Search

Your search keyword '"Kevin D Bunker"' showing total 1 results
Start Over Author "Kevin D Bunker" Database Academic Search Index
1 results on '"Kevin D Bunker"'

1. Scalable Synthesis of 1-Bicyclo[1.1.1]pentylamine via a Hydrohydrazination Reaction.

Author

Kevin D. Bunker, Neal W. Sach, Qinhua Huang, and Paul F. Richardson

Subjects
*AMINES, *ORGANIC synthesis, *CHEMICAL reactions, *PROPELLANES, *CARBOXYLIC acids, *MAGNESIUM
Abstract

The reaction of [1.1.1]propellane with di-tert-butyl azodicarboxylate and phenylsilane in the presence of Mn(dpm)3to give di-tert-butyl 1-(bicyclo[1.1.1]pentan-1-yl)hydrazine-1,2-dicarboxylate is described. Subsequent deprotection gives 1-bicyclo[1.1.1]pentylhydrazine followed by reduction to give 1-bicyclo[1.1.1]pentylamine. The reported route marks a significant improvement over the previous syntheses of 1-bicyclo[1.1.1]pentylamine in terms of scalability, yield, safety, and cost. [ABSTRACT FROM AUTHOR]

Published
2011
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results