1. Ricin: an ancient toxicant, but still an evergreen.
- Author
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Bolt, Hermann M. and Hengstler, Jan G.
- Subjects
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RICIN , *POISONS , *CELL receptors , *PLANT toxins , *BIOLOGICAL assay - Abstract
After sample enrichment, mass spectrometry may simultaneously identify ricin peptide fingerprints and in vitro RNA substrates that have been deadenylated by the ricin A-chain and would allow for quick and sensitive detection of biological active ricin. Reports in the lay press on intended terrorist attacks with ricin or castor seeds have reached recent publicity (Anonymous [3]; Noryskiewicz [15]), reminiscent of earlier cases in the United States (Audi et al [4]) and elsewhere (Abbes et al [1]). Assays have been developed, where ricin is enriched from samples using ricin-specific antibodies. According to recent evidence antibody cocktails consisting of chain A and chain B antibodies show better neutralizing activity at lower antibody doses compared to antibodies directed against only one chain (Rong et al [20], Orsini Delgado [17]). [Extracted from the article]
- Published
- 2023
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