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The article offers information on significance of age to the occurrence of glycogenic acanthosis in patients. The disorder can be identified through endoscopic procedure wherein it usually appears in the lower esophagus than in the upper esophagus and is believed to be as a normal accompaniment of aging. Although the pathogenesis of the condition remains vague, it is said to be associated with gastroesophageal reflux, an outward flow of the stomach contents to the esophagus.

Magnetic properties of sol-gel and conventional ceramic processed Ba3Co2Fe2O41 hexaferrite were investigated and compared for terrestrial digital multimedia broadcasting (T-DMB) antenna application. All of the synthesized powder and sintered body showed almost single Z-phase. The loss tan δ of sol-gel processed and sintered Co2Z hexaferrite was 0.010 at 200 MHz, while conventional ceramic processed and sintered Co2Z showed 0.068. The ωd (resonance frequency of domain wall) and ωs (resonance frequency of spin components) of sol-gel and ceramic processed hexaferrites were estimated to be 10 and 1160 MHz and 17 and 1025 MHz, respectively. The frequency difference between ωd and ωs (1150 MHz) for the sol-gel processed hexaferrite is wider than that (1008 MHz) for the ceramic processed hexaferrite. The permeabilities of sol-gel and ceramic processed hexaferrites were 6.91 and 9.23 at 200 MHz, respectively. Both permeabilities are higher than 6.88 and 7.64 of corresponding permittivities at the same frequency, respectively. It is found that the sol-gel processed and sintered Z-type hexaferrite meet desired low-loss tan δ and broadband for T-DMB antenna. [ABSTRACT FROM AUTHOR]

Summary: Background: CCR3 is the cognate receptor for major human eosinophil chemoattractants from the eotaxin family of proteins that are elevated in asthma and correlate with disease severity. Objective: This proof‐of‐mechanism study examined the effect of AXP1275, an oral, small‐molecule inhibitor of CCR3, on airway responses to inhaled allergen challenge. Methods: Twenty‐one subjects with mild atopic asthma and documented early and late asthmatic responses to an inhaled aeroallergen completed a randomized double‐blind cross‐over study to compare early and late allergen‐induced asthmatic responses, methacholine PC20, blood and sputum eosinophils and exhaled nitric oxide after 2 weeks of treatment with once‐daily doses of AXP1275 (50 mg) or placebo. Results: There was a significant increase in methacholine PC20 after 12 days of AXP1275 treatment compared to placebo (increase of 0.92 doubling doses versus 0.17 doubling doses, P = .01), but this protection was lost post‐allergen challenge. There was no effect of AXP1275 on allergen‐induced late asthmatic responses, or eosinophils in blood and sputum. The early asthmatic response and exhaled nitric oxide levels were slightly lower with AXP1275, but this did not reach statistical significance. The number of subjects who experienced treatment‐emergent adverse events while receiving AXP1275 was comparable placebo. Conclusions & Clinical Relevance: AXP1275 50 mg administered daily was safe and well tolerated, and there was no difference in the type, severity or frequency of treatment‐emergent adverse events in subjects while receiving AXP1275 compared to placebo. AXP1275 increased the methacholine PC20; however, the low and variable exposure to APX1275 over a short treatment period may have contributed to poor efficacy on other outcomes. [ABSTRACT FROM AUTHOR]

Z-type barium hexaferrite particles were synthesized by a one-step mixing-calcination process (MCP) and its magnetic properties were characterized and compared to the sol-gel (SGP) and the conventional ceramic (CCP) processed Z-type Ba hexaferrite with two-step calcination. We have used 71.2% pure M-type (BaFe12O19) and 83.8% pure V-type (Ba2Co2Fe12O22) precursors to synthesize Z-type by the MCP. As a result, 77.8% pure Co2Z hexaferrite particles were obtained. The purities of Co2Z hexaferrite particles processed by SGP and CCP were 75.1% and 70.7%, respectively. It was found that purity of Z-phase was controllable by purity of M- and V-type precursor particles in the MCP. Loss tan δ of sintered MCP Co2Z decreased from 0.17 at 50 MHz to 0.068 at 300 MHz, while loss tan δ of sintered SGP and CCP Co2Z were 0.12 and 0.09 at 300 MHz. It is found that this loss tan δ is controllable by the purity of Z-phase and sintering process. These results imply that our new process is potentially applicable to synthesis of any other hexaferrites and also cost-effective. [ABSTRACT FROM AUTHOR]

Background: PTEN tumor suppressor gene mutations are the most frequent genetic lesions in endometrial adenocarcinomas of the endometrioid subtype. Testing the hypothesis that altered PTEN function precedes the appearance of endometrial adenocarcinoma has been difficult, however, partly because of uncertainties in precancer diagnosis.Methods: Two series of endometrial cancer and precancer (endometrial intraepithelial neoplasia, as diagnosed by computerized morphometric analysis) tissue samples were studied, one for PTEN mutations by the use of denaturing gradient gel electrophoresis and another for PTEN protein expression by immunohistochemistry. Endometria altered by high estrogen levels that are unopposed by progestins-conditions known to increase cancer risk-were also studied by immunohistochemistry. Fisher's exact test was used for statistical analysis.Results: The PTEN mutation rate was 83% (25 of 30) in endometrioid endometrial adenocarcinomas and 55% (16 of 29) in precancers, and the difference in number of mutations was statistically significant (two-sided P =.025). No normal endometria showed PTEN mutations. Although most precancers and cancers had a mutation in only one PTEN allele, endometrioid endometrial adenocarcinomas showed complete loss of PTEN protein expression in 61% (20 of 33) of cases, and 97% (32 of 33) showed at least some diminution in expression. Cancers and most precancers exhibited contiguous groups of PTEN-negative glands, while endometria altered by unopposed estrogens showed isolated PTEN-negative glands.Conclusions: Loss of PTEN function by mutational or other mechanisms is an early event in endometrial tumorigenesis that may occur in response to known endocrine risk factors and offers an informative immunohistochemical biomarker for premalignant disease. Individual PTEN-negative glands in estrogen-exposed endometria are the earliest recognizable stage of endometrial carcinogenesis. Proliferation into dense clusters that form discrete premalignant lesions follows. [ABSTRACT FROM AUTHOR]