498 results on '"Kaplan, David E"'
Search Results
2. Phenotyping Hepatic Immune-Related Adverse Events in the Setting of Immune Checkpoint Inhibitor Therapy.
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Feldman, Theodore C., Kaplan, David E., Lin, Albert, La, Jennifer, Lee, Jerry S.H., Aljehani, Mayada, Tuck, David P., Brophy, Mary T., Fillmore, Nathanael R., and Do, Nhan V.
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DRUG side effects , *IMMUNE checkpoint inhibitors , *BIG data , *HEPATOCELLULAR carcinoma - Abstract
PURPOSE: We present and validate a rule-based algorithm for the detection of moderate to severe liver-related immune-related adverse events (irAEs) in a real-world patient cohort. The algorithm can be applied to studies of irAEs in large data sets. METHODS: We developed a set of criteria to define hepatic irAEs. The criteria include: the temporality of elevated laboratory measurements in the first 2-14 weeks of immune checkpoint inhibitor (ICI) treatment, steroid intervention within 2 weeks of the onset of elevated laboratory measurements, and intervention with a duration of at least 2 weeks. These criteria are based on the kinetics of patients who experienced moderate to severe hepatotoxicity (Common Terminology Criteria for Adverse Events grades 2-4). We applied these criteria to a retrospective cohort of 682 patients diagnosed with hepatocellular carcinoma and treated with ICI. All patients were required to have baseline laboratory measurements before and after the initiation of ICI. RESULTS: A set of 63 equally sampled patients were reviewed by two blinded, clinical adjudicators. Disagreements were reviewed and consensus was taken to be the ground truth. Of these, 25 patients with irAEs were identified, 16 were determined to be hepatic irAEs, 36 patients were nonadverse events, and two patients were of indeterminant status. Reviewers agreed in 44 of 63 patients, including 19 patients with irAEs (0.70 concordance, Fleiss' kappa: 0.43). By comparison, the algorithm achieved a sensitivity and specificity of identifying hepatic irAEs of 0.63 and 0.81, respectively, with a test efficiency (percent correctly classified) of 0.78 and outcome-weighted F1 score of 0.74. CONCLUSION: The algorithm achieves greater concordance with the ground truth than either individual clinical adjudicator for the detection of irAEs. Three (sometimes 4) rules to identify hepatic immune-related adverse events in the setting of ICI. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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- View/download PDF
3. Binary collisions of dark matter blobs.
- Author
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Diamond, Melissa D., Kaplan, David E., and Rajendran, Surjeet
- Abstract
We describe the model-independent mechanism by which dark matter and dark matter structures heavier than ~ 8 × 1011 GeV form binary pairs in the early Universe that spin down and merge both in the present and throughout the Universe’s history, producing potentially observable signals. Sufficiently dense dark objects will dominantly collide through binary mergers instead of random collisions. We detail how one would estimate the merger rate accounting for finite size effects, multibody interactions, and friction with the thermal bath. We predict how mergers of dark dense objects could be detected through gravitational and electromagnetic signals, noting that such mergers could be a unique source of high frequency gravitational waves. We rule out objects whose presence would contradict observations of the CMB and diffuse gamma-rays. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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4. Algorithms to Identify Alcoholic Hepatitis Hospitalizations in Patients with Cirrhosis.
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Panchal, Sarjukumar A., Kaplan, David E., Goldberg, David S., and Mahmud, Nadim
- Abstract
Background: Alcoholic hepatitis (AH) is a clinically diagnosed syndrome with high short-term mortality for which liver transplantation may be curative. A lack of validated algorithms to identify AH hospitalizations has hindered clinical epidemiology research. Methods: This was a retrospective cohort study of patients with cirrhosis using Veterans Health Administration (VHA) data from 2008 to 2015. We randomly sampled hospitalizations based upon abnormal liver tests and administrative codes for acute hepatitis or alcohol-associated liver disease (ALD). Hospitalizations were manually adjudicated for AH per society guidelines. A priori algorithms were evaluated to compute positive predicted value (PPV) and positive likelihood ratio (LR+), and were tested in an external University of Pennsylvania Health System (UPHS) cohort. Results: Of 368 hospitalizations, 142 (38.6%) were adjudicated as AH. AH patients were younger (55 vs. 58 years, p < 0.001), less likely to have prior cirrhosis decompensation (57% vs. 73.9%, p < 0.001), and had higher AST-to-ALT ratios (median 2.9 vs. 1.9 mg/dL, p < 0.001) and higher bilirubin levels (median 2.9 vs. 1.9 mg/dL, p < 0.001). Algorithms combining clinical laboratory criteria (AST > 85 U/L but < 450 U/L, AST-to-ALT ratio > 2, total bilirubin > 5 mg/dL) and administrative coding criteria yielded the highest PPV (96.4%, 95% CI 87.7–99.6) and the highest LR+ (43.0, 95% CI 10.6–173.5). Several algorithms demonstrated 100% PPV for definite AH in the UPHS external cohort. Conclusion: We have identified algorithms for AH hospitalizations with excellent PPV and LR+. These high-specificity algorithms may be used in VHA datasets to identify patients with high likelihood of AH, but should not be used to study AH incidence. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
5. Inpatient Gastroenterology Consultation and Outcomes of Cirrhosis-Related Hospitalizations in Two Large National Cohorts.
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Serper, Marina, Kaplan, David E., Lin, Menghan, Taddei, Tamar H., Parikh, Neehar D., Werner, Rachel M., and Tapper, Elliot B.
