6 results on '"Jeffrey Brent"'
Search Results
2. Effect of Localized Vibration Massage on Popliteal Blood Flow.
- Author
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Needs, Devin, Blotter, Jonathan, Cowan, Madison, Fellingham, Gilbert, Johnson, A. Wayne, and Feland, Jeffrey Brent
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VIBRATION therapy , *BLOOD flow , *WHOLE-body vibration , *POPLITEAL artery , *BLOOD flow measurement , *PARTICLE image velocimetry - Abstract
There is a broad scope of literature investigating whole-body vibration (WBV) effects on blood flow (BF). However, it is unclear how therapeutic localized vibrations alter BF. Low-frequency massage guns are advertised to enhance muscle recovery, which may be through BF changes; however, studies using these devices are lacking. Thus, the purpose of this study was to determine if popliteal artery BF increases from localized vibration to the calf. Twenty-six healthy, recreationally active university students (fourteen males, twelve females, mean age 22.3 years) participated. Each subject received eight therapeutic conditions randomized on different days with ultrasound blood flow measurements. The eight conditions combined either control, 30 Hz, 38 Hz, or 47 Hz for a duration of 5 or 10 min. BF measurements of mean blood velocity, arterial diameter, volume flow, and heart rate were measured. Using a cell means mixed model, we found that both control conditions resulted in decreased BF and that both 38 Hz and 47 Hz resulted in significant increases in volume flow and mean blood velocity, which remained elevated longer than the BF induced by 30 Hz. This study demonstrates localized vibrations at 38 Hz and 47 Hz significantly increase BF without affecting the heart rate and may support muscle recovery. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
3. Effect of High-Speed Treadmill Training With a Body Weight Support System in a Sport Acceleration Program With Female Soccer Players.
- Author
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Johnson, A. Wayne, Eastman, Carie S., Feland, Jeffrey Brent, Mitchell, Ulrike H., Mortensen, Bartley Brett, and Eggett, Dennis
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KNEE physiology , *PHYSICAL training & conditioning , *ISOMETRIC exercise , *ANTHROPOMETRY , *ATHLETIC ability , *CLINICAL trials , *EXERCISE physiology , *EXERCISE tests , *RANGE of motion of joints , *MUSCLE strength , *MUSCLE strength testing , *RUNNING , *STATISTICAL sampling , *SOCCER , *STATISTICAL power analysis , *TREADMILLS , *RANDOMIZED controlled trials , *PRE-tests & post-tests , *DATA analysis software , *WEIGHT-bearing (Orthopedics) , *DESCRIPTIVE statistics - Abstract
The article presents information on a study aimed at determine the effect of a high-speed treadmill (HST) with the use of a body weight support (BWS) system. The study was conducted on female soccer athlete in a 6-week sport acceleration program (SAP). The study found that participants in the standard trademill (ST) group had higher rate of shin splints and foot pain.
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- 2013
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4. In‐vitro evaluation of a ciprofloxacin and azithromycin sinus stent for Pseudomonas aeruginosa biofilms.
- Author
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Lim, Dong‐Jin, Skinner, Daniel, Mclemore, John, Rivers, Nick, Elder, Jeffrey Brent, Allen, Mark, Koch, Connor, West, John, Zhang, Shaoyan, Thompson, Harrison M., McCormick, Justin P., Grayson, Jessica W., Cho, Do‐Yeon, and Woodworth, Bradford A.
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PSEUDOMONAS aeruginosa , *DRUG side effects , *SPECIFIC gravity , *OPACITY (Optics) , *AZITHROMYCIN - Abstract
Background: Chronic rhinosinusitis (CRS) is a chronic inflammatory disease characterized by persistent inflammation and bacterial infection. Ciprofloxacin and azithromycin are commonly prescribed antibiotics for CRS, but the ability to provide targeted release in the sinuses could mitigate side effects and improve drug concentrations at the infected site. This study was aimed to evaluate the efficacy of the novel ciprofloxacin‐azithromycin sinus stent (CASS) in vitro. Methods: The CASS was created by coating ciprofloxacin (hydrophilic, inner layer) and azithromycin (hydrophobic, outer layer) onto a biodegradable poly‐l‐lactic acid (PLLA) stent. In‐vitro evaluation included: (1) assessment of drug‐coating stability within the stent using scanning electron microscopy (SEM); (2) determination of ciprofloxacin and azithromycin release kinetics; and (3) assessment of anti‐biofilm activities against Pseudomonas aeruginosa. Results: The ciprofloxacin nanoparticle suspension in the inner layer was confirmed by zeta potential. Both ciprofloxacin (60 µg) and azithromycin (3 mg) were uniformly coated on the surface of the PLLA stents. The CASS showed ciprofloxacin/azithromycin sustained release patterns, with 80.55 ± 11.61% of ciprofloxacin and 93.85 ± 6.9% of azithromycin released by 28 days. The CASS also significantly reduced P aeruginosa biofilm mass compared with bare stents and controls (relative optical density units at 590‐nm optical density: CASS, 0.037 ± 0.006; bare stent, 0.911 ± 0.015; control, 1.000 ± 0.000; p < 0.001; n = 3). Conclusion: The CASS maintains a uniform coating and sustained delivery of ciprofloxacin and azithromycin, providing anti‐biofilm activities against P aeruginosa. Further studies evaluating the efficacy of CASS in a preclinical model are planned. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
