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Objective: The aim of this study was to determine whether patients treated with platelet-poor plasma after an acute thigh muscle injury would have a faster return to activity compared with patients treated with platelet-rich plasma. Design: This quasi-experimental study included 100 patients (ages 16–45) with an acute thigh muscle injury diagnosed by sports ultrasound and treated with either platelet-rich plasma or platelet-poor plasma followed by a course of structured rehabilitation. The primary outcome was the number of days until unrestricted participation in sport, while the secondary outcome was the rate of recurrent injury within 12 mos. Result: The time until full, unrestricted participation in sport was significantly lower in the platelet-poor plasma group compared with the platelet-rich plasma group for all injury grades, with patients in the platelet-poor plasma group on average returning to unrestricted participation in sport 22.89 days more quickly than the platelet-rich plasma group (P < 0.001). In addition, no significant difference in recurrent injury up to 12 mos after procedure was seen between groups (P = 0.967). Conclusions: Platelet-poor plasma resulted in faster return to sport than platelet-rich plasma for acute thigh muscle injuries with a noninferior injury recurrence rate. These findings suggest that future high level studies comparing platelet-poor plasma and platelet-rich plasma for the treatment of thigh muscle injuries should be considered. [ABSTRACT FROM AUTHOR]

Spatial networks are widely used in various fields to represent and analyze interactions or relationships between locations or spatially distributed entities. Existing studies have proposed methods for hub identification and community detection in spatial networks, but relatively few have focused on quantifying the strength or density of connections shared within a community of hubs across space and time. Borrowing from network science, there is a relevant concept known as the rich club phenomenon, which describes the tendency of rich nodes to form densely interconnected subnetworks. Although there are established methods to quantify topological, weighted, and temporal rich clubs individually, there is limited research on measuring the rich club effect in spatially weighted temporal networks, which could be particularly useful for studying dynamic spatial interaction networks. To address this gap, we introduce the spatially weighted temporal rich club (WTRC), a metric that quantifies the strength and consistency of connections between rich nodes in a spatiotemporal network. Additionally, we present a unified rich club framework that distinguishes the WTRC effect from other rich club effects, providing a way to measure topological, weighted, and temporal rich club effects together. Through two case studies of human mobility networks at different spatial scales, we demonstrate how the WTRC is able to identify significant weighted temporal rich club effects, whereas the unweighted equivalent in the same network either fails to detect a rich club effect or inaccurately estimates its significance. In each case study, we explore the spatial layout and temporal variations revealed by the WTRC analysis, showcasing its value in studying spatiotemporal interaction networks. This research offers new insights into the study of spatiotemporal networks, with critical implications for applications such as transportation, redistricting, and epidemiology. [ABSTRACT FROM AUTHOR]

Adequate fluid therapy is crucial to maintain organ function after burn trauma. Major burns lead to a systemic response with fluid loss and cardiac dysfunction. To guide fluid therapy, measurement of cardiac pre- and afterload is helpful. Whereas cardiac function is usually measured after admission to intensive care unit (ICU), in this study, hemodynamic monitoring was performed directly after arrival at hospital. We conducted a prospective cohort study with inclusion of 19 patients (male/female 13/6, 55 ± 18 years, mean total body surface area 36 ± 19%). Arterial waveform analysis (PulsioFlexProAqt®, Getinge) was implemented immediately after admission to hospital to measure cardiac pre- and afterload and to guide resuscitation therapy. Cardiac parameters 3.75 (2.67-6.0) h after trauma were normal regarding cardiac index (3.45 ± 0.82) L/min/m², systemic vascular resistance index (1749 ± 533) dyn sec/cm5 m2, and stroke volume (SV; 80 ± 20) mL. Stroke volume variation (SVV) was increased (21 ± 7) % and associated with mortality (mean SVV survivors vs nonsurvivors 18.92 (±6.37) % vs 27.6 (±5.68) %, P =.017). Stroke volume was associated with mortality at the time of ICU-admission (mean SV survivors vs nonsurvivors 90 (±20) mL vs 50 (±0) mL, P =.004). Changes after volume challenge were significant for SVV (24 ± 9 vs19 ± 8%, P =.01) and SV (68 ± 24 vs 76 ± 26 mL, P =.03). We described association of SVV and SV with survival of severely burned patients in an observational study. This indicates high valence of those parameters in the early postburn period. The use of an autocalibrated device enables a very early monitoring of parameters relevant to burn shock survival. [ABSTRACT FROM AUTHOR]

Background: The newborn transphyseal fracture of the distal humerus is frequently misdiagnosed with an elbow dislocation due to the absence of the lateral condyle ossification node. No consensus has been reported either for the diagnosis or the management of these rare fractures. This study aimed to analyze a series of newborns with transphyseal distal humerus fractures. Methods: All consecutive infants treated between 2005 and 2020 for a transphyseal fracture of the distal humerus before the age of 6 months were retrospectively included. All radiological examinations were analyzed (X-ray, ultrasound, and magnetic resonance imaging (MRI)) as well as the therapeutic management (orthopedic or surgical treatment). The patients were seen at outpatient clinic visits with a minimum of 2-year follow-up. Results: Nine newborns were treated. The main cause was an obstetrical traumatism (n = 8). The diagnosis was made on physical examination and addressed by obstetric departments with standard biplanar radiographs in four cases. The fracture was suspected on physical examination in the remaining five cases and confirmed by complementary imaging (ultrasound (2), MRI (1), and both (3)). A total of six patients were treated conservatively and three surgically with an open reduction. At a mean follow-up of 79 months, two complications occurred: one axillary abscess due to the cast and one cubitus varus deformity. All children had a full functional recovery. Conclusions: The transphyseal fracture of the distal humerus in newborns is a rare entity that should be managed conservatively. Additional imaging examinations are recommended to clarify the diagnosis. Level of evidence: Level IV, cohort study. [ABSTRACT FROM AUTHOR]

The article discusses the risks of iatrogenic injuries to the circumflex artery during mitral valve surgery, which occur in 0.3 to 1.8% of cases. The study analyzed mitral anatomy using advanced imaging software in 313 patients who underwent minimally invasive mitral valve surgery. The findings showed that a close location of the circumflex artery to the mitral valve with a distance <4 mm increased the risk of injury, highlighting the importance of preoperative assessment using advanced CT imaging software. [Extracted from the article]

The study published in the journal "Thoracic & Cardiovascular Surgeon" examines the relationship between MELD Score and outcomes in patients undergoing surgery for infective endocarditis. The MELD Score, which assesses liver function, was found to be strongly associated with postoperative mortality and morbidity, with higher scores correlating with increased risk. Patients with a MELD Score over 30 had poor outcomes, indicating futility. The study suggests further research to determine if MELD assessment provides additional benefits compared to traditional assessment methods like EuroSCORE II. [Extracted from the article]

The nature of science (NOS) is a fundamental aspect of scientific literacy to support students' understanding of science content, socio-scientific issues, and science media. Unfortunately, NOS is often left out of science instruction or limited to ineffective implicit approaches. The activity described in this article engages students in inquiry and problem-solving as they attempt to uncover the mechanism of a magic trick. While the trick engages students, the accompanying discussions encourage students to think more deeply about the ways scientists work and think. Through explicit questions, we leverage students' experiences to guide students toward deeper thinking about the nature of science. Importantly, this activity is an introduction to key NOS ideas and we return to NOS in the context of our content instruction throughout the year. Yet, activities such as these can lay a strong foundation for those later conversations. [ABSTRACT FROM AUTHOR]

