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This article discusses the successful treatment of four patients with refractory systemic lupus erythematosus (SLE) and neuropsychiatric manifestations using anifrolumab, a monoclonal antibody. The patients had various clinical characteristics, including acute confusional state, anxiety disorder, mood disorder, cerebrovascular disease, myelopathy, panniculitis, nephritis, pericarditis, leucopenia, haemolytic anaemia, thrombocytopenia, and aseptic meningitis. Anifrolumab treatment resulted in improvements in symptoms and serological abnormalities, allowing for the tapering of prednisolone without relapse of neuropsychiatric symptoms. The study suggests that anifrolumab may be an effective treatment option for refractory SLE with neuropsychiatric manifestations, although further research is needed. [Extracted from the article]

Strip-Readout Parallel Plate Avalanche Counters (SR-PPACs) have been developed in Center for Nuclear Study (CNS) aiming at high detection efficiency for high-intensity heavy ions based on Delay-line-readout PPAC. A readout circuit board was newly designed for the strip-readout method, and an analysis method using charge difference among two adjacent strips was developed. We achieved high detection efficiency above 99% for 115-MeV/nucleon -132Xe beams with a beam intensity of 700 kppp (particles per pulse). The achieved position resolution was about 240 μ m (FWHM). • A PPAC with strip-readout technique (SR-PPAC) has developed in Center for Nuclear Study. • SR-PPAC has high detection efficiency for heavy-ion beams with a near 1 MHz counting rate. • SR-PPAC has a position resolution as good as a multi-wire drift chamber for heavy-ion beams. [ABSTRACT FROM AUTHOR]

Thrombotic microangiopathy (TMA) is a rare, life-threatening condition involving microvascular occlusion in multiple systems ([1]). B-cell depletion therapy with RTX has shown efficacy in several open-labelled studies, but failed to demonstrate benefits in two randomized trials of non-LN and LN patients ([3]). However, the European League Against Rheumatism stated that RTX should be considered in organ-threatening, refractory lupus ([4], [5]), and no guidelines for the treatment of TMA in the patient with LN have been established. [Extracted from the article]

Cervical magnetic resonance imaging (MRI) showed enhancement effects on cervical interspinous ligament and sacroiliac MRI showed bilateral sacroiliitis (Fig. A case of psoriatic spondyloarthritis exacerbation triggered by COVID-19 messenger RNA vaccine Most exacerbations occurred after the second vaccination dose.3,4 However, there were no significant differences regarding the exacerbation of psoriasis between the vaccine types.3,4 Although a high safety profile against the COVID-19 mRNA vaccine was observed in almost all psoriasis patients, and psoriasis patients should be recommended to receive COVID-19 vaccine,7,8 factors associated with psoriasis exacerbation after the COVID-19 vaccination have not been clarified yet. [Extracted from the article]

A 72-year-old Japanese man developed anterior chest pain the day after receiving a fourth dose of a severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccine (BNT162b2; Pfizer-BioNTech). Chest pain persisted and contrast-enhanced computed tomography (CT) was performed on day 5 after vaccination, showing swelling of the ascending aortic wall and the surrounding soft tissue (Figure 1A). Although differential diagnoses for large-vessel vasculitis in our patient included giant cell arteritis, aortitis due to rheumatoid arthritis and infectious aortitis related to I T.pallidum i or I Mycobacterium tuberculosis i ,[1] no other findings indicative of these diseases were observed. [Extracted from the article]

A 75-year-old woman with rheumatoid arthritis (RA) was admitted to our hospital for further assessment of interstitial lung disease (ILD). On the other hand, pre-existing ILD thought to be a risk factor for MTX-associated pneumonitis.[1] MTX-associated pneumonitis could develop not only in patients with RA but also in those with other diseases such as psoriasis, psoriatic arthritis and inflammatory bowel disease.[3] Spontaneous resolution could be expected with early withdrawal of MTX. She had been diagnosed with RA 5 years earlier, and at the time of admission was receiving oral salazosulfapyridine (1000 mg/day) and methotrexate (MTX) (8 mg/week). [Extracted from the article]