- Abstract
Background: Little is known about use of specialty care among patients admitted with cirrhosis complications. Aims: We sought to characterize the use and impact of gastroenterology/hepatology (GI/HEP) consultations in hospitalized patients with cirrhosis. We studied two national cohorts—the Veterans Affairs Costs and Outcomes in Liver Disease (VOCAL) and a nationally representative database of commercially insured patients (Optum Clinformatics™ DataMart). Methods: Cirrhosis-related admissions were classified by ICD9/10 codes for ascites, hepatic encephalopathy, alcohol-associated hepatitis, spontaneous bacterial peritonitis, or infection related. We included 20,287/222,166 index admissions from VOCAL/Optum from 2010 to 2016. Propensity-matched analyses were conducted to balance clinical characteristics. Mortality and readmission were evaluated using competing risk regression (subhazard ratios, sHR), and length of stay (LOS) was assessed using negative binomial regression. Results: GI/HEP consultations were completed among 37% and 42% patients in VOCAL and Optum, respectively. In propensity-matched analyses for VOCAL, GI/HEP consultation was associated with adjusted estimates of increased LOS (1.55 + 1.03 additional days), 90-day mortality (sHR 1.23, 95% CI 1.14–1.36), and lower 30-day readmissions (sHR 0.82, 95% CI 0.75–0.89). In Optum, inpatient consultation was associated with higher LOS (1.13 + 1.01 additional days), higher 90-day mortality (sHR 1.57, 95% CI 1.43–1.72), and higher 30-day readmission risk (sHR 1.04, 95% CI 1.02–1.05). Post-discharge primary and specialty care was higher among admissions receiving GI/HEP consultation in both cohorts. Conclusions: Use of GI/HEP consultation for cirrhosis-related admissions was low. Patients who received consultation had higher disease severity, and consultation was not associated with lower mortality but was associated with lower 30-day readmissions in the VA cohort only. [ABSTRACT FROM AUTHOR]
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- 2022
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6. Constraints on relic magnetic black holes.
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Diamond, Melissa D. and Kaplan, David E.
- Abstract
We present current direct and astrophysical limits on the cosmological abundance of black holes with extremal magnetic charge. Such black holes do not Hawking radiate, allowing those normally too light to survive to the present to do so. The dominant constraints come from white dwarf destruction for low and intermediate masses (2 × 10−5 g – 4 × 1012 g) and Galactic gas cloud heating for heavier masses (> 4 × 1012 g). Extremal magnetic black holes may catalyze proton decay. We derive robust limits — independent of the catalysis cross section — from the effect this has on white dwarfs. We discuss other bounds from neutron star heating, solar neutrino production, binary formation and annihilation into gamma-rays, and magnetic field destruction. Stable magnetically charged black holes can assist in the formation of neutron star mass black holes. [ABSTRACT FROM AUTHOR]
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- 2022
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7. Neutrino interactions in the late universe.
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Green, Daniel, Kaplan, David E., and Rajendran, Surjeet
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The cosmic neutrino background is both a dramatic prediction of the hot Big Bang and a compelling target for current and future observations. The impact of relativistic neutrinos in the early universe has been observed at high significance in a number of cosmological probes. In addition, the non-zero mass of neutrinos alters the growth of structure at late times, and this signature is a target for a number of upcoming surveys. These measurements are sensitive to the physics of the neutrino and could be used to probe physics beyond the standard model in the neutrino sector. We explore an intriguing possibility where light right-handed neutrinos are coupled to all, or a fraction of, the dark matter through a mediator. In a wide range of parameter space, this interaction only becomes important at late times and is uniquely probed by late-time cosmological observables. Due to this coupling, the dark matter and neutrinos behave as a single fluid with a non-trivial sound speed, leading to a suppression of power on small scales. In current and near-term cosmological surveys, this signature is equivalent to an increase in the sum of the neutrino masses. Given current limits, we show that at most 0.5% of the dark matter could be coupled to neutrinos in this way. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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8. Impact of SGLT2 inhibitors in comparison with DPP4 inhibitors on ascites and death in veterans with cirrhosis on metformin.
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Saffo, Saad, Kaplan, David E., Mahmud, Nadim, Serper, Marina, John, Binu V., Ross, Joseph S., and Taddei, Tamar
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NON-alcoholic fatty liver disease , *SODIUM-glucose cotransporter 2 inhibitors , *METFORMIN , *CD26 antigen , *ASCITES , *OVERALL survival - Abstract
Sodium‐glucose cotransporter 2 inhibitors (SGLT2i) may have favourable neurohumoral and metabolic effects in patients with chronic liver disease. However, studies examining SGLT2i in this population have been limited to patients with non‐alcoholic fatty liver disease and have focused on surrogate biomarkers. Our aim was to evaluate whether SGLT2i can reduce the incidence of ascites and death over a period of 36 months in patients with cirrhosis and diabetes mellitus. Using electronic health data from Veterans Affairs hospitals in the United States, we conducted a propensity score matched intention‐to‐treat analysis among veterans on metformin who subsequently received either SGLT2i or dipeptidyl peptidase‐4 inhibitors. Among 423 matched pairs (in total, 846 patients), we found no significant difference in the risk for ascites (hazard ratio 0.68 for SGLT2i, 95% confidence interval 0.37‐1.25; p =.22) but did find that SGLT2i users had a reduced risk for death (adjusted hazard ratio 0.33, 95% confidence interval 0.11‐0.99; p <.05). In comparison with dipeptidyl peptidase‐4 inhibitors, SGLT2i may improve survival for patients with cirrhosis who require additional pharmacotherapy for diabetes mellitus beyond metformin, but confirmatory studies are necessary. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
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9. Statins in Cirrhosis: Trial Data Are in but the Jury Is Still Out.
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Kaplan, David E.
