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The purpose of this descriptive study was to survey and compare. A sample of 32 people who have a developmental disability were asked to complete five questionnaires (i.e., demographics, sexual orientation, sexual history, recalled childhood gender identity and adult gender identity). Comparisons were made regarding their sexual orientation and gender identity, as well as differences based on their diagnosis that may not have been related to their developmental disability. One case study was presented to aid in better understanding of a transgendered individual. Research results showed that most subjects perceived themselves as heterosexual (87%), followed by those that saw themselves as bisexual or questioning (9.7%) and lastly those that reported that they were interested in same sex partners (3.2%). No differences were found for diagnostic category. Four subjects scored within the range to indicate that they had gender identity dysphoria (GID). Again, no differences were found for diagnostic category. Interesting findings resulted when comparisons were made to other measures and to other studies. It is proposed that it is good practice for professionals to rule out the possibility of ambivalence about gender and sexual issues caused by social and life experiences, especially regarding abuse and the lack of information/education. However, their identities, gender identity and/or sexual identity, must be honored as we do with the general population. [ABSTRACT FROM AUTHOR]

Background: Stem cell transplantation is a promising method for the treatment of chronic obstructive pulmonary disease (COPD), and mesenchymal stem cells (MSCs) have clinical potential for lung repair/regeneration. However, the rates of engraftment and differentiation are generally low following MSC therapy for lung injury. In previous studies, we constructed a pulmonary surfactant-associated protein A (SPA) suicide gene system, rAAV-SPA-TK, which induced apoptosis in alveolar epithelial type II (AT II) cells and vacated the AT II cell niche. We hypothesized that this system would increase the rates of MSC engraftment and repair in COPD rats. Methods: The MSC engraftment rate and morphometric changes in lung tissue in vivo were investigated by in situ hybridization, hematoxylin and eosin staining, Masson's trichrome staining, immunohistochemistry, and real-time PCR. The expression of hypoxia inducible factor (HIF-1α) and stromal cell-derived factor-1 (SDF-1), and relationship between HIF-1α and SDF-1 in a hypoxic cell model were analyzed by real-time PCR, western blotting, and enzyme-linked immunosorbent assay. Results: rAAV-SPA-TK transfection increased the recruitment of MSCs but induced pulmonary fibrosis in COPD rats. HIF-1α and SDF-1 expression were enhanced after rAAV-SPA-TK transfection. Hypoxia increased the expression of HIF-1α and SDF-1 in the hypoxic cell model, and SDF-1 expression was augmented by HIF-1α under hypoxic conditions. Conclusions: Vacant AT II cell niches increase the homing and recruitment of MSCs to the lung in COPD rats. MSCs play an important role in lung repair and promote collagen fiber deposition after induction of secondary damage in AT II cells by rAAV-SPA-TK, which involves HIF-1α and SDF-1 signaling. [ABSTRACT FROM AUTHOR]

In an open-circuit dissipative photovoltaic (PV) crystal, by considering the diffusion effect, the deflection of bright dissipative photovoltaic (DPV) solitons has been investigated by employing numerical technique and perturbational procedure. The relevant results show that the centre of the optical beam moves along a parabolic trajectory, while the central spatial-frequency component shifts linearly with the propagation distance; furthermore, both the spatial deflection and the angular derivation are associated with the photovoltaic field. Such DPV solitons have a fixed deflection degree completely determined by the parameters of the dissipative system. The small bending cannot affect the formation of the DPV soliton via two-wave mixing. [ABSTRACT FROM AUTHOR]