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Purpose: To clarify the association between dietary diversity and inflammatory status in Japanese workers. Methods: Of 1,460 men and women aged 20–64 years in 2010 (baseline), those who were followed-up at least once between 2011 and 2018 were included in this study; 1,433 participants and 745 participants were included in the cross-sectional and longitudinal analyses, respectively. Dietary intake was assessed using a food frequency questionnaire at baseline, and the dietary diversity score was determined using the Quantitative Index for Dietary Diversity (QUANTIDD). High-sensitivity C-reactive protein (hs-CRP) was taken to indicate inflammatory status at the baseline and follow-up surveys. In the cross-sectional analysis using baseline data, a generalized linear model was used to calculate adjusted means and 95% confidence intervals (CIs) for hs-CRP according to the QUANTIDD score. In the longitudinal analysis, generalized estimating equations were used to calculate the adjusted mean (95% CI) for hs-CRP in follow-up according to the QUANTIDD score at baseline. Results: In the cross-sectional analysis, the hs-CRP concentration in male participants was significantly lower in those who had a high QUANTIDD score (adjusted mean [95% CI]: 0.074 [0.009—0.140] mg/dL in the lower group vs. 0.038 [-0.029—0.105] mg/dL in the higher group, p-value = 0.034). In the longitudinal analysis, the hs-CRP concentration of male participants also tended to be lower in those with higher QUANTIDD scores (p-value = 0.103). In both the cross-sectional and longitudinal analyses in women, there was no significant difference between the lower and higher QUANTIDD score groups. Conclusion: These findings suggest that, in male Japanese workers, higher dietary diversity might be important for maintaining a low inflammatory status. [ABSTRACT FROM AUTHOR]

