1. Tricyclic 2â²-C-Modified Nucleosides as Potential Anti-HCV Therapeutics.
- Author
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Orrette R. Wauchope, Matthew J. Tomney, Joseph L. Pepper, Brent E. Korba, and Katherine L. Seley-Radtke
- Subjects
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ANTIVIRAL nucleosides , *HEPATITIS C transmission , *HEPATITIS C virus , *ORGANIC cyclic compounds , *RNA polymerases , *CHEMICAL structure - Abstract
Promising biological activity in a number of therapeutic areas has been reported for both tricyclic nucleosides and 2â²-modified nucleosides. In particular, disubstitution at the C-2â² position of nucleosides has resulted in significant activity against the hepatitis C virus (HCV). Combining this with the observation that tricyclic nucleosides developed in our laboratory have been shown to inhibit the RNA-dependent RNA polymerase NS5B led to the design of a series of 2â²-modified tricyclic nucleosides. Details of the synthesis, structural characterization, and preliminary biological results are reported. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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