit, providing valuable contributions to the academic field and highlighting gamification as a promising approach to address the complexities of attention in the educational environment. [ABSTRACT FROM AUTHOR]

Across the Republic of Fiji, the combination of slow onset climate change and extreme weather events continues to wreak havoc. In addition to direct damages sustained from climate impacts, the uncertainties associated with changes to natural systems in combination with depletion of natural resources and declines in biodiversity provide substantial challenges for Indigenous cultures and rural semi-subsistence livelihoods. Consequently, the concept of social resilience in terms of peoples' capacities to cope and adapt to social and ecological changes remains important. In this study, we examine local Indigenous systems of social resilience constructed in alignment with the traditional value of relationalism, and concomitant practices of solesolevaki (working together) and kerekere (requesting, gifting, sharing) to (i). understand how social resilience in this local setting is both reproduced and sustained, and (ii).to examine how moral conflicts and ambiguities arising between traditional modes of living and being, and newer, introduced ontologies attributed to late liberalism are affecting social resilience. We present an ethnographic sketch drawn from fieldwork observations and narratives undertaken in rural Fiji since 2016 and apply Robbins' (2017) theorising of culture and values to examine how people reconcile competing value systems attached to two porous social orders that structure the practices and rhythms of daily life, which Merlan (2005) refers to as the intercultural. [ABSTRACT FROM AUTHOR]

Mental illness is prevalent among people living with HIV (PLHIV) and hinders engagement in HIV care. While financial incentives are effective at improving mental health and retention in care, the specific effect of such incentives on the mental health of PLHIV lacks quantifiable evidence. We evaluated the impact of a three-arm randomized controlled trial of a financial incentive program on the mental health of adult antiretroviral therapy (ART) initiates in Tanzania. Participants were randomized 1:1:1 into one of two cash incentive (combined; provided monthly conditional on clinic attendance) or the control arm. We measured the prevalence of emotional distress, depression, and anxiety via a difference-in-differences model which quantifies changes in the outcomes by arm over time. Baseline prevalence of emotional distress, depression, and anxiety among the 530 participants (346 intervention, 184 control) was 23.8%, 26.6%, and 19.8%, respectively. The prevalence of these outcomes decreased substantially over the study period; additional benefit of the cash incentives was not detected. In conclusion, poor mental health was common although the prevalence declined rapidly during the first six months on ART. The cash incentives did not increase these improvements, however they may have indirect benefit by motivating early linkage to and retention in care. Clinical Trial Number: NCT03341556 [ABSTRACT FROM AUTHOR]

This essay argues that contemporary Taiwan, as a democratic, functionally independent polity, constitutes the crucial exception to disavowals by the Republic of China (ROC) and People's Republic of China (PRC) of imperialist claims and ambitions. As such, it explores how the ideal of a single China spanning the Taiwan Strait ('one China') depends on the erasure of a (proto-) national Taiwanese identity, and possibly the suppression of the people who claim it. 'One China' narratives seek to naturalize Taiwan's absorption into the ROC in the 1940s and its potential future annexation by the PRC, hiding the pressures placed on Taiwanese people today to give up their hard-fought democracy, as well as the bloodshed that would be involved in any military conquest. [ABSTRACT FROM AUTHOR]

The Coronavirus disease 2019 (COVID-19) pandemic caused by Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) is an ongoing threat to global public health. To this end, intense efforts are underway to develop reagents to aid in diagnostics, enhance preventative measures, and provide therapeutics for managing COVID-19. The recent emergence of SARS-CoV-2 Omicron variants with enhanced transmissibility, altered antigenicity, and significant escape of existing monoclonal antibodies and vaccines underlines the importance of the continued development of such agents. The SARS-CoV-2 spike protein and its receptor binding domain (RBD) are critical to viral attachment and host cell entry and are primary targets for antibodies elicited from both vaccination and natural infection. In this study, mice were immunized with two synthetic peptides (Pep 1 and Pep 2) within the RBD of the original Wuhan SARS-CoV-2, as well as the whole RBD as a recombinant protein (rRBD). Hybridomas were generated, and a panel of three monoclonal antibodies, mAb CU-P1-1 against Pep 1, mAb CU-P2-20 against Pep 2, and mAb CU-28-24 against rRBD, was generated and further characterized. These mAbs were shown by ELISA to be specific for each immunogen/antigen. Monoclonal antibody CU-P1-1 has limited applicability other than in ELISA approaches and basic immunoblotting. Monoclonal antibody CU-P2-20 is shown to be favorable for ELISA, immunoblotting, and immunohistochemistry (IHC), however, not live virus neutralization. In contrast, mAb CU-28-24 is most effective at live virus neutralization as well as ELISA and IHC. Moreover, mAb CU-28-24 is active against rRBD proteins from Omicron variants BA.2 and BA.4.5 as determined by ELISA, suggesting this mAb may neutralize live virus of these variants. Each of the immunoglobulin genes has been sequenced using Next Generation Sequencing, which allows the expression of respective recombinant proteins, thereby eliminating the need for long-term hybridoma maintenance. The synthetic peptides and hybridomas/mAbs and quantitative antigen-binding data are under the intellectual property management of the Clemson University Research Foundation, and the three CDRs have been submitted as an invention disclosure for further patenting and commercialization. [ABSTRACT FROM AUTHOR]