In Europe, the tendency among immigrants and descendants to seek out and interact with other coethnics has raised concern for their integration as it can reduce contact with the ethnic majority. Though policymakers implement large-scale integration programs to counteract these trends, it remains empirically and theoretically ambiguous whether exposure to coethnic peers impedes integration, and causal evidence is more limited for the growing population of migrant children. In this article, I use high-quality Danish administrative panel data over 28 y to investigate whether the ethnic composition experienced in childhood among immigrants and descendants with a non-EU background affects a core behavioral indicator of integration: naturalization. To isolate the causal effect of the childhood ethnic composition, I use the quasi-experimental assignment of siblings into different school grades in the same school. I find that being exposed to coethnic peers in the school grade increases the probability of naturalizing later in life. The main explanation is that exposure to some coethnic peers improves academic skills which are positively correlated with citizenship acquisition. These findings demonstrate the causal importance of non-EU migrant children's social environment for their later integration into the national community showing that the modest presence of coethnic peers can be a precondition for, not a barrier to, integration. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the relationship between high school sport participation among university students and whether previous sports participation was associated with current levels of exercise-self efficacy, resilience, and psychological need satisfaction physical activity behaviors. Participants: College freshmen (n = 152) in the United States responded to an electronic survey sent out by their university. Methods: Participants completed a set of questionnaires assessing resilience, psychological need satisfaction in exercise, self-efficacy, and current PA. Results: Analysis of variance, Kruskal-Wallis H tests, independent samples t-tests, and ordinary least squares regression modeling were used. Total PA and having met moderate PA guidelines were both associated with exercise SE and PNSE. HS GPA, total PA, and being a college athlete were associated with both resilience and exercise SE. Conclusions: Sport participation may serve as an effective method for students to develop exercise SE, resilience, and PNSE. The development of these skills may support lifelong PA behaviors. [ABSTRACT FROM AUTHOR]

Parent–child co‐sleeping is a common practice in many cultures, although in Western countries, families who engage in parent–child co‐sleeping can encounter attitudes about co‐sleeping that feel critical from the people around them, as it is not commonly accepted and often stigmatized. This systematic scoping review examined and synthesized the available literature on the attitudes about parent–child co‐sleeping that people encounter, their origins, and their effect on parents' own attitudes and behaviors. A total of 9796 abstracts were screened, and 33 studies were included. While the scope of the literature on this topic was narrow, this review demonstrated that parents/caregivers mostly encounter encouraging attitudes about co‐sleeping from their extended family members and within their culture and discouraging attitudes from healthcare professionals. Findings suggest that encouraging attitudes enhance the likelihood of parents engaging and continuing with co‐sleeping behavior, while discouraging attitudes can lead to the avoidance of parents discussing sleep with their healthcare professionals and can cause conflicts with other family members, including partners. Based on these findings, we conclude that further research is needed in several areas related to co‐sleeping in Western culture, most specifically in how external attitudes influence the decision to co‐sleep, as well as other behaviors and cognitions such as engagement with healthcare professionals, family satisfaction, parental self‐efficacy, and overall mental health. [ABSTRACT FROM AUTHOR]

The analysis of the splitting signature of XKS phases is crucial for constraining seismic anisotropy patterns, especially in complex subduction settings such as outward-dipping double subduction. A natural example of this is found in the Central Mediterranean, where the Apennine and the Dinaride slabs subduct in opposite directions, with the Adriatic plate separating them. To assess the capability of XKS-splitting analysis in revealing anisotropic seismic properties, such as fast polarization directions and shear wave anisotropy (in per cent), we use three-dimensional numerical geodynamic models combined with texture evolution simulations. In these models, two identical outward-dipping oceanic plates are separated by a continental plate. Using the full elastic tensors – directly derived from the texture evolution simulations – we compute anisotropic seismic properties and synthetic teleseismic waveforms. From these waveforms synthetic observables are determined, including apparent splitting parameters (fast polarization directions and delay times) and splitting intensities. Based on these observables, we (1) derive models for a single anisotropic layer (one-layer model), (2) identify regions with significant depth-dependent anisotropic seismic properties, and (3) perform inversions at selected locations in terms of two anisotropic layers (two-layer model). We consider two geodynamic models: one with a strong (M1) and one with a weak (M2) continental plate. Model M1 exhibits significant retreat of the subducting plates with no horizontal stretching of the continental plate, whereas Model M2 shows less retreat, substantial horizontal stretching, and detachment of the subducting plates. These different subduction styles result in distinct flow and deformation patterns in the upper mantle, which are reflected in the anisotropic seismic properties. In Model M1, the fast polarization directions below the continental plate are predominantly trench-parallel, whereas in Model M2, they are mostly trench-normal. In most regions of both models, the one-layer models are sufficient to resolve the anisotropic seismic properties, as these properties are nearly constant with depth. However, for both models, we identify some isolated regions – primarily near the tips of the subducting plates and beneath the continental plate – where fast polarization directions exhibit significant variations with depth. Inverting the apparent splitting parameters in these regions yields multiple two-layer models at each location that excellently fit the observables. However, their anisotropic seismic properties can vary significantly, and not all these two-layer models adequately approximate the true depth variations. This ambiguity can be partially reduced by selecting two-layer models in which the summed shear wave anisotropy closely matches that of one of the one-layer models, as these models better capture the true variations. [ABSTRACT FROM AUTHOR]

This geographical note revisits the town of Point Pleasant, West Virginia and provides an update on a paper published in 2015. Long known as the site of the Battle of Point Pleasant, The Silver Bridge Tragedy, and alleged sightings of a winged, red-eyed creature called the "Mothman," Point Pleasant and Mason County are currently in the midst of an economic transformation. This paper reveals how the growth of the Mothman Festival and the effects of the COVID-19 pandemic have provided new opportunities for economic development, and helped attract three new industries to the area. Drawing from interviews with two town leaders and a lifelong resident, this essay offers a perspective on how recent innovations, strong leadership, and continuity anchored in a strong sense of place are moving the town forward towards prosperity. [ABSTRACT FROM AUTHOR]

The contemporary normative climate regarding sexual violence affects how perpetrators of such violence relate to their harmful acts. In this article, we analyze how men convicted of sex offences are affected by how perpetrators of such offences are often represented as monsters and ask what this tells us about what characterizes the Monster as a figure. While people convicted of sexual offences are likened to monsters in many contexts, there is little research that unpacks the characteristics of this figure and how it is contingent on ideas about and the regulation of sex offending. By analyzing data from qualitative interviews with 17 men convicted of sexual offences in Norway, we found that, although they presented themselves and the acts they were convicted of committing differently, they had a common fear of being identified as a monster. In these narratives, a monster was characterized by (1) intentionality—having intentionally harmed others, (2) preference—having a sexual preference for harmful, nonconsensual sex, and (3) authenticity—being authentically violent. We conceive of the narrative processes that the participants engage in as forms of social abjection and discuss the consequences that abjection may have for accountability, rehabilitation, and justice. [ABSTRACT FROM AUTHOR]