5. Herbal dry extract BNO 1011 improves clinical and mucociliary parameters in a rabbit model of chronic rhinosinusitis.
- Author
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Cho, Do‐Yeon, Skinner, Daniel, Mackey, Calvin, Lampkin, Harold B, Elder, Jeffrey Brent, Lim, Dong Jin, Zhang, Shaoyan, McCormick, Justin, Tearney, Guillermo J., Rowe, Steven M., and Woodworth, Bradford A.
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MUCOCILIARY system , *RABBITS , *LIQUID surfaces , *OPTICAL coherence tomography - Abstract
Background: Enhancing chloride (Cl–) secretion in sinus epithelia represents a novel therapeutic approach to chronic rhinosinusitis (CRS). Herbal dry extract BNO 1011 enhances mucociliary clearance (MCC) via upregulation of Cl– secretion in sinonasal cultures in vitro and murine epithelium in vivo. The objective of this study is to evaluate whether the BNO 1011 improves MCC and clinical parameters in a rabbit model of CRS. Methods: After the development of CRS in 30 New Zealand white rabbits, animals were randomly assigned to receive oral placebo (n = 10), BNO 1011 (low dose [LD], 25 mg/kg/daily) (n = 10), or BNO1011 (high dose [HD], 125 mg/kg/daily) (n = 10) for 4 weeks. Outcomes included sinus opacification (Kerschner's rabbit sinus CT grade), maxillary epithelial Cl− secretion (sinus potential difference [PD] assay), airway surface liquid (ASL) depth using micro‐optical coherence tomography (μOCT), and submucosal gland density (SMD) on histopathology. Outcome parameters were analyzed by 2 blinded investigators. Results: BNO 1011 significantly cleared sinus opacification (HD = 1.21 ± 0.63, LD = 1.26 ± 0.37,) compared to placebo (4.02 ± 0.92) (p = 0.009). BNO 1011 resulted in markedly greater mean sinus PD polarization (HD = –12.23 ± 1.4 mV, LD = –12.0 ± 3.0 mV) when compared to rabbits treated with placebo (–4.1 ± 1.1 mV) (p = 0.03). ASL depth was significantly improved when treated with HD (4.08 ± 0.06 μm) and LD (4.05 ± 0.06 μm) compared to placebo (3.5 ± 0.05 μm) (post hoc analysis, p < 0.0001). Histologically, epithelial thickness (HD = 10.0 ± 0.7 μm; LD = 13.7 ± 0.9 μm; placebo = 21.1 ± 2.3 μm; p < 0.005), subepithelial thickness (HD = 63.1 ± 6.6 μm; LD = 103.2 ± 6.7 μm; placebo = 113.3 ± 6.0 μm; p < 0.001), and SMD (HD = 22.2 ± 2.9%; LD = 31.8 ± 1.1%; placebo = 43.8 ± 1.7%; p < 0.0001) were noticeably better with the HD. Conclusion: Herbal dry extract BNO 1011 improves radiographic, histologic, and MCC parameters in a rabbit model of CRS. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
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6. Targeted Subcutaneous Vibration With Single-Neuron Electrophysiology As a Novel Method for Understanding the Central Effects of Peripheral Vibrational Therapy in a Rodent Model.
- Author
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Bills, Kyle B., Clarke, Travis, Major, George H., Jacobson, Cecil B., Blotter, Jonathan D., Feland, Jeffrey Brent, and Steffensen, Scott C.
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MUSCULOSKELETAL system , *CENTRAL nervous system - Abstract
Very little is known about the effects of whole body vibration on the supraspinal central nervous system. Though much clinical outcome data and mechanistic data about peripheral neural and musculoskeletal mechanisms have been explored, the lack of central understanding is a barrier to evidence-based, best practice guidelines in the use of vibrational therapy. Disparate methods of administration render study to study comparisons difficult. To address this lack of uniformity, we present the use of targeted subcutaneous vibration combined with simultaneous in vivo electrophysiological recordings as a method of exploring the central effects of peripheral vibration therapy. We used implanted motors driven by both Grass stimulators and programmed microcontrollers to vary frequency and location of stimulation in an anesthetized in vivo rat model while simultaneously recording firing rate from gamma-aminobutyric acid (GABA) neurons in the ventral tegmental area. We show that peripheral vibration can alter GABA neuron firing rate in a location- and frequency-dependent manner. We include detailed schematics and code to aid others in the replication of this technique. This method allows for control of previous weaknesses in the literature including variability in body position, vibrational intensity, node and anti-node interactions with areas of differing mechanoreceptor densities, and prefrontal cortex influence. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
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