Objective: The aim of this study was to determine the associations between dietary diversity and risk of dyslipidemia in Japanese workers.The cross-sectional study included 1399 participants aged 20–63 years and the longitudinal study included 751 participants aged 20–60 years in 2012–2013 (baseline) who participated at least once from 2013 to 2017 with cumulative participation times of 4.9 times. Dietary intake was assessed using a food frequency questionnaire, and dietary diversity score (DDS) was determined using the Quantitative Index for Dietary Diversity. Dyslipidemia was diagnosed when at least one of the following conditions was met: hypertriglyceridemia, high LDL-cholesterol, low HDL-cholesterol, high non-HDL-cholesterol, and a history of dyslipidemia. Multivariable logistic regression was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for dyslipidemia with control of confounding factors in cross-sectional analysis. Generalized estimating equations were used for calculating the ORs (95% CI) for dyslipidemia in the follow-up period according to the DDS at baseline with control of confounding factors in longitudinal analysis.Cross-sectional analysis showed that the highest DDS reduced the odds of dyslipidemia in men (OR [95% CI] in Tertile 3: 0.67 [0.48–0.95], p value = 0.023). In longitudinal analysis, a moderate DDS reduced the risk of dyslipidemia (OR [95% CI] in Tertile 2: 0.21 [0.07–0.60], p value = 0.003) in women.The results of cross-sectional analysis in this study suggest that the higher diversity of diet might reduce the presence of dyslipidemia in men and the results of longitudinal analysis suggest that a moderate DDS might reduce the risk of dyslipidemia in women. Further studies are needed since the results of cross-sectional and longitudinal analyses in this study were inconsistent.Methods: The aim of this study was to determine the associations between dietary diversity and risk of dyslipidemia in Japanese workers.The cross-sectional study included 1399 participants aged 20–63 years and the longitudinal study included 751 participants aged 20–60 years in 2012–2013 (baseline) who participated at least once from 2013 to 2017 with cumulative participation times of 4.9 times. Dietary intake was assessed using a food frequency questionnaire, and dietary diversity score (DDS) was determined using the Quantitative Index for Dietary Diversity. Dyslipidemia was diagnosed when at least one of the following conditions was met: hypertriglyceridemia, high LDL-cholesterol, low HDL-cholesterol, high non-HDL-cholesterol, and a history of dyslipidemia. Multivariable logistic regression was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for dyslipidemia with control of confounding factors in cross-sectional analysis. Generalized estimating equations were used for calculating the ORs (95% CI) for dyslipidemia in the follow-up period according to the DDS at baseline with control of confounding factors in longitudinal analysis.Cross-sectional analysis showed that the highest DDS reduced the odds of dyslipidemia in men (OR [95% CI] in Tertile 3: 0.67 [0.48–0.95], p value = 0.023). In longitudinal analysis, a moderate DDS reduced the risk of dyslipidemia (OR [95% CI] in Tertile 2: 0.21 [0.07–0.60], p value = 0.003) in women.The results of cross-sectional analysis in this study suggest that the higher diversity of diet might reduce the presence of dyslipidemia in men and the results of longitudinal analysis suggest that a moderate DDS might reduce the risk of dyslipidemia in women. Further studies are needed since the results of cross-sectional and longitudinal analyses in this study were inconsistent.Results: The aim of this study was to determine the associations between dietary diversity and risk of dyslipidemia in Japanese workers.The cross-sectional study included 1399 participants aged 20–63 years and the longitudinal study included 751 participants aged 20–60 years in 2012–2013 (baseline) who participated at least once from 2013 to 2017 with cumulative participation times of 4.9 times. Dietary intake was assessed using a food frequency questionnaire, and dietary diversity score (DDS) was determined using the Quantitative Index for Dietary Diversity. Dyslipidemia was diagnosed when at least one of the following conditions was met: hypertriglyceridemia, high LDL-cholesterol, low HDL-cholesterol, high non-HDL-cholesterol, and a history of dyslipidemia. Multivariable logistic regression was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for dyslipidemia with control of confounding factors in cross-sectional analysis. Generalized estimating equations were used for calculating the ORs (95% CI) for dyslipidemia in the follow-up period according to the DDS at baseline with control of confounding factors in longitudinal analysis.Cross-sectional analysis showed that the highest DDS reduced the odds of dyslipidemia in men (OR [95% CI] in Tertile 3: 0.67 [0.48–0.95], p value = 0.023). In longitudinal analysis, a moderate DDS reduced the risk of dyslipidemia (OR [95% CI] in Tertile 2: 0.21 [0.07–0.60], p value = 0.003) in women.The results of cross-sectional analysis in this study suggest that the higher diversity of diet might reduce the presence of dyslipidemia in men and the results of longitudinal analysis suggest that a moderate DDS might reduce the risk of dyslipidemia in women. Further studies are needed since the results of cross-sectional and longitudinal analyses in this study were inconsistent.Conclusions: The aim of this study was to determine the associations between dietary diversity and risk of dyslipidemia in Japanese workers.The cross-sectional study included 1399 participants aged 20–63 years and the longitudinal study included 751 participants aged 20–60 years in 2012–2013 (baseline) who participated at least once from 2013 to 2017 with cumulative participation times of 4.9 times. Dietary intake was assessed using a food frequency questionnaire, and dietary diversity score (DDS) was determined using the Quantitative Index for Dietary Diversity. Dyslipidemia was diagnosed when at least one of the following conditions was met: hypertriglyceridemia, high LDL-cholesterol, low HDL-cholesterol, high non-HDL-cholesterol, and a history of dyslipidemia. Multivariable logistic regression was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for dyslipidemia with control of confounding factors in cross-sectional analysis. Generalized estimating equations were used for calculating the ORs (95% CI) for dyslipidemia in the follow-up period according to the DDS at baseline with control of confounding factors in longitudinal analysis.Cross-sectional analysis showed that the highest DDS reduced the odds of dyslipidemia in men (OR [95% CI] in Tertile 3: 0.67 [0.48–0.95], p value = 0.023). In longitudinal analysis, a moderate DDS reduced the risk of dyslipidemia (OR [95% CI] in Tertile 2: 0.21 [0.07–0.60], p value = 0.003) in women.The results of cross-sectional analysis in this study suggest that the higher diversity of diet might reduce the presence of dyslipidemia in men and the results of longitudinal analysis suggest that a moderate DDS might reduce the risk of dyslipidemia in women. Further studies are needed since the results of cross-sectional and longitudinal analyses in this study were inconsistent. [ABSTRACT FROM AUTHOR]

The purpose of the present study was to evaluate the efficacy of a newly designed rehabilitation program for postoperative patients with breast cancer. This was achieved through examinations to clarify the range of motion (ROM) of the shoulder joint, postoperative pain and recovery of activities of daily living (ADL). The ROM of the shoulder joint was evaluated with respect to five items and determinations were carried out five times. Patients were orally questioned four times regarding their pain after surgery, movement-associated chest pain, pain at night and operative wound pain. Evaluation of the ADL after discharge was conducted using a three-level rating method at postoperative week 4 and week 12. A total of 72 patients were studied, comprising 39 who underwent pectoral muscle-conserving mastectomy and 33 who underwent breast-conserving surgery. The arm movement of forward raising showed the greatest decline, followed by lateral raising of the arm. Postoperative time-course changes in internal/external arm rotation, as well as backward arm raising were slight. Comparison of the operative procedures revealed differences only for lateral arm raising at postoperative week 4, while there were no differences in any of the shoulder joint movements. Lowering of the ROM of the shoulder joint was more marked at an earlier time (week 1 to week 2) after surgery, but it was not statistically significant. Pain at night and operative wound pain were prolonged over the period, and reported in postoperative week 1 to week 12 by 3–15% of patients. All ADL items became almost normal in approximately 90% of patients at postoperative week 4. The efficacy of the present rehabilitation program early after surgery was demonstrated in terms of recovery of ADL as well as the ROM of the arm on the affected side. [ABSTRACT FROM AUTHOR]

