1. Altered splenic miRNA expression profile in H1N1 swine influenza.
- Author
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Huang, Liangzong, Ma, Jun, Sun, Yankuo, Lv, Yanli, Lin, Wen, Liu, Mingjie, Tu, Changsong, Zhou, Pei, Gu, Wanjun, Su, Shuo, and Zhang, Guihong
- Subjects
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H1N1 influenza , *MICRORNA , *TOLL-like receptors , *HOSTS (Biology) , *IMMUNE response , *GENE expression in viruses , *CELLULAR signal transduction , *VIRUSES - Abstract
Previous studies have demonstrated the key regulatory roles played by microRNAs (miRNAs) in influenza virus-host interactions. To gain more insight into the contribution of miRNAs to the host immune response, spleen tissues from mice infected with A/Swine/GD/2/12 (H1N1) virus were harvested 5 days postinfection, and miRNA deep sequencing was performed. The results showed that 50 miRNAs were modulated. Interestingly, pathway analysis of miRNAs and targets showed that upregulated miR-124-3p interacts with innate immune-related pathways such as the Toll-like receptor pathway, RIG-I-like receptor signaling pathway, NOD-like receptor signaling pathway and JAK-STAT signaling pathway, and this might play a major role in the anti-inflammatory response. Further understanding of the roles played by these miRNAs in influenza virus infection will provide new insights into host-pathogen interactions. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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