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CIRRHOSIS of the liver , *STATINS (Cardiovascular agents) , *JURY , *PORTAL hypertension - Abstract
In future trial design and in clinical practice, patients with CTP C cirrhosis or total bilirubin >= 3 mg/dl should not be initiated on statins and if already taking should discontinue therapy. Two CTP C patients developed myonecrosis in this study; it was only patients with CTP C cirrhosis in the Bleeding Prevention With Simvastatin (BLEPS) trial that developed rhabdomyolysis [[6]]. [Extracted from the article]
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- 2023
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10. Care quality and outcomes among US veterans with chronic hepatitis B in the hepatitis C direct‐acting antiviral era.
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Kaplan, David E., Medvedeva, Elina, and Serper, Marina
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CHRONIC hepatitis B , *HEPATITIS B , *HEPATITIS C , *VIRAL hepatitis , *HEPATITIS B virus , *VETERANS , *LIVER diseases , *DATA warehousing - Abstract
Adherence to guideline‐recommended hepatitis B virus (HBV) care is suboptimal. We hypothesized that national hepatitis C eradication efforts during the era from 2015 to 2017 would improve the quality of care for cHBV given increased recognition and specialty referrals for liver disease. The study described herein is a retrospective cohort study of veterans with at least one positive HBsAg (HBsAg+) result from 1 January 2003 to 31 December 2017 using the VA Corporate Data Warehouse (CDW) analysed by era (2003‐2004, 2005‐2009, 2010‐2014, 2015‐2017). Relevant covariates such as HCV co‐infection, demographics, cirrhosis and baseline laboratory testing were obtained through previously validated approaches. We evaluated completion of process measures within 2 years of the index HBsAg + result: specialty care referral; testing of ALT, HBV‐DNA, HBeAg and anti‐HBe; testing for co‐infection and/or vaccination for HAV, HCV, HDV and HIV; and hepatocellular carcinoma (HCC) surveillance among those meeting criteria. We also measured use of antiviral therapy in appropriate candidates (ALT ≥ 2 × ULN, HBV‐DNA ≥ 2000 IU/mL). Of the 16 673 individuals with HBsAg + test results, 9,521 were confirmed as chronic HBV. Era‐related (Era 3:2010‐2014 vs Era 4:2015‐2017) increases in guideline‐recommended process measures included the following: outpatient visits with GI/ID specialists (78%‐89%), HBV‐DNA testing (73%‐79%), HDV testing (27%‐35%), appropriate HBV antiviral utilization (55%‐70%) and HCC surveillance (40%‐43%); all P <.0001. In the subset of HBV/HCV‐co‐infected patients, HCV DAA therapy was associated with a trend towards improved overall survival. In conclusion, the overall quality of care for HBV has significantly improved in the era of widespread HCV DAA therapy in an integrated health system possibly due to increased recognition and referral for liver disease. [ABSTRACT FROM AUTHOR]
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- 2020
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11. Hepatitis C Virus.
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Kaplan, David E.
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HEPATITIS C virus , *PRIMARY care , *HEPATITIS C diagnosis , *HEPATITIS C prevention , *HEPATITIS C transmission , *ANTIVIRAL agents , *COMPARATIVE studies , *HEPATITIS C , *HEPATITIS viruses , *RESEARCH methodology , *MEDICAL cooperation , *MEDICAL screening , *RESEARCH , *EVALUATION research - Published
- 2020
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12. Multidisciplinary Approach to HCC Management: How Can This Be Done?
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Gadsden, Melissa M. and Kaplan, David E.
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ONCOLOGISTS , *HEPATOCELLULAR carcinoma , *PATIENT satisfaction - Abstract
Multidisciplinary tumor boards have evolved to address the increasing complexity of cancer care management. Given that hepatocellular carcinoma (HCC) often arises in the setting of underlying cirrhosis, expert input from hepatologists alongside hepatobiliary and transplant surgeons, radiation oncologists, interventional and body radiologists, and medical oncologists has become increasingly important in order to offer patients appropriate cancer treatments. The MDLTB structure has evolved since the early 2000s to bring these specialists together at regularly scheduled meetings to develop a therapeutic treatment plan for HCC management. MDLTBs have reduced the time to treatment and improved patient satisfaction. Standardized documentation with common data elements has been recommended to ensure adequate communication from MDLTB to referring healthcare providers. Retrospective studies consistently highlight the frequency of changes in treatment plans after MDLTB review to better adhere to guideline recommended care. Despite several decades of MDLTBs implementation, few studies describe clinical outcomes associated with MDLTBs such as patient survival and cost benefits. More research is needed in this area to further justify the heavy use of resources that are needed to maintain MDLTBs. Development and use of a centralized database to store such information may assist with future studies of clinical outcomes and inform quality improvement projects. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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13. FOREIGN AFFAIRS.
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Kaplan, David E. and Ekman, Monica M.
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SEX discrimination , *DOUBLE standard , *WOMEN spies , *LABOR policy , *EMPLOYEES - Abstract
The article examines an alleged double standard in the Central Intelligence Agency (CIA) about male operatives and female operatives. In 1995 the CIA paid nearly a million dollars to over 400 women over sex discrimination. The CIA has been under fire for turning away potential recruits because of their foreign relatives. At least 25 women have complained to the U.S. Equal Employment Opportunity Commission citing they are held to a higher standard concerning sexual affairs than men. INSET: Suspicious Minds.
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- 2007
14. PLAYING DEFENSE.
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Kaplan, David E. and Whitelaw, Kevin
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MILITARY intelligence , *RECONNAISSANCE operations , *COUNTERTERRORISM , *LAW enforcement - Abstract
This article discusses the military intelligence industry in the United States during 2006. The article notes that, while the intelligence industry has come under fire due to scandals involving eavesdropping and secret prisons, the intelligence industry serves a valuable purpose in preventing terrorism and aiding law enforcement. INSETS: THE U.S. INTELLIGENCE COMMUNITY;A Man Who's Not Getting Much Sleep.