In order to study magnetic levitation easily, we develop a cryo-cooled large magnetic field gradient superconducting magnet as the insert magnet for a large bore (220 mm cylindrical room temperature bore) cryo-cooled superconducting magnet. The insert magnet consists of a modified cusp coil and generates large magnetic field gradient. Combined with the background magnet, this magnet system realizes the stable magnetic levitation for the diamagnetic materials. The magnet system is designed to generate 1400 T² /m for the magnetic levitation of water. As a result, this cryo-cooled magnet system quenched from the insert magnet, but could achieve nearly 1050 T² /m. As a performance test, a bismuth tip was levitated using the newly developed cryo-cooled superconducting magnet. [ABSTRACT FROM AUTHOR]

Cost reduction study of 100 MW/500 kwh SMES for load compensation and frequency regulation is performed under Japanese national project. A newly designed CIC (Cable In Conduit) Conductor is developed for the SMES (Superconducting Magnetic Energy Storage). The number of superconducting strand in the cable is reduced with segregated Cu strands. The cross-sectional structure or a strand with CuNi sheath is simplified from the previous design. To reduce AC loss time constant, strands are twisted up to second degree, which is much lower than that of the previous cable design. A short sample of the conductor is manufactured and tested. The test results show that the conductor has good performance for the SMES. [ABSTRACT FROM AUTHOR]

Reports on studies on the mechanical behavior of superconducting coils for superconducting magnetic energy storage (SMES). Mechanical displacements of a model coil for one kilowatthour SMES; Analysis of non-linear behaviors such as friction and sliding between conductors and spacers; Preliminary stress conditions caused by refrigeration; Test coil specifications.

Discusses the performance of alternating current (AC) losses of the superconducting magnetic energy storage (SMES) model coil for the SMES pilot plant. Description of the coupling loss in the coil; Coupling current loop with long time constant; Lateral force effect on AC loss.

Describes the development of the mass flow quench detection system for the 100kWh superconducting magnetic energy storage forced-flow model coil. Optimized parameters of orifice flow meter; Design and fabrication of three orifice types; Relationship between quench detection time and the joule heat of the conductor.

Focuses on the development of a high-temperature superconducting split magnet for Si single-crystal growth applications through the collaboration of Toshiba Corp., Sumitomo Electric Industries Ltd. and Shin-Etsu Handotai Co. Ltd. Factors affecting the design and winding of the magnet; Magnet design parameters; Operating test using two pancake coils.

The OEDO-SHARAQ system is the world's first beamline characterized by the energy-degrading of RI beams. The system also has high performance on high-resolution nuclear spectroscopy with RI beams. A minor update of the system, performed in 2021, provided multifaceted improvements to the system in both effective energy-degrading and high-resolution spectroscopy with RI beams. We report here the achievements of the renewed OEDO-SHARAQ system and the experimental studies performed recently. Additionally we compactly introduce perspectives about upcoming physics programs. • OEDO-SHARAQ system provide multifaceted experimental opportunities with radioactive isotope beams. • Discovery of the four-neutron state revised the significance of physics in multi-neutron systems. • Mass measurements using OEDO-SHARAQ explore the shell evolutions towards the dripline nuclei. • Reaction measurements using OEDO-SHARAQ address neutron captures in explosive nucleosynthesis. [ABSTRACT FROM AUTHOR]

Abstract: We have successfully developed a cryocooled superconducting magnet which generates the world’s highest magnetic field of 18.1 T. This conduction-cooled superconducting magnet has a 52-mm room temperature bore. The magnet consists of three sections; a high- superconducting insert coil, four Nb3 Sn coils, and an outer NbTi coil. Each section was energized by an individual power supply. The superconducting coils are cooled conductively by a Gifford-McMahon–Joule-Thomson (GM–JT) cryocooler with a cooling capacity of 4.3 W at 4.3 K. The ramp-up time to 18 T is 60 min. The high- insert coil is composed of 25 double- pancake coils using Ag/(Bi,Pb)2 Sr2 Ca2 Cu3 O10 (Bi2223) high- superconducting tape with stainless steel tape reinforcement. The reinforcement co-winding reduces the effective hoop stress down to 48 MPa, and, hence, Bi2223 tape can be used. The innermost of the Nb3 Sn section is made of an internal-tin-processed Nb3 Sn wire because this wire can withstand high critical current density in high magnetic fields. Other three coils require high mechanical strength. They experience hoop stress of 230 MPa, and in this case, bronze-processed high-strength Nb3 Sn wires were used. The magnet has a distinctive feature, that is the high- insert coil is replaceable. It indicates that the magnet can be used as a 15.5 T back-up magnet for a new insert coil. A Y123 coil is a candidate for the replacement. [Copyright &y& Elsevier]