Microorganisms have evolved sophisticated sensor-actuator circuits to perform taxis in response to various environmental stimuli. How any given circuit can select between different taxis responses in noisy vs. saturated stimuli conditions is unclear. Here, we investigate how Euglena gracilis can select between positive vs. negative phototaxis under low vs. high light intensities, respectively. We propose three general selection mechanisms for phototactic microswimmers, and biophysical modeling demonstrates their effectiveness. Perturbation and high-speed imaging experiments show that of these three mechanisms, the "photoresponse inversion mechanism" is implemented in E. gracilis: a fast, light-intensity-dependent switching between two flagellar beat states responsible for swimming and turning causes positive vs. negative phototaxis at low vs. high light intensity via run-and-tumble vs. helical klinotaxis strategies, respectively. This coordinated beat-switching mechanism then also accounts for a larger set of previously reported E. gracilis behaviors; furthermore, it suggests key design principles for other natural as well as synthetic microswimmers. [ABSTRACT FROM AUTHOR]

This article presents new empirical insights into European metropolitan regions, addressing a gap in the existing literature by examining the sectoral specialization and its impact on the productivity growth of metropolitan regions. The lack of evidence for European metropolitan regions contrasts with the empirical evidence for U.S. metropolitan regions, highlighting a significant research gap. By employing panel-regression analysis and leveraging unique regional data encompassing European metropolitan regions from 2000 to 2020, the authors unveil a multitude of significant findings. Key findings are that higher income countries (EU-15) tend to experience greater benefits from sectoral specialization in metropolitan regions compared to Eastern European regions (EU-NMS), suggesting that generalizing conclusions for EU-27 may be misleading. The study reveals a productivity gap resulting from sectoral specialization between metropolitan and non-metropolitan regions: Results suggest a higher concentration of specialized sectors in metropolitan regions. Policy implications are highlighted within the discussion on the framework of smart specialization in the context of metropolitan regions. [ABSTRACT FROM AUTHOR]

Background: Hospitalization provides a key opportunity to address tobacco use. Few studies have examined cessation treatment in hospitals in low- and middle-income countries (LMIC). We aimed to measure tobacco abstinence among individuals discharged from a Mumbai hospital after the implementation of cessation counseling compared to abstinence among those discharged pre-implementation. Methods: Pre-post intervention study in the Prince Aly Khan Hospital, Mumbai pre- (11/2015-10/2016) and post-implementation (02/2018-02/2020) of LifeFirst counseling. LifeFirst is multi-session (up to six sessions) counseling extending from hospitalization up to six months post-discharge. Primary analyses compare self-reported 6-month continuous abstinence among hospitalized individuals post-implementation (intervention) with pre-implementation (comparator) using an intent-to-treat approach that includes all participants offered LifeFirst post-implementation in the intervention group. Secondary analyses compare those who received ≥ 1 LifeFirst session with the pre-implementation group. Results: We enrolled n = 437 individuals pre-implementation (8.7% dual use, 57.7% smokeless tobacco, 33.6% smoking) and n = 561 post-implementation (8.6% dual use, 64.3% smokeless tobacco, 27.1% smoking). Post-implementation, 490 patients (87.3%) accepted ≥ 1 counseling session. Continuous abstinence 6-months post-discharge was higher post-implementation (post: 41.6% vs. pre: 20.0%; adjusted odds ratio [aOR]: 2.86, 95% confidence interval [CI] 1.94–4.21). Those who received LifeFirst had higher odds of continuous abstinence compared to pre-implementation (aOR: 2.95, 95% CI 1.98–4.40). Conclusion: Post-discharge abstinence was more common after implementation of a multi-session tobacco counseling program for hospitalized patients compared to abstinence among patients hospitalized before implementation. These findings represent observational evidence of a promising association between post-discharge abstinence and a hospital-based tobacco cessation program implemented within routine practice in an LMIC setting. [ABSTRACT FROM AUTHOR]

Jamie Kruse of smudge studio is interviewed by co-editor, Valerie Triggs, in this special issue of the Review of Education, Pedagogy, and Cultural Studies, regarding smudge studio's site-specific project, OBSERVATORY. Kruse explains OBSERVATORY as a geo-cosmo field station workshop and tea hut where contemporary practices of tea drinking are offered to guests for experiencing tea's distinctive expressions of the forces of sun, earth, season, and cultural wisdom. Kruse discuss the ways in which tea, as an object, has pedagogic potential for reweaving human consciousness and imagination in relation to the cosmos as well as how it has become a personified force for smudge studio's ongoing collaboration. [ABSTRACT FROM AUTHOR]

Aim: We review evidence for effects of physical activity before and during gestation on the course of pregnancy and ask if there are circumstances where physical activity can stress the fetus due to competition for oxygen and energy substrates. Results: We first summarize physiological responses to exercise in nonpregnant people and known physiological adaptations to pregnancy. Comparing the two, we conclude that physical activity prior to and continuing during gestation is beneficial to pregnancy outcome. The effect of starting an exercise regimen during pregnancy is less easy to assess as few studies have been undertaken. Results from animal models suggest that the effects of maternal exercise on the fetus are transient; the fetus can readily compensate for a short‐term reduction in oxygen supply. Conclusion: In general, we conclude that physical activity before and during pregnancy is beneficial, and exercise started during pregnancy is unlikely to affect fetal development. We caution, however, that there are circumstances where this may not apply. They include the intensive exercise regimens of elite athletes and pregnancies at high altitudes where hypoxia occurs even in the resting state. [ABSTRACT FROM AUTHOR]

Stress generation by the actin cytoskeleton shapes cells and tissues. Despite impressive progress in live imaging and quantitative physical descriptions of cytoskeletal network dynamics, the connection between processes at molecular scales and spatiotemporal patterns at the cellular scale is still unclear. Here, we review studies reporting actomyosin clusters of micrometre size and with lifetimes of several minutes in a large number of organisms, ranging from fission yeast to humans. Such structures have also been found in reconstituted systems in vitro and in theoretical analyses of cytoskeletal dynamics. We propose that tracking these clusters could provide a simple readout for characterising living matter. Spatiotemporal patterns of clusters could serve as determinants of morphogenetic processes that have similar roles in diverse organisms. Kruse et al. review studies of actomyosin clusters in different biological systems and discuss the physical properties of these clusters, linking such properties to specific morphogenetic processes. They propose that tracking these clusters could provide a simple readout for characterising living matter and that spatiotemporal patterns of clusters could serve as morphogenetic determinants. [ABSTRACT FROM AUTHOR]