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- 2006
15. HEY LET'S PLAY BALL.
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Kaplan, David E.
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WAR on Terrorism, 2001-2009 , *COUNTERTERRORISM , *NATIONAL security , *INTELLIGENCE officers , *FORUMS - Abstract
The article discusses the Summer Hard Problems workshop (SHARP), a new aspect of the war on terror. SHARP was organized by the Office of the Director of National Intelligence in order to discuss the motivations behind the spread of extremism around the globe and how to stop it. Participants in SHARP workshops include intelligence experts as well as experts from the social sciences, including anthropologists and social psychologists. The article presents an account of a SHARP meeting.
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- 2006
16. BLOWN AWAY.
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Whitelaw, Kevin, Kaplan, David E., and Mulrine, Anna
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TERRORISM , *BOMBINGS , *TERRORISTS ,UNITED States armed forces ,FOREIGN relations of the United States, 2001-2009 ,UNITED States politics & government - Abstract
The article discusses the bomb attack in Iraq in June 2006 which killed Iraq's most wanted terrorist Abu Musab Zarqawi. The article details the operation which was eventually responsible for Zarqawi's death but also questions whether or not the death will lead to much, if any, real change in the area of terrorism in Iraq.
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- 2006
17. SPIES AMONG US.
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Kaplan, David E., Ekman, Monica M., Marek, Angie C., and D. E. K.
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NATIONAL security , *POLICE-community relations , *COUNTERTERRORISM , *POLICE surveillance , *INTELLIGENCE service - Abstract
The article reports that the police across the U.S. are keeping tabs on ordinary Americans. City and county police in the name of homeland security have surveilled or harassed animal-rights and antiwar protesters, union activists, and even library patrons surfing the Web. The U.S. Departments of Justice and Homeland Security have spent important sums of money into building up local and state police intelligence operations. INSET: When the Cops Only Saw Red.
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- 2006
18. PAYING FOR TERROR.
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Kaplan, David E., Fang, Bay, and Sangwan, Soni
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TERRORISM , *ORGANIZED crime , *TERRORISM financing , *MADRID Train Bombings, Madrid, Spain, 2004 , *SEPTEMBER 11 Terrorist Attacks, 2001 , *TERRORISTS , *INTERNATIONAL crimes , *CRIMES against public safety - Abstract
The article looks at how jihadist terrorist groups are using organized-crime tactics and profits to finance attacks around the world. The terrorist attacks on Bombay in 1993 and the attacks in the U.S. on September 11, 2001, are examples of organized terrorism aimed at the heart of a nation's financial center and intended to maximize civilian casualties. The terrorist attacks in Bombay were linked to gangster Dawood Ibrahim. Dawood is accused of supporting Islamic terrorist organizations. The link of terrorist organizations with organized crime allows the terrorist groups to increase their survivability. The article references the book "Al Qaeda in Europe," by Lorenzo Vidino. Drug dealers were behind the Madrid train bombings in Spain. INSETS: A Godfather's Lethal Mix of Business and Politics;An Unlikely Criminal Crossroads.
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- 2005
19. Hearts, Minds, and Dollars.
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Kaplan, David E., Latif, Aamir, Whitelaw, Kevin, and Barnes, Julian E.
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TERRORISM , *RELIGION , *WAR , *RELIGION & politics , *ISLAM , *ISLAMIC leadership , *RESEARCH institutes , *MUSLIMS ,UNITED States politics & government, 2001-2009 - Abstract
Examines how the United States is spending millions in the war on terrorism to change the very face of Islam. How the U.S. government has embarked on a campaign of political warfare unmatched since the height of the Cold War; Campaign to influence not only Muslim societies but Islam itself--from military psychological operations teams and covert operatives to openly funded media and think tanks; Views of many U.S. officials that the U.S. can no longer sit on the sidelines as radicals and moderates fight over the future of a politicized religion with over a billion followers; Growing effort to influence what officials describe as an Islamic reformation.
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- 2005
20. MISSION IMPOSSIBLE.
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Kaplan, David E., Whitelaw, Kevin, and Ekman, Monica M.
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SECURITY management , *SEPTEMBER 11 Terrorist Attacks, 2001 , *NATIONAL security ,UNITED States politics & government, 2001-2009 - Abstract
Profiles the efforts of groups in the United States government to reform the intelligence agencies of the nation as investigations regarding the attacks of September 11, 2001 continue. Details of the programs under works by central intelligence; Efforts of the 9/11 Commission to find new information regarding Al Qaeda and the terror attacks; Role of Richard Clarke of the National Security Council; Lists and identities of CIA "spooks"; Quotes from analysts; Role of India as a nuclear power.
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- 2004
21. THE MAN WITH THE SECRETS.
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Kaplan, David E., Pound, Edward T., Robinson, Linda, Levine, Samantha, Samuel, Terence, Walsh, Kenneth T., and Ragavan, Chitra
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RESIGNATION from public office , *COUNTERTERRORISM , *SEPTEMBER 11 Terrorist Attacks, 2001 , *IRAQ War, 2003-2011 , *WEAPONS of mass destruction , *NUCLEAR weapons , *INTERNATIONAL trade ,UNITED States politics & government, 2001-2009 - Abstract
Reports on the resignation of U.S. Central Intelligence Agency director George Tenet. Discussion of the controversies surrounding Tenet and the CIA during his seven-year tenure as director; Details of the challenges Tenet faced when he took over the post in 1997; Tenet's achievements as director; Claim that Tenet is particularly proud of the CIA's work in the war on terrorism, the Middle East peace process, and the agency's unraveling of the nuclear black market that stretched from Pakistan to Libya and North Korea; Comparison between Tenet and the last long-serving CIA director, William Casey; Discussion of the CIA's biggest blunders under Tenet: the agency's failure to stop the terrorist attacks of September 11, 2001, and its flawed intelligence on weapons of mass destruction in Iraq; Speculation about whether the CIA will be able to regain its status as the world's leading intelligence agency after these and other glaring failures; Speculation about why Tenet resigned last week; Speculation about who will replace Tenet.