This paper describes a design of a cryocooler-cooled 19 T superconducting magnet. The technical features of the magnet are a Bi2223 insert coil composed of 25 double pancake coils, Nb3 Sn coils using a Nb3 Sn wire reinforced with Nb-Ti-Cu compound, and a cooling structure using two types of cryocoolers. Coil protection from quenching was confirmed by numerical analysis. A preliminary experiment was carried out in order to investigate the influence of the bending strain upon a maximum permissible hoop stress of Ag-sheathed Bi2223 tape conductor. [ABSTRACT FROM AUTHOR]

A cryogen-free 20 T superconducting magnet with a 52 mm room-temperature bore was developed and installed in Tohoku University in 2013. This magnet consists of a Bi2223 insert coil, which generates 4.5 T, and outer low-temperature superconducting (LTS) coils. Both coils were cooled by a GM/JT cryocooler with 4.2 W-class cooling capacity at 4.3 K. To generate a higher magnetic field, a new cryogen-free 25 T superconducting magnet using a REBCO insert coil, which generates 11.5 T, and new outer LTS coils is now under development. The magnetic field contribution of this REBCO insert coil is considerably higher than that of the previous Bi2223 insert coil, and the ac-loss of the insert coil during field ramping rises to approximately 9.7 W. The LTS coils have to operate at about 4 K, but the REBCO coil can operate at various temperatures above 4 K. In addition, the cooling capacity of a GM cryocooler is greater than that of a GM/JT cryocooler around 10 K. Thus, the REBCO insert coil is cooled to about 10 K by using two GM cryocoolers, independently of the LTS coils, which are cooled by two GM/JT cryocoolers. To protect the cryocoolers from the leakage field of the magnet, the two GM cryocoolers cool circulating helium gas through heat exchangers, and the gas is transported over a long distance to another heat exchanger provided for the REBCO insert coil. The maximum temperature of the REBCO insert coil was calculated under the most severe condition where an insert coil ac-loss of 9.7 W was generated continuously. And it was confirmed to be less than the target maximum temperature of 12 K. [ABSTRACT FROM PUBLISHER]

Internally reinforced Nb3Sn strands with CuNb-reinforcing stabilizer (CuNb/Nb3Sn) have been developed for realizing a compact high-field superconducting magnet. The Rutherford flat cables composed of sixteen strands were made with a 0.8 mm diameter CuNb/Nb3Sn strand. The designed critical current of the CuNb/Nb3Sn Rutherford flat cable is Ic=1890\ \rm A at 13 T and 4.2 K in case of an ordinary heat-treatment at 670^\circC for 96 h, which is two times higher than an operation current desired for safety margin. [ABSTRACT FROM PUBLISHER]

We have successfully constructed an 18.1 T superconducting magnet conductively cooled by a GM/JT cryocooler. The double-pancake insert using Ag-sheathed BiSrCaCuO (Bi2223) tape with stainless steel reinforcement tape generated 2.5 T in a 15.6 T background magnet. In order to develop a cryogen-free high-field superconducting magnet producing over 20 T, an YBaCuO (Y123) coated conductor insert is intended for upgrading the cryogen-free 18 T superconducting magnet. The Bi2223 insert, whose size is 176 mm outer diameter, 90 mm inner diameter, and 252 mm coil height, is now excited at 162 A operation current, and will be replaced by a new Y123 insert. We have already confirmed excellent mechanical properties of 1000 MPa hoop stress tolerance for Y123 coated conductor tape with Hastelloy substrate. This means that we no longer need stainless steel reinforcement for the insert. As a result, an Y123 insert with almost the same size as the Bi2223 insert is designed to generate 7.5 T at 187 A, because the number of turns can be improved extremely. A cryogen-free 23 T superconducting magnet can sufficiently be developed for a long-term experiment at a constant high magnetic field. [ABSTRACT FROM AUTHOR]