Background: Oral function tests have been shown to reliably detect impaired bulbar function in adults with spinal muscular atrophy (SMA). Although not routinely recorded, it is known that persons with SMA are affected to varying degrees. Detecting differences in bite and tongue force, endurance, and maximum mouth opening has become particularly promising since the introduction of causal therapy for SMA. This study aimed to compare oral function among adult persons with SMA with different SMA types, walking abilities, and treatment status to a healthy control group. Methods: Data from oral function tests conducted on 58 persons with SMA and 45 healthy individuals were analyzed. Differences in oral function between SMA subgroups were pairwise tested and compared to the healthy control group using Wilcoxon rank sum tests. Results: In an overall comparison, three out of five oral function tests revealed lower values for the SMA group compared to the control group. Subgroup analyses indicated lower scores for most oral function tests in non-ambulatory, untreated patients with SMA type 2 compared to controls. Ambulatory, treated patients with SMA type 3 achieved strength and endurance values comparable to those of healthy individuals. Conclusions: The impairment of oral function varies across persons with SMA. Routine measurement of oral function is warranted to determine individual bulbar involvement stages. Further evaluation should be scheduled if indicators such as restricted maximum mouth opening arise. Trial registration DRKS, DRKS00015842. Registered 30 July 2019, https://drks.de/register/de/trial/DRKS00015842/preview. [ABSTRACT FROM AUTHOR]

The PP2A-B55 phosphatase regulates a plethora of signaling pathways throughout eukaryotes. How PP2A-B55 selects its substrates presents a severe knowledge gap. By integrating AlphaFold modeling with comprehensive high-resolution mutational scanning, we show that a helices in substrates bind B55 through an evolutionary conserved mechanism. Despite a large diversity in sequence and composition, these a helices share key amino acid determinants that engage discrete hydrophobic and electrostatic patches. Using deep learning protein design, we generate a specific and potent competitive peptide inhibitor of PP2A-B55 substrate interactions. With this inhibitor, we uncover that PP2A-B55 regulates the nuclear exosome targeting (NEXT) complex by binding to an α-helical recruitment module in the RNA binding protein 7 (RBM7), a component of the NEXT complex. Collectively, our findings provide a framework for the understanding and interrogation of PP2A-B55 function in health and disease. [ABSTRACT FROM AUTHOR]

We prove the convergence of Araki–Haag detectors in any Haag–Kastler quantum field theory with an upper and lower mass gap. We cover the case of a single Araki–Haag detector on states of bounded energy, which are selected from the absolutely continuous part of the energy-momentum spectrum sufficiently close to the lower boundary of the multi-particle spectrum. These states essentially encompass those states in the multi-particle spectrum lying below the three-particle threshold. In our proof, we draw on insights from proofs of asymptotic completeness in quantum mechanics. Notably, we apply Mourre’s conjugate operator method for the first time within the framework of Haag–Kastler quantum field theory. Furthermore, we discuss applications of our findings for the problem of asymptotic completeness in local relativistic quantum field theory. [ABSTRACT FROM AUTHOR]

Objective: Nearly 45% of Australian families intentionally or unintentionally co-sleep, including bedshare. Parents' intentionality to co-sleep can influence their perceptions of sleep quality, family functioning and overall satisfaction. Yet very little is known about fathers' perspectives and experiences of co-sleeping with their children. This mixed-method study aimed to explore paternal co-sleeping intention and its association with perceived sleep quality. Method: Fathers with children who co-slept completed an online survey about their sleep arrangements and intentionality from the Sleep Practices Questionnaire, and their sleep quality from the Sleep Quality Scale. Open-ended responses about intentionality were analysed thematically. Results: One hundred and forty-one fathers were included in the analysis. Quantitative analysis found that fathers' whose children were sleeping where definitely intended had significantly better perceived sleep quality than fathers whose children were sleeping in an unintended location. A thematic analysis provided insight into the reasons for this relationship. Conclusions: This study offers insight into fathers' experiences of co-sleeping including bedsharing, and responsive night-time infant care practices. Paternal night-time involvement in infant care can influence father-infant bonding, maternal and paternal mental health and overall family functioning. The results and their implications for professionals working with fathers during the perinatal period are discussed. Key Points: What is already known about this topic: Co-sleeping (bedsharing and roomsharing) occurs in Australian families, both intentionally and unintentionally. Intentionality to co-sleep can influence a mother's perceptions of sleep quality, satisfaction and family functioning. Little research has examined fathers' role in co-sleeping, including their intentionality. What this topic adds: Shows how fathers' intention to co-sleep is related to their perception of sleep quality. Provides insight into how fathers who intend to co-sleep see the benefits for the child and the family. Provides insight into fathers' experiences of co-sleeping with their children. [ABSTRACT FROM AUTHOR]

Mechanical force has repeatedly been highlighted to be involved in T cell activation. However, the biological significance of mechanical force for T cell receptor signaling remains under active consideration. Here, guided by theoretical analysis, we provide a perspective on how mechanical forces between a T cell and an antigen-presenting cell can influence the bond of a single T cell receptor major histocompatibility complex during early T cell activation. We point out that the lifetime of T cell receptor bonds and thus the degree of their phosphorylation which is essential for T cell activation depends considerably on the T cell receptor rigidity and the average magnitude and frequency of an applied oscillatory force. Such forces could be, for example, produced by protrusions like microvilli during early T cell activation or invadosomes during full T cell activation. These features are suggestive of mechanical force being exploited by T cells to advance self-nonself discrimination in early T cell activation. [ABSTRACT FROM AUTHOR]

Identifying candidates for extracorporeal cardiopulmonary resuscitation (eCPR) is challenging, and novel predictive markers are urgently needed. Hyperfibrinolysis is linked to tissue hypoxia and is associated with poor outcomes in out-of-hospital cardiac arrest (OHCA). Rotational thromboelastometry (ROTEM) can detect or rule out hyperfibrinolysis, and could, therefore, provide decision support for initiation of eCPR. We explored early detection of hyperfibrinolysis in patients with refractory OHCA referred for eCPR. We analysed ROTEM results and resuscitation parameters of 57 adult patients with ongoing OHCA who presented to our ICU for eCPR evaluation. Hyperfibrinolysis, defined as maximum lysis ≥15%, was present in 36 patients (63%) and was associated with higher serum lactate, lower arterial blood pH, and increased low-flow intervals. Of 42 patients who achieved return of circulation, 28 had a poor 30-day outcome. The incidence of hyperfibrinolysis was higher in the poor outcome group compared with patients with good outcomes (75% [21 of 28] vs 7.1% [1 of 14]; P <0.001). The ratio of EXTEM A5 to lactate concentration showed good predictive value in detecting hyperfibrinolysis (AUC of 0.89 [95% confidence interval 0.8–1]). Hyperfibrinolysis was common in patients with refractory cardiac arrest, and was associated with poor prognosis. The combination of high lactate with early clot firmness values, such as EXTEM A5, appears promising for early detection of hyperfibrinolysis. This finding could facilitate decisions to perform eCPR, particularly for patients with prolonged low-flow duration but lacking hyperfibrinolysis. [ABSTRACT FROM AUTHOR]

