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The article offers a review of the LomoKino, a 35-millimeter movie camera, from Lomography.

Reviews the film "King Lear," directed by Peter Brook, starring Paul Scofield and Irene Worth.

The number and the importance of web applications have increased rapidly over the last years. At the same time, the quantity and impact of security vulnerabilities in such applications have grown as well. Since manual code reviews are time-consuming, error-prone and costly, the need for automated solutions has become evident. In this paper, we address the problem of vulnerable web applications by means of static source code analysis. More precisely, we use flow-sensitive, interprocedural and context-sensitive data flow analysis to discover vulnerable points in a program. In addition to the taint analysis at the core of our engine, we employ a precise alias analysis targeted at the unique reference semantics commonly found in scripting languages. Moreover, we enhance the quality and quantity of the generated vulnerability reports by employing an iterative two-phase algorithm for fast and precise resolution of file inclusions. The presented concepts are targeted at the general class of taint-style vulnerabilities and can be easily applied to the detection of vulnerability types such as SQL injection, cross-site scripting (XSS), and command injection. We implemented the presented concepts in Pixy, a high-precision static analysis tool aimed at detecting cross-site scripting and SQL injection vulnerabilities in PHP programs. To demonstrate the effectiveness of our techniques, we analyzed a number of popular, open-source web applications and discovered hundreds of previously unknown vulnerabilities. Both the high analysis speed as well as the low number of generated false positives show that our techniques can be used for conducting effective security audits. [ABSTRACT FROM AUTHOR]

Aquaporin-4 (AQP4) water channels and gap junction proteins (connexins) are two classes of astrocytic membrane proteins critically involved in brain water and ion homeostasis. AQP4 channels are anchored by α1-syntrophin to the perivascular astrocytic endfoot membrane domains where they control water flux at the blood-brain interface while connexins cluster at the lateral aspects of the astrocytic endfeet forming gap junctions that allow water and ions to dissipate through the astrocyte syncytium. Recent studies have pointed to an interdependence between astrocytic AQP4 and astrocytic gap junctions but the underlying mechanism remains to be explored. Here we use a novel transgenic mouse line to unravel whether β1-syntrophin (coexpressed with α1-syntrophin in astrocytic plasma membranes) is implicated in the expression of AQP4 isoforms and formation of gap junctions in brain. Our results show that while the effect of β1-syntrophin deletion is rather limited, double knockout of α1- and β1-syntrophin causes a downregulation of the novel AQP4 isoform AQP4ex and an increase in the number of astrocytic gap junctions. The present study highlight the importance of syntrophins in orchestrating specialized functional domains of brain astrocytes. [Display omitted] • Knockout of AQP4 leads to increased number of astrocytic gap junctions. • AQP4 is anchored to the perivascular astrocytic endfeet by α1-syntrophin. • Knockout of α1- or β1 syntrophin has no effect on the number gap junctions. • Double knockout of α1- and β1 syntrophin causes a downregulation of AQP4ex isoform. • Double knockout of α1- and β1 syntrophin leads to increase in number of gap junctions. [ABSTRACT FROM AUTHOR]

Objective: The aim of our study was to find the best model with sufficient power to improve the risk stratification in major vascular surgery patients during the first 30 days after this procedure. The discriminatory power of 4 biomarkers (troponin I [TnI], N-terminal prohormone of brain natriuretic peptide [NT-proBNP], creatine kinase-MB isoenzyme [CK-MB], high-sensitivity C-reactive protein [hs-CRP]) was tested as well as 2 risk assessment models and 13 different combinations of them.Subjects and Methods: The study included 122 patients (77% men, 23% women) with an average age of 67.03 ± 4.5 years. An aortobifemoral bypass was performed in 6.56% of the patients, a femoropopliteal bypass in 18.85%, and 49.18% received open surgical reconstruction of the carotid arteries. A total of 25.41% of the patients were given an aortobi-iliac bypass.Results: During the first 30 days, 13 patients (10.7%) had 17 cardiac complications. The most common complication was the new onset of atrial fibrillation (35.3%). During the first 10 days, 10 patients had 1 complication and 2 patients had 2 cardiac events, while 1 patient had 3 complications. By comparing combinations of scores and markers, it was shown that revised cardiac risk index (RCRI) + Vascular Portsmouth Physiological and Operative Severity Score (V-POSSUM) + hsTnI and RCRI + V-POSSUM + hsTnI + NT-proBNP with 100% sensitivity, > 80% specificity had the best discriminatory ability (AUC 0.924 and 0.933, respectively; p < 0.001 for both models) for cardiac complications during the 30 days after surgery.Conclusion: Combinations of traditional preoperative risk factors and scores can enhance the assessment of major adverse cardiac events (MACE) in patients preparing for large vascular surgery. Using only one risk score in these patients seems to be underperforming in preoperative risk assessment. [ABSTRACT FROM AUTHOR]