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Abstract Objective  The purpose of this study was to compare the time-course of contrast-enhancement in spleen and liver using Exia 160 in comparison with Fenestra LC and VC in healthy mice. Procedures  Healthy C57bl/6 mice were used in this study. Fenestra LC and VC was administered intravenously at a dose of 0.1 ml/20 g or 0.2 ml/20 g. Exia 160 at a dose of 0.05 ml/20 g or 0.1 ml/20 g. Each animal underwent a micro-CT scan before contrast injection (baseline) and immediately after contrast injection. Additional scans were performed at 1, 2, 3, 4, 24, and 48 h after contrast administration. The mice who received Exia 160 were also scanned after 15, 30, and 45 min. Results  The peak enhancement of Exia 160 occurred after 15 min for the spleen and after 30 min for the liver. Conclusions  Exia 160 allows rapid spleen and liver enhancement. The high iodine content results in small injection volumes. [ABSTRACT FROM AUTHOR]