Introduction: Mobile health diagnostics have demonstrated effectiveness in detecting and managing chronic diseases. This method comparison study aims to assess the accuracy and precision of the previously evaluated OptiBP™ technology over a four-week study period. This device uses optical signals recorded by placing a patient's fingertip on a smartphone's camera to estimate blood pressure (BP). Methods: In adult participants without cardiac arrhythmias and minimal interarm blood pressure difference (systolic arterial pressure (SAP) < 15 mmHg or diastolic arterial pressure (DAP) < 10 mmHg), three pairs of 30 s BP measurements with the OptiBP™ (test method) were simultaneously compared using three pairs of measurements with the non-invasive oscillometric brachial cuff (reference method) on the opposite arm over a period of four consecutive weeks at a rate of two measurements per week (one in the morning and one in the afternoon). The agreement of BP values between the two technologies was analyzed using Bland–Altman and error grid analyses. The performance of the smartphone application was investigated using the International Organization for Standardization (ISO) definitions, which require the bias ± standard deviation (SD) between two technologies to be lower than 5 ± 8 mmHg. Results: Among the 65 eligible volunteers, 53 participants had adequate OptiBP™ BP values. In 12 patients, no OptiBP™ BP could be measured due to inadequate signals. Only nine participants had known chronic arterial hypertension and 76% of those patients were treated. The mean bias ± SD between both technologies was −1.4 mmHg ± 10.1 mmHg for systolic arterial pressure (SAP), 0.2 mmHg ± 6.5 mmHg for diastolic arterial pressure (DAP) and −0.5 mmHg ± 6.9 mmHg for mean arterial pressure (MAP). Error grid analyses indicated that 100% of the pairs of BP measurements were located in zones A (no risk) and B (low risk). Conclusions: In a cohort of volunteers, we observed an acceptable agreement between BP values obtained with the OptiBPTM and those obtained with the reference method over a four-week period. The OptiBPTM fulfills the ISO standards for MAP and DAP (but not SAP). The error grid analyses showed that 100% measurements were located in risk zones A and B. Despite the need for some technological improvements, this application may become an important tool to measure BP in the future. [ABSTRACT FROM AUTHOR]

This study aimed to evaluate the fluctuation of infestation with Varroa mites on honeybee colonies. Research was carried out at the apiary of beekeeping research department at Dokki, Giza, Governorate, from March to December 2019 and January to February 2020. Infestation percentages reached 18.39, 16.73. 17.86 and 19.73 in broods and reached 12.53, 10.8, 13.0 and 14.27 in the same seasons on adult bees, respectively. Mean number of units covered with bees reached 8.0, 8.83, 7.17 and 4.66 per colony during spring, summer, autumn and winter, respectively. Adult females of Apis mellifera infected in Egypt were collected and examined by SEM. Varroa destructor was found to have a markedly different shape among the local populations (Giza, Behera and Benisuef) [ABSTRACT FROM AUTHOR]