We have been developing high-strength Nb3 Sn strand cables to construct a high-field superconducting outsert for a 45 T hybrid magnet with a 25 T water-cooled resistive magnet. Evidence for cold work strengthening of repeated bending treatment (prebending effect) on Nb3 Sn strands internally reinforced with CuNb stabilizer, which exhibits significant enhancement of the critical current density, has been found in the superconducting magnet fabrication process using a react-and-wind method. The strand cables were designed by controlling the constituent number of CuNb/Nb3 Sn strands with the prebending effect and stainless steel strands, which are expected to have a stress limit 580 MPa at 0.4% strain. In order to design a compact superconducting outsert, high-strength strand cables are adopted in a magnetic field region below 14 T to maintain relatively large engineering current densities (Je). In a higher-field region above 14 T, YBa2Cu3O7 (Y123) coated conductors are employed for an insert coil. Using combination of V 123, Nb3 Sn and NbTi superconductors, a 20 T superconducting outsert with a room temperature bore of 400 mm consisting of three layers made of Y123, two layers of CuNb/Nb3 Sn and two layers of NbTi was designed. The coil parameters are 440 mm inner diameter, 1080 mm outer diameter and 1138 mm coil height. A very compact 20 T superconducting outsert with a stored magnetic energy 72 MJ at an operation current 903 A can be developed for a 45 T hybrid magnet. [ABSTRACT FROM AUTHOR]

The High Field Laboratory for Superconducting Materials (HFLSM) and the Tsukuba Magnet Laboratory (TML) conducted in collaboration a case study on development of a 50 T-class hybrid magnet. To construct a high magnetic field magnet with compact and energy-saving design as well as with easy operation and maintenance, one has to develop high-strength Nb3 Sn strand cables, with maximized superconducting characteristics and which can withstand a large electromagnetic force over 500 MPa. For this purpose, the HFLSM has proposed and investigated the effect of repeated bending treatment (prebending) on Nb3 Sn strands internally reinforced with CuNb stabilizer leading to significant enhancement of the critical current density. In this report we present our results on application of the prebending effect to the development of high-strength strand cables. The designed prebent-strand cables are composed of three CuNb/Nb3Sn strands (3 x Φ = 1.73 mm) and four stainless steel strands (4 x Φ = 1.73 mm). High-strength CuNb/Nb3Sn strand cables have shown a stress limit of 552 MPa at 0.4% strain, and a critical current of Ic = 1000 A at 18.5 T and 2.0 K. For such high-strength strand cables, a 20 T superconducting magnet with a room temperature bore (4 = 400 mm) consisting of five layers made of CuNb/Nb3Sn and two layers of NbTi was designed. The coil parameters are: inner diameter Φ = 440 mm, outer diameter Φ = 1332 mm, coil height 1321 mm, inductance 350 H and magnetic stored energy 144 MJ at 908 A of the operation current. Winding of the coil was experimentally successfully simulated using dummy 3 + 4 strands cable composed of three Cu strands and 4 stainless steel strands with a similar design to the 3 + 4 strands superconducting cable presented above. The 20 T superconducting coil will be used as a 20 T outsert for a 25 T water-cooled resistive insert to obtain a 45 T hybrid magnet. [ABSTRACT FROM AUTHOR]

A superconducting magnetic energy storage system (SMES) was developed and has been tested in the field (at a large LCD TV plant in Japan) in order to confirm its performance at bridging instantaneous voltage dips, its long-term reliability and its standby loss. The developed SMES system can store up to 7.34 MJ of magnetic energy in superconducting coils using a NbTi Rutherford conductor with a maxim um electric output of 5 MVA. The field tests began in July 2003. During operation, the performing compensatory action of the SMES system on instantaneous voltage dips within the actual system was confirmed. Through the field tests of the SMES system, technical proof of the specifications required to provide instant, effective compensation for instantaneous voltage dips was verified. [ABSTRACT FROM AUTHOR]

In order to obtain a high-intensity neutron beam for neutron scattering experiments, strong sextupole magnets with large apertures are useful as a focusing element. We have started the development of a Nb3Sn sextupole magnet for this purpose. The design field strength of the sextupole is 12780 T/m² and the aperture of the coil is 46 mm in diameter. As a first step of the development, three model coils have been made in order to learn about Nb3Sn technology and to evaluate the fabrication techniques. Single-pole tests of these coils have been performed to assess the conductor stability and training behavior of the Nb3Sn coils. This paper describes the design of the magnet, the fabrication of the model coils and the results of single-pole tests. [ABSTRACT FROM AUTHOR]