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- 2004
22. SEEING RED.
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Whitelaw, Kevin, Kaplan, David E., Walsh, Kenneth T., and Marek, Angie C.
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SEPTEMBER 11 Terrorist Attacks, 2001 , *INVESTIGATIONS , *PRESIDENTS of the United States , *COUNTERTERRORISM , *IRAQ War, 2003-2011 , *NATIONAL security - Abstract
Reports on the reaction of the administration of U.S. president George W. Bush of criticisms of their record on terrorism by former counterterrorism czar Richard A. Clarke. Details of Clarke's testimony before the commission investigating the terrorist attacks of September 11, 2001; Details of charges made by Clarke against the Bush and Clinton administrations in his book, "Against All Enemies;" Report on the controversy surrounding national security advisor Condoleezza Rice's refusal to testify under oath before the commission; Speculation about whether Clarke's criticisms of Bush could raise doubts about his effectiveness as a wartime leader; Details of the media campaign by the White House to counter Clarke's charges and undermine his credibility; Response of Clarke and his supporters to the White House attacks; Potential impact of Clarke's assertions that the Bush administration failed to take seriously the threat posed by Al Qaeda prior to September 11; Potential impact of Clarke's sharp criticisms of Bush's decision to go to war Iraq; Details of the findings of the September 11 commission; Speculation about whether the CIA was serious about plans to assassinate Osama bin Laden prior to September 11; Details of testimony by CIA director George Tenet. INSET: THE TRAIL OF TERROR.
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- 2004
23. THE SAUDI CONNECTION.
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Kaplan, David E., Ekman, Monica, and Latif, Aamir
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TERRORISM financing , *CHARITIES , *JIHAD , *POLITICAL participation of Muslims , *TERRORISTS , *RELIGION & politics , *WAR on Terrorism, 2001-2009 , *INTELLIGENCE service ,SAUDI Arabian politics & government - Abstract
Reports on Saudi Arabia with the view that Saudi oil money supported the creation of a global terror network. The role of Saudi Islamic charities in funding jihadists in many countries; Details of how charities were used to spread Wahhabism; The role of Osama bin Laden, the Taliban, al Qaeda, and Afghanistan in forging bonds among Muslims who promote violence; Focus on the Muslim World League, Al Haramain Foundation, and the International Islamic Relief Organization; Background on the U.S. Central Intelligence Agency investigation of foreign jihadists in Bosnia and other countries; Probe by the U.S. Federal Bureau of Investigation into terrorist fundraising; The issue of American desire for Saudi crude oil; Challenges facing Western intelligence services in penetrating terrorist cells; Idea that the Saudi royal family is trying to modernize the fundamentalist society; The lawsuit in U.S. courts filed against the Saudis by family members of terrorist victims.
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- 2003
24. PLAYING OFFENSE.
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Kaplan, David E., Whitelaw, Kevin, Latif, Aamir, Ozernoy, Ilana, Lande, Laurie, and Ekman, Monica M.
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COUNTERTERRORISM , *BOMBINGS - Abstract
Discusses the search for al Qaeda by U.S. terrorist hunters. Retracing of the war on terror; Impact of America's frontline agents on disabling the al Qaeda terrorist network; Concern over future terrorist attacks in the U.S.; Warnings from al Qaeda official Ayman al-Zawahiri following bombings in Morocco and Saudi Arabia.
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- 2003
25. Homegrown terrorists.
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Kaplan, David E. and Ekman, Monica M.
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TERRORISTS , *TOBACCO , *SMUGGLING - Abstract
Discusses the discovery of the top U.S. cell of Hezbollah, the Lebanon-based terrorist organization, in Charlotte, North Carolina. Sergeant Bob Fromme of the Bureau of Alcohol, Tobacco, and Firearms and his investigation that revealed a multimillion-dollar tobacco smuggling ring; Leader of the Hezbollah terrorist organization, Mohamad Hammoud, and his many faces in Lebanon; Tactics Ken Bell, a veteran prosecutor in the U.S. attorney's office in North Carolina, used to capture Hammoud.
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- 2003
26. MADE IN THE U.S.A.
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Kaplan, David E., Ekman, Monica M., Elliston, Jonathan, Latif, Aamir, Reynolds, Michael, and Roane, Kit R.
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JIHAD , *ISLAM , *TERRORISTS - Abstract
Discusses how hundreds of Americans have joined the jihad movement and ventured overseas to attack those they believe threaten Islam. Estimated number of American recruits by the U.S. Federal Bureau of Investigation; The key roles some have played in terrorism; Web sites that spread the call to holy war; John Walker Lindh, the best-known American jihadist. INSETS: ABU MALIK;HIRAM TORRES;ISA ABDULLAH ALI;KHALID ABU AL-DAHAB
- Published
- 2002
27. A new state of fear.
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Kaplan, David E., Boyce, Nell, Cannon, Angie, Pasternak, Douglas, Ragavan, Chitra, Roane, Kit R., Robinson, Linda, Schmitt, Christopher H., Schultz, Stacey, Streisand, Betsy, and Griffin, Lisa
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BIOTERRORISM , *ANTHRAX , *BIOLOGICAL weapons , *TERRORISM - Abstract
Reports on bioterrorism in the United States. Envelopes containing white power sent to a Microsoft office in Reno, Nevada, National Broadcasting Co. Inc.'s offices in New York, and to American Media Inc. in Boca Raton, Florida; Difficulties in launching biological terrorism attacks. INSET: A once and future scourge.