Carbohydrates are critical for high‐intensity exercise performance. However, the effects of carbohydrate supplementation on muscle metabolism and performance during short‐duration high‐intensity intermittent exercise remain inadequately explored. Our aim was to address this aspect in a randomized, counterbalanced, double‐blinded crossover design. Eleven moderately‐to‐well‐trained males performed high‐intensity intermittent cycling receiving carbohydrate (CHO, ~55 g/h) or placebo (PLA) fluid supplementation. Three exercise periods (EX1‐EX3) were completed comprising 10 × 45 s at ~105% Wmax interspersed with 135 s rest between bouts and ~20 min between periods. Repeated sprint ability (5 × 6 s sprints with 24 s recovery) was assessed at baseline and after each period. Thigh muscle biopsies were obtained at baseline and before and after EX3 to determine whole‐muscle and fiber‐type‐specific glycogen depletion. No differences were found in muscle glycogen degradation at the whole‐muscle (p = 0.683) or fiber‐type‐specific level (p = 0.763–0.854) with similar post‐exercise whole‐muscle glycogen concentrations (146 ± 20 and 122 ± 15 mmol·kg−1 dw in CHO and PLA, respectively). Repeated sprint ability declined by ~9% after EX3 with no between‐condition differences (p = 0.971) and no overall differences in ratings of perceived exertion (p = 0.550). This was despite distinctions in blood glucose concentrations throughout exercise, reaching post‐exercise levels of 5.3 ± 0.2 and 4.1 ± 0.2 mmol·L−1 (p < 0.001) in CHO and PLA, respectively, accompanied by fivefold higher plasma insulin levels in CHO (p < 0.001). In conclusion, we observed no effects of carbohydrate ingestion on net muscle glycogen breakdown or sprint performance during short‐duration high‐intensity intermittent exercise despite elevated blood glucose and insulin levels. These results therefore question the efficacy of carbohydrate supplementation strategies in high‐intensity intermittent sports. [ABSTRACT FROM AUTHOR]

Background: The association between social and built environments plays a crucial role in influencing physical activity levels. However, a thorough understanding of their combined impact remains unclear. This scoping review seeks to clarify the interplay between social environments and opportunities for physical activity within different built environments, with a particular focus on the implications of socioeconomic status and urban planning on physical activity participation. Methods: We conducted a systematic literature search across several databases to identify studies exploring the associations between social factors, built environment characteristics, and physical activity levels. The inclusion criteria were studies published in English between 2000 and 2022, encompassing urban, suburban, and rural contexts. Thematic analysis was employed to categorise studies based on the specific aspects of the built environment they investigated (walking infrastructure, cycling infrastructure, parks and open spaces, and sports facilities) and the social determinants they examined. Results: A total of 72 studies were included in the review, illustrating a multifaceted relationship between access to physical activity opportunities and social determinants such as socioeconomic status, community engagement, and urban design. The findings highlight the significant role of socioeconomic factors and the quality of PA infrastructure in promoting or hindering PA across communities. Effective urban planning was identified as crucial in providing expanded physical activity opportunities, notably through more pedestrian-friendly environments, comprehensive cycling infrastructure, and accessible green spaces and sports facilities. Conclusions: This review emphasises the significant impact of socioeconomic status and urban planning on access to physical activity opportunities. This underscores the necessity for urban planning policies to adopt an inclusive approach, considering the varied needs of different population groups to ensure equitable access to physical activity resources. Such strategies are crucial for public health initiatives aimed at enhancing physical activity levels across diverse community sectors, offering a potential avenue to alleviate health disparities associated with inactivity. [ABSTRACT FROM AUTHOR]

We demonstrate thermosalient behavior in anthracene-9-thiocarboxamide. Upon cooling, the crystalline material spontaneously fractures and jumps. Strong anisotropic thermal expansion precedes thermosalience, and the combination of hydrogen bonds and weaker interlayer interactions affords the macroscopic response. By incorporating structural moieties from different classes of thermosalient solids and using an underexplored supramolecular synthon, a dynamic, multi-functional material is achieved. [ABSTRACT FROM AUTHOR]

Small organic molecules absorbing and emitting in the shortwave infrared (SWIR, 1000–2000 nm) region are desirable for biological imaging applications due to low auto‐fluorescence, reduce photon scattering, and good tissue penetration depth of photons which allows for in vivo imaging with high resolution and sensitivity. Si‐substituted xanthene‐based fluorophores with indolizine donors have demonstrated some of the longest wavelengths of absorption and emission from organic dyes. This work seeks to compare an indolizine heterocyclic nitrogen with dimethyl aniline nitrogen donors on otherwise identical Si‐substituted xanthene fluorophores via optical spectroscopy, computational chemistry and electrochemistry. Three donors are compared including an indolizine donor, a ubiquitous dimethyl aniline donor, and a vinyl dimethyl aniline group that keeps the number of π‐bonds consistent with indolizine. Significantly higher quantum yields and molar absorptivity are observed in these studies for a dimethylamine‐based donor relative to a simple indolizine donor absorbing and emitting at similar wavelengths (~1312 nm emission). Substantially longer wavelengths are obtainable by appending aniline‐based groups to the indolizine donor (~1700 nm) indicating longer wavelengths can be accessed with indolizine donors while stronger emitters can be accessed with anilines in place of indolizine. [ABSTRACT FROM AUTHOR]

A central task of theoretical physics is to analyse spectral properties of quantum mechanical observables. In this endeavour, Mourre’s conjugate operator method emerged as an effective tool in the spectral theory of Schrödinger operators. This paper introduces a novel class of examples from relativistic quantum field theory that are amenable to Mourre’s method. By assuming Lorentz covariance and the spectrum condition, we derive a limiting absorption principle for the energy-momentum operators and provide new proofs of the absolute continuity of the energy-momentum spectra. Moreover, under the assumption of dilation covariance, we show that the spectrum of the relativistic mass operator is purely absolutely continuous in (0 , ∞) . [ABSTRACT FROM AUTHOR]

Undergraduate education should accomplish graduates who are skilled to provide quality care for patients, who are aware of their scope of practice, competency level and limits and who are open to referring patients whose needs are beyond their own skills and experience. They should also become self‐efficacious. Quality performance begins with good diagnosis and decision‐making. Graduates should understand when to treat, why to treat, what to treat and how to treat. These guidelines include a list of capabilities that the graduating student will be expected to have achieved to provide a minimum level of competency in endodontics. Theoretical knowledge, practical skills, understanding and insight should be assessed, with both formative and summative assessment procedures, making use of reflection and feedback. Endodontic procedures should be undertaken within the context of comprehensive patient care and should be evidence based. Students should not perform treatments on patients until they have demonstrated in a pre‐clinical setting that they possess the required skills. Only if it is not possible to simulate a specific procedure sufficiently in a pre‐clinical setting should students learn this procedure by performing it clinically under close supervision. Clinical endodontics should ideally be supervised by endodontists or by staff with special knowledge, interest and self‐efficacy in endodontics. It is advised to ensure that students apply their knowledge and practice their skills periodically throughout the continuum of endodontic education until graduation. A philosophy of lifelong learning and evidence‐based practice should be instilled in all dental undergraduates. [ABSTRACT FROM AUTHOR]

