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Focuses on the secretion of nucleoside diphosphate kinase (Ndk) by mucoid Pseudomonas aeruginosa 8821. Involvement of a carboxy-terminal motif in secretion; Importance of the carboxy-terminal 8 amino acids of the Ndk for its secretion into the extracellular medium; Interdependence of membrane localization of Ndk and secretion of Ndk.

Investigates how an intracellular protease cleaves the 16-kDa form of the nucleoside diphosphate kinase (Ndk) enzyme to a 12-kDa form that undergoes autophosphorylation with an efficiency almost identical to that of the 16-kDa form. 12-kDa's association with pseudomonas aeruginosa cell; Characteristics of the 16-kDa form; Materials and techniques used in experiments; Results of study; References.

Studies the cellular function of elastase in Pseudomonas aeruginosa. Role of elastase in the cleavage of nucleoside diphosphate kinase and in alginate synthesis; Major virulence factors in Pseudomonas aeruginosa; Consequence of alginate synthesis in the cystic fibrosis lungs.