We have started a new project to develop a cryogen-free 19 T superconducting magnet with a 52-mm room temperature bore. The magnet is designed to be consisting of three sections, i.e., the innermost high-Tc superconducting coil section, the middle Nb3 Sn section and the outer NbTi section. The electromagnetic hoop stress is applied to the supercon- ducting wire due to the magnetic field generation. It is described to the products of magnetic field, transport current density, and winding radius. The maximum electromagnetic stress is estimated to exceed 200 MPa in the middle Nbc Sn section and 50 Pa in the high-Ta section. It is important to explore the mechanical characteristics to design the magnet. In this study, mechanical properties, i.e., stress-strain characteristics and stress dependence of the critical current, were investigated for oxide superconducting tapes. [ABSTRACT FROM AUTHOR]

MJ-class HTS SMES has been developed for bridging instantaneous voltage dips using newly-developed Bi-2212 cable. The developed Bi-2212 wire for SMES coils achieves high-performance conductive characteristics that do not deteriorate in high magnetic fields beyond 10 T, which enable compactly arranged SMES coils to be operated in a high magnetic field, and SMES coils of the Bi-2212 wire can be adequately insulated due to a high temperature margin. Therefore it is possible for the SMES coils to enhance dielectric strength and output power. The insulating, cooling and conductive characteristics of 4 unit coils (Outer Diameter: 700 mm, Height: 127 mm, Stored Energy: 90 kJ) were checked under a variety of conditions. Moreover, fundamental performance tests were done on bridging instantaneous voltage dips, using a 125 kW resistance and 50 kW motor as imitation loads. Testing showed that the HTS SMES operated reliably. Up to the present, 11 unit coils (Outer Diameter: 700 mm, Height: 390 mm, Stored Energy: 560 kJ) have been stacked and tested. [ABSTRACT FROM AUTHOR]

The superconducting magnetic energy storage system (SMES) of output 5 MVA has been developed to bridge instantaneous voltage dips. The field examination is executed by setting up this system at the new and large liquid crystal factory in Japan. The developed SMES system can store up to 7.34 MJ of magnetic energy in superconducting coils using the NbTi Rutherford conductor. The maximum output of the developed SMES is 5 MVA, and the system can discharge the output for one s. The operating current of the coil is 2.7 kA, and the rated voltage is 2.5 kV. The field examination was started in July 2003. During the field test, we will confirm the performance of bridging instantaneous voltage dips by SMES, the long-term drive reliability and the standby loss characteristic. [ABSTRACT FROM AUTHOR]

Since 1999, a Japanese national project to realize commercially feasible SMES for designated applications has been promoted. Model coils for power system stabilization, load fluctuation compensation and frequency control have been fabricated and tested. In this paper, we introduce the present status of the project, including feasibility studies of an HTS SMES. [ABSTRACT FROM AUTHOR]

Single-nucleotide polymorphisms (SNPs) located in coding regions (coding SNPs; cSNPs) with amino acid substitution can potentially alter protein function. Therefore, identification of the nonsynonymous cSNPs of the genes of common diseases is valuable in tests of association with phenotypes. In this study, we validated 525 candidate cSNPs from 179 hypertension candidate genes deposited in the publicly available database dbSNP by DNA sequencing of samples from 32 Japanese individuals. We identified a total of 143 SNPs (27%) in 93 hypertension candidate genes. We also identified 16 new SNPs, for a total of 159 SNPs. Of the 159 SNPs thus identified, 104 were nonsynonymous. We estimate that approximately 20% of the SNPs deposited in dbSNP database showed a minor allele frequency of over 5%. The candidate SNPs for hypertension identified in this study would be valuable for association studies with hypertension to accelerate the identification of hypertension genes. [ABSTRACT FROM AUTHOR]

Examines the design and performance of a high temperature superconducting split magnet system for use in silicon single-crystal growth applications. Coil cooling using a cryocooler; Stored energy of the coil; Heat generation of the coil.

Studies the mechanical properties of Bi-2212 large capacity superconducting cable. Strans manufacture; Conductor manufacture and properties; Long length Rutherford cable characteristics.

Describes a mechanism that causes an additional alternating current (AC) loss in a large cable-in-conduit conductor (CICC) coil. Generation of additional AC loss by long current loops in the CIC conductor; Observation of magnetic field decays of the loops with various long time constants; Composition of the CICC by several staged sub-cables; Mechanisms causing long time constants.