- Published
- 2001
28. The CEO of Terror Inc.
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Kaplan, David E., Whitelaw, Kevin, Pound, Edward T., Keating, Nora, and Griffin, Lisa
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TERRORISTS , *TERRORISM - Abstract
Focuses on Osama bin Laden, who runs a terror network from his Afghan hideouts. How his son's marriage to an Egyptian fused two of the world's top terror organizations; Details of bin Laden's network, al Qaeda, and the ways it evolved; Role of al Qaeda associate Ramzi Ahmed Yousef, who bombed New York's World Trade Center in 1993; Biographical details; Why bin Laden turned his wrath on the United States; View that al Qaeda will rally new supporters.
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- 2001
29. Under Siege.
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Pound, Edward T., Kaplan, David E., Pasternak, Douglas, Ragavan, Chitra, Robinson, Linda, Cannon, Angie, Newman, Richard J., Mazzetti, Mark, Auster, Bruce B., Whitelaw, Kevin, Borger, Gloria, Tackett, Michael, Sharpe, Rochelle, Castillo, Ricardo, and Hilliard, Juli Cragg
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SEPTEMBER 11 Terrorist Attacks, 2001 , *PATRIOTISM - Abstract
Focuses on the terrorist attack on the United States Pentagon in Washington D.C., and the World Trade Center in New York City. Reaction of the country to the attack; Declaration of war by U.S. President George W. Bush; Support which the U.S. has received from other countries; Role of Pakistan in retaliation efforts of the U.S.; Need for the terrorists to be identified; Evidence suggesting that terrorist Osama bin Laden was involved in the attacks; Way that Americans have united after the attacks. INSETS: Anatomy of a collapse;A five-sided nightmare.
- Published
- 2001
30. FBI INC.
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Ragavan, Chitra, Kaplan, David E., and Pasternak, Douglas
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CRIMINAL justice system , *ACTIONS & defenses (Law) - Abstract
Discusses the United States Federal Bureau of Investigation (FBI). How public support of the FBI has eroded due to its failure to disclose evidence to the lawyers of convicted Oklahoma City bomber Timothy McVeigh's lawyers and to the discovery that veteran agent Robert Hanssen was a Russian spy; Problems which occurred while Louis Freeh was director, from 1993 to 2001; Slowness with which the FBI adopts technology; Penchant of the FBI for keeping secrets; Outlook for the FBI under a director to be named by President George W. Bush. INSETS: Success and failure;The greatest hits.
- Published
- 2001
31. To Tell the Truth.
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Whitelaw, Kevin and Kaplan, David E.
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ESPIONAGE , *UNITED States governmental investigations - Abstract
Discusses investigations at the United States Federal Bureau of Investigation (FBI) and Department of Energy, prompted by the arrest of FBI agent Robert Hanssen and unproven spy allegations against physicist Wen Ho Lee. Damage done by counterintelligence investigations at the Central Intelligence Agency (CIA) after the arrest of double spy Aldrich Ames; Question of whether polygraphs are helpful in such investigations; How the agencies must guard national security, but not at the expense of agents' individual rights. INSET: Pandora's box.
- Published
- 2001
32. A war in the shadows.
- Author
-
Strobel, Warren P., Kaplan, David E., Newman, Richard J., Whitelaw, Kevin, and Grose, Thomas
- Subjects
- *
TERRORISM , *COUNTERTERRORISM policy , *TERRORISTS - Abstract
Reports on the efforts of the United States to control acts of terrorism. Discussion of Saudi exile Osama bin Laden, who is believed to be the mastermind behind the terrorist attack on the USS Cole; Discussion of terrorist cells, which are placed under surveillance; Use of a legal process called rendition in which suspects are returned to their home country; Role of the U.S. Central Intelligence Agency (CIA); Discussion of the mujahideen underground railroad, which recruits young terrorists to Afghanistan.
- Published
- 2001
33. A Matter of TACEte: Plain Vanilla or Combination?
- Author
-
Kaplan, David E.
- Subjects
- *
VANILLA , *SURGICAL excision , *CATHETER ablation , *HEPATOCELLULAR carcinoma , *LIVER tumors , *PLANTS , *CHEMOEMBOLIZATION - Published
- 2020
- Full Text
- View/download PDF
34. Why auto theft is going global.
- Author
-
Ragavan, Chitra, Kaplan, David E., Mandel-Campbell, Andrea, and Robinson, Linda
- Subjects
- *
AUTOMOBILE theft , *AUTOMOBILE theft investigation , *SMUGGLING , *GOVERNMENT policy - Abstract
Discusses the international car theft trade. Industry dominated by crime syndicates; Number and costs of vehicles stolen yearly in the United States; Number of US stolen cars smuggled abroad in 1997; Profits which can be made on US stolen cars overseas; Soft penalties for car smuggling; Drug dealers who steal cars; US cars that end up in Mexico; Use of high technology to track down car thieves; Views of the Federal Bureau of Investigation (FBI). INSET: Protecting your car from a pro, by Richard Folkers.
- Published
- 1999
35. The wiseguy regime.
- Author
-
Kaplan, David E., Butler, Steven, and Madden, Mark
- Subjects
- *
CORRUPTION , *PUBLIC officers , *DRUG control , *METHAMPHETAMINE ,NORTH Korean politics & government - Abstract
Describes the illegal activities conducted by officials from North Korea. The country's vast criminal enterprise; Smuggling and drug trafficking since the 1970s; Evidence of corruption; The country's need for cash; Funding the nuclear program with drug profits; Cultivation of opium poppies since the 1980s; North Koreans targeting the drug trade in Europe; Drug of the future for North Korea seen to be methamphetamine; Use of counterfeit money.