Serum 1,5-anhydroglucitol (1,5-AG) is a useful clinical indicator for short-term glycemic control status, which exhibits a rapid decrease if blood glucose levels are poorly controlled in diabetic patients. Interestingly, some cross-sectional studies have suggested that serum 1,5-AG level decreases even before the onset of type 2 diabetes. Thus, the aim of the present study was to examine whether there is an association between a decrease in serum 1,5-AG level and the incidence of abnormal glucose metabolism (AbGM) or metabolic syndrome (MetS) in Japanese in a prospective cohort study. We here report a prospective occupational-based cohort study, which was conducted during 2010-2017 in Japan. Briefly, 1) 837 male workers without AbGM and 2) 843 male workers without MetS aged over 20 years were followed up prospectively. AbGM was defined as either: 1) fasting plasma glucose ≥ 110 mg/dl, 2) HbA1c ≥ 6.0% or 3) medication for hyperglycemia. In multivariate analysis after adjusting for age, BMI, smoking habit, alcohol intake, regular exercise and estimated glomerular filtration rate, the HR of developing MetS was 1.81 [95%CI: 1.12 to 2.92, P=0.01] in the lowest quartile of baseline serum 1,5-AG, compared with the highest quartile. In addition, the incidence and multivariate-adjusted HR of AbGM or MetS also increased with decreasing quartile of serum 1,5-AG (P for trend for both <0.05). Our findings suggest that a decrease in serum 1,5-AG level is a predictive marker for the future onset of AbGM or MetS in male Japanese. Disclosure: A. Hata: None. N. Aki: None. T. Ichihara: None. A. Tamura: None. T. Minagawa: None. Y. Kuwamura: None. M. Funaki: None. Funding: Tokushima Prefecture [ABSTRACT FROM AUTHOR]

Few prospective cohort studies have examined the association between serum fatty acid (FA) proportions and type 2 diabetes (T2D). In addition, the involvement of serum FAs in the development of early stage abnormality of glucose homeostasis remains unclear. The present study investigated the association between serum FA proportions or FA ratios, which reflect desaturase activity, and the incidence of early stage abnormal glucose metabolism before the actual onset of T2D. We here report a prospective occupational-based cohort study, which has been conducted since 2008 in Japan. A total of 396 male workers without abnormal glucose metabolism aged 20 to 60 years were followed-up prospectively (mean follow-up period: 5.9 years). Abnormal glucose metabolism was defined as either: 1) fasting plasma glucose ≥ 110 mg/dl, 2) HbA1c ≥ 6.0% or 3) medication for hyperglycemia. We evaluated serum FA proportions and the activities of ⊿5desaturase, ⊿6desaturase and ⊿9desaturase, which reflect desaturation of FAs estimated from the FA product-to-precursor ratios. In multivariate analysis after adjusting for age, BMI, smoking habit, alcohol intake, regular exercise, HDL cholesterol, triglycerides, family history of diabetes, and hypertension, the HR of developing abnormal glucose metabolism was 4.42 [95% CI: 1.81 to 10.76, P=0.001] in the highest quartile of baseline serum dihomo-γ-linolenic acid proportion, compared with the lowest quartile. In addition, the age-adjusted incidence and multivariate-adjusted HR of abnormal glucose metabolism also increased with increasing quartile of ⊿6desaturase (P for trend for both <0.01). Our findings suggest that increased serum dihomo-γ-linolenic acid proportion and enhanced activity of ⊿6desaturase are predictive markers for the development of early stage abnormal glucose metabolism in male Japanese. These results imply that altered FA metabolism may associate with early stage disorders of glucose metabolism. Disclosure: A. Hata: None. N. Aki: None. T. Ichihara: None. A. Tamura: None. T. Minagawa: None. Y. Kuwamura: None. M. Funaki: Consultant; Self; Happy, Inc. Research Support; Self; Otsuka Holdings Co., Ltd. Funding: Japan Ministry of Education, Culture, Sports, Science and Technology [ABSTRACT FROM AUTHOR]

