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ObjectivesTo determine the productivity of village-based ‘key informants’ (KIs) in identifying blind children.Materials and methodsNgabu subdistrict (population 101 000) of Chikwawa district was divided into KI catchment areas. KIs, selected by local village leaders, were trained to register children reported to be blind or with severe visual impairment. These children were clinically assessed at designated centres.ResultsIn total, 44 KIs were selected and trained to cover 196 villages in Ngabu. They identified and referred 151 children, 37 of whom were blind (presenting vision <3/60 best eye). Overall, village leaders tended to choose female KIs (80%) compared to male KIs (20%); however, male KIs tended to be more productive, identifying 4.22 children each (compared to 3.23 for female KIs). Male KIs were 2.7 times more likely to identify blind children compared to female KIs. Only 25% of all identified blind children of school going age were in school.ConclusionsKIs may be effective in identifying blind children in the community; however, additional work is needed to determine who will be the most effective KI in a community and whether gender roles will limit interpretation of findings from KIs activities.Eye (2009) 23, 7–9; doi:10.1038/eye.2008.49; published online 14 March 2008 [ABSTRACT FROM AUTHOR]

Background: We hypothesized that mass distribution of a broad-spectrum antibiotic agent to preschool children would reduce mortality in areas of sub-Saharan Africa that are currently far from meeting the Sustainable Development Goals of the United Nations.Methods: In this cluster-randomized trial, we assigned communities in Malawi, Niger, and Tanzania to four twice-yearly mass distributions of either oral azithromycin (approximately 20 mg per kilogram of body weight) or placebo. Children 1 to 59 months of age were identified in twice-yearly censuses and were offered participation in the trial. Vital status was determined at subsequent censuses. The primary outcome was aggregate all-cause mortality; country-specific rates were assessed in prespecified subgroup analyses.Results: A total of 1533 communities underwent randomization, 190,238 children were identified in the census at baseline, and 323,302 person-years were monitored. The mean (±SD) azithromycin and placebo coverage over the four twice-yearly distributions was 90.4±10.4%. The overall annual mortality rate was 14.6 deaths per 1000 person-years in communities that received azithromycin (9.1 in Malawi, 22.5 in Niger, and 5.4 in Tanzania) and 16.5 deaths per 1000 person-years in communities that received placebo (9.6 in Malawi, 27.5 in Niger, and 5.5 in Tanzania). Mortality was 13.5% lower overall (95% confidence interval [CI], 6.7 to 19.8) in communities that received azithromycin than in communities that received placebo (P<0.001); the rate was 5.7% lower in Malawi (95% CI, -9.7 to 18.9), 18.1% lower in Niger (95% CI, 10.0 to 25.5), and 3.4% lower in Tanzania (95% CI, -21.2 to 23.0). Children in the age group of 1 to 5 months had the greatest effect from azithromycin (24.9% lower mortality than that with placebo; 95% CI, 10.6 to 37.0). Serious adverse events occurring within a week after administration of the trial drug or placebo were uncommon, and the rate did not differ significantly between the groups. Evaluation of selection for antibiotic resistance is ongoing.Conclusions: Among postneonatal, preschool children in sub-Saharan Africa, childhood mortality was lower in communities randomly assigned to mass distribution of azithromycin than in those assigned to placebo, with the largest effect seen in Niger. Any implementation of a policy of mass distribution would need to strongly consider the potential effect of such a strategy on antibiotic resistance. (Funded by the Bill and Melinda Gates Foundation; MORDOR ClinicalTrials.gov number, NCT02047981 .). [ABSTRACT FROM AUTHOR]

The authors reflect on VISION 2020: The Right to Sight global initiative which aims to eliminate avoidable blindness by 2020. They discuss topics on the three pillars of the initiative including disease control and human resource development for eye care, the shortage of eye care workers facing Sub Saharan Africa, and the options for developing countries such as Malawi in training surgeons. They also mention residents' expected surgical experience in Malawi.

Background: This study focuses on the refractive implications of albinism in Malawi, which is mostly associated with the burden of visual impairment. The main goal was to describe the refractive errors and to analyze whether patients with albinism in Malawi, Sub-Saharan Africa, benefit from refraction. Methods: Age, sex, refractive data, uncorrected and best-corrected visual acuity (UCVA, BCVA), colour vision, contrast sensitivity, and the prescription of sunglasses and low vision devices were collected for a group of 120 albino individuals with oculocutaneous albinism (OCA). Refractive errors were evaluated objectively and subjectively by retinoscopy, and followed by cycloplegic refraction to reconfirm the results. Best-corrected visual acuity (BCVA) was also assessed binocularly. Results: One hundred and twenty albino subjects were examined, ranging in age from 4 to 25 years (median 12 years), 71 (59 %) boys and 49 (41 %) girls. All exhibited horizontal pendular nystagmus. Mean visual acuity improved from 0.98 (0.33) logMAR to 0.77 (0.15) logMAR after refraction ( p < 0.001). The best improvement of VA was achieved in patients with mild to moderate myopia. Patients with albinism who were hyperopic more than +1.5 D hardly improved from refraction. With the rule (WTR) astigmatism was more present (37.5 %) than against the rule (ATR) astigmatism (3.8 %). Patients with astigmatism less than 1.5 D improved in 15/32 of cases (47 %) by 2 lines or more. Patients with astigmatism equal to or more than 1.5 D in any axis improved in 26/54 of cases (48 %) by 2 lines or more. Conclusions: Refraction improves visual acuity of children with oculocutaneous albinism in a Sub-Saharan African population in Malawi. The mean improvement was 2 logMAR units. [ABSTRACT FROM AUTHOR]

Objective: Trachoma is the oldest blinding ocular infection that has well known predisposing risk factors for its transmission. The prevalence of trachoma in Rwanda has been unknown as no trachoma population-based survey had ever been undertaken. The aim of this study was to determine the prevalence of Trachoma and assess associated risk factors for its transmission. Methods: A population-based cross-sectional study of children aged 1 to 9 years and adult women aged 15 and above. Study setting was Gatsibo (Eastern Province) and Nyaruguru (Southern Province) Districts, Rwanda. Clusters were selected through probability proportion-to-size sampling and eligible persons were sampled using a systematic random sampling method. Data were collected using three generic survey questionnaires (village, household and individual level) as recommended by the World Health Organization (WHO). Results: 3,451 children and 1,841 adult women underwent ocular examination for trachoma assessment. The prevalence of trachomatous inflammation-follicular (TF) among children was 1.32 % [95% CI, 0.77-1.86] in Gatsibo and 0.73% [95% CI, 0.33-1.13] in Nyaruguru Districts, respectively; with both districts having a prevalence below the WHO/International Trachoma Initiative (ITI) cut-off point of 10% for trachoma to be taken as disease of public health importance. There was no case of blinding trachomatous trichiasis and corneal opacity in both districts. Risk factors present for trachoma transmission were minimal. Conclusion: Trachoma is not a disease of public health importance in Gatsibo and Nyaruguru Districts in Rwanda [ABSTRACT FROM AUTHOR]