The use of bioprostheses is increasing in younger patients, but it is associated with the risk of later valve deterioration, especially in the mitral position. A new bioprosthesis for mitral valve replacement offers possible longer-term durability and improved hemodynamics. Objectives: Here, we report the implantation of the novel Edwards MITRIS RESILIA mitral valve (Edwards Lifesciences Inc., Irvine, CA, USA) through microinvasive fully endoscopic access as an innovative surgical approach based on a series of twelve patients. Methods: Contrast-based ECG gated CT was preoperatively performed in all patients to determine the intravascular calcifications and vascular parameters, as well as to assess noticeable problems during the operation. CT software for cardiac interventions (3Mensio Medical Imaging BV) was used to simulate surgical prostheses digitally inside the native annulus. With this, a digital LVOT and neo LVOT was created, and the difference between the valve prostheses was measured. Implantation of the MITRIS RESILIA valve was performed in 12 patients according to the instructions for use through microinvasive access in a fully endoscopic fashion using 3D visualization. Results: The mean patient age was 56.50 years, and 7/12 (58.33%) were redo procedures. All patients survived the first 30 days after the procedure, the mean aortic cross-clamp time was 40.17 ± 13.72 min. and mean postoperative transvalvular gradient was 4.45 ± 1.74 mmHg. The neo LVOT in the CT-based simulation was measured with an average area of 414.98 ± 88.69 mm2. The average difference between the LVOT and neo LVOT area was 65.35 ± 34.99 mm2. There was no case of paravalvular leakage or obstruction of the left ventricular outflow tract. Conclusions: The novel MITRIS RESILIA valve is a promising new bioprosthesis for mitral valve replacement that offers improved features as compared to other prostheses. The ease of implantation is increased by this prosthesis by the improved pliability of the sewing cuff and the inward folding of the struts, which was confirmed by short operative times in our series. [ABSTRACT FROM AUTHOR]

SUMMARY: Pyrrolizidine alkaloids (PAs) are toxic specialized metabolites produced in several plant species and frequently contaminate herbal teas or livestock feed. In comfrey (Symphytum officinale, Boraginaceae), they are produced in two different organs of the plant, the root and young leaves. In this study, we demonstrate that homospermidine oxidase (HSO), a copper‐containing amine oxidase (CuAO) responsible for catalyzing the formation of the distinctive pyrrolizidine ring in PAs, is encoded by two individual genes. Specifically, SoCuAO1 is expressed in young leaves, while SoCuAO5 is expressed in roots. CRISPR/Cas9‐mediated knockout of socuao5 resulted in hairy roots (HRs) unable to produce PAs, supporting its function as HSO in roots. Plants regenerated from socuao5 knockout HRs remained completely PA‐free until the plants began to develop inflorescences, indicating the presence of another HSO that is expressed only during flower development. Stable expression of SoCuAO1 in socuao5 knockout HRs rescued the ability to produce PAs. In vitro assays of both enzymes transiently expressed in Nicotiana benthamiana confirmed their HSO activity and revealed the ability of HSO to control the stereospecific cyclization of the pyrrolizidine backbone. The observation that the first specific step of PA biosynthesis catalyzed by homospermidine synthase requires only one gene copy, while two independent paralogs are recruited for the subsequent homospermidine oxidation in different tissues of the plant, suggests a complex regulation of the pathway. This adds a new level of complexity to PA biosynthesis, a system already characterized by species‐specific, tight spatio‐temporal regulation, and independent evolutionary origins in multiple plant lineages. Significance Statement: Pyrrolizidine alkaloids are involved in the chemical defense of comfrey against herbivores and are synthesized in roots and young leaves. Using CRISPR/Cas9 genome editing and various biochemical experiments, we show that pyrrolizidine alkaloid biosynthesis in the two different organs of comfrey is realized by two different paralogs of homospermidine oxidase, revealing another aspect of biosynthetic complexity in plant specialized metabolism. [ABSTRACT FROM AUTHOR]

The aim of this study is to investigate circadian rhythms in independently living adults with obesity and mental disease, exploring the interplay between biological markers and lifestyle factors. Eighty participants divided equally into four groups; (i) people with obesity and schizophrenia; (ii) people with obesity and bipolar disorder; (iii) people with obesity without mental disease or sleep disorders, and (iv) people without obesity, mental disease or sleep disorders. Over two consecutive days, participants engage in repeated self-sampling of hair follicle and saliva; concurrently, data is collected on diet, body temperature, light exposure, sleep parameters, and physical activity by accelerometry. Hair follicles are analyzed for circadian gene expression, saliva samples for cortisol and melatonin concentrations. Circadian rhythms are investigated by cosinor analysis. The study employs a participant-tailored sampling schedule to minimize disruptions to daily routine and enhance ecological validity. The methodology aims to provide a comprehensive insight into the factors contributing to circadian disruptions in people with obesity, bipolar disorder and schizophrenia, potentially informing strategies for future management and mitigation. Trial registration: (ClinicalTrials.gov Identifier: NCT05413486). [ABSTRACT FROM AUTHOR]

Cross‐linking of polymers is an efficient method to tailor the end‐use properties of polymer materials. Cross‐linking using a chemical agent, e.g., dicumyl peroxide (DCP), allows for a spatially uniform network formation in the melt state. In addition, it is also associated with side reactions which influence the final properties of the plastic part. This work investigates the influence of DCP concentration on the tribological properties of a cross‐linked low‐density polyethylene (LDPE) grade. In particular, high DCP concentrations up to 20 phr are chosen in order to explore the effect of a high degree of cross‐linking. The viscoelastic properties below and above the melting temperature are studied in detail to support the interpretation of the tribological results. Rheological investigations allow one to monitor the cross‐linking of the long‐chain branched LDPE. The data and the subsequent optical analysis show that wear already is significantly reduced at a low DCP concentration of 1 phr because of the covalent bonds caused by cross‐linking. A high DCP concentration of 20 phr yields an increase of coefficient of friction which can be explained by the low stiffness and the resulting high contact area in the case of highly cross‐linked LDPE. [ABSTRACT FROM AUTHOR]

Redistricting is the process by which electoral district boundaries are drawn so as to capture coherent communities of interest (COIs). While states rely on various proxies for community illustration, such as compactness and municipal split counts, to guide redistricting, recent legal challenges and scholarly works have shown the difficulty of balancing multiple criteria in district plan creation. To address these issues, we propose the use of spatial interaction to directly quantify the degree to which districts capture the underlying COIs. Using large-scale human mobility flow data, we condense spatial interaction community capture for a set of districts into a single number, the interaction ratio (IR), for redistricting plan evaluation. To compare the IR to traditional redistricting criteria (compactness and fairness), we employ a Markov chain-based regionalization algorithm (ReCom) to produce ensembles of valid plans and calculate the degree to which they capture spatial interaction communities. Furthermore, we propose two methods for biasing the ReCom algorithm towards different IR values. We perform a multi-criteria assessment of the space of valid maps, and present the results in an interactive web map. The experiments on Wisconsin congressional districting plans demonstrate the effectiveness of our methods for biasing sampling towards higher or lower IR values. Furthermore, the analysis of the districts produced with these methods suggests that districts with higher IR and compactness values tend to produce district plans that are more proportional with regard to seats allocated to each of the two major parties. [ABSTRACT FROM AUTHOR]