Saadia Al-Fayyumi was one of the medieval scholars of Jewish law who lived in Muslim societies. He was the first in Iraq to defend Rabbinic Judaism against the opponents and skeptics of its religious heritage and he was influenced in his defense by Islamic thought. Previous studies discussed Saadia’s defense of the Written and Oral law and illustrated Saadia’s polemical writings against the Karaites. The current paper discusses the influence of Islam on Saadia’s method in defending Rabbinic Judaism. Also, this essay illustrates the influence of Islamic thought on Saadia’s arguments to pave the way for the Rabbis to use reason like the Mu’tazilah to defend their beliefs and provided them with arguments and proofs. Clearly, Islamic thought was a principle for Saadia to establish the foundations of faith. He laid down the principles of faith just as the Mu’tazilah and was influenced by Mu’tazilah’s thoughts, Muslim jurists, Islamic theological doctrines, and their various ideas related to religious matters. Also, Saadia agreed with the Islamic theological sects in using logical evidences and religious texts as defensive tools to defend his beliefs. This Islamic influence on Jewish thought was a factor in its development, especially in light of the Arab-Islamic civilization in the medieval ages between 10th and the 15th centuries CE. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this study is to measure the technical efficiency of 20 Algerian insurance companies from 2016 to 2020, by using slacks-based measure (slacks-based measure [SBM] data envelopment analysis [DEA]) model. This research aims to provide a comprehensive assessment of this companies' efficiency, taking into account both the desirable and undesirable outputs. Design/methodology/approach: The study uses a nonoriented, SBM model with the assumption of constant returns to scale to estimate the technical efficiency of commercial insurance companies over a five-year period. The inputs used are labor expense, agent expense and investments, while the outputs included are gross premiums and investment income as desirable outputs and gross claims as undesirable output. Findings: Among 20 insurance companies evaluated, only 5 companies consistently achieved technical efficiency during the study period (Caisse Nationale de Mutualité Agricole [CNMA], MACIR, CARDIF, MUTUALISTE and AGLIC); so they represent the best practices in the Algerian insurance sector, with overall average of the technical efficiency is 81%. However, the reference sets analysis showed that CNMA and AGLIC had high robustness. Also, the results demonstrate the impact of ignoring the undesirable outputs on the accuracy of the assessment. Research limitations/implications: The sample of the study consists of the active insurance companies in Algeria, based on the Annual Insurance Reports of Algeria; there are 20 companies as shown in the table. The data are taken from the annual reports of insurance companies during the 2020 period, issued by the Algerian Ministry of Finance. Practical implications: The challenge for insurance company is how to find a balance between reducing claims paid and simultaneously improving the quality of insurance services. In fact, it is observed that studies evaluating their efficiency ignore claims in the analysis process. Therefore, the study highlights the importance of considering undesirable outputs within the DEA framework; this allows for a more accurate assessment of the company's performance and helps in improvement. Furthermore, although the insurance sector plays a crucial role, it has not received enough research attention compared to other financial sectors, especially in Arab and developing countries. Originality/value: The literature on efficiency assessment in the insurance companies shows a lack of addressing undesirable outputs (such as claims) within the DEA framework; so this study aims at bridging this research gap. Also, the study provides an overview of the efficiency of Algerian insurance companies. [ABSTRACT FROM AUTHOR]

The aim of this research was to examine the prediction of aspects of subjective wellbeing based on resilience and seven basic personality traits in users of gerontological centers, and the incremental contribution of basic personality traits in explaining adaptation to old age, beyond the variance explained by resilience. The sample consisted of 151 participants (54.3% female) with an average age of 80 years. Satisfaction with life, as cognitive indicator, and emotional distress (anxiety, depression, and stress) were used as indicators of subjective well-being. The results showed that resilience, neuroticism (in the negative direction) and positive valence predicted life satisfaction in the elderly. In predicting emotional distress, neuroticism stood out as a key predictor, while the significant contribution of resilience is dimnished by introducing personality traits into the model. The results provide a more complete picture of the relationships between resilience, personality traiits, and subjective well-being in a sample of the elderly in Serbia, and confirm the importance of studying these relationships from a developmental perspective. [ABSTRACT FROM AUTHOR]

The 18th century was a period in which the practice of gedik increased visibly in Ottoman tradesmen. In this period, the introduction of the inhisar method in Ottoman tradesmen gave a new meaning to the concept of gedik. In this context, in the secondary literature, the concept of gedik has been mostly defined on the basis of the new meaning it has gained as of the 18th century. Therefore, it is possible to draw an indirect conclusion from the definitions of the gedik in the literature, prevents the increase in employment in tradesmen. At this point, the question arises whether the gediks prevent the increase in employment in the tradesmen. Although there are studies in the literature on various branches of tradesmen and the number of shops in these sectors over the years, there is no study that deals with the subject in the context of gedik and its effect on employment. Since the effect of gedik on the employment rate is not the same in every period and in every sector, it was deemed appropriate to select a certain period and sector within the scope of the study. In this context, the aim of the study is to determine to what extent and in which direction the gedik system affects the employment rate and quality of bakery tradesmen. The 18th century, which was the period when the inhisar method was adopted by the state, was preferred as the period. The reason why bakery tradesmen are preferred as a sector is that bakery is one of the sectors that met the gedik system in the earliest and most intense way. Thus, it is aimed to evaluate the policy pursued by the state regarding the production of compulsory foodstuffs and the connection of this policy with the gediks. [ABSTRACT FROM AUTHOR]