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Hard type-II hollow superconductors are well suited for low frequency magnetic shielding. The properties and performances of superconducting magnetic shields subjected to homogeneous magnetic fields have been extensively discussed in the literature. In the present work, we investigate the magnetic shielding and the penetration of magnetic flux in a bulk high temperature superconducting tube subjected to the inhomogeneous fringe field of a solenoidal coil. Thanks to a bespoke microdisplacement measurement system, we measure the magnetic field distribution around the tube. We develop a full 3D finite element model based on an H formulation to understand the flux penetration mechanisms and predict the shape of the current loops. Using constitutive law parameters obtained from previous independent experiments, our model is found to be in excellent agreement with the measurements. We discuss how to assess the degree of inhomogeneity of the magnetic field and show that, in our case study, the field can be treated as the magnetic field of an equivalent magnetic dipole. We also show that some features of the flux penetration in inhomogeneous field can be also observed when the tube is subjected to an oblique homogeneous magnetic field, which offers a better understanding of the shielding current density distribution inside the shield. Finally, we discuss the magnetic field concentration occurring around the shield for different magnetic field configurations. In particular, we show that the extremities of the tube on the side not facing the magnetic field source experience the highest flux concentration. [ABSTRACT FROM AUTHOR]

Bulk type-II irreversible superconductors can act as excellent passive magnetic shields, with a strong attenuation of low frequency magnetic fields. Up to now, the performances of superconducting magnetic shields have mainly been studied in a homogenous magnetic field, considering only immunity problems, i.e. when the field is applied outside the tube and the inner field should ideally be zero. In this paper, we aim to investigate experimentally and numerically the magnetic response of a high-Tc bulk superconducting hollow cylinder at 77 K in an emission problem, i.e. when subjected to the non-uniform magnetic field generated by a source coil placed inside the tube. A bespoke 3D mapping system coupled with a three-axis Hall probe is used to measure the magnetic flux density distribution outside the superconducting magnetic shield. A finite element model is developed to understand how the magnetic field penetrates into the superconductor and how the induced superconducting shielding currents flow inside the shield in the case where the emitting coil is placed coaxially inside the tube. The finite element modelling is found to be in excellent agreement with the experimental data. Results show that a concentration of the magnetic flux lines occurs between the emitting coil and the superconducting screen. This effect is observed both with the modelling and the experiment. In the case of a long tube, we show that the main features of the field penetration in the superconducting walls can be reproduced with a simple analytical 1D model. This model is used to estimate the maximum flux density of the emitting coil that can be shielded by the superconductor. [ABSTRACT FROM AUTHOR]

The synthesis and characterization of a novel polycyclic azaindole based derivative is disclosed, and its binding to JAK2 is described. The compound is further evaluated for its ability to block the EPO/JAK2 signaling cascade in vitro and in vivo. [ABSTRACT FROM AUTHOR]