Background and Objectives: The aim of this study was to determine the associations of intake of soy products and isoflavones with allergic diseases.Methods and Study Design: We conducted a cross-sectional study in 1437 participants (aged 20-64 years) who were living in Tokushima Prefecture, Japan during the period 2010- 2011. We obtained anthropometric data and information on life style characteristics including dietary intake and current medical histories of allergic diseases using a structural self-administered questionnaire. Multiple logistic regression models were used to assess the associations of soy products and isoflavones with allergic diseases after controlling for age, family history of allergic diseases, smoking, drinking, physical activity, energy intake, BMI and dietary factors.Results: Intake of soy products showed significant inverse dose-response relationships with allergic rhinitis. The third quartile for soy products had an adjusted OR of 0.56 (95% CI: 0.35-0.91) compared to the reference group (first quartile), though intake of soy products showed no dose-response relationship with atopic dermatitis. Intake of soy isoflavones showed a significant inverse dose-response relationship with atopic dermatitis, though the association between intake of soy isoflavones and atopic dermatitis was U-shaped after adjustments for potential confounders. On the other hand, the associations between intake of soy isoflavones and other allergic diseases were not significant.Conclusions: The results indicate that higher intake of soy products is associated with reduced risk of allergic rhinitis in Japanese workers. Furthermore, moderate intake amounts of soy products and soy isoflavones are associated with inverse risk of atopic dermatitis. [ABSTRACT FROM AUTHOR]

Aim: To determine the optimal cut-off value of serum total adiponectin for managing the risk of developing metabolic syndrome (MetS) in male Japanese workers. Methods: A total of 365 subjects without MetS aged 20–60 years were followed up prospectively for a mean of 3.1 years. The accelerated failure-time model was used to estimate time ratio (TR) and cut-off value for developing MetS. Results: During follow-up, 45 subjects developed MetS. Age-adjusted TR significantly declined with decreasing total adiponectin level (≤ 4.9, 5.0–6.6, 6.7–8.8 and ≥ 8.9 μg/ml, P for trend = 0.003). In multivariate analyses, TR of MetS was 0.12 (95% CI 0.02–0.78; P = 0.03) in subjects with total adiponectin level of 5.0–6.6 μg/ml, and 0.15 (95% CI 0.02–0.97; P = 0.047) in subjects with total adiponectin level ≤ 4.9 μg/ml compared with those with total adiponectin level ≥ 8.9 μg/ml. The accelerated failure-time model showed that the optimal cut-off value of total adiponectin for managing the risk of developing MetS was 6.2 μg/ml. In the multivariate-adjusted model, the mean time to the development of MetS was 78% shorter for total adiponectin level ≤ 6.2 μg/ml compared with > 6.2 μg/ml (TR 0.22, 95% CI: 0.08–0.64, P = 0.005). Conclusion: Our findings suggest that the cut-off value for managing the risk of developing MetS is 6.2 μg/ml in male Japanese workers. Subjects with total adiponectin level ≤ 6.2 μg/ml developed MetS more rapidly than did those with total adiponectin level > 6.2 μg/ml. [ABSTRACT FROM AUTHOR]

Emerging evidence suggests that adiponectin secreted from adipocytes may have a preventive effect on the development of type 2 diabetes, attributable to an increase in insulin sensitivity and suppression of inflammation. However, when the East Asian population is considered, dysfunction of insulin secretion, besides insulin resistance and inflammation, has been assumed to play a significant role in the development of diabetes. Thus, the aim of the present study was to examine whether there is an association between a decrease in serum total adiponectin level and the incidence of diabetes in male Japanese, with consideration of insulin secretory function. We here report a prospective occupational-based cohort study, which was conducted during 2010-2019 in Japan. Briefly, 851 male workers without diabetes aged over 20 years were followed up prospectively. Diabetes was defined as either: 1) fasting plasma glucose ≥ 126 mg/dl, 2) HbA1c ≥ 6.5%, 3) medication for hyperglycemia or 4) postprandial plasma glucose ≥ 200 mg/dl during the follow-up period. Hazard ratios (HRs) with 95% confidence intervals (CIs) of serum total adiponectin level for the incidence of diabetes were estimated using a Cox proportional hazards model. In multivariate analysis after adjusting for age, BMI, smoking habit, alcohol intake, regular exercise, family history of diabetes, HDL-C, triglyceride, hypertension and HOMA-β, HR of developing diabetes was 8.61 [95%CI: 1.87 to 39.77, P=0.01] in the lowest quartile of serum total adiponectin, compared with the highest quartile. Furthermore, the risk of diabetes was 36% higher (P<0.01) per 1 µg/ml decrement of serum total adiponectin level in the multivariate-adjusted model. These results suggest that serum total adiponectin level could be a biomarker for the onset of diabetes in male Japanese, even with consideration of the ability of fasting insulin secretion and adjustment of its impact. Disclosure: A. Hata: None. M. Miyoshi: None. T. Nakao: None. T. Ichihara: None. A. Tamura: None. T. Minagawa: None. Y. Kuwamura: None. M. Funaki: Board Member; Self; Mechanogenic, Inc., Consultant; Self; Happy, Inc., Research Support; Self; Japan Tobacco Inc. [ABSTRACT FROM AUTHOR]