- Published
- 1999
36. On terrorism's trail.
- Author
-
Kaplan, David E. and Lovgren, Stefan
- Subjects
- *
INTERNATIONAL cooperation on criminal investigations , *BOMBINGS , *ACTIONS & defenses (Law) - Abstract
Describes efforts of the United States Federal Bureau of Investigation (FBI) in investigating the US embassy bombings in Nairobi, Kenya, and Dar es Salaam, Tanzania. Work of Special Agent Sheila Horan; The FBI's largest overseas investigation; Indictment of Osama bin Laden; Highlights of the investigation; FBI work with authorities in Kenya and Tanzania; Collection of evidence; Interrogation of suspects.
- Published
- 1998
37. The looting of Russia.
- Author
-
Kaplan, David E. and Caryl, Christian
- Subjects
- *
CULTURAL property , *LARCENY , *ACTIONS & defenses (Law) - Abstract
Details the investigation of the theft of millions of dollars worth of valuables from the Russian national treasury. Work of Joe Davidson, of the United States Federal Bureau of Investigation (FBI); Theft scheme reaching to the highest levels of the Russian government; Theft through the company Golden ADA; The company's owners, Andrei Kozlenok, and Ashot and David Shagirian; The company's operations and shipments; More.
- Published
- 1998
38. Yakuza inc.
- Author
-
Kaplan, David E. and Butler, Steven
- Subjects
- *
ORGANIZED crime , *FINANCIAL institutions - Abstract
Focuses on the corrupt or criminal groups involved with the Japanese financial system. Involvement of crime syndicates or mobsters known as Yakuza; Concerns of investors from the United States; Efforts of Japan to reform the system; Impact of the financial crisis; Discussion of the impact of organized crime; Efforts to investigate firms and investments before investing; Tolerance for criminal activity in Japan.
- Published
- 1998
39. Terrorism's next wave.
- Author
-
Kaplan, David E. and Pasternak, Douglas
- Subjects
- *
BACTERIAL toxins , *CHEMICAL weapons , *TERRORISM - Abstract
Focuses on the increase in individuals suspected of using or planning to use radiological, biological, or chemical agents in terrorist attacks in the United States. Background on suspects James Dalton Bell, Larry Wayne Harris, suspects from the Minnesota Patriots Council, and followers of Bhagwan Shree Rajneesh; Other suspects; Why exotic poisons are attracting terrorists and other criminals.
- Published
- 1997
40. OUT OF A BLACK HOLE.
- Author
-
Whitelaw, Kevin, Kaplan, David E., and Mulrine, Anna
- Subjects
- *
SEPTEMBER 11 Terrorist Attacks, 2001 , *TERRORISTS , *QUESTIONING ,GENEVA Conventions (1949) - Abstract
The article explores the U.S. Supreme Court ruling against President George W. Bush's post-September 11 policy that the Geneva Conventions did not apply to al Qaeda terrorist suspects. The president revealed the transfer of top al Qaeda suspects from Central Intelligence Agency (CIA) overseas prisons to the U.S. military prison in Guantanamo Bay (Cuba). He maintains, along with CIA officials, that techniques employed at the secret prisons provided necessary intelligence gains. INSETS: TERROR'S TRAIL;Gitmo Bound.
- Published
- 2006
41. CAN THIS MAN SAVE THE CIA?
- Author
-
Whitelaw, Kevin and Kaplan, David E.
- Subjects
- *
EAVESDROPPING ,UNITED States politics & government, 2001-2009 - Abstract
The article questions whether General Michael Hayden can reform the Central Intelligence Agency (CIA) in the same way he did the National Security Agency (NSA) after the Cold War. As President George W. Bush's appointee for the position of CIA director, Hayden is set to undo the mistake of predecessor Porter Goss. His nomination is contentious, the main concern being his role in implementing the warrantless wiretaps and information mining that comprise the NSA's domestic surveillance program.
- Published
- 2006
42. THE EYES HAVE IT.
- Author
-
Kaplan, David E., Marek, Angie, and Walsh, Ken
- Subjects
- *
NATIONAL security , *CIVIL rights , *COUNTERTERRORISM , *WARRANTS (Law) - Abstract
This article looks at the news that the U.S. government has been monitoring and eavesdropping on Americans without appropriate warrants. The National Security Agency and the FBI have been running counterterrorism investigations on animal rights, environmental, antiwar, and peace activist groups without warrants. President George W. Bush has authorized the warrantless searches on at least thirty occasions and plans to continue. He believes that Americans want him to err on the side of security. Civil liberties watchdogs believe that the security agencies have gone overboard. INSET: The Good Old Bad Old Days.
- Published
- 2006
43. TANGLED ROOTS OF AN ATROCITY.
- Author
-
Kaplan, David E.
- Subjects
- *
TERRORISTS , *CHECHENS , *JIHAD , *NATIONALISM , *TERRORISM financing - Abstract
The article discusses Chechen terrorism in Russia. This southern Russian community of 30,000 endures the heartbreaking aftermath of Russia's worst terrorist attack: the takeover of Beslan's Middle School No. 1, in which at least 368 people were killed and hundreds of others injured by explosions and gunfire. The killings are but the latest of a dozen bloody attacks that have claimed nearly 1,000 lives in Russia over the past two years. Among the targets: airliners, commuter trains and subway stations, government buildings, a hospital, a rock concert, and a Moscow theater. Russian officials blame all these attacks on terrorists from Chechnya, a Muslim republic with the legacy of a dogged independence movement, and a growing influence of Islamic radicals from abroad who have found there both a battlefield for jihad and an inspiration for their global cause. The Russians call them the Vakhabity--the Wahhabis--using the name for adherents of Saudi Islam to describe religious militants in their Muslim republics. They began appearing as early as 1987, before the Soviet Union broke up, according to Alex Alexiev, a terrorism specialist at the Center for Security Policy. Among the key funders, investigators say: the Riyadh-based al Haramain Foundation, through its offices in nearby Azerbaijan and Dagestan as well as in the United States. Just last week, Treasury officials officially blacklisted al Haramain's U.S. branch, based in Oregon, for alleged ties to al Qaeda and fund transfers to Chechnya. Another foundation, Benevolence International in suburban Chicago, sent hundreds of thousands of dollars to Chechen fighters, according to court records.
