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B Background: b Data on secondary resections of colorectal liver-only metastases (CRLM) are difficult to interpret due to lack of consensus on resectability criteria. B Conclusion: b Prospective evaluation of CRLM patients by a expert panel according to uniform criteria with feedback of surgical outcomes is a unique aspect of CAIRO5. [Extracted from the article]

Implementing the Cochrane risk of bias (RoB) assessment items through standardized forms in trial registries would benefit transparency and eventually improve quality of research. This study assessed the possibilities of registration of RoB in the 5 largest trial registries and provides a proposal for the registration of RoB. B Methods: b The 5 largest trial registries were assessed for the presence and type of implementation of an option to provide information on all Cochrane collaboration RoB assessment tool items. [Extracted from the article]

B Conclusion: b Comparable disease free survival and overall survival were found in patients who underwent portal vein embolization before major liver resection compared to matched controls treated with major surgery alone. PVE is a valuable tool to improve resectability rate of patients with colorectal liver metastases and does not affect long term oncological outcomes in patients proceeding with liver resection. [Extracted from the article]

Implementing the Cochrane risk of bias (RoB) assessment items through standardized forms in trial registries would benefit transparency and eventually improve quality of research. This study assessed the possibilities of registration of RoB in the 5 largest trial registries and provides a proposal for the registration of RoB. B Methods: b The 5 largest trial registries were assessed for the presence and type of implementation of an option to provide information on all Cochrane collaboration RoB assessment tool items. [Extracted from the article]

B Conclusion: b Comparable disease free survival and overall survival were found in patients who underwent portal vein embolization before major liver resection compared to matched controls treated with major surgery alone. PVE is a valuable tool to improve resectability rate of patients with colorectal liver metastases and does not affect long term oncological outcomes in patients proceeding with liver resection. [Extracted from the article]

B Background: b Data on secondary resections of colorectal liver-only metastases (CRLM) are difficult to interpret due to lack of consensus on resectability criteria. B Conclusion: b Prospective evaluation of CRLM patients by a expert panel according to uniform criteria with feedback of surgical outcomes is a unique aspect of CAIRO5. [Extracted from the article]

Background The objective of this study was to map referral patterns in patients with synchronous colorectal liver metastases (SCLM) and to investigate if type, volume and location of the hospital of diagnosis are associated with whether or not patients underwent liver resection. Methods This population-based study includes all patients diagnosed with SCLM between 2008 and 2012, based on the Netherlands Cancer Registry. To study inter-hospital variation, the proportion of patients undergoing liver surgery was calculated per hospital of diagnosis. Multivariable multilevel logistic regression analysis was used to investigate the association between hospital characteristics and liver resection. Results Of 10,520 patients with SCLM, 12% (n = 1259) underwent liver surgery. Of these patients, 58% (n = 733) were referred to another hospital to undergo liver surgery. In 53% of the patients (n = 647), liver resection was performed in a university hospital, in 39% (n = 482) in a dedicated liver centre and in 8% (n = 102) in a general hospital. There was a large inter-hospital variation in the proportion of patients undergoing liver resection (2–26%). In a multilevel logistic regression model, the odds of undergoing liver surgery were higher when patients were diagnosed in hospitals where liver surgery was performed compared with the general hospitals (dedicated liver centre: odds ratio 1.36 [95% confidence intervals 1.08–1.70], university hospital: odds ratio 1.69 [95% confidence intervals 1.22–2.34]). Conclusion There is a large inter-hospital and inter-regional variation in the utilisation of liver resection. Patients diagnosed with SCLM in expert centres had a higher chance of undergoing liver resection. [ABSTRACT FROM AUTHOR]