Adequate fluid therapy is crucial for resuscitation after major burns. To adapt this to individual patient demands, standard is adjustment of volume to laboratory parameters and values of enhanced hemodynamic monitoring. To implement calibrated parameters, patients must have reached the intensive care unit (ICU). The aim of this study was, to evaluate the use of an auto-calibrated enhanced hemodynamic monitoring device to improve fluid management before admission to ICU. We used PulsioflexProAqt® (Getinge) during initial treatment and burn shock resuscitation. Analysis was performed regarding time of measurement, volume management, organ dysfunction, and mortality. We conducted a monocentre, prospective cohort study of 20 severely burned patients, >20% total body surface area (TBSA), receiving monitoring immediately after admission. We compared to 57 patients, matched in terms of TBSA, age, sex, and existence of inhalation injury out of a retrospective control group, who received standard care. Hemodynamic measurement with autocalibrated monitoring started significantly earlier: 3.75(2.67-6.0) hours (h) after trauma in the study group versus 13.6(8.1-17.5) h in the control group (P <.001). Study group received less fluid after 6 h: 1.7(1.2-2.2) versus 2.3(1.6-2.8) ml/TBSA%/kg, P =.043 and 12 h: 3.0(2.5-4.0) versus 4.2(3.1-5.0) ml/TBSA%/kg, P =.047. Dosage of norepinephrine was higher after 18 h in the study group: 0.20(0.12-0.3) versus 0.08(0.02-0.18) µg/kg/min, P =.014. The study group showed no adult respiratory distress syndrome versus 21% in the control group, P =.031. There was no difference in other organ failures, organ replacement therapy, and mortality. The use of auto-calibrated enhanced hemodynamic monitoring is a fast and feasible way to guide early fluid therapy after burn trauma. It reduces the time to reach information about patient's volume capacity. Management of fluid application changed to a more restrictive fluid use in the early period of burn shock and led to a reduction of pulmonary complications. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the long-termefficacy and safety of an ultrasonic fasciotomy for plantar fasciopathy.Design: Prospective observational study. Setting: Tertiary care academic medical center. Participants: Patients with chronic plantar fasciopathy refractory to standard, conservative treatments were included in this study. Interventions: Patients underwent ultrasonic fas- ciotomy of the plantar fascia.MainOutcomeMeasures: The primary outcomemeasures were change in visual analog scale at 12 and 52 weeks post-procedure compared with baseline as well as patients' self-reported satisfaction with the procedure. Results: Sixty-seven patients were included. There was a significant improvement in visual analog scale at all follow-up time points, with an average overall improvement of 5.87 (P < 0.0001). 94% of patients reported satisfaction with the outcomes of their procedure at 12 and 52 weeks. No procedural complications were seen. Conclusions: This study demonstrates that an ultrasonic fasciotomy is a safe and effective treatment option for chronic plantar fasciopathy, with continued symptomimprovement and a high degree of patient satisfaction up to 52 weeks post-procedure. Clinical Relevance: These findings suggest that an ultrasonic fasciotomy should be considered for patients with chronic plantar fasciopathy refractory to conservative treatments. [ABSTRACT FROM AUTHOR]

Aim: The aim of this observational study was to determine the immune status and function in young adults with cerebral palsy (CP) in comparison to typically developing individuals. Method: Blood samples from 12 individuals with CP (five males, seven females; mean age: 25 years 1 month (5 years 9 months); age range: 19–38 years) and 17 typically developing individuals (eight males, nine females; mean age: 31 years 4 months (6 years 2 months); age range: 20–40 years) were collected before, immediately after, and 1 hour after 45 minutes of frame running or running respectively. Independent t‐tests were used to compare heart rate, level of exertion, and baseline cell proportions between groups. Mixed model analysis of variance was utilized to investigate immune cell responses to exercise across groups. Results: Baseline levels of gamma delta (TCRγδ+) T‐cells were significantly higher (absolute percentage: +2.65, p = 0.028) in the individuals with CP. Several cell populations showed similar significant changes after exercise in both CP and typically developing groups. Cytotoxic (CD8+) T‐cells were only significantly elevated immediately after exercise in the typically developing participants (p < 0.01). Individuals with CP exhibited significantly lower heart rates (−11.1%, p < 0.01), despite similar ratings of perceived exertion. Interpretation: Elevated baseline TCRγδ+ T‐cells may indicate low‐grade inflammation in adults with CP. Although most of the cell populations showed typical responses to endurance exercise, the absence of response in CD8+ T‐cells in individuals with CP may indicate the need for higher intensity during exercise. What this paper adds: TCRγδ+ T‐cell baseline levels are elevated in adults with cerebral palsy (CP).The CD8+ T‐cell response to exercise was blunted in adults with CP.Exercise intensity is decisive for CD8+ T‐cell responses in individuals with CP. [ABSTRACT FROM AUTHOR]

To investigate how music educators engage their students with Hip-Hop, we adopted a "research remix" approach, combining elements of case study and constructivist grounded theory. This approach allowed us to privilege Hip-Hop culture and to construct new understandings about Hip-Hop teaching and learning. Six elementary and middle school music teachers implemented Hip-Hop-focused instruction in their classrooms while also attending professional development workshops. Data included videos of classroom instruction, participant interviews, and videos of the workshops with co-facilitation from Hip-Hop artists and the researchers. Educators encountered tensions and challenges related to a perceived Hip-Hop "realness" and a lack of musical and pedagogical skills. To address these challenges, participants remixed their approaches by blending elements of Hip-Hop music and culture with their established teaching strategies. Teachers' dispositions and feedback from students and colleagues engendered critical reflections about their positionalities in relation to Hip-Hop. We constructed a visual model of a DJ as a metaphor to describe participants' approaches to remixing their teaching with Hip-Hop within their contexts. Implications include a need for increased emphasis on Hip-Hop in U.S. music teacher education programs and institutional pathways for Hip-Hop musicians to become music educators. [ABSTRACT FROM AUTHOR]

Visual processing relies on the identification of both local and global features of visual stimuli. While well investigated at the behavioral level, the underlying brain mechanisms are less clear, especially in the context of aging. Using fMRI, we aimed to investigate the neural correlates underlying local and global processing in early and late adulthood. We recruited 77 healthy adults aged 19–77 who completed a visual search task based on 2-level hierarchical stimuli made of squares and/or circles. Participants were instructed to detect a target (a square) at either a local (small) or global (large) level of a hierarchical geometrical form, in the presence or absence of other hierarchical geometrical forms (distractors). At the behavioral level, we revealed high accuracy for all participants, but older participants were slower to detect local targets, specifically in presence of distractors. At the brain level, while both local and global processing were associated with occipital activation, local processing also recruited the anterior insula and dorsal anterior cingulate cortex, that are core regions of the salience network. However, while the presence of distractors in the local condition elicited specifically stronger activation within the right anterior insula for the young group, it was not observed for older participants. In addition, older participants showed less activation than younger participants in the occipital cortex, especially for the most complex conditions. Our findings suggest that the brain correlates underlying local and global processing change with aging, especially for complex visual patterns. These results are discussed in terms of top-down reduction effects from the salience network on primary visual areas, that may lead to specific difficulties to process local visual details in older adults. [ABSTRACT FROM AUTHOR]

