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Inkjet 3D printing has potential in the additive manufacturing of electronic circuits and devices. However, inks that can be used for printing layers with T5%>300 °C or hardness>200 MPa have been rarely reported. Cyanate ester (CE) polymers have excellent thermal stability, high strength, and low shrinkage compared to other common dielectric inks for inkjet 3D printing, but cannot be quickly shaped by ultraviolet (UV) irradiation or thermal treatment. Combining CEs with UV-curable monomers may be a possible way to accelerate crosslinking, but there are challenges from the adverse effects of the dilution of both monomers. In this study, dielectric inks with acrylate and cyanate moieties were developed. The low viscosity and surface tension of the CE precursor (Bisphenol E cyanate ester) were combined with photocurable acrylate diluent monomers and cross-linker to realize an ink suitable for inkjet 3D printing. An internal dual three-dimensional cross-linked network structure resin was prepared by a combination of photocuring and thermal curing with T5% up to 326.69 °C, hardness up to 431.84 MPa, dielectric constant of 2.70 at 8 GHz, and shrinkage of 1.64%. The developed dielectric inks can be applied to the 3D printing of printed circuit boards and other electronic devices that require dielectric properties. [ABSTRACT FROM AUTHOR]

Purpose: The aim of this was to discover disease‐causing gene mutations linked to genetic epilepsy with febrile seizures plus (GEFS+) in a family in the Southern Chinese Han population. Of a three‐generation pedigree of 18 members in this family, 4 were affected with GEFS+. Method: Blood samples of 7 family members—3 affected and 4 unaffected individuals—were collected. Whole‐exome sequencing was performed to assess for genetic mutations in two of the affected individuals and two of the unaffected individuals. Results: Fourteen potentially consequential mutations were found in the two affected individuals and were validated with the Sanger sequencing method. Blood DNA tested in polymerase chain reaction with KCNAB3 primers revealed that one novel missense mutation, c.773A>G (p.H258R) in the KCNAB3 gene, which encoded the potassium voltage‐gated channel subfamily A regulatory β subunit 3 (KCNAB3), was shared by all three affected and one unaffected family member. However, this mutation did not appear in 300 unrelated control subjects. According to the bioinformatics tools SIFT and PROVEAN, p.H258R was thought to affect protein function. Functional verification showed that the KCNAB3 mutation could accelerate the inactivation of potassium channels, thus inhibiting potassium current, increasing neuronal excitability, and promoting epileptic convulsion. Conclusions: These results reveal that mutations in the KCNAB3 gene may be associated with GEFS+. [ABSTRACT FROM AUTHOR]

Fulminant myocarditis (FM) is a life-threatening disease in children. With a rapid, progressive course of deterioration, it causes refractory cardiorespiratory failure even with optimal clinical intervention. We present the case of a 9-year-old girl with FM complicated by cardiogenic shock, malignant arrhythmia, and refractory cardiac arrest. She received effective cardiopulmonary resuscitation, therapeutic hypothermia, and other supportive treatments. However, the patient rapidly worsened into pulseless ventricular tachycardia and refractory cardiac arrest. Therefore, we performed extracorporeal membrane oxygenation (ECMO) to establish spontaneous circulation after the failure of standard resuscitation measures. The girl recovered with intact cardiac and neurocognitive functions after continued ECMO treatment for 221 hours. Therefore, ECMO is an effective rescue therapeutics for FM, especially when complicated with refractory cardiac arrest. [ABSTRACT FROM AUTHOR]