- Published
- 2004
44. DON'T ASK, DON'T TELL.
- Author
-
Whitelaw, Kevin and Kaplan, David E.
- Subjects
- *
INTELLIGENCE service , *UNITED States legislators , *PARTISANSHIP , *NATIONAL security ,UNITED States Congressional committees - Abstract
Considers the role of the United States Congress in overseeing the nation's intelligence agencies. Criticism of Congress by the 9/11 commission for lacking the power, influence, and sustained capability to properly oversee the nation's 15 intelligence agencies; Impact of partisanship on a collapse of the oversight system; Challenges faced by members of the intelligence committees because term limits keep them from building up the knowledge they need; Use of experience by intelligence officials to intimidate congressmen and deflect tough questions; Focus on "turf battles" in Congress.
- Published
- 2004
45. Pieces of the 9/11 Puzzle.
- Author
-
Kaplan, David E., Whitelaw, Kevin, Pound, Edward T., and Ragavan, Chitra
- Subjects
- *
ELECTRONICS in criminal investigation , *NATIONAL security , *ESPIONAGE , *INTELLIGENCE service , *ELECTRONIC surveillance , *SEPTEMBER 11 Terrorist Attacks, 2001 - Abstract
Looks at the independent investigation being conducted on intelligence failures on September 11, 2001. A link to Osama Bin Laden and others through eavesdropping by the National Security Agency (NSA) a year before the attacks; One suspect who turned out to be Khalid al-Mihdar, one of the hijackers who would die that day; Failure to discover al-Mihdar was in the United States at the time of the tapings; Questions of why the calls were not traced and followed up; Claim by the agency that it foiled several plots over the next three years; Findings of inquiry so far; Limitations of the U.S. intelligence services.
- Published
- 2004
46. THE SHADOW OVER THE SUMMIT.
- Author
-
Kaplan, David E., Davis, Anthony, Dillon, Paul, and Ragavan, Chitra
- Subjects
- *
COUNTERTERRORISM , *SUBVERSIVE activities , *SUMMIT meetings , *HEADS of state , *TERRORISTS - Abstract
Discusses the anti-terrorist actions in Southeast Asia. Preparations for a summit meeting of 21 presidents and prime ministers from around the world; Sign that the region is finally taking terrorism seriously; Past terrorists who have met in Southeast Asia, which has been known to harbor al Qaeda and its network; Jemaah Islamiyah, an ambitious home-grown network with cells that stretch from Thailand to Australia.
- Published
- 2003
47. A tightening noose.
- Author
-
Whitelaw, Kevin, Kaplan, David E., Ragavan, Chitra, Latif, Aamir, Lande, Laurie, and Boston, William
- Subjects
- *
DETENTION of persons , *TERRORISTS , *ACTIONS & defenses (Law) - Abstract
Reports on the effect of the arrest of Khalid Sheikh Mohammed in the manhunt for Osama bin Laden. Evidence that was seized in the arrest; Region where they are searching for bin Laden; Risks associated with his arrest, such as increased terrorist attacks by al Qaeda and sympathizers; Details of the investigation which led to his arrest.
- Published
- 2003
48. Run and Gun.
- Author
-
Kaplan, David E., Cannon, Angie, Mazzetti, Mark, Pasternak, Douglas, Whitelaw, Kevin, and Latif, Aamir
- Subjects
- *
WAR on Terrorism, 2001-2009 , *INTELLIGENCE service , *TERRORISTS - Abstract
Reports on the arrests of al Qaeda terrorists, and victories in the United States war on terrorism. Exploitation of intelligence documents and interrogations; Use of informants; Capture of terrorist Ramzi Binalshibh; Status of high alert for U.S. officials; Investigation of Osama Bin Laden's training camps; Risk of intelligence failures.
- Published
- 2002
49. Pieces of the puzzle.
- Author
-
Auster, Bruce B., Kaplan, David E., Whitelaw, Kevin, and Ragavan, Chitra
- Subjects
- *
UNITED States governmental investigations , *SEPTEMBER 11 Terrorist Attacks, 2001 , *TERRORISM - Abstract
Discusses the investigation into the terrorist attacks on the United States, and the efforts of investigators in the U.S. to link Osama bin Laden to the attacks. Actions of U.S. Federal Bureau of Investigation director Robert Mueller; Arrest of people thought to be linked to the attacks; Outlook for the cooperation of suspects; Need for evidence against bin Laden before an attack can be launched by the U.S. against the Al Qaeda organization.
- Published
- 2001
50. The golden age of crime.
- Author
-
Kaplan, David E., Willan, Philip P., Dimmler, Eleni, Salguero, Carol, and Madden, Mark
- Subjects
- *
DRUG traffic , *GOLD industry , *GOLD , *MONEY laundering , *DRUGS & crime , *CORRUPTION , *INTERNATIONAL trade - Abstract
Discusses why international drug traffickers are invading the global gold trade. Evidence that gold is joining the United States dollar as the standard currency of the drug trade; Imports of gold from the cocaine production centers of Colombia and Peru; How the gold buying and money laundering schemes work; How the gold trade challenges law enforcement.
- Published
- 1999
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