Background: Febrile illnesses that persist despite initial treatment are common clinical challenges in (sub)tropical low-resource settings. Our aim is to review infectious etiologies of "prolonged fevers" (persistent febrile illnesses, PFI) and to quantify relative contributions of selected neglected target diseases with limited diagnostic options, often overlooked, causing inadequate antibiotic prescriptions, or requiring prolonged and potentially toxic treatments. Methods: We performed a systematic review of articles addressing the infectious etiologies of PFI in adults and children in sub-/tropical low- and middle-income countries (LMICs) using the PRISMA guidelines. A list of target diseases, including neglected parasites and zoonotic bacteria (e.g., Leishmania and Brucella), were identified by infectious diseases and tropical medicine specialists and prioritized in the search. Malaria and tuberculosis (TB) were not included as target diseases due to well-established epidemiology and diagnostic options. Four co-investigators independently extracted data from the identified articles while assessing for risk of bias. Results: 196 articles from 52 countries were included, 117 from Africa (33 countries), 71 from Asia (16 countries), and 8 from Central and -South America (3 countries). Target diseases were reported as the cause of PFI in almost half of the articles, most frequently rickettsioses (including scrub typhus), relapsing fever borreliosis (RF-borreliosis), brucellosis, enteric fever, leptospirosis, Q fever and leishmaniasis. Among those, RF-borreliosis was by far the most frequently reported disease in Africa, particularly in Eastern Africa. Rickettsioses (including scrub typhus) were often described in both Africa and Asia. Leishmaniasis, toxoplasmosis and amoebiasis were the most frequent parasitic etiologies. Non-target diseases and non-tropical organisms (Streptococcus pneumoniae, Escherichia coli, and non-typhoidal Salmonella spp) were documented in a fifth of articles. Conclusions: Clinicians faced with PFI in sub-/tropical LMICs should consider a wide differential diagnosis including enteric fever and zoonotic bacterial diseases (e.g., rickettsiosis, RF-borreliosis and brucellosis), or parasite infections (e.g., leishmaniasis) depending on geography and syndromes. In the absence of adequate diagnostic capacity, a trial of antibiotics targeting relevant intra-cellular bacteria, such as doxycycline or azithromycin, may be considered. Author summary: "Prolonged" or "Persistent" Febrile illnesses (PFI) are common challenging diagnostic entities in LMICs. Symptoms and signs can be non-specific and diagnostic tests are often not available, and antibiotics inadequate. This systematic review aimed to investigate important causes of PFI in different geographical regions, as well as to highlight lack of data in these areas to stimulate discussion for future research. We found that zoonotic bacterial and neglected parasitic diseases accounted for substantial proportions of PFI cases, in particular rickettsiosis, borreliosis, brucellosis, leptospirosis, melioidosis, leishmaniasis, toxoplasmosis and amoebiasis. Although data is very limited for many regions, our results suggest that the geographical context can help inform clinicians on the likelihood of different infections in a patient with PFI. [ABSTRACT FROM AUTHOR]

Actinides are inherently radioactive; thus, ionizing radiation is emitted by these elements can have profound effects on its surrounding chemical environment through the formation of free radical species. While previous work has noted that the presence of free radicals in the system impacts the redox state of the actinides, there is little atomistic understanding of how these metal cations interact with free radicals. Herein, we explore the effects of radiation (UV and γ) on three U(VI) trinitrate complexes, M[UO2(NO3)3] (where M=K+, Rb+, Cs+), and their respective nitrate salts in the solid state via electron paramagnetic resonance (EPR) and Raman spectroscopy paired with Density Functional Theory (DFT) methods. We find that the alkali salts form nitrate radicals under UV and γ irradiation, but also note the presence of additional degradation products. M[UO2(NO3)3] solids also form nitrate radicals and additional DFT calculations indicate the species corresponds to a change from the bidentate bound nitrate anion into a monodentate NO3• radical. Computational studies also highlight the need to include the second sphere coordination environment around the [UO2(NO3)3]0,1 species to gain agreement between the experimental and predicted EPR signatures. [ABSTRACT FROM AUTHOR]

Early in 1 John, the author portrays authentic Christian living as involving honest and ongoing acknowledgment of one's sins, God's forgiveness of the same, and the cleansing from all unrighteousness (1:8-9). However, later in the same letter, while seeking to distinguish his opponents from those who were the true children of God, he says: 'No one who abides in him sins; no one who sins has either seen him or known him' (3:6); and 'those who have been born of God do not sin, because God's seed abides in them; they cannot sin, because they have been born of God.' (3:9). These latter statements stand in tension with his earlier statement which says that anyone claiming to be without sin is a liar. In one place he rejects sinless perfection, in the other he appears to assume it. In this article these apparently contradictory statements are examined and a possible resolution of the tension existing between them is suggested. [ABSTRACT FROM AUTHOR]

The second victim experience is defined as a healthcare professional who is traumatized by adverse events that have occurred to the patient, the first victim. This traumatization can cause a range of symptoms such as guilt, anxiety, disturbed sleep, and decreased job satisfaction. The purposes of this study were to understand certified registered nurse anesthetists' (CRNAs') second victim distress, perceived support, and the impact of the second victim experience on absenteeism and turnover intention. A survey was administered to CRNAs from the Michigan Association of Nurse Anesthetists, with a total of 172 responses suitable for analysis. Psychological distress was experienced by 20.3% (n = 35) of CRNAs. Additionally, 16.3% (n = 28) and 15.1% (n = 26) of CRNAs experienced physical distress and professional self-efficacy issues respectively where CRNAs doubted whether they were a good healthcare provider and questioned their professional abilities. Turnover intentions and absenteeism were also evaluated with 11.6% of CRNAs wanting to take a job outside of patient care and/or quit their job, and 13% identified that they needed a mental health day and/or time away from work after their experience. Organizations must consider offering peer support and supportive counseling for practitioners who have suffered from traumatic events and identify desired forms of support among staff. [ABSTRACT FROM AUTHOR]

Expression of microRNAs, such as miR-365, is known to be dysregulated in many tumors, including oral cancers, although little is known about their role or functions. The objective of this project is to evaluate the downstream targets of miR-365 to determine any potential pathways or effects. Downstream targets for miR-365 (miRdatabase target scores > 90) were used for qPCR screening of oral cancer cell lines (SCC4, SCC9, SCC15, SCC25, CAL27). Each oral cancer cell line expressed miR-365 downstream targets molybdenum cofactor synthesis-2 (MOCS2), erythropoietin receptor (EPOR), IQ motif containing-K (IQCK), carboxypeptidase A3 (CPA3), solute carrier family 24 member-3 (SLC24A3), and coiled-coil domain containing 47 (CCDC47)—although the expression levels varied somewhat. However, differential results were observed with ubiquitin protein ligase E3 component n-recognin-3 (UBR3), nudix hydrolase-12 (NUDT12), zinc finger CCHC-type containing-14 (ZCCHC14), and homeobox and leucine zipper encoding (HOMEZ). These data suggest that many of the miR-365 targets are expressed in the oral cancers screened, with the differential expression of UBR3, ZCCHC14, HOMEZ, and NUDT12, which may be correlated with chemoresistance among two specific oral cancer cell lines (SCC25, SCC9). These results suggest this differential expression may signal potential targets for patient treatment with tumors exhibiting miR-365 and chemotherapeutic resistance. [ABSTRACT FROM AUTHOR]