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The compression packer rubber is one of the core components of the packer. According to the sealing mechanism of the compression packers rubber, the deformation of rubber between the central tube and casing tube is analyzed in the initial and working stages. The compression rubber is also strained radially against the support ring by means of a controlled tubular expansion process. In this paper, the theoretical model for the deformation analysis is established by the structure and working characteristics of rubber tube. In addition, the nonlinear relationship between the material, geometry and stress in the constrained and stable deformation stages is analyzed by application of pressure methods. The analytical results show the contact pressure and shear stress distribution on the sealing surface of the rubber and the effect of rubber geometry and its material properties on sealing performance in terms of maximum sealing pressure. Then, the criterion of sealing performance evaluation of the rubber is established by the numerical results. This analytical model will provide a theoretical basis and guidance for the structural design of the compression packer rubber and it will be of great significance to improve the sealing performance and reliability of packer rubber. [ABSTRACT FROM AUTHOR]

The aberrant expression of lncRNAs has been inferred to be closely related with the progression of neural ischemia/reperfusion (I/R) injury. RMRP is an lncRNA associated with I/R injury. In order to determine the role of RMRP in I/R injury, the effects of RMRP knockdown on oxygen-glucose deprivation/re-oxygenation (OGD/R)-induced injury in SH-SY5Y cells were evaluated. The effect of OGD/R administration on the expression of RMRP and apoptosis in SH-SY5Y cells, and the effect of suppression by siRNA on the impairments of cells proliferation and mobility potential due to OGD/R administration were assessed in the current study. At the molecular level, the current study detected the expressions of indicators involved in autophagy and PI3K/Akt/mTOR-mediated apoptosis pathways. The OGD/R administration induced the expression of RMRP and apoptosis in SH-SY5Y cells. After RMRP knockdown, the proliferation potential of SH-SY5Y cells was restored, and apoptosis and cell cycle arrest were inhibited. Moreover, RMRP inhibition also increased the invasion and migration of SH-SY5Y cells which were treated with OGD/R. The effects of RMRP suppression on the phenotypes of SH-SY5Y were associated with the inhibition of LC3II, p-PI3K, p-Akt, and p-mTOR as well as the induction of P62 and Bcl-2. Inhibition of RMRP contributed to the improvement of OGD/R-induced neuronal injury, which might be mediated through the inhibition of autophagy and apoptosis pathways. [ABSTRACT FROM AUTHOR]

Objective: This study investigated the expression of genes in cashmere goats at different periods of their fetal development. Methods: Bioinformatics analysis was used to evaluate data obtained by transcriptome sequencing of fetus skin samples collected from Inner Mongolia cashmere goats on days 45, 55, and 65 of fetal age. Results: We found that FoxN1, FoxE1, and FoxI3 genes of the Fox gene family were probably involved in the growth and development of the follicle and the formation of hair, which is consistent with previous findings. Real-time quantitative polymerase chain reaction detecting system and Western blot analysis were employed to study the relative differentially expressed genes FoxN1, FoxE1, and FoxI3 in the body skin of cashmere goat fetuses and adult individuals. Conclusion: This study provided new fundamental information for further investigation of the genes related to follicle development and exploration of their roles in hair follicle initiation, growth, and development. [ABSTRACT FROM AUTHOR]

The western Kuqa fold-thrust belt of Xinjiang Province, China, hosts a series of surface salt structures. Here we present preliminary analysis of the geometry, kinematics, and surface processes of three of these structures: the Quele open-toed salt thrust sheet, Tuzimazha salt wall, and Awate salt fountain. The first two are line-sourced, the third appears to be point-sourced, and all are active. The ~35-km-long, 200-m-thick Quele open-toed salt thrust sheet features internal folding, salt-lined transfer structures, dissolution topography, flanking growth strata, and alluvial fan/stream-network interactions. The ~10-km-long, 50-m-wide Tuzimazha salt wall marks a local topographic high, such that fluvial stream networks are deflected by the rising weak tabular salt body. The salt wall is also flanked by growth strata and normal faults. The ~2-km-long Awate salt fountain represents salt exhumation coincident with the intersection of multiple structures and a river. Therefore this salt body may respond to local structural and/or erosional variations, or it may play a key role determining such variations-or both. Activity along all three structures confirms that active deformation occurs from foreland to hinterland across the western Kuqa fold-thrust belt. Gradual lateral transition from bedded strata to flow-banded halite observed within the Quele open-toed salt thrust sheet implies that similar transitions observed in seismic reflection data do not require interpretation as diapiric cut-offrelationships. The surface salt structures of the western Kuqa fold-thrust belt display a variety of erosiontectonics interactions, with nuances reflecting the low viscosity and high erodibility of salt, including stream deflections, potential tectonic aneurysm development, and even an upper-crustal test site for channel flow- focused denudation models. [ABSTRACT FROM AUTHOR]

We focus on solving Stochastic Job Shop Scheduling Problem (SJSSP) with random processing time to minimize the expected sum of earliness and tardiness costs of all jobs. To further enhance the efficiency of the simulation optimization technique of embedding Evolutionary Strategy in Ordinal Optimization (ESOO) which is based on Monte Carlo simulation, we embed Optimal Computing Budget Allocation (OCBA) technique into the exploration stage of ESOO to optimize the performance evaluation process by controlling the allocation of simulation times. However, while pursuing a good set of schedules, "super individuals," which can absorb most of the given computation while others hardly get any simulation budget, may emerge according to the allocating equation of OCBA. Consequently, the schedules cannot be evaluated exactly, and thus the probability of correct selection (PCS) tends to be low. Therefore, we modify OCBA to balance the computation allocation: (1) set a threshold of simulation times to detect "super individuals" and (2) follow an exclusion mechanism to marginalize them. Finally, the proposed approach is applied to an SJSSP comprising 8 jobs on 8 machines with random processing time in truncated normal, uniform, and exponential distributions, respectively. The results demonstrate that our method outperforms the ESOO method by achieving better solutions. [ABSTRACT FROM AUTHOR]